Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Immunogen sequence: MELDLSPPHL SSSPEDLCPA PGTPPGTPRP PDTPLPEEVK RSQPLLIPTT GRKLREEERR ATSLPSIPNP FPELCSPPSQ SPILGGPSSA RGLLPRDASR PHVVKVYSED GACRSVEVAA GATARHVCEM LVQRAHALSD; Positive Samples: SKOV3, 22Rv1, HeLa; Cellular Location: Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic granule, Cytoplasmic side, Peripheral membrane protein, focal adhesion
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Alternative splicing results in multiple transcript variants encoding different isoforms, although the full-length natures of only two of the variants have been determined to date.
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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: B47; Epidermal growth factor receptor GRB-7; GRB7 adapter protein; Growth factor receptor-bound protein 7; OTTHUMP00000164352
Gene Aliases: GRB7
UniProt ID: (Human) Q14451
Entrez Gene ID: (Human) 2886
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