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Product Details
PA5-32858
Product Specifications
Species Reactivity
Bat,
Bovine,
Chicken,
Horse,
Human,
Mouse,
Non-human primate,
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 15 amino acid peptide from internal region of human GRK5.
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2550319
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Mouse, Rat, Bat, Bovine, Panda, Horse, Pig, Opossum, Turkey, Chicken, Platypus (100%); Orangutan, Dog, Elephant, Xenopus (93%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
GRK5 is a serine/threonine kinase that regulates the activity of a variety of G protein-coupled receptors and the motility of polymorphonuclear leukocytes. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha-CP4; FP2025; G protein-coupled receptor kinase 5; G protein-coupled receptor kinase GRK5; GRK; GRK-pan; Pan-GRK; Poly(rC)-binding protein 4
Gene Aliases: 1200003L19Rik; AlphaCP-4; GPRK5; GRK5; Pcbp4
UniProt ID: (Bovine) P43249, (Human) P34947, (Mouse) Q8VEB1, (Rat) Q62833, (Mouse) P57724
Entrez Gene ID: (Bovine) 281801, (Human) 2869, (Chicken) 423929, (Horse) 100065919, (Pig) 100152937, (Mouse) 14773, (Rat) 59075, (Mouse) 59092
protein serine/threonine kinase activity
G-protein coupled receptor kinase activity
ATP binding
lipid binding
beta-adrenergic receptor kinase activity
protein kinase C binding
protein binding
phospholipid binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
nucleic acid binding
DNA binding
RNA binding
poly(A) RNA binding
RNA metabolism protein
non-receptor serine/threonine protein kinase
apoptotic process
tachykinin receptor signaling pathway
positive regulation of cell proliferation
Wnt signaling pathway
negative regulation of apoptotic process
fat cell differentiation
protein autophosphorylation
regulation of cell cycle
desensitization of G-protein coupled receptor protein signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
regulation of G-protein coupled receptor protein signaling pathway
response to drug
protein phosphorylation
signal transduction
phosphorylation
termination of G-protein coupled receptor signaling pathway
negative regulation of mRNA splicing, via spliceosome
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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