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Invitrogen
GSK3 alpha Recombinant Rabbit Monoclonal Antibody (23GB855)
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 4
GSK3 alpha Antibody (MA5-54226) in ICC/IF
Immunocytochemistry analysis of GSK3 alpha in HepG2 cells. Nuclei were stained blue with DAPI; GSK3 alpha recombinant monoclonal antibody (Product # MA5-54226) with a dilution of 1:1,000 was stained magenta with Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
Product Details
MA5-54226
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
23GB855
Immunogen
A synthetic peptide of human GSK3A (50-100AA).
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Target Information
Glycogen synthase kinase 3 alpha (GSK3A) is a multifunctional protein serine/threonine kinase implicated in the control of several regulatory proteins and transcription factors. (GSK3A Alias: DKFZp686D0638). Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686D0638; FA; Factor A; Glycogen synthase kinase-3 alpha; GSK-3 alpha; gsk-3-alpha; OTTHUMP00000198368; Serine/threonine-protein kinase GSK3A
Gene Aliases: 2700086H06Rik; GSK3A
UniProt ID: (Human) P49840, (Rat) P18265, (Mouse) Q2NL51
Entrez Gene ID: (Human) 2931, (Rat) 50686, (Mouse) 606496
protein serine/threonine kinase activity
protein binding
ATP binding
protein kinase A catalytic subunit binding
tau-protein kinase activity
protein kinase activity
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
regulation of systemic arterial blood pressure
cardiac left ventricle morphogenesis
glycogen metabolic process
protein phosphorylation
dopamine receptor signaling pathway
nervous system development
insulin receptor signaling pathway
negative regulation of UDP-glucose catabolic process
Wnt signaling pathway
positive regulation of cAMP biosynthetic process
negative regulation of TOR signaling
cellular response to insulin stimulus
cellular response to interleukin-3
IRE1-mediated unfolded protein response
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of glycogen biosynthetic process
positive regulation of protein catabolic process
positive regulation of heart contraction
negative regulation of glucose import
negative regulation of insulin receptor signaling pathway
negative regulation of cell growth involved in cardiac muscle cell development
positive regulation of adrenergic receptor signaling pathway
negative regulation of canonical Wnt signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand
chemical synaptic transmission, postsynaptic
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
regulation of mitophagy
positive regulation of protein targeting to mitochondrion
negative regulation of glycogen synthase activity, transferring glucose-1-phosphate
negative regulation of type B pancreatic cell development
negative regulation of glycogen (starch) synthase activity
positive regulation of glycogen (starch) synthase activity
regulation of gene expression by genetic imprinting
signal transduction
positive regulation of peptidyl-threonine phosphorylation
cell migration
positive regulation of peptidyl-serine phosphorylation
hypermethylation of CpG island
positive regulation of transcription from RNA polymerase II promoter
negative regulation of transferase activity
cellular response to lithium ion
cellular response to organic cyclic compound
carbohydrate metabolic process
negative regulation of signal transduction
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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