Product References
Non-SMC condensin I complex subunit H participates in anti-programmed cell death-1 resistance of clear cell renal cell carcinomas.
Cell proliferation
Chen Z,Ruan W,Guo C,Chen K,Li L,Tian J,Hu Z,Peng D,Zeng X
Published figure using Granzyme B monoclonal antibody (Product # MA1-80734) in Western Blot
Sat Jul 01 00:00:00 EDT 2023
Lymph node CXCR5+ NK cells associate with control of chronic SHIV infection.
JCI insight
Rahman SA,Billingsley JM,Sharma AA,Styles TM,Govindaraj S,Shanmugasundaram U,Babu H,Riberio SP,Ali SA,Tharp GK,Ibegbu C,Waggoner SN,Johnson RP,Sekaly RP,Villinger F,Bosinger SE,Amara RR,Velu V
Published figure using Granzyme B monoclonal antibody (Product # MA1-80734) in Immunohistochemistry
Fri Apr 22 00:00:00 EDT 2022
Synthetic Essentiality of Tryptophan 2,3-Dioxygenase 2 in APC-Mutated Colorectal Cancer.
Cancer discovery
Lee R,Li J,Li J,Wu CJ,Jiang S,Hsu WH,Chakravarti D,Chen P,LaBella KA,Li J,Spring DJ,Zhao D,Wang YA,DePinho RA
MA1-80734 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation to establish that the TDO2-Kyn-AhR axis serves a critical role in promoting APC-deficient tumor growth via cancer cell autonomous (metabolism and proliferation) and non-autonomous mechanisms (tumor immunity).
Wed Jul 06 00:00:00 EDT 2022
Selection of tumor‑resistant variants following sustained natural killer cell‑mediated immune stress.
Oncology reports
Carré T,Thiery J,Janji B,Terry S,Gros G,Meurice G,Kieda C,Olive D,Chouaib S
Published figure using Granzyme B monoclonal antibody (Product # MA1-80734) in Immunocytochemistry
Mon Feb 01 00:00:00 EST 2021
Selection of tumor‑resistant variants following sustained natural killer cell‑mediated immune stress.
Oncology reports
Carré T,Thiery J,Janji B,Terry S,Gros G,Meurice G,Kieda C,Olive D,Chouaib S
Published figure using Granzyme B monoclonal antibody (Product # MA1-80734) in Immunocytochemistry
Mon Feb 01 00:00:00 EST 2021
Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity.
Cancer cell
Hutton C,Heider F,Blanco-Gomez A,Banyard A,Kononov A,Zhang X,Karim S,Paulus-Hock V,Watt D,Steele N,Kemp S,Hogg EKJ,Kelly J,Jackstadt RF,Lopes F,Menotti M,Chisholm L,Lamarca A,Valle J,Sansom OJ,Springer C,Malliri A,Marais R,Pasca di Magliano M,Zelenay S,Morton JP,Jørgensen C
MA1-80734 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation to reveal two functionally distinct pancreatic fibroblast lineages and highlight the importance of mesenchymal and immune cell interactions in restricting tumor growth.
Mon Sep 13 00:00:00 EDT 2021
A distinct innate immune signature marks progression from mild to severe COVID-19.
Cell reports. Medicine
Chevrier S,Zurbuchen Y,Cervia C,Adamo S,Raeber ME,de Souza N,Sivapatham S,Jacobs A,Bachli E,Rudiger A,Stüssi-Helbling M,Huber LC,Schaer DJ,Nilsson J,Boyman O,Bodenmiller B
MA1-80734 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation to profile the innate immune response of patients with mild or severe COVID-19 and of healthy individuals.
Tue Jan 19 00:00:00 EST 2021
Protection of Batf3-deficient mice from experimental cerebral malaria correlates with impaired cytotoxic T-cell responses and immune regulation.
Immunology
Kuehlwein JM,Borsche M,Korir PJ,Risch F,Mueller AK,Hübner MP,Hildner K,Hoerauf A,Dunay IR,Schumak B
MA1-80734 was used in Flow cytometry/Cell sorting to investigate the inflammatory immune responses to plasmodium parasite infections which lead to cerebral malaria using a mouse model.
Sat Feb 01 00:00:00 EST 2020
Protection of Batf3-deficient mice from experimental cerebral malaria correlates with impaired cytotoxic T-cell responses and immune regulation.
Immunology
Kuehlwein JM,Borsche M,Korir PJ,Risch F,Mueller AK,Hübner MP,Hildner K,Hoerauf A,Dunay IR,Schumak B
MA1-80734 was used in Flow cytometry/Cell sorting to investigate the inflammatory immune responses to plasmodium parasite infections which lead to cerebral malaria using a mouse model.
Sat Feb 01 00:00:00 EST 2020
Comprehensive Analysis of the Immune and Stromal Compartments of the CNS in EAE Mice Reveal Pathways by Which Chloroquine Suppresses Neuroinflammation.
Brain sciences
Thome R,Boehm A,Ishikawa LLW,Casella G,Munhoz J,Ciric B,Zhang GX,Rostami A
MA1-80734 was used in Flow Cytometry to analyse the CNS of experimental autoimmune encephalomyelitis mice to identify and characterize the cells that are affected by chloroquine.
Fri Jun 05 00:00:00 EDT 2020
TIGIT limits immune pathology during viral infections.
Nature communications
Schorer M,Rakebrandt N,Lambert K,Hunziker A,Pallmer K,Oxenius A,Kipar A,Stertz S,Joller N
MA1-80734 was used in Flow Cytometry to identify a function of TIGIT in limiting immune pathology that is independent of viral clearance.
Mon Mar 09 00:00:00 EDT 2020
TLR2 Stimulation Increases Cellular Metabolism in CD8+ T Cells and Thereby Enhances CD8+ T Cell Activation, Function, and Antiviral Activity.
Journal of immunology (Baltimore, Md. : 1950)
Zhang E,Ma Z,Li Q,Yan H,Liu J,Wu W,Guo J,Zhang X,Kirschning CJ,Xu H,Lang PA,Yang D,Dittmer U,Yan H,Lu M
MA1-80734 was used in Flow Cytometry to study how TLR2 signalling modulates CD8+ T cell function.
Sun Dec 01 00:00:00 EST 2019
CD56 expression in breast cancer induces sensitivity to natural killer-mediated cytotoxicity by enhancing the formation of cytotoxic immunological synapse.
Scientific reports
Taouk G,Hussein O,Zekak M,Abouelghar A,Al-Sarraj Y,Abdelalim EM,Karam M
MA1-80734 was used in Immunocytochemistry-immunoflourescence to identify CD56 as a predictive biomarker for breast cancer responsiveness to novel NK-92-cell based immunotherapy.
Wed Jun 19 00:00:00 EDT 2019
Multiplexed imaging of immune cells in staged multiple sclerosis lesions by mass cytometry.
eLife
Ramaglia V,Sheikh-Mohamed S,Legg K,Park C,Rojas OL,Zandee S,Fu F,Ornatsky O,Swanson EC,Pitt D,Prat A,McKee TD,Gommerman JL
MA1-80734 was used in Immunohistochemistry-immunofluorescence to analyse the ability of imaging mass cytometry to discriminate between different types of lesions in multiple sclerosis.
Thu Aug 01 00:00:00 EDT 2019
Human γδ T-cell receptor repertoire is shaped by influenza viruses, age and tissue compartmentalisation.
Clinical & translational immunology
Sant S,Jenkins MR,Dash P,Watson KA,Wang Z,Pizzolla A,Koutsakos M,Nguyen TH,Lappas M,Crowe J,Loudovaris T,Mannering SI,Westall GP,Kotsimbos TC,Cheng AC,Wakim L,Doherty PC,Thomas PG,Loh L,Kedzierska K
MA1-80734 was used in Flow cytometry/Cell sorting to assess the cytotoxic profiles of γδ T cells in influenza-infected patients and IFN-γ production towards influenza-infected lung epithelial cells.
Sun Apr 10 00:00:00 EDT 2022
Mass cytometry reveals innate lymphoid cell differentiation pathways in the human fetal intestine.
The Journal of experimental medicine
Li N,van Unen V,Höllt T,Thompson A,van Bergen J,Pezzotti N,Eisemann E,Vilanova A,Chuva de Sousa Lopes SM,Lelieveldt BPF,Koning F
MA1-80734 was used in Flow cytometry/Cell sorting to identify a previously unknown intermediate innate subset that can differentiate into ILC3 and NK cells.
Mon May 07 00:00:00 EDT 2018
Human CD40 ligand-expressing type 3 innate lymphoid cells induce IL-10-producing immature transitional regulatory B cells.
The Journal of allergy and clinical immunology
Komlósi ZI,Kovács N,van de Veen W,Kirsch AI,Fahrner HB,Wawrzyniak M,Rebane A,Stanic B,Palomares O,Rückert B,Menz G,Akdis M,Losonczy G,Akdis CA
MA1-80734 was used in Flow cytometry/Cell sorting to investigate the ILC3-B-cell interaction that probably takes place in human tonsils.
Sun Jul 01 00:00:00 EDT 2018
Canonical TGF-β Signaling Pathway Represses Human NK Cell Metabolism.
Journal of immunology (Baltimore, Md. : 1950)
Zaiatz-Bittencourt V,Finlay DK,Gardiner CM
MA1-80734 was used in Flow cytometry/Cell sorting to suggest that pharmacological inhibition of TGF-β could provide a metabolic advantage to NK cells that is likely to result in improved functional responses.
Fri Jun 15 00:00:00 EDT 2018
Long-term outcomes of a phase I study of agonist CD40 antibody and CTLA-4 blockade in patients with metastatic melanoma.
Oncoimmunology
Bajor DL,Mick R,Riese MJ,Huang AC,Sullivan B,Richman LP,Torigian DA,George SM,Stelekati E,Chen F,Melenhorst JJ,Lacey SF,Xu X,Wherry EJ,Gangadhar TC,Amaravadi RK,Schuchter LM,Vonderheide RH
MA1-80734 was used in Flow cytometry/Cell sorting to report long-term clinical outcomes and immune responses observed from a phase 1 trial of agonist CD40 monoclonal antibody and blocking CTLA-4 mAb in patients with metastatic melanoma.
Tue Jan 12 00:00:00 EST 2021
Phosphoinositide 3-kinase δ inhibition promotes antitumor responses but antagonizes checkpoint inhibitors.
JCI insight
Lim EL,Cugliandolo FM,Rosner DR,Gyori D,Roychoudhuri R,Okkenhaug K
MA1-80734 was used in Flow cytometry/Cell sorting to show antitimour responses can be conferred by phosphoinositide 3-kinase δ inhibition.
Thu Jun 07 00:00:00 EDT 2018
Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion.
Proceedings of the National Academy of Sciences of the United States of America
Miosge LA,Sontani Y,Chuah A,Horikawa K,Russell TA,Mei Y,Wagle MV,Howard DR,Enders A,Tscharke DC,Goodnow CC,Parish IA
MA1-80734 was used in Flow cytometry/Cell sorting to identify a crucial role for ETAA1 in this process by surveying random germ line mutations in mice using exome sequencing and bioinformatic annotation to prioritise mutations in genes of unknown function with potential effects on the immune system.
Tue Jun 27 00:00:00 EDT 2017
Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology.
PLoS pathogens
Pyle CJ,Uwadiae FI,Swieboda DP,Harker JA
MA1-80734 was used in Flow Cytometry to show that during respiratory virus infection the prototypic inflammatory cytokine IL-6 is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27.
Fri Sep 01 00:00:00 EDT 2017
Low-dose interleukin-2 promotes STAT-5 phosphorylation, Treg survival and CTLA-4-dependent function in autoimmune liver diseases.
Clinical and experimental immunology
Jeffery HC,Jeffery LE,Lutz P,Corrigan M,Webb GJ,Hirschfield GM,Adams DH,Oo YH
MA180734 was used in flow cytometry to examine the potential of IL-2 to enhance T regulatory cell therapy
Thu Jun 01 00:00:00 EDT 2017
NKG2C/E Marks the Unique Cytotoxic CD4 T Cell Subset, ThCTL, Generated by Influenza Infection.
Journal of immunology (Baltimore, Md. : 1950)
Marshall NB,Vong AM,Devarajan P,Brauner MD,Kuang Y,Nayar R,Schutten EA,Castonguay CH,Berg LJ,Nutt SL,Swain SL
MA1-80734 was used in Flow Cytometry to show that NKG2C/E identifies the ThCTL that develop in the lung during influenza A virus infection in mice.
Wed Feb 01 00:00:00 EST 2017
Perturbed CD8+ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals.
Scientific reports
Tauriainen J,Scharf L,Frederiksen J,Naji A,Ljunggren HG,Sönnerborg A,Lund O,Reyes-Terán G,Hecht FM,Deeks SG,Betts MR,Buggert M,Karlsson AC
MA180734 was used in flow cytometry to show T cell immunoglobulin and ITIM domain expression increases over time despite early initiation of antiretroviral treatment
Fri Jan 13 00:00:00 EST 2017
Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity.
Nature
Luo CT,Liao W,Dadi S,Toure A,Li MO
MA1-80734 was used in flow cytometry to examine the contribution of Foxo1 to activated T cells
Thu Jan 28 00:00:00 EST 2016
Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity.
Nature
Luo CT,Liao W,Dadi S,Toure A,Li MO
MA1-80734 was used in flow cytometry to examine the contribution of Foxo1 to activated T cells
Thu Jan 28 00:00:00 EST 2016
Type 1 interferon licenses naïve CD8 T cells to mediate anti-viral cytotoxicity.
Virology
Urban SL,Berg LJ,Welsh RM
Published figure using Granzyme B monoclonal antibody (Product # MA1-80734) in Flow Cytometry
Wed Jun 01 00:00:00 EDT 2016
Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells.
The Journal of experimental medicine
Herz J,Johnson KR,McGavern DB
MA180734 was used in flow cytometry to determine if therapeutic antiviral T cells eliminate viral load in the brain of mice persistently infected from birth with lymphocytic choriomeningitis virus without causing blood-brain barrier breakdown or tissue damage
Mon Jul 27 00:00:00 EDT 2015
The Interferon-Stimulated Gene Ifi27l2a Restricts West Nile Virus Infection and Pathogenesis in a Cell-Type- and Region-Specific Manner.
Journal of virology
Lucas TM,Richner JM,Diamond MS
MA1-80734 was used in flow cytometry to elucidate restriction of west nile virus infection and pathogenesis in a region-specific and cell-type manner by the interferon-stimulated gene Ifi2712a
Wed Dec 23 00:00:00 EST 2015
Nonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell (Treg) suppression by HLA-DR-CD25hiCD127lo Tregs in multiple sclerosis and in response to IL-6.
Journal of immunology (Baltimore, Md. : 1950)
Bhela S,Kempsell C,Manohar M,Dominguez-Villar M,Griffin R,Bhatt P,Kivisakk-Webb P,Fuhlbrigge R,Kupper T,Weiner H,Baecher-Allan C
MA180734 was used in flow cytometry to investigate the role of granzyme B in T regulatory cell resistance
Sun Mar 01 00:00:00 EST 2015
Activated regulatory T cells suppress effector NK cell responses by an IL-2-mediated mechanism during an acute retroviral infection.
Retrovirology
Littwitz-Salomon E,Akhmetzyanova I,Vallet C,Francois S,Dittmer U,Gibbert K
MA1-80734 was used in flow cytometry to test if anti-retroviral natural killer cell functions are inhibited by T regulatory cells during an acute Friend retrovirus infection
Thu Jul 30 00:00:00 EDT 2015
GPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment.
The Journal of experimental medicine
Wang X,Sumida H,Cyster JG
MA1-80734 was used in flow cytometry to examine the role of GPR18 in intestinal intraepithelial lymphocytes
Mon Nov 17 00:00:00 EST 2014
Immunological Outcome in Haploidentical-HSC Transplanted Patients Treated with IL-10-Anergized Donor T Cells.
Frontiers in immunology
Bacchetta R,Lucarelli B,Sartirana C,Gregori S,Lupo Stanghellini MT,Miqueu P,Tomiuk S,Hernandez-Fuentes M,Gianolini ME,Greco R,Bernardi M,Zappone E,Rossini S,Janssen U,Ambrosi A,Salomoni M,Peccatori J,Ciceri F,Roncarolo MG
MA1-80734 was used in flow cytometry to assess T regulatory type 1 cell therapy in patients with high-risk/advanced stage hematologic malignancies
Wed Feb 19 00:00:00 EST 2014
Out-of-sequence signal 3 as a mechanism for virus-induced immune suppression of CD8 T cell responses.
PLoS pathogens
Urban SL,Welsh RM
MA1-80734 was used in flow cytometry to determine virus-induced immune suppression of CD8 T cell responses caused by out-of-sequence signal 3
Mon Sep 01 00:00:00 EDT 2014
The phenotype and activation status of regulatory T cells during Friend retrovirus infection.
Virologica Sinica
Joedicke JJ,Dietze KK,Zelinskyy G,Dittmer U
MA1-80734 was used in flow cytometry to characterize the Treg populations the Friend retrovirus mouse model
Sat Feb 01 00:00:00 EST 2014
Midline 1 directs lytic granule exocytosis and cytotoxicity of mouse killer T cells.
European journal of immunology
Boding L,Hansen AK,Meroni G,Johansen BB,Braunstein TH,Bonefeld CM,Kongsbak M,Jensen BA,Woetmann A,Thomsen AR,Odum N,von Essen MR,Geisler C
MA1-80734 was used in flow cytometry to show that MID1 regulates cytotoxic lymphocytes responses
Wed Oct 01 00:00:00 EDT 2014
Rapid proliferation and differentiation impairs the development of memory CD8+ T cells in early life.
Journal of immunology (Baltimore, Md. : 1950)
Smith NL,Wissink E,Wang J,Pinello JF,Davenport MP,Grimson A,Rudd BD
MA1-80734 was used in flow cytometry to investigate incomplete immunity against intracellular pathogens in neonates
Tue Jul 01 00:00:00 EDT 2014
Immunomodulatory action of SGI-110, a hypomethylating agent, in acute myeloid leukemia cells and xenografts.
Leukemia research
Srivastava P,Paluch BE,Matsuzaki J,James SR,Collamat-Lai G,Karbach J,Nemeth MJ,Taverna P,Karpf AR,Griffiths EA
MA1-80734 was used in flow cytometry to investigate the effect of SGI-110 on cancer testis antigen gene-regulated expression
Sat Nov 01 00:00:00 EDT 2014
Role of NK cells in host defense against pulmonary type A Francisella tularensis infection.
Microbes and infection
Schmitt DM,O'Dee DM,Brown MJ,Horzempa J,Russo BC,Morel PA,Nau GJ
MA1-80734 was used in flow cytometry to study the pulmonary immune response to Francisella tularensis.
Fri Mar 01 00:00:00 EST 2013
CD4+ T cells develop antiretroviral cytotoxic activity in the absence of regulatory T cells and CD8+ T cells.
Journal of virology
Manzke N,Akhmetzyanova I,Hasenkrug KJ,Trilling M,Zelinskyy G,Dittmer U
MA1-80734 was used in flow cytometry to investigate the suppressive activity of Tregs on effector CD4(+) T cells in retroviral infection.
Sat Jun 01 00:00:00 EDT 2013
FoxO1 controls effector-to-memory transition and maintenance of functional CD8 T cell memory.
Journal of immunology (Baltimore, Md. : 1950)
Tejera MM,Kim EH,Sullivan JA,Plisch EH,Suresh M
MA1-80734 was used in flow cytometry to report that FoxO1 regulates effector-to-memory transition and functional maturation of memory CD4 and CD8 T cells.
Mon Jul 01 00:00:00 EDT 2013
Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity.
Molecular biology of the cell
Tuli A,Thiery J,James AM,Michelet X,Sharma M,Garg S,Sanborn KB,Orange JS,Lieberman J,Brenner MB
MA1-80734 was used in immunocytochemistry and western blot to identify ADP-ribosylation factor-like 8b as a factor required for natural killer cell-mediated cytotoxicity
Sun Dec 01 00:00:00 EST 2013
TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation.
Nature immunology
Zhang N,Bevan MJ
MA1-80734 was used in flow cytometry to elucidate how TGF-beta signaling regulates the self-reactivity of peripheral T cells
Sun May 27 00:00:00 EDT 2012
Chronic HIV infection affects the expression of the 2 transcription factors required for CD8 T-cell differentiation into cytolytic effectors.
Blood
Ribeiro-dos-Santos P,Turnbull EL,Monteiro M,Legrand A,Conrod K,Baalwa J,Pellegrino P,Shaw GM,Williams I,Borrow P,Rocha B
MA1-80734 was used in flow cytometry to study HIV-specific CD8 T cells.
Thu May 24 00:00:00 EDT 2012
IL-7 and IL-15 do not synergize during CD8 T cell recall response against an obligate intracellular parasite.
Microbes and infection
Bhadra R,Khan IA
MA1-80734 was used in flow cytometry to study the role of IL-15 and IL-7 on CD8 T cells during infection with Toxoplasma gondii.
Thu Nov 01 00:00:00 EDT 2012
Primary severe acute respiratory syndrome coronavirus infection limits replication but not lung inflammation upon homologous rechallenge.
Journal of virology
Clay C,Donart N,Fomukong N,Knight JB,Lei W,Price L,Hahn F,Van Westrienen J,Harrod KS
Published figure using Granzyme B monoclonal antibody (Product # MA1-80734) in Flow Cytometry
Sun Apr 01 00:00:00 EDT 2012
Cutting edge: tumor-targeting antibodies enhance NKG2D-mediated NK cell cytotoxicity by stabilizing NK cell-tumor cell interactions.
Journal of immunology (Baltimore, Md. : 1950)
Deguine J,Breart B,Lemaître F,Bousso P
MA1-80734 was used in flow cytometry to examine how NK cells integrate signals induced by stress and antibody-coated cells.
Sat Dec 15 00:00:00 EST 2012
An optimized SIV DNA vaccine can serve as a boost for Ad5 and provide partial protection from a high-dose SIVmac251 challenge.
Vaccine
Hutnick NA,Myles DJ,Hirao L,Scott VL,Ferraro B,Khan AS,Lewis MG,Miller CJ,Bett AJ,Casimiro D,Sardesai NY,Kim JJ,Shiver J,Weiner DB
MA1-80734 was used in flow cytometry to optimize a DNA vaccine to boost cellular immune responses induced by Ad5 prime
Wed May 02 00:00:00 EDT 2012
DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice.
The Journal of experimental medicine
Randall KL,Chan SS,Ma CS,Fung I,Mei Y,Yabas M,Tan A,Arkwright PD,Al Suwairi W,Lugo Reyes SO,Yamazaki-Nakashimada MA,Garcia-Cruz Mde L,Smart JM,Picard C,Okada S,Jouanguy E,Casanova JL,Lambe T,Cornall RJ,Russell S,Oliaro J,Tangye SG,Bertram EM,Goodnow CC
MA1-80734 was used in flow cytometry to determine the role for DOCK8 in peripheral CD8 T cell survival and function
Mon Oct 24 00:00:00 EDT 2011
A CD8α(-) subpopulation of macaque circulatory natural killer cells can mediate both antibody-dependent and antibody-independent cytotoxic activities.
Immunology
Vargas-Inchaustegui DA,Demberg T,Robert-Guroff M
MA1-80734 was used in flow cytometry to characterize different macaque NK cell subpopulations.
Tue Nov 01 00:00:00 EDT 2011
Virus-specific CD8+ T cells upregulate programmed death-1 expression during acute friend retrovirus infection but are highly cytotoxic and control virus replication.
Journal of immunology (Baltimore, Md. : 1950)
Zelinskyy G,Myers L,Dietze KK,Gibbert K,Roggendorf M,Liu J,Lu M,Kraft AR,Teichgräber V,Hasenkrug KJ,Dittmer U
MA1-80734 was used in flow cytometry to suggest that PD-1 expression during acute infection is not a marker of T cell exhaustion.
Sat Oct 01 00:00:00 EDT 2011
Early induction of polyfunctional simian immunodeficiency virus (SIV)-specific T lymphocytes and rapid disappearance of SIV from lymph nodes of sooty mangabeys during primary infection.
Journal of immunology (Baltimore, Md. : 1950)
Meythaler M,Wang Z,Martinot A,Pryputniewicz S,Kasheta M,McClure HM,O'Neil SP,Kaur A
MA1-80734 was used in flow cytometry to study the contribution of the cellular immune response in maintaining nonpathogenic SIV infection in sooty mangabeys.
Sun May 01 00:00:00 EDT 2011
The magnitude of the T cell response to a clinically significant dose of influenza virus is regulated by TRAIL.
Journal of immunology (Baltimore, Md. : 1950)
Brincks EL,Gurung P,Langlois RA,Hemann EA,Legge KL,Griffith TS
MA1-80734 was used in flow cytometry to elucidate the role of TRAIL in the pulmonary CD8 T cell response to influenza A virus.
Tue Nov 01 00:00:00 EDT 2011
Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis.
Blood
Thiery J,Keefe D,Saffarian S,Martinvalet D,Walch M,Boucrot E,Kirchhausen T,Lieberman J
MA1-80734 was used in immunocytochemistry to investigate the effect of perforin on specific endocytosis process
Thu Feb 25 00:00:00 EST 2010
Immune infiltration of spontaneous mouse astrocytomas is dominated by immunosuppressive cells from early stages of tumor development.
Cancer research
Tran Thang NN,Derouazi M,Philippin G,Arcidiaco S,Di Berardino-Besson W,Masson F,Hoepner S,Riccadonna C,Burkhardt K,Guha A,Dietrich PY,Walker PR
MA1-80734 was used in flow cytometry to use a transgenic mouse model of spontaneous astrocytoma to study immune infiltrate
Tue Jun 15 00:00:00 EDT 2010
IFN-alpha beta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions.
Journal of immunology (Baltimore, Md. : 1950)
Marshall HD,Prince AL,Berg LJ,Welsh RM
MA1-80734 was used in flow cytometry to investigate how bystander CD8 cells are impacted during viral infection
Sun Aug 01 00:00:00 EDT 2010
IL-15 trans-presentation promotes human NK cell development and differentiation in vivo.
The Journal of experimental medicine
Huntington ND,Legrand N,Alves NL,Jaron B,Weijer K,Plet A,Corcuff E,Mortier E,Jacques Y,Spits H,Di Santo JP
MA1-80734 was used in flow cytometry to elucidate the role of interleukin-15 in human natural killer cell development
Fri Jan 16 00:00:00 EST 2009
Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge.
Journal of immunology (Baltimore, Md. : 1950)
Hamada H,Garcia-Hernandez Mde L,Reome JB,Misra SK,Strutt TM,McKinstry KK,Cooper AM,Swain SL,Dutton RW
MA1-80734 was used in flow cytometry to elucidate the role of IL-17 in influenza A infection
Sun Mar 15 00:00:00 EDT 2009
IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells.
Cellular immunology
Brown DM,Kamperschroer C,Dilzer AM,Roberts DM,Swain SL
MA1-80734 was used in flow cytometry to explore how naive CD4 cells differentiate into class II restricted killers.
Tue May 26 00:00:00 EDT 2009
CD8 T cells utilize TRAIL to control influenza virus infection.
Journal of immunology (Baltimore, Md. : 1950)
Brincks EL,Katewa A,Kucaba TA,Griffith TS,Legge KL
MA1-80734 was used in flow cytometry to determine the importance of TRAIL to influenza-specific CD8(+) T cell immunity and control of the infection.
Wed Oct 01 00:00:00 EDT 2008
A phase I/II study of a MUC1 peptide pulsed autologous dendritic cell vaccine as adjuvant therapy in patients with resected pancreatic and biliary tumors.
Cancer therapy
Lepisto AJ,Moser AJ,Zeh H,Lee K,Bartlett D,McKolanis JR,Geller BA,Schmotzer A,Potter DP,Whiteside T,Finn OJ,Ramanathan RK
MA1-80734 was used in Flow Cytometry to study the use of a MUC1 peptide pulsed autologous dendritic cell vaccine as adjuvant therapy in patients with resected pancreatic and biliary tumours.
Wed Oct 20 00:00:00 EDT 2021
CTLA-4 ablation and interleukin-12 driven differentiation synergistically augment cardiac pathogenicity of cytotoxic T lymphocytes.
Circulation research
Love VA,Grabie N,Duramad P,Stavrakis G,Sharpe A,Lichtman A
MA1-80734 was used in flow cytometry to elucidate CTLA-4 regulation of cytotoxic T lymphocytes in a transgenic model of CD8+ T-cell-mediated myocarditis
Fri Aug 03 00:00:00 EDT 2007
IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production.
Journal of immunology (Baltimore, Md. : 1950)
Coquet JM,Kyparissoudis K,Pellicci DG,Besra G,Berzins SP,Smyth MJ,Godfrey DI
MA1-80734 was used in flow cytometry to report that NKT cells produce IL-21 and that IL-21 regulates NKT function
Thu Mar 01 00:00:00 EST 2007
Brain microenvironment promotes the final functional maturation of tumor-specific effector CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Masson F,Calzascia T,Di Berardino-Besson W,de Tribolet N,Dietrich PY,Walker PR
MA1-80734 was used in flow cytometry to determine if clonal expansion and acquisition of effector functions driven by antigen presenting cells is reshaped during the effector phase to adapt to the effector site microenvironment in murine brain tumor mode
Sun Jul 15 00:00:00 EDT 2007
T-bet concomitantly controls migration, survival, and effector functions during the development of Valpha14i NKT cells.
Blood
Matsuda JL,Zhang Q,Ndonye R,Richardson SK,Howell AR,Gapin L
MA1-80734 was used in flow cytometry to examine the role of T-bet in Valpha14i natural killer T cell function
Sat Apr 01 00:00:00 EST 2006
Gammaherpesvirus persistence alters key CD8 T-cell memory characteristics and enhances antiviral protection.
Journal of virology
Obar JJ,Fuse S,Leung EK,Bellfy SC,Usherwood EJ
MA1-80734 was used in flow cytometry to study CD8+ T cell responses during herpesvirus infection
Fri Sep 01 00:00:00 EDT 2006
The CD8+ T cell population elicited by recombinant adenovirus displays a novel partially exhausted phenotype associated with prolonged antigen presentation that nonetheless provides long-term immunity.
Journal of immunology (Baltimore, Md. : 1950)
Yang TC,Millar J,Groves T,Grinshtein N,Parsons R,Takenaka S,Wan Y,Bramson JL
MA1-80734 was used in flow cytometry to study the effects of prolonged antigen exposure
Sun Jan 01 00:00:00 EST 2006
Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells.
Proceedings of the National Academy of Sciences of the United States of America
Klebanoff CA,Gattinoni L,Torabi-Parizi P,Kerstann K,Cardones AR,Finkelstein SE,Palmer DC,Antony PA,Hwang ST,Rosenberg SA,Waldmann TA,Restifo NP
MA1-80734 was used in flow cytometry to evaluate the therapeutic potential of different tumor-reactive CD8+ T cell memory subsets in vivo
Tue Jul 05 00:00:00 EDT 2005
