Product References
Identification of multiple isoforms of glucocorticoid receptor in nasal polyps of patients with chronic rhinosinusitis.
Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
Shao S,Wang Y,Zhao Y,Xu Y,Wang T,Du K,Bao S,Wang X,Zhang L
PA1-516 was used in Western Blotting to provide evidence that nasal tissues express multiple GR protein isoforms.
Sat Jun 11 00:00:00 EDT 2022
Spatiotemporal control of axillary meristem formation by interacting transcriptional regulators.
Development (Cambridge, England)
Zhang C,Wang J,Wenkel S,Chandler JW,Werr W,Jiao Y
PA1-516 was used in Chromatin immunoprecipitation to show that modules of interacting transcriptional regulators control shoot meristemless expression and axillary meristem initiation.
Mon Dec 10 00:00:00 EST 2018
Coordination of meristem and boundary functions by transcription factors in the SHOOT MERISTEMLESS regulatory network.
Development (Cambridge, England)
Scofield S,Murison A,Jones A,Fozard J,Aida M,Band LR,Bennett M,Murray JAH
PA1-516 was used in Chromatin immunoprecipitation to highlight the central role for the SHOOT MERISTEMLESS gene regulatory network in coordinating shoot apical meristem functions.
Mon Apr 30 00:00:00 EDT 2018
Corticosteroid receptors adopt distinct cyclical transcriptional signatures.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Le Billan F,Amazit L,Bleakley K,Xue QY,Pussard E,Lhadj C,Kolkhof P,Viengchareun S,Fagart J,Lombès M
PA1-516 was used in Western Blotting to suggest a novel level of MR-GR target gene regulation, which should be considered for a better and integrated understanding of corticosteroid-related pathophysiology.
Mon Oct 01 00:00:00 EDT 2018
The Role of S-Palmitoylation of the Human Glucocorticoid Receptor (hGR) in Mediating the Nongenomic Glucocorticoid Actions.
Journal of molecular biochemistry
Nicolaides NC,Kino T,Roberts ML,Katsantoni E,Sertedaki A,Moutsatsou P,Psarra AG,Chrousos GP,Charmandari E
PA1-516 was used in Immunocytochemistry-immunoflourescence to identify that the motif 663YLCMKTLLL671 does not play a role in membrane localisation of human glucocorticoid receptor α and does not mediate nongenomic glucocorticoid actions.
Thu Oct 01 00:00:00 EDT 2020
Annexin A1 in blood mononuclear cells from patients with coronary artery disease: Its association with inflammatory status and glucocorticoid sensitivity.
PloS one
Bergström I,Lundberg AK,Jönsson S,Särndahl E,Ernerudh J,Jonasson L
PA1516 was used in flow cytometry to examine AnxA1 in peripheral blood mononuclear cells from patients with coronary artery disease
Tue Aug 22 00:00:00 EDT 2017
The bHLH transcription factor SPATULA enables cytokinin signaling, and both activate auxin biosynthesis and transport genes at the medial domain of the gynoecium.
PLoS genetics
Reyes-Olalde JI,Zúñiga-Mayo VM,Serwatowska J,Chavez Montes RA,Lozano-Sotomayor P,Herrera-Ubaldo H,Gonzalez-Aguilera KL,Ballester P,Ripoll JJ,Ezquer I,Paolo D,Heyl A,Colombo L,Yanofsky MF,Ferrandiz C,Marsch-Martínez N,de Folter S
PA1-516 was used in Chromatin immunoprecipitation to reveal that cytokinin signalling is enabled by the transcription factor SPATULA in the medial domain.
Sat Apr 01 00:00:00 EDT 2017
Three Novel Heterozygous Point Mutations of NR3C1 Causing Glucocorticoid Resistance.
Human mutation
Vitellius G,Fagart J,Delemer B,Amazit L,Ramos N,Bouligand J,Le Billan F,Castinetti F,Guiochon-Mantel A,Trabado S,Lombès M
PA1-516 was used in western blot to determine the cause of glucocorticoid resistance by three novel heterozygous point mutations of NR3C1
Mon Aug 01 00:00:00 EDT 2016
Additive anti-inflammatory effects of corticosteroids and phosphodiesterase-4 inhibitors in COPD CD8 cells.
Respiratory research
Grundy S,Plumb J,Kaur M,Ray D,Singh D
PA1-516 was used in immunocytochemistry to examine the effect of corticosteroid and PDE4 inhibitors on circulating and pulmonary CD8 cells
Mon Jan 25 00:00:00 EST 2016
Two-Step Regulation of a Meristematic Cell Population Acting in Shoot Branching in Arabidopsis.
PLoS genetics
Shi B,Zhang C,Tian C,Wang J,Wang Q,Xu T,Xu Y,Ohno C,Sablowski R,Heisler MG,Theres K,Wang Y,Jiao Y
PA1-516 was used in Chromatin immunoprecipitation to show that the initiation of axillary meristems requires a meristematic cell population continuously expressing the meristem marker SHOOT MERISTEMLESS.
Fri Jul 01 00:00:00 EDT 2016
A kinase-independent activity of Cdk9 modulates glucocorticoid receptor-mediated gene induction.
Biochemistry
Zhu R,Lu X,Pradhan M,Armstrong SP,Storchan GB,Chow CC,Simons SS
PA1-516 was used in western blot to study regulation of GR-mediated gene expression by Cdk9 independently of its kinase activity
Tue Mar 25 00:00:00 EDT 2014
Dynamics of chromatin accessibility and gene regulation by MADS-domain transcription factors in flower development.
Genome biology
Pajoro A,Madrigal P,Muiño JM,Matus JT,Jin J,Mecchia MA,Debernardi JM,Palatnik JF,Balazadeh S,Arif M,Ó'Maoiléidigh DS,Wellmer F,Krajewski P,Riechmann JL,Angenent GC,Kaufmann K
PA1-516 was used in ChIP assay to study the dynamics of flower development and how MADS-domain transcription factors regulate genes and chromatin accessibility
Mon Mar 03 00:00:00 EST 2014
Glucocorticoid signaling in myeloid cells worsens acute CNS injury and inflammation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sorrells SF,Caso JR,Munhoz CD,Hu CK,Tran KV,Miguel ZD,Chien BY,Sapolsky RM
PA1-516 was used in immunohistochemistry to study the deleterious effects of myeloid cell glucocorticoid signaling on acute CNS inflammation and neuronal survival
Wed May 01 00:00:00 EDT 2013
The cholinergic and non-cholinergic effects of organophosphates and oximes in cultured human myoblasts.
Chemico-biological interactions
Katalinić M,Miš K,Pirkmajer S,Grubič Z,Kovarik Z,Marš T
PA1-516 was used in western blot to study the effect of organophosphates and oximes on cholinergic and non-cholinergic processes in human myoblasts
Mon Mar 25 00:00:00 EDT 2013
Effect of ionizing radiation on human skeletal muscle precursor cells.
Radiology and oncology
Jurdana M,Cemazar M,Pegan K,Mars T
PA1-516 was used in western blot to study the response of human skeletal muscle myoblasts to long-term ionizing radiation
Mon Dec 02 00:00:00 EST 2013
PA1 protein, a new competitive decelerator acting at more than one step to impede glucocorticoid receptor-mediated transactivation.
The Journal of biological chemistry
Zhang Z,Sun Y,Cho YW,Chow CC,Simons SS
PA1-516 was used in western blot to study the inhibition of glucocorticoid receptor transactivation by PA1
Fri Jan 04 00:00:00 EST 2013
Identification of location and kinetically defined mechanism of cofactors and reporter genes in the cascade of steroid-regulated transactivation.
The Journal of biological chemistry
Blackford JA,Guo C,Zhu R,Dougherty EJ,Chow CC,Simons SS
PA1-516 was used in western blot to use a novel competition assay to study the spatial and temporal binding of cofactors and reporter genes involved in steroid-regulated transactivation
Fri Nov 30 00:00:00 EST 2012
Abnormal glucocorticoid receptor mRNA and protein isoform expression in the prefrontal cortex in psychiatric illness.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Sinclair D,Tsai SY,Woon HG,Weickert CS
PA1-516 was used in Western Blotting to confirm total glucocorticoid receptor mRNA reductions in schizophrenia and glucocorticoid receptor protein isoform abnormalities in schizophrenia and bipolar disorder.
Thu Dec 01 00:00:00 EST 2011
Expression of glucocorticoid receptors in the regenerating human skeletal muscle.
Physiological research
Filipović D,Pirkmajer S,Mis K,Mars T,Grubic Z
PA1-516 was used in western blot to investigate glucocorticoid receptors in cultured human myoblasts and myotubes
Tue Feb 07 00:00:00 EST 2012
Enhanced neutrophil expression of annexin-1 in coronary artery disease.
Metabolism: clinical and experimental
Särndahl E,Bergström I,Nijm J,Forslund T,Perretti M,Jonasson L
PA1-516 was used in flow cytometry to investigate the expression of annexin-1 in neutrophils in coronary artery disease patients
Mon Mar 01 00:00:00 EST 2010
HIF-1alpha response to hypoxia is functionally separated from the glucocorticoid stress response in the in vitro regenerating human skeletal muscle.
American journal of physiology. Regulatory, integrative and comparative physiology
Pirkmajer S,Filipovic D,Mars T,Mis K,Grubic Z
PA1-516 was used in western blot to differentiate between HIF-1alpha response and glucocorticoid stress response in human skeletal muscle
Wed Dec 01 00:00:00 EST 2010
Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells.
BMC medical genomics
Nehmé A,Lobenhofer EK,Stamer WD,Edelman JL
PA1-516 was used in western blot to investigate the role of glucocorticoids with different chemical structures but similar glucocorticoid receptor potency during gene expression in human trabecular meshwork cells
Thu Sep 10 00:00:00 EDT 2009
Potential role of glucocorticoid signaling in the formation of pancreatic islets in the human fetus.
Pediatric research
Phan-Hug F,Guimiot F,Lelièvre V,Delezoide AL,Czernichow P,Breant B,Blondeau B
PA1-516 was used in immunohistochemistry to study the role of glucocorticoid receptor in the development of pancreatic islets
Wed Oct 01 00:00:00 EDT 2008
Mutations of glucocorticoid receptor differentially affect AF2 domain activity in a steroid-selective manner to alter the potency and efficacy of gene induction and repression.
Biochemistry
Tao YG,Xu Y,Xu HE,Simons SS
PA1-516 was used in western blot to characterize the effects of glucocorticoid receptor mutations
Tue Jul 22 00:00:00 EDT 2008
ATF2 impairs glucocorticoid receptor-mediated transactivation in human CD8+ T cells.
Blood
Li LB,Leung DY,Strand MJ,Goleva E
PA1-516 was used in immunocytochemistry to investigate the role of the ATF2 during the glucocorticoid receptor-mediated transactivation.
Sat Sep 01 00:00:00 EDT 2007
Participation of the Arabidopsis bHLH factor GL3 in trichome initiation regulatory events.
Plant physiology
Morohashi K,Zhao M,Yang M,Read B,Lloyd A,Lamb R,Grotewold E
Published figure using Glucocorticoid Receptor alpha polyclonal antibody (Product # PA1-516) in ChIP assay
Thu Nov 01 00:00:00 EDT 2007
STAMP, a novel predicted factor assisting TIF2 actions in glucocorticoid receptor-mediated induction and repression.
Molecular and cellular biology
He Y,Simons SS
PA1-516 was used in Immunoprecipitation to isolate and characterise a novel predicted factor assisting TIF2 actions in glucocorticoid receptor-mediated induction and repression.
Thu Feb 01 00:00:00 EST 2007
Distribution of glucocorticoid receptor alpha and beta subtypes in the idiopathic inflammatory myopathies.
Neuromuscular disorders : NMD
De Bleecker JL,De Paepe B,Vervaet VL,Arys B,Creus KK,Werbrouck BF,Martin JJ
PA1-516 was used in immunohistochemistry and western blot to study the distribution of glucocorticoid receptor alpha and beta subtypes in idiopathic inflammatory myopathies
Thu Feb 01 00:00:00 EST 2007
CD38 expression is insensitive to steroid action in cells treated with tumor necrosis factor-alpha and interferon-gamma by a mechanism involving the up-regulation of the glucocorticoid receptor beta isoform.
Molecular pharmacology
Tliba O,Cidlowski JA,Amrani Y
PA1-516 was used in western blot to investigate the effect of glucocorticoid (GC) on CD38 expression in ASM cells treated with tumor necrosis factor-alpha and interferons
Wed Feb 01 00:00:00 EST 2006
Increased glucocorticoid receptor and 11{beta}-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the phenotype of type 2 diabetes in db/db mice.
Diabetes
Liu Y,Nakagawa Y,Wang Y,Sakurai R,Tripathi PV,Lutfy K,Friedman TC
PA1-516 was used in western blot to investigate the role of glucocorticoid receptor and 11{beta}-hydroxysteroid dehydrogenase type 1 expression upregulation in hepatocytes of db/db mice
Sat Jan 01 00:00:00 EST 2005
The Smad6-histone deacetylase 3 complex silences the transcriptional activity of the glucocorticoid receptor: potential clinical implications.
The Journal of biological chemistry
Ichijo T,Voutetakis A,Cotrim AP,Bhattachryya N,Fujii M,Chrousos GP,Kino T
PA1-516 was used in chromatin immunoprecipitation to demonstrate the effect of the Smad6-histone deacetylase 3 complex on the transcription of the glucocorticoid receptor.
Fri Dec 23 00:00:00 EST 2005
Superantigen-induced corticosteroid resistance of human T cells occurs through activation of the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK-ERK) pathway.
The Journal of allergy and clinical immunology
Li LB,Goleva E,Hall CF,Ou LS,Leung DY
PA1-516 was used in immunocytochemistry to study the mechanism for the superantigen-induced corticosteroid resistance of human T cells
Mon Nov 01 00:00:00 EST 2004
Natural glucocorticoid receptor mutants causing generalized glucocorticoid resistance: molecular genotype, genetic transmission, and clinical phenotype.
The Journal of clinical endocrinology and metabolism
Charmandari E,Kino T,Souvatzoglou E,Vottero A,Bhattacharyya N,Chrousos GP
PA1-516 was used in immunocytochemistry to study the effect of glucocorticoid receptor mutations
Thu Apr 01 00:00:00 EST 2004
CD56+ cells induce steroid resistance in B cells exposed to IL-15.
Journal of immunology (Baltimore, Md. : 1950)
Xu Q,Goleva E,Ou LS,Li LB,Leung DY
PA1-516 was used in immunocytochemistry to demonstrate the effects of interleukin 15 on CD56+ cells and B cell resistance to steroids
Tue Jun 01 00:00:00 EDT 2004
Steroid-responsive sequences in the human glucocorticoid receptor gene 1A promoter.
Molecular endocrinology (Baltimore, Md.)
Geng CD,Vedeckis WV
PA1-516 was used in EMSA to investigate which promoter of the human glucocorticoid receptor protein gene contains the steroid-responsive sequences.
Thu Apr 01 00:00:00 EST 2004
Effect of labor on glucocorticoid receptor (GR(Total), GRalpha, and GRbeta) proteins in ovine intrauterine tissues.
Journal of the Society for Gynecologic Investigation
Gupta S,Gyomorey S,Lye SJ,Gibb W,Challis JR
PA1-516 was used in western blot to determine the temporal and tissue-specific expression profiles of glucocorticoid receptors
Tue Apr 01 00:00:00 EST 2003
Decreased steroid responsiveness at night in nocturnal asthma. Is the macrophage responsible?
American journal of respiratory and critical care medicine
Kraft M,Hamid Q,Chrousos GP,Martin RJ,Leung DY
PA1-516 was used in immunocytochemistry to investigate the relationship between decreased steroid responsiveness in nocturnal asthma and airway macrophages
Sun Apr 01 00:00:00 EST 2001
High constitutive glucocorticoid receptor beta in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids.
The Journal of experimental medicine
Strickland I,Kisich K,Hauk PJ,Vottero A,Chrousos GP,Klemm DJ,Leung DY
PA1-516 was used in immunocytochemistry to determine the relative amounts of each GR isoform in human neutrophil and its impact on cell death.
Mon Mar 05 00:00:00 EST 2001
GRKO mice express an aberrant dexamethasone-binding glucocorticoid receptor, but are profoundly glucocorticoid resistant.
Molecular and cellular endocrinology
Cole TJ,Myles K,Purton JF,Brereton PS,Solomon NM,Godfrey DI,Funder JW
PA1-516 was used in western blot To characterize the changes in glucocorticoid receptor expression and response to glucocorticoid treatment in glucocorticoid receptor knock-out mice
Wed Feb 28 00:00:00 EST 2001