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Gemin 3 Antibody (PA5-68831) in IHC
Immunohistochemistry was performed on mouse gut tissue using a Gemin 3 polyclonal primary antibody (Product # PA5-68831) with a dilution of 1:50, goat anti-rabbit Cy3 with a secondary antibody dilution of 1:1500 and Ddx20 (Green) and Neural crest cells (red).
Product Details
PA5-68831
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the N terminal region of human Gemin 3
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2688340
Product Specific Information
This target displays homology in the following species: Mouse: 100%; Rat: 86%
Target Information
Gemin 3 is a member of the DEAD box protein family which are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. DEAD box proteins such as Gemin 3 are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of DEAD box family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Gemin 3 has an ATPase activity and a component of the survival of motor neurons (SMN) complex. The Gemin 3 protein may play a catalytic role in the function of the SMN complex on RNPs. Diseases associated with Gemin 3 protein dysfunction include spinal muscular dystrophy and muscular atrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Component of gems 3; DDX 20; DEAD box protein 20; DEAD box protein DP 103; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20; DEAD/H BOX 20; DKFZP434H052; DP 103; Gemin-3; Probable ATP-dependent RNA helicase DDX20; Regulator of steroidogenic factor 1; ROSF-1
Gene Aliases: Ddx20; Dp103; GEMIN3
UniProt ID: (Mouse) Q9JJY4
Entrez Gene ID: (Mouse) 53975
negative regulation of transcription from RNA polymerase II promoter
spliceosomal snRNP assembly
mRNA processing
RNA splicing
RNA secondary structure unwinding
positive regulation of apoptotic process
negative regulation of transcription, DNA-templated
oogenesis
regulation of steroid biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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