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Invitrogen
Glutamine Synthetase Recombinant Superclonal Antibody (7HCLC)
Advanced Verification
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 4
Glutamine Synthetase Antibody (710963) in ICC/IF
Immunofluorescence was performed on fixed and permeabilized HepG2 cells for detection of Glutamine synthetase using Glutamine synthetase Recombinant Rabbit Polyclonal Antibody (Product # 710963, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detectio... View More
Product Details
710963
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Superclonal
Type
Antibody
Clone
7HCLC
Immunogen
Protein corresponding to Human GLUL (aa 2-373)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.2
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2609400
Product Specific Information
This antibody is predicted to react with Monkey, Cat and Rat.
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
Target Information
Glutamine synthase is part of the glutamine synthetase family. Ammonia incorporation in animals occurs through the actions of glutamate dehydrogenase and glutamine synthase. Glutamate plays the central role in mammalian nitrogen flow, serving as both a nitrogen donor and nitrogen acceptor. It also has an important role in controlling metabolic regulations of neurotransmitter glutamate. Because of the multiple functions and importance of GS in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of GS is controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer's disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cell proliferation-inducing protein 59; GLNA; Glutamate ammonia ligase; glutamate decarboxylase; Glutamate--ammonia ligase; glutamine synthase; Glutamine synthetase; glutamine synthetase I; GS; Palmitoyltransferase GLUL; Proliferation inducing protein 43; proliferation-inducing protein 43
Gene Aliases: GLNS; GLUL; GS; PIG43; PIG59
UniProt ID: (Human) P15104
Entrez Gene ID: (Human) 2752
neurotransmitter uptake
glutamate catabolic process
glutamine biosynthetic process
cell proliferation
cellular amino acid biosynthetic process
cellular response to starvation
response to glucose
ammonia assimilation cycle
positive regulation of insulin secretion
positive regulation of epithelial cell proliferation
protein homooligomerization
positive regulation of synaptic transmission, glutamatergic
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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