Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
ABS 052-121-02
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Cat,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
121
Immunogen
Synthetic ghrelin (14-28).
Conjugate
Form
Liquid
Concentration
0.9 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
4° C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2536230
Product Specific Information
Specificity: ABS 052-121-02 cross-reacts with rat ghrelin, and is predicted to react with mouse, dog and cat based on sequence homology.
Reactivity: ABS 052-121-02 binds human ghrelin in solution. ABS 052-121-02 can be used as a detection antibody in a sandwich ELISA with capture antibody ABS 050-45-02.
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
Target Information
GHRL encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an the ligand for the growth hormone secretagogue receptor type 1 and is involved in regulating growth hormone release. Ghrelin has an appeptite-stimulating effect and induces adiposity and stimulates gastric acid secretion. Obestatin may be the ligand for the orphan G protein-coupled receptor GPR39 and is involved in satiety and can have an appetite-reducing effect resulting in decreased food intake.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: AMCBX1; Appetite-regulating hormone; Fip3p; ghrelin; ghrelin 27; ghrelin 28; ghrelin, growth hormone secretagogue receptor ligand; ghrelin/obestatin; ghrelin/obestatin preprohormone; Growth hormone secretagogue; Growth hormone-releasing peptide; IKK-gamma; In2c-preproghrelin; IP1; IP2; IPD2; motilin related peptide; Motilin-related peptide; OTTHUMP00000207794; OTTHUMP00000207795; OTTHUMP00000207796; OTTHUMP00000207798; prepro-appetite regulatory hormone; preproghrelin; proghrelin; Protein M46
Gene Aliases: 2210006E23Rik; Ghr; GHRL; m46; MTLRP; MTLRP-AP; MTLRPAP; UNQ524/PRO1066
UniProt ID: (Human) Q9UBU3, (Dog) Q9BEF8, (Cat) Q6BEG6, (Rat) Q9QYH7, (Mouse) Q9EQX0
Entrez Gene ID: (Human) 51738, (Dog) 403587, (Cat) 493844, (Rat) 59301, (Mouse) 58991
activation of MAPK activity
gastric acid secretion
negative regulation of endothelial cell proliferation
glucose metabolic process
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
actin polymerization or depolymerization
adult feeding behavior
response to hormone
hormone-mediated signaling pathway
dendrite development
negative regulation of angiogenesis
growth hormone secretion
positive regulation of insulin secretion
regulation of response to food
positive regulation of appetite
negative regulation of interleukin-1 beta production
negative regulation of locomotion
positive regulation of multicellular organism growth
regulation of cell proliferation
negative regulation of circadian sleep/wake cycle, REM sleep
negative regulation of tumor necrosis factor biosynthetic process
negative regulation of apoptotic process
cortisol secretion
response to estrogen
negative regulation of interleukin-6 biosynthetic process
positive regulation of circadian sleep/wake cycle, non-REM sleep
negative regulation of insulin secretion
decidualization
negative regulation of inflammatory response
cartilage development
positive regulation of corticotropin secretion
positive regulation of cortisol secretion
positive regulation of synapse assembly
excitatory postsynaptic potential
positive regulation of growth hormone secretion
positive regulation of growth hormone receptor signaling pathway
positive regulation of protein tyrosine kinase activity
negative regulation of energy homeostasis
positive regulation of energy homeostasis
positive regulation of response to food
negative regulation of interleukin-6 production
positive regulation of cold-induced thermogenesis
visual learning
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support