Proteintech

GSTT1 Polyclonal Antibody

GSTT1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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GSTT1 Antibody (15838-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human kidney tissue slide using 15838-1-AP (GSTT1 Antibody) at dilution of 1:50 (under 40x lens).

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Product Details

15838-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Hamster, Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GSTT1 Fusion Protein Ag8588 (1-240 aa encoded by BC007065)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MGLELYLDL LSQPCRAVYI FAKKNDIPFE LRIVDLIKGQ HLSDACAQVN PLKKVPALKD GDFTLTESVA ILLYLTRKYK VPDYWYPQDL QARARVDEYL AWQHTTLRRS CLRALWHKVM FPVFLGEPVS PQTLAATLAE LDVTLQLLED KFLQNKAFLT GPHISLADLV AITELMHPVG AGCQVFEGRP KLATWRQRVE AAVGEDLFQE AHEVILKAKD FPPADPTIKQ KLMPWVLAMI R (1-240 aa encoded by BC007065)

Target Information

Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

COPS5 Conferred the Platinum Resistance in Epithelial Ovarian Cancer.

Current issues in molecular biology

Zhang H,Yan T,Zhong A,Guo L,Lu R

Thu Sep 01 00:00:00 EDT 2022

Gstm1/Gstt1 is essential for reducing cisplatin ototoxicity in CBA/CaJ mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Li P,Liu Z,Wang J,Bi X,Xiao Y,Qiao R,Zhou X,Guo S,Wan P,Chang M,Hong G,Liu Z,Ming X,Gao J,Fu X

Wed Jun 01 00:00:00 EDT 2022

The hepatic compensatory response to elevated systemic sulfide promotes diabetes.

Cell reports

Carter RN,Gibbins MTG,Barrios-Llerena ME,Wilkie SE,Freddolino PL,Libiad M,Vitvitsky V,Emerson B,Le Bihan T,Brice M,Su H,Denham SG,Homer NZM,Mc Fadden C,Tailleux A,Faresse N,Sulpice T,Briand F,Gillingwater T,Ahn KH,Singha S,McMaster C,Hartley RC,Staels B,Gray GA,Finch AJ,Selman C,Banerjee R,Morton NM

Tue Nov 09 00:00:00 EST 2021

Rare Disease Mechanisms Identified by Genealogical Proteomics of Copper Homeostasis Mutant Pedigrees.

Cell systems

Zlatic SA,Vrailas-Mortimer A,Gokhale A,Carey LJ,Scott E,Burch R,McCall MM,Rudin-Rush S,Davis JB,Hartwig C,Werner E,Li L,Petris M,Faundez V

Wed Mar 28 00:00:00 EDT 2018

Determination of Hepatotoxicity and Its Underlying Metabolic Basis of 1,2-Dichloropropane in Male Syrian Hamsters and B6C3F1 Mice.

Toxicological sciences : an official journal of the Society of Toxicology

Gi M,Fujioka M,Yamano S,Shimomura E,Ishii N,Kakehashi A,Takeshita M,Wanibuchi H

Fri May 01 00:00:00 EDT 2015

Determination of Hepatotoxicity and Its Underlying Metabolic Basis of 1,2-Dichloropropane in Male Syrian Hamsters and B6C3F1 Mice.

Toxicological sciences : an official journal of the Society of Toxicology

Gi M,Fujioka M,Yamano S,Shimomura E,Ishii N,Kakehashi A,Takeshita M,Wanibuchi H

Fri May 01 00:00:00 EDT 2015

A trial to find appropriate animal models of dichloropropane-induced cholangiocarcinoma based on the hepatic distribution of glutathione S-transferases.

Journal of occupational health

Zhang L,Zong C,Ichihara S,Naito H,Toyokuni S,Kumagai S,Ichihara G

Thu Sep 29 00:00:00 EDT 2016

A trial to find appropriate animal models of dichloropropane-induced cholangiocarcinoma based on the hepatic distribution of glutathione S-transferases.

Journal of occupational health

Zhang L,Zong C,Ichihara S,Naito H,Toyokuni S,Kumagai S,Ichihara G

Thu Sep 29 00:00:00 EDT 2016

Modifying effects of 1,2-dichloropropane on N-nitrosobis(2-oxopropyl)amine-induced cholangiocarcinogenesis in male Syrian hamsters.

The Journal of toxicological sciences

Gi M,Fujioka M,Yamano S,Shimomura E,Kanki M,Kawachi S,Tachibana H,Tatsumi K,Fang H,Ishii N,Kakehashi A,Wanibuchi H

Thu Jun 09 00:00:00 EDT 2016

Modifying effects of 1,2-dichloropropane on N-nitrosobis(2-oxopropyl)amine-induced cholangiocarcinogenesis in male Syrian hamsters.

The Journal of toxicological sciences

Gi M,Fujioka M,Yamano S,Shimomura E,Kanki M,Kawachi S,Tachibana H,Tatsumi K,Fang H,Ishii N,Kakehashi A,Wanibuchi H

Thu Jun 09 00:00:00 EDT 2016

Different carcinogenic process in cholangiocarcinoma cases epidemically developing among workers of a printing company in Japan.

International journal of clinical and experimental pathology

Sato Y,Kubo S,Takemura S,Sugawara Y,Tanaka S,Fujikawa M,Arimoto A,Harada K,Sasaki M,Nakanuma Y

Tue Jun 09 00:00:00 EDT 2015

Different carcinogenic process in cholangiocarcinoma cases epidemically developing among workers of a printing company in Japan.

International journal of clinical and experimental pathology

Sato Y,Kubo S,Takemura S,Sugawara Y,Tanaka S,Fujikawa M,Arimoto A,Harada K,Sasaki M,Nakanuma Y

Tue Jun 09 00:00:00 EDT 2015

Evaluation of hepatic glutathione transferase Mu 1 and Theta 1 activities in humans and mice using genotype information.

Drug metabolism and disposition: the biological fate of chemicals

Arakawa S,Fujimoto K,Kato A,Endo S,Fukahori A,Shinagawa A,Fischer T,Mueller J,Takasaki W

Thu Mar 01 00:00:00 EST 2012

Evaluation of hepatic glutathione transferase Mu 1 and Theta 1 activities in humans and mice using genotype information.

Drug metabolism and disposition: the biological fate of chemicals

Arakawa S,Fujimoto K,Kato A,Endo S,Fukahori A,Shinagawa A,Fischer T,Mueller J,Takasaki W

Thu Mar 01 00:00:00 EST 2012

Bioinformatics

Protein Aliases: Glutathione S-transferase 1 (theta); Glutathione S-transferase 5; Glutathione S-transferase theta-1; Glutathione transferase T1-1; GST 5-5; GST class-theta-1

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Gene Aliases: AI255817; GSTT1; Gstt1-1; GSTYRS

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UniProt ID: (Human) P30711, (Rat) Q01579, (Mouse) Q64471

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Entrez Gene ID: (Human) 2952, (Rat) 25260, (Mouse) 14871

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Function(s)

glutathione transferase activity glutathione peroxidase activity alkylhalidase activity transferase activity

Process(es)

glutathione metabolic process cellular oxidant detoxification glutathione derivative biosynthetic process DNA modification response to salicylic acid response to selenium ion response to organic cyclic compound dichloromethane metabolic process response to vitamin E response to drug oxidation-reduction process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GSTT1 Polyclonal Antibody

GSTT1 Antibody (15838-1-AP) in IHC (P)

Product Details

15838-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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