Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: MSGRPRTTS FAESCKPVQQ PSAFGSMKVS RDKDGSKVTT VVATPGQGPD RPQEVSYTDT KVIGNGSFGV VYQAKLCDSG ELVAIKKVLQ DKRFKNRELQ IMRKLDHCNI VRLRYFFYSS GEKKDEVYLN LVLDYVPETV YRVARHYSRA KQTLPVIYVK LYMYQLFRSL AYIHSFGICH RDIKPQNLLL DPDTAVLKLC DFGSAKQLVR GEPNVSYICS RYYRAPELIF GATDYTSSID VWSAGCVLAE LLLGQPIFPG DSGVDQLVEI IKVLGTPTRE QIREMNPNYT EFKFPQIKAH PWTKDSSGTG HFTSGVRVFR PRTPPEAIAL CSRLLEYTPT ARLTPLEACA HSFFDELRDP NVKLPNGRDT PALFNFTTQE LSSNPPLATI LIPPHARIQA AASTPTNATA ASDANTGDRG QTNNAASASA SNST (1-433 aa encoded by BC000251)
GSK3B is a proline-directed serine/threonine protein kinase involved in energy metabolism, neuronal cell development and body pattern formation. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. GSK3B is a critical component of the Wnt/beta-catenin signaling pathway, and its activity results in the inhibition of Wnt signaling by mediating the degradation of beta-catenin. GSK3B is also involved in the Hedgehog, Notch, and insulin signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EC 2.7.11.26; Glycogen synthase kinase-3 beta; GSK 3 beta; GSK 3B; GSK-3 beta; GSK-3 beta GSK3B; GSK-3b; GSK3 beta; GSK3beta isoform; Serine/threonine-protein kinase GSK3B
Gene Aliases: 7330414F15Rik; 8430431H08Rik; C86142; GSK-3; GSK-3beta; GSK3; GSK3B
UniProt ID: (Human) P49841, (Mouse) Q9WV60
Entrez Gene ID: (Human) 2932, (Mouse) 56637
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support