Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
H00026585-M04
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
4C2
Immunogen
GREM1 (NP_037504, 75 a.a. approximately 184 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: ESSQEALHVT ERKYLKRDWC KTQPLKQTIH EEGCNSRTII NRFCYGQCNS FYIPRHIRKE EGSFQSCSFC KPKKFTTMMV TLNCPELQPP TKKKRVTRVK QCRCISIDLD
Target Information
In Xenopus, Gremlin belongs to a novel gene family that act as BMP antagonists in embryonic explants. The human homolog of Drm/Gremlin (CKTFS1B1) is localized on human chromosome 15q13--> q15. DRM-specific mRNA is expressed in different human tissues, including brain, ovary, intestine and colon. It has been suggested that down-regulation of DRM is associated with tumor progression, and support the hypothesis that human DRM may play an important role during both neuroembryological development and carcinogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Cell proliferation-inducing gene 2 protein; colorectal adenoma and carcinoma 1; Cysteine knot superfamily 1, BMP antagonist 1; DAN domain family member 2; Down-regulated in Mos-transformed cells protein; gremlin 1, cysteine knot superfamily, homolog; gremlin 1-like protein; Gremlin-1; IHG-2; Increased in high glucose protein 2; increased in high glucose-2
Gene Aliases: C15DUPq; CKTSF1B1; CRAC1; CRCS4; DAND2; DRM; DUP15q; GREM1; GREMLIN; HMPS; HMPS1; IHG-2; MPSH; PIG2
UniProt ID: (Human) O60565
Entrez Gene ID: (Human) 26585
cell morphogenesis
branching involved in ureteric bud morphogenesis
cell migration involved in sprouting angiogenesis
positive regulation of receptor internalization
positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
mesenchymal to epithelial transition involved in metanephros morphogenesis
apoptotic process
signal transduction
activation of transmembrane receptor protein tyrosine kinase activity
cell-cell signaling
positive regulation of cell proliferation
proximal/distal pattern formation
regulation of epithelial to mesenchymal transition
collagen fibril organization
negative regulation of cell growth
embryonic limb morphogenesis
negative regulation of bone mineralization
negative regulation of BMP signaling pathway
negative regulation of chondrocyte differentiation
regulation of stress-activated MAPK cascade
negative regulation of osteoblast proliferation
positive regulation of NF-kappaB import into nucleus
negative regulation of apoptotic process
positive regulation of angiogenesis
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of bone remodeling
determination of dorsal identity
positive regulation of NF-kappaB transcription factor activity
regulation of focal adhesion assembly
positive regulation of telomerase activity
limb development
negative regulation of pathway-restricted SMAD protein phosphorylation
ureteric bud formation
positive regulation of protein tyrosine kinase activity
signal transduction by p53 class mediator
negative regulation of monocyte chemotaxis
negative regulation of canonical Wnt signaling pathway
positive regulation of branching involved in ureteric bud morphogenesis
negative regulation of branching involved in ureteric bud morphogenesis
negative regulation of osteoclast proliferation
positive regulation of peptidyl-tyrosine autophosphorylation
negative regulation of bone trabecula formation
negative regulation of bone mineralization involved in bone maturation
positive regulation of receptor activity
positive regulation of cardiac muscle cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support