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GluR2 (GluA2) (extracellular) Antibody (AGC-005-GP200UL) in ICC/IF
Expression of GluA2 in rat PC12 cells - Cell surface detection of GluA2 in live intact rat pheochromocytoma PC12 cells. A. Extracellular staining of cells using Guinea pig Anti-GluR2 (GluA2) (extracellular) Antibody (#AGC-005-GP), (1:50) followed by goat Anti-guinea pig-AlexaFluor-594 secondary Antibody (red). B. Live image of the cells. C. Merge of A and B.
Product Details
AGC-005-GP200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Guinea pig
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NVGNINNDKKDETYR(C), corresponding to amino acid residues179-193 of rat GluR2, Extracellular, N-terminus
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
Target Information
The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5 -methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct Glutamate Receptor Subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain. The GluR2 subunit is thought to play a key role in forms of synaptic plasticity such as LTD.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AMPA selective glutamate receptor; AMPA-selective glutamate receptor 2; GluR-2; GluR-B; GluR-K2; glutamate receptor; Glutamate receptor 2; glutamate receptor B; Glutamate receptor ionotropic, AMPA 2; OTTHUMP00000165324; OTTHUMP00000220942; OTTHUMP00000220943
Gene Aliases: GluA2; Glur-2; GluR-B; GluR-K2; GluR2; Gria2
UniProt ID: (Rat) P19491
Entrez Gene ID: (Mouse) 14800, (Rat) 29627
receptor activity
ionotropic glutamate receptor activity
AMPA glutamate receptor activity
ion channel activity
extracellular-glutamate-gated ion channel activity
protein binding
kainate selective glutamate receptor activity
protein kinase binding
PDZ domain binding
identical protein binding
calcium channel regulator activity
transmembrane signal receptor
regulation of receptor recycling
transport
ion transport
chemical synaptic transmission
receptor internalization
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
establishment of protein localization
positive regulation of synaptic transmission
protein tetramerization
regulation of synaptic transmission, glutamatergic
response to lithium ion
response to fungicide
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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