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Invitrogen
Gelsolin Recombinant Rabbit Monoclonal Antibody (5O10O1)
FIGURE: 1 / 3
Gelsolin Antibody (MA5-42787) in IHC (P)
Immunohistochemistry analysis of Gelsolin in paraffin-embedded mouse brain. Samples were incubated with Gelsolin Monoclonal antibody (Product # MA5-42787) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Product Details
MA5-42787
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
5O10O1
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human Gelsolin (NP_0001681)
Conjugate
Form
Liquid
Concentration
1.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2911928
Product Specific Information
Positive test controls include: C2C12, Mouse lung, HeLa, A-549, RD. The target is usually found in the following locations: Cytoplasm, Secreted, cytoskeleton.
Immunogen sequence: DQTDGLGLSY LSSHIANVER VPFDAATLHT STAMAAQHGM DDDGTGQKQI WRIEGSNKVP VDPATYGQFY GGDSYIILYN YRHGGRQGQI IYNWQGAQST Q
Target Information
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Actin-depolymerizing factor; ADF; ADFBrevin; AGEL; Brevin; DKFZp313L0718; Gelsolin; RP11-477J21.1
Gene Aliases: ADF; AGEL; Gsb; GSN
UniProt ID: (Human) P06396, (Mouse) P13020
Entrez Gene ID: (Human) 2934, (Mouse) 227753
phagocytosis, engulfment
aging
positive regulation of gene expression
oligodendrocyte development
striated muscle atrophy
extracellular matrix disassembly
actin filament polymerization
protein destabilization
tissue regeneration
sequestering of actin monomers
cellular protein metabolic process
actin nucleation
response to ethanol
negative regulation of viral entry into host cell
phosphatidylinositol-mediated signaling
actin filament severing
barbed-end actin filament capping
positive regulation of actin nucleation
response to folic acid
actin filament capping
cilium morphogenesis
cellular response to cadmium ion
regulation of podosome assembly
actin filament reorganization
renal protein absorption
hepatocyte apoptotic process
positive regulation of keratinocyte apoptotic process
regulation of wound healing, spreading of epidermal cells
regulation of establishment of T cell polarity
regulation of plasma membrane raft polarization
regulation of receptor clustering
positive regulation of protein processing in phagocytic vesicle
amyloid fibril formation
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
apoptotic process
actin polymerization or depolymerization
vesicle-mediated transport
cell projection organization
regulation of cell adhesion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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