Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Girdin is a Galpha-interacting protein that can enhance the activation of the protein kinase Akt, remodel the actin cytoskeleton, and is thought to be involved in the regulation of cell migration and cancer metastasis. It has recently been shown that Girdin interacts with Disrupted-in-Schizophrenia 1 (DISC1), a susceptibility gene for major psychiatric disorders. DISC1 is thought to be involved in the migration, positioning and differentiation of dentate granule cells (DGCs) during development; depletion of Girdin or blocking the Girdin-DISC1 interaction results in defects in axonal sprouting in the CA3 region of the hippocampus and overextended migration of mispositioning of DGCs, suggesting the Girdin plays a role in postnatal neurogenesis in the dentate gyrus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Akt phosphorylation enhancer; AKT-phosphorylation enhancer; APE; coiled coil domain containing 88A; Coiled-coil domain-containing protein 88A; G alpha-interacting vesicle-associated protein; Galpha-interacting vesicle-associated protein; Girders of actin filament; girders of actin filaments; Girdin; GIV; HkRP1; Hook-related protein 1
Gene Aliases: A430106J12Rik; AI848406; APE; C130096N06Rik; C330012F17Rik; CCDC88A; D130005J21Rik; GIRDIN; GIV; GRDN; HkRP1; KIAA1212; RGD1306694
UniProt ID: (Human) Q3V6T2, (Mouse) Q5SNZ0
Entrez Gene ID: (Human) 55704, (Rat) 305605, (Mouse) 108686
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support