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Product Details
17052-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GTF2IRD1 Fusion Protein Ag10718 (610-959 aa encoded by BC018136)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ISLRRPNCF GIAKLRKILE ASNSIQFVIK RPELLTEGVK EPIVDSQGTA SSLGFSPPAL PPERDSGDPL VDESLKRQGF QENYDARLSR IDIANTLREQ VQDLFNKKYG EALGIKYPVQ VPYKRIKSNP GSVIIEGLPP GIPFRKPCTF GSQNLERILA VADKIKFTVT RPFQGLIPKP DEDDANRLGE KVILREQVKE LFNEKYGEAL GLNRPVLVPY KLIRDSPDAV EVTGLPDDIP FRNPNTYDIH RLEKILKARE HVRMVIINQL QPFAEICNDA KVPAKDSSIP KRKRKRVSEG NSVSSSSSSS SSSSSNPDSV ASANQISLVQ WPMYMVDYAG LNVQLPGPLN Y (610-959 aa encoded by BC018136)
Target Information
Williams-Beuren syndrome (WBS) is a developmental disorder caused by the hemizygous microdeletion on chromosome 7q11.23. WBS is an autosomal dominant genetic condition that is characterized by physical, cognitive and behavioral traits. The physical traits associated with WBS include facial dysmorphology, vascular stenoses, growth deficiencies, dental anomalies and neurologic and musculoskeletal abnormalities. Mild retardation, a weakness in visual-spatial skills, anxiety and a short attention span are typical cognitive and behavioral traits of WBS patients. The WBSCR11 gene is located within the WBS deletion and may contribute to the developmental symptoms found in WBS because of a loss of the encoded transcription factor. WBSCR11 is also designated GRF2IRD1, GTF3, Cream1 and MusTRD1 in human and BEN in mouse, due to slight differences in gene structure. WBSCR11 is expressed in all adult tissues as several variants and has discrete spatial and temporal expression during embryogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alb-c-myc line 166.8; Alb/c-myc line 166.8; Binding factor for early enhancer; c-myc line 166.8; general transcription factor 3; general transcription factor II I repeat domain-containing 1; General transcription factor II-I repeat domain-containing protein 1; General transcription factor III; GTF2I repeat domain-containing 1; GTF2I repeat domain-containing protein 1; Muscle TFII-I repeat domain-containing protein 1; muscle TFII-I repeat domain-containing protein 1 alpha 1; MusTRD1/BEN; Slow-muscle-fiber enhancer-binding protein; transcription factor GTF3 alpha 2; transcription factor GTF3 gamma 2; USE B1-binding protein; Williams-Beuren syndrome chromosomal region 11 protein; Williams-Beuren syndrome chromosomal region 12 protein; Williams-Beuren syndrome chromosome region 11
Gene Aliases: 1700012P16Rik; BEN; CREAM1; ESTM9; Gtf2il; GTF2IRD1; GTF3; hMusTRD1alpha1; MUSTRD1; RBAP2; Tg(Alb1-Myc)166.8Sst; WBS; WBSCR11; WBSCR12; X83320
UniProt ID: (Human) Q9UHL9, (Mouse) Q9JI57
Entrez Gene ID: (Human) 9569, (Mouse) 57080, (Rat) 246770
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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