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Gamma cystathionase Monoclonal Antibody (2C7F9)

Gamma cystathionase Antibody in Immunocytochemistry (ICC/IF)

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Gamma cystathionase Antibody (60234-1-IG) in ICC/IF

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed HepG2 cells using 60234-1-IG (Gamma cystathionase antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Mouse IGG (H+L).

Gamma cystathionase Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Gamma cystathionase Antibody in Western Blot (WB)

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Product Details

60234-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:6,000

View 18 publications 18 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:800

Immunocytochemistry (ICC/IF)

1:20-1:200

View 3 publications 3 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Dog, Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

2C7F9

Immunogen

Gamma cystathionase Fusion Protein Ag2872 (74-406 aa encoded by BC015807)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: AVAALDGAK YCLAFASGLA ATVTITHLLK AGDQIICMDD VYGGTNRYFR QVASEFGLKI SFVDCSKIKL LEAAITPETK LVWIETPTNP TQKVIDIEGC AHIVHKHGDI ILVVDNTFMS PYFQRPLALG ADISMYSATK YMNGHSDVVM GLVSVNCESL HNRLRFLQNS LGAVPSPIDC YLCNRGLKTL HVRMEKHFKN GMAVAQFLES NPWVEKVIYP GLPSHPQHEL VKRQCTGCTG MVTFYIKGTL QHAEIFLKNL KLFTLAESLG GFESLAELPA IMTHASVLKN DRDVLGISDT LIRLSVGLED EEDLLEDLDQ ALKAAHPPSG SHS (74-406 aa encoded by BC015807)

Target Information

This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Hydrogen sulfide alleviates heart failure with preserved ejection fraction in mice by targeting mitochondrial abnormalities via PGC-1α.

Nitric oxide : biology and chemistry

Huang S,Chen X,Pan J,Zhang H,Ke J,Gao L,Yu Chang AC,Zhang J,Zhang H

Sat Jul 01 00:00:00 EDT 2023

Hydrogen sulfide attenuates TMAO‑induced macrophage inflammation through increased SIRT1 sulfhydration.

Molecular medicine reports

Liu MH,Lin XL,Xiao LL

Sat Jul 01 00:00:00 EDT 2023

Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor-induced dipeptidase-1 expression and glutathione depletion.

Science advances

von Mässenhausen A,Zamora Gonzalez N,Maremonti F,Belavgeni A,Tonnus W,Meyer C,Beer K,Hannani MT,Lau A,Peitzsch M,Hoppenz P,Locke S,Chavakis T,Kramann R,Muruve DA,Hugo C,Bornstein SR,Linkermann A

Fri Feb 04 00:00:00 EST 2022

Vascular smooth muscle cell-derived hydrogen sulfide promotes atherosclerotic plaque stability via TFEB (transcription factor EB)-mediated autophagy.

Autophagy

Chen Z,Ouyang C,Zhang H,Gu Y,Deng Y,Du C,Cui C,Li S,Wang W,Kong W,Chen J,Cai J,Geng B

Sat Oct 01 00:00:00 EDT 2022

Altered transsulfuration pathway enzymes and redox homeostasis in inherited retinal degenerative diseases.

Experimental eye research

Badiei A,Beltran WA,Aguirre GD

Tue Feb 01 00:00:00 EST 2022

Altered transsulfuration pathway enzymes and redox homeostasis in inherited retinal degenerative diseases.

Experimental eye research

Badiei A,Beltran WA,Aguirre GD

Tue Feb 01 00:00:00 EST 2022

Hydrogen sulfide ameliorated preeclampsia via suppression of toll-like receptor 4-activated inflammation in the rostral ventrolateral medulla of rats.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Du J,Wang P,Gou Q,Jin S,Xue H,Li D,Tian D,Sun J,Zhang X,Teng X,Wu Y

Wed Jun 01 00:00:00 EDT 2022

Endogenous and exogenous hydrogen sulfide modulates urothelial bladder carcinoma development in human cell lines.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Panza E,Bello I,Smimmo M,Brancaleone V,Mitidieri E,Bucci M,Cirino G,Sorrentino R,D Emmanuele di Villa Bianca R

Fri Jul 01 00:00:00 EDT 2022

Vasoactive Effects of Chronic Treatment with Fructose and Slow-Releasing H₂S Donor GYY-4137 in Spontaneously Hypertensive Rats: The Role of Nitroso and Sulfide Signalization.

International journal of molecular sciences

Berenyiova A,Cebova M,Aydemir BG,Golas S,Majzunova M,Cacanyiova S

Tue Aug 16 00:00:00 EDT 2022

Vascular Effects of Low-Dose ACE2 Inhibitor MLN-4760-Benefit or Detriment in Essential Hypertension?

Biomedicines

Berenyiova A,Bernatova I,Zemancikova A,Drobna M,Cebova M,Golas S,Balis P,Liskova S,Valaskova Z,Krskova K,Zorad S,Dayar E,Cacanyiova S

Fri Dec 24 00:00:00 EST 2021

Endogenous hydrogen sulfide regulates xCT stability through persulfidation of OTUB1 at cysteine 91 in colon cancer cells.

Neoplasia (New York, N.Y.)

Chen S,Bu D,Zhu J,Yue T,Guo S,Wang X,Pan Y,Liu Y,Wang P

Sat May 01 00:00:00 EDT 2021

Fructose Intake Impairs the Synergistic Vasomotor Manifestation of Nitric Oxide and Hydrogen Sulfide in Rat Aorta.

International journal of molecular sciences

Berenyiova A,Golas S,Drobna M,Cebova M,Cacanyiova S

Fri Apr 30 00:00:00 EDT 2021

In vitro evidence for the involvement of H₂S pathway in the effect of clodronate during inflammatory response.

Scientific reports

Montanaro R,D'Addona A,Izzo A,Ruosi C,Brancaleone V

Tue Jul 20 00:00:00 EDT 2021

The Vasoactive Role of Perivascular Adipose Tissue and the Sulfide Signaling Pathway in a Nonobese Model of Metabolic Syndrome.

Biomolecules

Cacanyiova S,Golas S,Zemancikova A,Majzunova M,Cebova M,Malinska H,Hüttl M,Markova I,Berenyiova A

Fri Jan 15 00:00:00 EST 2021

Sodium Tanshinone IIA Sulfonate Attenuates Erectile Dysfunction in Rats with Hyperlipidemia.

Oxidative medicine and cellular longevity

Zhong L,Ding W,Zeng Q,He B,Zhang H,Wang L,Fan J,He S,Zhang Y,Wei A

Wed Oct 21 00:00:00 EDT 2020

Sodium Tanshinone IIA Sulfonate Attenuates Erectile Dysfunction in Rats with Hyperlipidemia.

Oxidative medicine and cellular longevity

Zhong L,Ding W,Zeng Q,He B,Zhang H,Wang L,Fan J,He S,Zhang Y,Wei A

Wed Oct 21 00:00:00 EDT 2020

Arterial Hypertension and Plasma Glucose Modulate the Vasoactive Effects of Nitroso-Sulfide Coupled Signaling in Human Intrarenal Arteries.

Molecules (Basel, Switzerland)

Cacanyiova S,Krskova K,Zorad S,Frimmel K,Drobna M,Valaskova Z,Misak A,Golas S,Breza J,Breza J,Berenyiova A

Tue Jun 23 00:00:00 EDT 2020

Comparative localization of cystathionine beta synthases and cystathionine gamma lyase in canine, non-human primate and human retina.

Experimental eye research

Badiei A,Sudharsan R,Santana E,Dunaief JL,Aguirre GD

Mon Apr 01 00:00:00 EDT 2019

Comparative localization of cystathionine beta synthases and cystathionine gamma lyase in canine, non-human primate and human retina.

Experimental eye research

Badiei A,Sudharsan R,Santana E,Dunaief JL,Aguirre GD

Mon Apr 01 00:00:00 EDT 2019

Comparative localization of cystathionine beta synthases and cystathionine gamma lyase in canine, non-human primate and human retina.

Experimental eye research

Badiei A,Sudharsan R,Santana E,Dunaief JL,Aguirre GD

Mon Apr 01 00:00:00 EDT 2019

Comparative localization of cystathionine beta synthases and cystathionine gamma lyase in canine, non-human primate and human retina.

Experimental eye research

Badiei A,Sudharsan R,Santana E,Dunaief JL,Aguirre GD

Mon Apr 01 00:00:00 EDT 2019

Decreased Expression of Cystathionine β-Synthase Exacerbates Intestinal Barrier Injury in Ulcerative Colitis.

Journal of Crohn's & colitis

Chen S,Zuo S,Zhu J,Yue T,Bu D,Wang X,Wang P,Pan Y,Liu Y

Wed Aug 14 00:00:00 EDT 2019

Cystathionine‑γ‑lyase promotes the metastasis of breast cancer via the VEGF signaling pathway.

International journal of oncology

Wang L,Shi H,Liu Y,Zhang W,Duan X,Li M,Shi X,Wang T

Thu Aug 01 00:00:00 EDT 2019

Cystathionine γ-lyase protects vascular endothelium: a role for inhibition of histone deacetylase 6.

American journal of physiology. Heart and circulatory physiology

Leucker TM,Nomura Y,Kim JH,Bhatta A,Wang V,Wecker A,Jandu S,Santhanam L,Berkowitz D,Romer L,Pandey D

Sat Apr 01 00:00:00 EDT 2017

Cystathionine γ-lyase protects vascular endothelium: a role for inhibition of histone deacetylase 6.

American journal of physiology. Heart and circulatory physiology

Leucker TM,Nomura Y,Kim JH,Bhatta A,Wang V,Wecker A,Jandu S,Santhanam L,Berkowitz D,Romer L,Pandey D

Sat Apr 01 00:00:00 EDT 2017

Cystathionine γ-lyase protects vascular endothelium: a role for inhibition of histone deacetylase 6.

American journal of physiology. Heart and circulatory physiology

Leucker TM,Nomura Y,Kim JH,Bhatta A,Wang V,Wecker A,Jandu S,Santhanam L,Berkowitz D,Romer L,Pandey D

Sat Apr 01 00:00:00 EDT 2017

Hydrogen Sulphide Treatment Increases Insulin Sensitivity and Improves Oxidant Metabolism through the CaMKKbeta-AMPK Pathway in PA-Induced IR C2C12 Cells.

Scientific reports

Chen X,Zhao X,Lan F,Zhou T,Cai H,Sun H,Kong W,Kong W

Mon Oct 16 00:00:00 EDT 2017

Hydrogen Sulphide Treatment Increases Insulin Sensitivity and Improves Oxidant Metabolism through the CaMKKbeta-AMPK Pathway in PA-Induced IR C2C12 Cells.

Scientific reports

Chen X,Zhao X,Lan F,Zhou T,Cai H,Sun H,Kong W,Kong W

Mon Oct 16 00:00:00 EDT 2017

The novel H₂S-donor 4-carboxyphenyl isothiocyanate promotes cardioprotective effects against ischemia/reperfusion injury through activation of mitoK_ATP channels and reduction of oxidative stress.

Pharmacological research

Testai L,Marino A,Piano I,Brancaleone V,Tomita K,Di Cesare Mannelli L,Martelli A,Citi V,Breschi MC,Levi R,Gargini C,Bucci M,Cirino G,Ghelardini C,Calderone V

Tue Nov 01 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: CGL; CTL target antigen; cystathionase (cystathionine gamma-lyase); Cystathionine gamma-lyase; Cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; Homocysteine desulfhydrase; homoserine deaminase; homoserine dehydratase; MGC9471; PRB-RA; Probasin-related antigen

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Gene Aliases: 0610010I13Rik; AI314617; BC019483; CSE; CTH; Cys3; H

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UniProt ID: (Human) P32929, (Rat) P18757, (Mouse) Q8VCN5

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Entrez Gene ID: (Human) 1491, (Rat) 24962, (Mouse) 107869

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Function(s)

cystathionine gamma-synthase activity cystathionine gamma-lyase activity protein binding calmodulin binding carbon-sulfur lyase activity pyridoxal phosphate binding L-cystine L-cysteine-lyase (deaminating) homocysteine desulfhydrase activity L-cysteine desulfhydrase activity cystathionine beta-lyase activity catalytic activity lyase activity lyase

Process(es)

sulfur amino acid catabolic process cysteine metabolic process protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine cysteine biosynthetic process via cystathionine cysteine biosynthetic process transsulfuration endoplasmic reticulum unfolded protein response positive regulation of I-kappaB kinase/NF-kappaB signaling protein sulfhydration positive regulation of NF-kappaB transcription factor activity protein homotetramerization hydrogen sulfide biosynthetic process 'de novo' L-methionine biosynthetic process positive regulation of aortic smooth muscle cell differentiation negative regulation of apoptotic signaling pathway glutathione metabolic process negative regulation of cell proliferation negative regulation of cell growth negative regulation of apoptotic process homocysteine metabolic process cellular amino acid biosynthetic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Gamma cystathionase Monoclonal Antibody (2C7F9)

Gamma cystathionase Antibody (60234-1-IG) in ICC/IF

Product Details

60234-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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