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Invitrogen
Glutamine Synthetase Recombinant Rabbit Monoclonal Antibody (23GB1345)
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 4
Glutamine Synthetase Antibody (MA5-54014) in ICC/IF
Immunocytochemistry analysis of Glutamine Synthetase in HeLa cells. Nuclei were stained blue with DAPI; Glutamine Synthetase recombinant monoclonal antibody (Product # MA5-54014) with a dilution of 1:1,000 was stained magenta with Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
Product Details
MA5-54014
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
23GB1345
Immunogen
A synthesized peptide derived from human Glutamine Synthetase (260-310AA).
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Target Information
Glutamine synthase is part of the glutamine synthetase family. Ammonia incorporation in animals occurs through the actions of glutamate dehydrogenase and glutamine synthase. Glutamate plays the central role in mammalian nitrogen flow, serving as both a nitrogen donor and nitrogen acceptor. It also has an important role in controlling metabolic regulations of neurotransmitter glutamate. Because of the multiple functions and importance of GS in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of GS is controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer's disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cell proliferation-inducing protein 59; GLNA; Glutamate ammonia ligase; glutamate decarboxylase; Glutamate--ammonia ligase; glutamate-ammonia ligase (glutamine synthase); glutamate-ammonia ligase (glutamine synthetase); glutamine synthase; Glutamine synthetase; Glutamine synthetase (glutamate-ammonia ligase); glutamine synthetase 1; glutamine synthetase I; GS; Palmitoyltransferase GLUL; Proliferation inducing protein 43; proliferation-inducing protein 43
Gene Aliases: GLNS; GLUL; GS; PIG43; PIG59
UniProt ID: (Human) P15104, (Mouse) P15105, (Rat) P09606
Entrez Gene ID: (Human) 2752, (Mouse) 14645, (Rat) 24957
neurotransmitter uptake
glutamate catabolic process
glutamine biosynthetic process
cell proliferation
cellular amino acid biosynthetic process
cellular response to starvation
response to glucose
ammonia assimilation cycle
positive regulation of insulin secretion
positive regulation of epithelial cell proliferation
protein homooligomerization
positive regulation of synaptic transmission, glutamatergic
glutamate metabolic process
nitrogen compound metabolic process
neurotransmitter metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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