Product References
MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain.
Nature communications
Becht DC,Klein BJ,Kanai A,Jang SM,Cox KL,Zhou BR,Phanor SK,Zhang Y,Chen RW,Ebmeier CC,Lachance C,Galloy M,Fradet-Turcotte A,Bulyk ML,Bai Y,Poirier MG,Côté J,Yokoyama A,Kutateladze TG
A-11131 was used in ChIP Assay, Flow Cytometry, Immunocytochemistry, Western Blot to identify and characterize two structured winged helix (WH) domains, WH1 and WH2, in MORF and MOZ.
Wed Feb 08 00:00:00 EST 2023
PPARγ lipodystrophy mutants reveal intermolecular interactions required for enhancer activation.
Nature communications
Madsen MS,Broekema MF,Madsen MR,Koppen A,Borgman A,Gräwe C,Thomsen EGK,Westland D,Kranendonk MEG,Koerkamp MG,Hamers N,Bonvin AMJJ,Pittol JMR,Natarajan KN,Kersten S,Holstege FCP,Monajemi H,van Mil SWC,Vermeulen M,Kragelund BB,Cassiman D,Mandrup S,Kalkhoven E
A-11131 was used in Flow Cytometry, Immunocytochemistry, Western Blot to demonstrate how in-depth analyses of lipodystrophy mutants can unravel molecular mechanisms of PPARγ function.
Sat Nov 19 00:00:00 EST 2022
SARS-CoV-2 Envelope (E) Protein Binds and Activates TLR2 Pathway: A Novel Molecular Target for COVID-19 Interventions.
Viruses
Planès R,Bert JB,Tairi S,BenMohamed L,Bahraoui E
A-11131 was used in Flow cytometry/Cell sorting to exhibit molecular characterization of the interaction between the SARS-CoV-2 envelope (E) protein and TLR2, for therapeutic potential.
Sun May 08 00:00:00 EDT 2022
The common YAP activation mediates corneal epithelial regeneration and repair with different-sized wounds.
NPJ Regenerative medicine
Li Y,Ge L,Chen X,Mao Y,Gu X,Ren B,Zeng Y,Chen M,Chen S,Liu J,Yang Y,Xu H
Published figure using GST Tag polyclonal antibody (Product # A-11131) in Immunohistochemistry
Fri Mar 26 00:00:00 EDT 2021
The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands.
Science advances
Stielow B,Zhou Y,Cao Y,Simon C,Pogoda HM,Jiang J,Ren Y,Phanor SK,Rohner I,Nist A,Stiewe T,Hammerschmidt M,Shi Y,Bulyk ML,Wang Z,Liefke R
Published figure using GST Tag polyclonal antibody (Product # A-11131) in Protein Assays and Analysis
Sat May 01 00:00:00 EDT 2021
The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands.
Science advances
Stielow B,Zhou Y,Cao Y,Simon C,Pogoda HM,Jiang J,Ren Y,Phanor SK,Rohner I,Nist A,Stiewe T,Hammerschmidt M,Shi Y,Bulyk ML,Wang Z,Liefke R
Published figure using GST Tag polyclonal antibody (Product # A-11131) in Protein Assays and Analysis
Sat May 01 00:00:00 EDT 2021
Context and number of noncanonical repeat variable diresidues impede the design of TALE proteins with improved DNA targeting.
Protein science : a publication of the Protein Society
Anderson JT,Rogers JM,Barrera LA,Bulyk ML
A-11131 was used in Immunocytochemistry to investigate RVD-nucleotide specificities in multiple protein contexts and suggest that a balance between canonical and noncanonical RVDs is needed to build TALEs with improved specificity.
Sat Feb 01 00:00:00 EST 2020
The selective glucocorticoid receptor antagonist CORT125281 has tissue-specific activity.
The Journal of endocrinology
Koorneef LL,Kroon J,Viho EMG,Wahl LF,Heckmans KML,van Dorst MMAR,Hoekstra M,Houtman R,Hunt H,Meijer OC
A-11131 was used in Binding experiments to characterize the tissue-specific properties of the selective glucocorticoid receptor antagonist CORT125281.
Wed Jul 01 00:00:00 EDT 2020
The selective glucocorticoid receptor antagonist CORT125281 has tissue-specific activity.
The Journal of endocrinology
Koorneef LL,Kroon J,Viho EMG,Wahl LF,Heckmans KML,van Dorst MMAR,Hoekstra M,Houtman R,Hunt H,Meijer OC
A-11131 was used in Binding experiments to characterize the tissue-specific properties of the selective glucocorticoid receptor antagonist CORT125281.
Wed Jul 01 00:00:00 EDT 2020
Bispecific Forkhead Transcription Factor FoxN3 Recognizes Two Distinct Motifs with Different DNA Shapes.
Molecular cell
Rogers JM,Waters CT,Seegar TCM,Jarrett SM,Hallworth AN,Blacklow SC,Bulyk ML
A-11131 was used in Protein Binding Microarray to reveal how a single TF binds two unrelated DNA sequences and the importance of DNA shape in the mechanism of bispecific recognition.
Thu Apr 18 00:00:00 EDT 2019
Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch.
Cell
Liu N,Hargreaves VV,Zhu Q,Kurland JV,Hong J,Kim W,Sher F,Macias-Trevino C,Rogers JM,Kurita R,Nakamura Y,Yuan GC,Bauer DE,Xu J,Bulyk ML,Orkin SH
A-11131 was used in Antibody array to establish a requirement for a zinc-finger cluster in BCL11A in repression and identify a preferred DNA recognition sequence.
Thu Apr 05 00:00:00 EDT 2018
DNA-binding landscape of IRF3, IRF5 and IRF7 dimers: implications for dimer-specific gene regulation.
Nucleic acids research
Andrilenas KK,Ramlall V,Kurland J,Leung B,Harbaugh AG,Siggers T
A-11131 was used in a Microarray to find that both DNA-binding affinity and affinity-independent mechanisms determine the function of DNA-bound IRF dimers.
Fri Mar 16 00:00:00 EDT 2018
Toward deciphering the mechanistic role of variations in the Rep1 repeat site in the transcription regulation of SNCA gene.
Neurogenetics
Afek A,Tagliafierro L,Glenn OC,Lukatsky DB,Gordan R,Chiba-Falek O
A-11131 was used in in vitro experiments to study the mechanism by which Rep1 affects the binding of transcription factors from the GATA and ELK families to their specific sites.
Wed Aug 01 00:00:00 EDT 2018
Selective Glucocorticoid Receptor Properties of GSK866 Analogs with Cysteine Reactive Warheads.
Frontiers in immunology
Chirumamilla CS,Palagani A,Kamaraj B,Declerck K,Verbeek MWC,Oksana R,De Bosscher K,Bougarne N,Ruttens B,Gevaert K,Houtman R,De Vos WH,Joossens J,Van Der Veken P,Augustyns K,Van Ostade X,Bogaerts A,De Winter H,Vanden Berghe W
A-11131 was used in Peptide array to develop GSK866 analogues with electrophilic covalent-binding warheads and potential selective glucocorticoid receptor agonist properties to improve their clinical safety profile for long-lasting topical skin disease applications.
Wed Nov 20 00:00:00 EST 2019
Differential modulation of FXR activity by chlorophacinone and ivermectin analogs.
Toxicology and applied pharmacology
Hsu CW,Hsieh JH,Huang R,Pijnenburg D,Khuc T,Hamm J,Zhao J,Lynch C,van Beuningen R,Chang X,Houtman R,Xia M
A-11131 was used in Peptide microarrays to study the farnesoid X receptor antagonist activity of selected structural classes.
Thu Dec 15 00:00:00 EST 2016
Expansion of GA Dinucleotide Repeats Increases the Density of CLAMP Binding Sites on the X-Chromosome to Promote Drosophila Dosage Compensation.
PLoS genetics
Kuzu G,Kaye EG,Chery J,Siggers T,Yang L,Dobson JR,Boor S,Bliss J,Liu W,Jogl G,Rohs R,Singh ND,Bulyk ML,Tolstorukov MY,Larschan E
A11131 was used to suggest that expansion of GA-dinucleotide repeats on the X-chromosome over evolutionary time helps to regulate dosage of gene expression
Fri Jul 01 00:00:00 EDT 2016
A Mixed Glucocorticoid/Mineralocorticoid Selective Modulator With Dominant Antagonism in the Male Rat Brain.
Endocrinology
Atucha E,Zalachoras I,van den Heuvel JK,van Weert LT,Melchers D,Mol IM,Belanoff JK,Houtman R,Hunt H,Roozendaal B,Meijer OC
A-11131 was used in ELISA to assess the effects of a mineralocorticoid and glucocorticoid receptor ligand on the brain
Sun Nov 01 00:00:00 EDT 2015
Identification and Characterization of the Interaction Site between cFLIPL and Calmodulin.
PloS one
Gaidos G,Panaitiu AE,Guo B,Pellegrini M,Mierke DF
Published figure using GST Tag polyclonal antibody (Product # A-11131) in ELISA
Fri Jun 10 00:00:00 EDT 2016
Context influences on TALE-DNA binding revealed by quantitative profiling.
Nature communications
Rogers JM,Barrera LA,Reyon D,Sander JD,Kellis M,Joung JK,Bulyk ML
A-11131 was used in ELISA to assess how quantitative profiling has contextual influences on TALE-DNA binding
Thu Jun 11 00:00:00 EDT 2015
Protein-DNA binding in the absence of specific base-pair recognition.
Proceedings of the National Academy of Sciences of the United States of America
Afek A,Schipper JL,Horton J,Gordân R,Lukatsky DB
A-11131 was used to study transcription factor-DNA binding
Tue Dec 02 00:00:00 EST 2014
Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor.
Chemical research in toxicology
Murayama N,van Beuningen R,Suemizu H,Guillouzo CG,Shibata N,Yajima K,Utoh M,Shimizu M,Chesné C,Nakamura M,Guengerich FP,Houtman R,Yamazaki H
A-11131 was used in immunocytochemistry to study the regulation of human hepatic drug metabolizing enzymes.
Mon Feb 17 00:00:00 EST 2014
Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator.
Proceedings of the National Academy of Sciences of the United States of America
Zalachoras I,Houtman R,Atucha E,Devos R,Tijssen AM,Hu P,Lockey PM,Datson NA,Belanoff JK,Lucassen PJ,Joëls M,de Kloet ER,Roozendaal B,Hunt H,Meijer OC
A-11131 was used in Binding experiments to demonstrate that C108297 induces a unique interaction profile between the glucocorticoid receptor and its downstream effector molecules compared with the full agonist dexamethasone and the antagonist RU486.
Tue May 07 00:00:00 EDT 2013
Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor γ.
Molecular and cellular biology
Alex S,Lange K,Amolo T,Grinstead JS,Haakonsson AK,Szalowska E,Koppen A,Mudde K,Haenen D,Al-Lahham S,Roelofsen H,Houtman R,van der Burg B,Mandrup S,Bonvin AM,Kalkhoven E,Müller M,Hooiveld GJ,Kersten S
A-11131 was used to elucidate how short-chain fatty acids regulate the expression of angiopoietin-like protein 4
Mon Apr 01 00:00:00 EDT 2013
Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL.
PloS one
Del Bianco C,Vedenko A,Choi SH,Berger MF,Shokri L,Bulyk ML,Blacklow SC
A-11131 was used to test if the association of Notch and Mastermind-like proteins affects the DNA binding preferences of CSL
Wed Nov 24 00:00:00 EST 2010
Universal protein-binding microarrays for the comprehensive characterization of the DNA-binding specificities of transcription factors.
Nature protocols
Berger MF,Bulyk ML
A-11131 was used to develop a protocol for the examination and analysis of transcription factor-binding specificities at high resolution using an 'all 10-mer' universal protein-binding microarray.
Fri Jun 12 00:00:00 EDT 2009
Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) but not PPARalpha serves as a plasma free fatty acid sensor in liver.
Molecular and cellular biology
Sanderson LM,Degenhardt T,Koppen A,Kalkhoven E,Desvergne B,Müller M,Kersten S
A-11131 was used to compare genes induced by Wy14643 treatment and fasting
Tue Dec 01 00:00:00 EST 2009
Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor.
Molecular & cellular proteomics : MCP
Koppen A,Houtman R,Pijnenburg D,Jeninga EH,Ruijtenbeek R,Kalkhoven E
A-11131 was used in immunoprecipitation to report a comprehensive overview of NR-coregulator interactions
Thu Oct 01 00:00:00 EDT 2009
Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor.
Molecular & cellular proteomics : MCP
Koppen A,Houtman R,Pijnenburg D,Jeninga EH,Ruijtenbeek R,Kalkhoven E
A-11131 was used in immunoprecipitation to report a comprehensive overview of NR-coregulator interactions
Thu Oct 01 00:00:00 EDT 2009
Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities.
Nature biotechnology
Berger MF,Philippakis AA,Qureshi AM,He FS,Estep PW,Bulyk ML
A-11131 was used to discuss the creation of an unbiased oligomer-based microarray
Wed Nov 01 00:00:00 EST 2006
Rapid analysis of the DNA-binding specificities of transcription factors with DNA microarrays.
Nature genetics
Mukherjee S,Berger MF,Jona G,Wang XS,Muzzey D,Snyder M,Young RA,Bulyk ML
A-11131 was used to utilize DNA microarrays to study rapid analysis of the DNA-binding specificities of transcription factors
Wed Dec 01 00:00:00 EST 2004
The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain.
Cell
Elia AE,Rellos P,Haire LF,Chao JW,Ivins FJ,Hoepker K,Mohammad D,Cantley LC,Smerdon SJ,Yaffe MB
A-11131 was used in immunocytochemistry to study the Polo-box domain as the molecular basis for phosphodependent substrate targeting and regulation of Plks
Fri Oct 03 00:00:00 EDT 2003
