Product References
Step-dose IL-7 treatment promotes systemic expansion of T cells and alters immune cell landscape in blood and lymph nodes.
iScience
Pandit H,Valentin A,Angel M,Deleage C,Bergamaschi C,Bear J,Sowder R,Felber BK,Pavlakis GN
MHGB04 was used in flow cytometry to study treatment of T cells and immune cell landscape in blood and lymph nodes.
Fri Feb 17 00:00:00 EST 2023
MYB orchestrates T cell exhaustion and response to checkpoint inhibition.
Nature
Tsui C,Kretschmer L,Rapelius S,Gabriel SS,Chisanga D,Knöpper K,Utzschneider DT,Nüssing S,Liao Y,Mason T,Torres SV,Wilcox SA,Kanev K,Jarosch S,Leube J,Nutt SL,Zehn D,Parish IA,Kastenmüller W,Shi W,Buchholz VR,Kallies A
MHGB04 was used in Flow cytometry/Cell sorting to identify CD62L+ TPEX cells as a stem-like population that is central to the maintenance of long-term antiviral immunity and responsiveness to immunotherapy.
Thu Sep 01 00:00:00 EDT 2022
Heterologous arenavirus vector prime-boost overrules self-tolerance for efficient tumor-specific CD8 T cell attack.
Cell reports. Medicine
Bonilla WV,Kirchhammer N,Marx AF,Kallert SM,Krzyzaniak MA,Lu M,Darbre S,Schmidt S,Raguz J,Berka U,Vincenti I,Pauzuolis M,Kerber R,Hoepner S,Günther S,Magnus C,Merkler D,Orlinger KK,Zippelius A,Pinschewer DD
MHGB04 was used in Flow Cytometry to establish an arenavirus-based immunotherapy regimen that allows reshuffling of immunodominance hierarchies and breaking self-directed tolerance for efficient tumor control.
Tue Mar 16 00:00:00 EDT 2021
Lymph node-resident dendritic cells drive TH2 cell development involving MARCH1.
Science immunology
Castellanos CA,Ren X,Gonzalez SL,Li HK,Schroeder AW,Liang HE,Laidlaw BJ,Hu D,Mak ACY,Eng C,Rodríguez-Santana JR,LeNoir M,Yan Q,Celedón JC,Burchard EG,Zamvil SS,Ishido S,Locksley RM,Cyster JG,Huang X,Shin JS
MHGB04 was used in Flow cytometry/Cell sorting to suggest that TH2 cell development depends on ubiquitin-mediated clearance of antigen-presenting and costimulatory molecules by LN-resident DCs and consequent control of TCR signaling.
Fri Oct 15 00:00:00 EDT 2021
Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms.
Immunity
Beltra JC,Manne S,Abdel-Hakeem MS,Kurachi M,Giles JR,Chen Z,Casella V,Ngiow SF,Khan O,Huang YJ,Yan P,Nzingha K,Xu W,Amaravadi RK,Xu X,Karakousis GC,Mitchell TC,Schuchter LM,Huang AC,Wherry EJ
MHGB04 was used in Flow cytometry/Cell sorting to reveal a four-stage developmental hierarchy for Tex cells and define the molecular, transcriptional, and epigenetic mechanisms that could provide opportunities to improve cancer immunotherapy.
Tue May 19 00:00:00 EDT 2020
Early precursor T cells establish and propagate T cell exhaustion in chronic infection.
Nature immunology
Utzschneider DT,Gabriel SS,Chisanga D,Gloury R,Gubser PM,Vasanthakumar A,Shi W,Kallies A
MHGB04 was used in Flow cytometry/Cell sorting to demonstrate that exhaustion manifests first in TCF1+ precursor T cells and is propagated subsequently to the pool of antigen-specific T cells.
Thu Oct 01 00:00:00 EDT 2020
Landscape of Exhausted Virus-Specific CD8 T Cells in Chronic LCMV Infection.
Cell reports
Sandu I,Cerletti D,Oetiker N,Borsa M,Wagen F,Spadafora I,Welten SPM,Stolz U,Oxenius A,Claassen M
MHGB04 was used in Flow Cytometry to reveal that exhausted cells are heterogeneous, adopt organ-specific transcriptomic profiles, and can be divided into five main functional subpopulations: advanced exhaustion, effector-like, intermediate, proliferating, or memory-like.
Tue Aug 25 00:00:00 EDT 2020
CD19-CAR-T Cells Bearing a KIR/PD-1-Based Inhibitory CAR Eradicate CD19+HLA-C1- Malignant B Cells While Sparing CD19+HLA-C1+ Healthy B Cells.
Cancers
Tao L,Farooq MA,Gao Y,Zhang L,Niu C,Ajmal I,Zhou Y,He C,Zhao G,Yao J,Liu M,Jiang W
MHGB04 was used in Flow cytometry/Cell sorting to engineer a novel KIR/PD-1-based inhibitory CAR (iKP CAR) by fusing the extracellular domain of killer cell immunoglobulin-like receptors (KIR) 2DL2 (KIR2DL2) and the intracellular domain of PD-1.
Sun Sep 13 00:00:00 EDT 2020
Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants.
Cell reports. Medicine
Marinaik CB,Kingstad-Bakke B,Lee W,Hatta M,Sonsalla M,Larsen A,Neldner B,Gasper DJ,Kedl RM,Kawaoka Y,Suresh M
MHGB04 was used in Flow cytometry/Cell sorting to provide further insights into vaccine-induced multifaceted mucosal T cell immunity with implications in the development of vaccines against respiratorypathogens, including influenza virus and SARS-CoV-2.
Tue Sep 22 00:00:00 EDT 2020
Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease.
Cell
Mayassi T,Ladell K,Gudjonson H,McLaren JE,Shaw DG,Tran MT,Rokicka JJ,Lawrence I,Grenier JC,van Unen V,Ciszewski C,Dimaano M,Sayegh HE,Kumar V,Wijmenga C,Green PHR,Gokhale R,Jericho H,Semrad CE,Guandalini S,Dinner AR,Kupfer SS,Reid HH,Barreiro LB,Rossjohn J,Price DA,Jabri B
MHGB04 was used in Flow cytometry/Cell sorting to determine the role of tissue-resident lymphocytes in chronic inflammation.
Thu Feb 21 00:00:00 EST 2019
Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer.
Frontiers in immunology
Lin W,Xu D,Austin CD,Caplazi P,Senger K,Sun Y,Jeet S,Young J,Delarosa D,Suto E,Huang Z,Zhang J,Yan D,Corzo C,Barck K,Rajan S,Looney C,Gandham V,Lesch J,Liang WC,Mai E,Ngu H,Ratti N,Chen Y,Misner D,Lin T,Danilenko D,Katavolos P,Doudemont E,Uppal H,Eastham J,Mak J,de Almeida PE,Bao K,Hadadianpour A,Keir M,Carano RAD,Diehl L,Xu M,Wu Y,Weimer RM,DeVoss J,Lee WP,Balazs M,Walsh K,Alatsis KR,Martin F,Zarrin AA
MHGB04 was used in Flow cytometry/Cell sorting to conclude that IL34 and CSF1 play non-redundant roles in macrophage differentiation, and therapeutic intervention targeting IL34 and/or CSF1 may provide an effective treatment in macrophage-driven immune-pathologies.
Mon Oct 19 00:00:00 EDT 2020
Vaccine induction of antibodies and tissue-resident CD8+ T cells enhances protection against mucosal SHIV-infection in young macaques.
JCI insight
Petitdemange C,Kasturi SP,Kozlowski PA,Nabi R,Quarnstrom CF,Reddy PBJ,Derdeyn CA,Spicer LM,Patel P,Legere T,Kovalenkov YO,Labranche CC,Villinger F,Tomai M,Vasilakos J,Haynes B,Kang CY,Gibbs JS,Yewdell JW,Barouch D,Wrammert J,Montefiori D,Hunter E,Amara RR,Masopust D,Pulendran B
MHGB04 was used in Flow Cytometry to demonstrate that vaccination strategies that induce both CD8+ T cell and antibody responses can confer enhanced protection against infection.
Thu Feb 21 00:00:00 EST 2019
Interleukin-27R Signaling Mediates Early Viral Containment and Impacts Innate and Adaptive Immunity after Chronic Lymphocytic Choriomeningitis Virus Infection.
Journal of virology
Harker JA,Wong KA,Dallari S,Bao P,Dolgoter A,Jo Y,Wehrens EJ,Macal M,Zuniga EI
MHGB04 was used in Flow cytometry/Cell sorting to investigate the role of interleukin-27 in the control of chronic infection.
Fri Jun 15 00:00:00 EDT 2018
Gag and env conserved element CE DNA vaccines elicit broad cytotoxic T cell responses targeting subdominant epitopes of HIV and SIV Able to recognize virus-infected cells in macaques.
Human vaccines & immunotherapeutics
Hu X,Lu Z,Valentin A,Rosati M,Broderick KE,Sardesai NY,Marx PA,Mullins JI,Pavlakis GN,Felber BK
MHGB04 was used in Flow cytometry/Cell sorting to study the cytotoxic T cell responses against conserved protein segments of SIV Gag and HIV Env following DNA vaccination.
Mon May 06 00:00:00 EDT 2019
Identification of Nascent Memory CD8 T Cells and Modeling of Their Ontogeny.
Cell systems
Crauste F,Mafille J,Boucinha L,Djebali S,Gandrillon O,Marvel J,Arpin C
MHGB04 was used in Flow Cytometry to identify Bcl2 and Mki67 as a marker combination that enables the tracking of nascent memory cells within the effector phase.
Wed Mar 22 00:00:00 EDT 2017
Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells.
PLoS pathogens
Danahy DB,Anthony SM,Jensen IJ,Hartwig SM,Shan Q,Xue HH,Harty JT,Griffith TS,Badovinac VP
MHGB04 was used in Flow cytometry/Cell sorting to directly examine the impact of sepsis on tissue resident memory CD8+ T cells in mice.
Fri Sep 01 00:00:00 EDT 2017
Cross-Presentation of Soluble and Cell-Associated Antigen by Murine Hepatocytes Is Enhanced by Collectrin Expression.
Journal of immunology (Baltimore, Md. : 1950)
Dolina JS,Cechova S,Rudy CK,Sung SJ,Tang WW,Lee J,Hahn YS,Le TH
MHGB04 was used in Flow cytometry/Cell sorting to identify the functional role of collectrin in the liver.
Wed Mar 15 00:00:00 EDT 2017
Radiotherapy enhances natural killer cell cytotoxicity and localization in pre-clinical canine sarcomas and first-in-dog clinical trial.
Journal for immunotherapy of cancer
Canter RJ,Grossenbacher SK,Foltz JA,Sturgill IR,Park JS,Luna JI,Kent MS,Culp WTN,Chen M,Modiano JF,Monjazeb AM,Lee DA,Murphy WJ
MHGB04 was used in Flow cytometry/Cell sorting to assess radiotherapy (RT) plus local autologous natural killer (NK) transfer in canine sarcomas.
Tue Dec 19 00:00:00 EST 2017
miR-150-Mediated Foxo1 Regulation Programs CD8+ T Cell Differentiation.
Cell reports
Ban YH,Oh SC,Seo SH,Kim SM,Choi IP,Greenberg PD,Chang J,Kim TD,Ha SJ
MHGB04 was used in Flow cytometry/Cell sorting to suggest that miR-150-mediated suppression of Foxo1 regulates the balance between effector and memory cell differentiation.
Tue Sep 12 00:00:00 EDT 2017
Characterization of Human CD8 T Cell Responses in Dengue Virus-Infected Patients from India.
Journal of virology
Chandele A,Sewatanon J,Gunisetty S,Singla M,Onlamoon N,Akondy RS,Kissick HT,Nayak K,Reddy ES,Kalam H,Kumar D,Verma A,Panda H,Wang S,Angkasekwinai N,Pattanapanyasat K,Chokephaibulkit K,Medigeshi GR,Lodha R,Kabra S,Ahmed R,Murali-Krishna K
MHGB04 was used in flow cytometry to characterize CD8 positive T cell subsets in dengue patients from India and Thailand
Thu Dec 15 00:00:00 EST 2016
DNA Prime-Boost Vaccine Regimen To Increase Breadth, Magnitude, and Cytotoxicity of the Cellular Immune Responses to Subdominant Gag Epitopes of Simian Immunodeficiency Virus and HIV.
Journal of immunology (Baltimore, Md. : 1950)
Hu X,Valentin A,Dayton F,Kulkarni V,Alicea C,Rosati M,Chowdhury B,Gautam R,Broderick KE,Sardesai NY,Martin MA,Mullins JI,Pavlakis GN,Felber BK
MHGB04 was used in flow cytometry to examine the contribution of HIV-derived conserved elements in vaccination
Tue Nov 15 00:00:00 EST 2016
Celiac Disease-Related Inflammation Is Marked by Reduction of Nkp44/Nkp46-Double Positive Natural Killer Cells.
PloS one
Marafini I,Monteleone I,Di Fusco D,Sedda S,Cupi ML,Fina D,Paoluzi AO,Pallone F,Monteleone G
MHGB04 was used in flow cytometry to elucidate the marked reduction of Nkp44/Nkp46-double positive natural killer cells by celiac disease-related inflammation
Mon Jul 10 00:00:00 EDT 2017
Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8+ T-Cell Responses Focused on a Single Nef Epitope Select for Escape Variants Shortly after Infection.
Journal of virology
Martins MA,Tully DC,Cruz MA,Power KA,Veloso de Santana MG,Bean DJ,Ogilvie CB,Gadgil R,Lima NS,Magnani DM,Ejima K,Allison DB,Piatak M,Altman JD,Parks CL,Rakasz EG,Capuano S,Galler R,Bonaldo MC,Lifson JD,Allen TM,Watkins DI
MHGB04 was used in Flow cytometry/Cell sorting to study the complexity and multidimensional nature of virologic control of lentivirus infection.
Sun Nov 01 00:00:00 EDT 2015
Granzyme B expression is enhanced in human monocytes by TLR8 agonists and contributes to antibody-dependent cellular cytotoxicity.
Journal of immunology (Baltimore, Md. : 1950)
Elavazhagan S,Fatehchand K,Santhanam V,Fang H,Ren L,Gautam S,Reader B,Mo X,Cheney C,Briercheck E,Vasilakos JP,Dietsch GN,Hershberg RM,Caligiuri M,Byrd JC,Butchar JP,Tridandapani S
MHGB04 was used in Flow cytometry/Cell sorting to show that human monocytes produce the protease granzyme B upon both FcγR and TLR8 activation.
Sun Mar 15 00:00:00 EDT 2015
Functional heterogeneity in the CD4+ T cell response to murine γ-herpesvirus 68.
Journal of immunology (Baltimore, Md. : 1950)
Hu Z,Blackman MA,Kaye KM,Usherwood EJ
MHGB04 was used in flow cytometry to investigate the differentiation and function of murine gamma-herpesvirus 68 (MHV-68)-specific CD4(+) T cells using gp150-specific TCR-transgenic mice
Sun Mar 15 00:00:00 EDT 2015
Type I IFN signaling in CD8- DCs impairs Th1-dependent malaria immunity.
The Journal of clinical investigation
Haque A,Best SE,Montes de Oca M,James KR,Ammerdorffer A,Edwards CL,de Labastida Rivera F,Amante FH,Bunn PT,Sheel M,Sebina I,Koyama M,Varelias A,Hertzog PJ,Kalinke U,Gun SY,Rénia L,Ruedl C,MacDonald KP,Hill GR,Engwerda CR
MHGB04 was used in Flow cytometry/Cell sorting to suggest abrogation of type I IFN signaling in CD8- splenic cDCs as an approach for enhancing Th1 responses against Plasmodium.
Sun Jun 01 00:00:00 EDT 2014
B-CLL cells acquire APC- and CTL-like phenotypic characteristics after stimulation with CpG ODN and IL-21.
International immunology
Hagn M,Blackwell SE,Beyer T,Ebel V,Fabricius D,Lindner S,Stilgenbauer S,Simmet T,Tam C,Neeson P,Trapani JA,Schrezenmeier H,Weiner GJ,Jahrsdörfer B
MHGB04 was used in flow cytometry to investigate the effect of CpG and IL-21 treatment on B-cell chronic lymphocytic leukemia.
Tue Jul 01 00:00:00 EDT 2014
FTY720 impairs CD8 T-cell function independently of the sphingosine-1-phosphate pathway.
Journal of neuroimmunology
Ntranos A,Hall O,Robinson DP,Grishkan IV,Schott JT,Tosi DM,Klein SL,Calabresi PA,Gocke AR
MHGB04 was used in flow cytometry to study the effect of FTY720 treatment on CD8 T-cells
Thu May 15 00:00:00 EDT 2014
Altered response hierarchy and increased T-cell breadth upon HIV-1 conserved element DNA vaccination in macaques.
PloS one
Kulkarni V,Valentin A,Rosati M,Alicea C,Singh AK,Jalah R,Broderick KE,Sardesai NY,Le Gall S,Mothe B,Brander C,Rolland M,Mullins JI,Pavlakis GN,Felber BK
MHGB04 was used in flow cytometry to compare vaccination with highly conserved gag elements verses full-length gag DNA.
Tue Nov 11 00:00:00 EST 2014
Elevated Granzyme B in Cytotoxic Lymphocytes is a Signature of Immune Activation in Hemophagocytic Lymphohistiocytosis.
Frontiers in immunology
Mellor-Heineke S,Villanueva J,Jordan MB,Marsh R,Zhang K,Bleesing JJ,Filipovich AH,Risma KA
MHGB04 was used in flow cytometry to conclude that increased detection of granzyme B in cytotoxic T cells and natural killer cells is an immune signature for lymphocyte activation in hemophagocytic lymphohistiocytosis
Tue Mar 26 00:00:00 EDT 2013
Alternative serotype adenovirus vaccine vectors elicit memory T cells with enhanced anamnestic capacity compared to Ad5 vectors.
Journal of virology
Penaloza-MacMaster P,Provine NM,Ra J,Borducchi EN,McNally A,Simmons NL,Iampietro MJ,Barouch DH
MHGB04 was used in flow cytometry to study T cell responses elicited by Ad5 and those of alternative-serotype Ad vectors.
Fri Feb 01 00:00:00 EST 2013
Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection.
Cell host & microbe
Walsh KB,Teijaro JR,Zuniga EI,Welch MJ,Fremgen DM,Blackburn SD,von Tiehl KF,Wherry EJ,Flavell RA,Oldstone MB
MHGB04 was used in flow cytometry to study TLR7 knockout mice infected with lymphocytic choriomeningitis virus.
Thu Jun 14 00:00:00 EDT 2012
Comparable polyfunctionality of ectromelia virus- and vaccinia virus-specific murine T cells despite markedly different in vivo replication and pathogenicity.
Journal of virology
Hersperger AR,Siciliano NA,Eisenlohr LC
MHGB04 was used in Flow cytometry/Cell sorting to provide a mechanism to explain the ability of VACV to induce protective T-cell responses against pathogenic poxviruses in their natural hosts and provide further support for the use of VACV as a vaccine platform able to induce polyfunctional T cells.
Sun Jul 01 00:00:00 EDT 2012
Docosahexaenoic acid inhibits invasion of human RT112 urinary bladder and PT45 pancreatic carcinoma cells via down-modulation of granzyme B expression.
The Journal of nutritional biochemistry
D'Eliseo D,Manzi L,Merendino N,Velotti F
MHGB04 was used in flow cytometry to examine the effect of n-3 PUFA-docosahexaenoic acid bladder and pancreatic cancer cells.
Tue May 01 00:00:00 EDT 2012
IL-10+ CTLA-4+ Th2 inhibitory cells form in a Foxp3-independent, IL-2-dependent manner from Th2 effectors during chronic inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Altin JA,Goodnow CC,Cook MC
MHGB04 was used in Flow cytometry/Cell sorting to investigate the mechanism and molecules involved in the formation of IL10+CTLA-4+Th2 inhibitory cells during chronic inflammation.
Fri Jun 01 00:00:00 EDT 2012
A role for Blimp1 in the transcriptional network controlling natural killer cell maturation.
Blood
Kallies A,Carotta S,Huntington ND,Bernard NJ,Tarlinton DM,Smyth MJ,Nutt SL
MHGB04 was used in flow cytometry to examine the IRF4-Blimp1-Bcl6 regulatory axis in NK development
Thu Feb 10 00:00:00 EST 2011
Minor antigens on transfused RBCs crossprime CD8 T cells but do not induce full effector function.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Desmarets M,Mylvaganam G,Waller EK,Josephson CD,Pack C,Lukacher AE,Zimring JC
MHGB04 was used in flow cytometry to examine red blood cells as an immunogen.
Thu Sep 01 00:00:00 EDT 2011
Granzyme B regulates antiviral CD8+ T cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Salti SM,Hammelev EM,Grewal JL,Reddy ST,Zemple SJ,Grossman WJ,Grayson MH,Verbsky JW
MHGB04 was used in flow cytometry to determine the role of granzyme B in immune regulation during viral infections.
Thu Dec 15 00:00:00 EST 2011
Age-related changes in durability and function of vaccine-elicited influenza-specific CD4(+) T-cell responses.
Vaccine
Mahnke YD,Saqr A,Hazenfeld S,Brady RC,Roederer M,Subbramanian RA
MHGB04 was used in flow cytometry to examine the HA-specific T-cell responses among a cohort of young and elderly influenza vaccines.
Thu Nov 03 00:00:00 EDT 2011
High parasite burdens cause liver damage in mice following Plasmodium berghei ANKA infection independently of CD8(+) T cell-mediated immune pathology.
Infection and immunity
Haque A,Best SE,Amante FH,Ammerdorffer A,de Labastida F,Pereira T,Ramm GA,Engwerda CR
MHGB04 was used in flow cytometry to investigate the role of CD8 T cells to the brain and liver damage observed during infection with Plasmodium berghei ANKA.
Sun May 01 00:00:00 EDT 2011
CD16- natural killer cells: enrichment in mucosal and secondary lymphoid tissues and altered function during chronic SIV infection.
Blood
Reeves RK,Gillis J,Wong FE,Yu Y,Connole M,Johnson RP
MHGB04 was used in flow cytometry to investigate changes to macaque NK-cell subsets during infection with SIV
Thu Jun 03 00:00:00 EDT 2010
Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway.
The Journal of experimental medicine
Hubert S,Rissiek B,Klages K,Huehn J,Sparwasser T,Haag F,Koch-Nolte F,Boyer O,Seman M,Adriouch S
MHGB04 was used in flow cytometry to report that NAD(+) regulates the survival, phenotype, and function of T regulatory cells via the ART2-P2X7 pathway
Mon Nov 22 00:00:00 EST 2010
Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma.
Cancer research
Klages K,Mayer CT,Lahl K,Loddenkemper C,Teng MW,Ngiow SF,Smyth MJ,Hamann A,Huehn J,Sparwasser T
MHGB04 was used in flow cytometry to test if selective depletion of Foxp3(+) Tregs reduces cancer
Fri Oct 15 00:00:00 EDT 2010
Impact of age, gender, and race on circulating γδ T cells.
Human immunology
Cairo C,Armstrong CL,Cummings JS,Deetz CO,Tan M,Lu C,Davis CE,Pauza CD
MHGB04 was used in flow cytometry to study Vgamma2Vdelta2 T cells from Caucasian or African American donors
Fri Oct 01 00:00:00 EDT 2010
Critical role for the transcription regulator CCCTC-binding factor in the control of Th2 cytokine expression.
Journal of immunology (Baltimore, Md. : 1950)
Ribeiro de Almeida C,Heath H,Krpic S,Dingjan GM,van Hamburg JP,Bergen I,van de Nobelen S,Sleutels F,Grosveld F,Galjart N,Hendriks RW
MHGB04 was used in flow cytometry to study the role of the transcription regulator CCCTC-binding factor in Th2 differentiation
Thu Jan 15 00:00:00 EST 2009
Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.
Journal of immunology (Baltimore, Md. : 1950)
Hagn M,Schwesinger E,Ebel V,Sontheimer K,Maier J,Beyer T,Syrovets T,Laumonnier Y,Fabricius D,Simmet T,Jahrsdörfer B
MHGB04 was used in flow cytometry to identify conditions in which granzyme B is produced by human B cells
Sat Aug 01 00:00:00 EDT 2009
The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination.
Nature medicine
Chiarle R,Martinengo C,Mastini C,Ambrogio C,D'Escamard V,Forni G,Inghirami G
MHGB04 was used in immunohistochemistry - paraffin section to test the efficacy of DNA vaccination with anaplastic lymphoma kinase in a mouse model of anaplastic large cell lymphoma
Sun Jun 01 00:00:00 EDT 2008
Single-dose protection against Plasmodium berghei by a simian adenovirus vector using a human cytomegalovirus promoter containing intron A.
Journal of virology
Sridhar S,Reyes-Sandoval A,Draper SJ,Moore AC,Gilbert SC,Gao GP,Wilson JM,Hill AV
MHGB04 was used in flow cytometry to analyze protection against Plasmodium berghei by a single-dose simian adenovirus vector using a human cytomegalovirus promoter containing intron A
Tue Apr 01 00:00:00 EDT 2008
Impacts of HIV infection on Vgamma2Vdelta2 T cell phenotype and function: a mechanism for reduced tumor immunity in AIDS.
Journal of leukocyte biology
Cummings JS,Cairo C,Armstrong C,Davis CE,Pauza CD
MHGB04 was used in flow cytometry to study Vgamma2Vdelta2 T cells in HIV infected patients
Fri Aug 01 00:00:00 EDT 2008
Expression of granzyme B in peripheral blood polymorphonuclear neutrophils (PMN), myeloid cell lines and in PMN derived from haemotopoietic stem cells in vitro.
Molecular immunology
Wagner C,Stegmaier S,Hänsch GM
MHGB04 was used in flow cytometry to test if granzyme B is produced in the myeloid cell lines HL-60 and U937, in CD34+ stem cells, and in PMN derived from CD34+ cells in vitro
Sat Mar 01 00:00:00 EST 2008
JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response.
European journal of immunology
Tao J,Gao Y,Li MO,He W,Chen L,Harvev B,Davis RJ,Flavell RA,Yin Z
MHGB04 was used in flow cytometry to investigate the role of JNK2 in CD8+ T cell response and effector functions
Thu Mar 01 00:00:00 EST 2007
CD56brightCD16- killer Ig-like receptor- NK cells display longer telomeres and acquire features of CD56dim NK cells upon activation.
Journal of immunology (Baltimore, Md. : 1950)
Romagnani C,Juelke K,Falco M,Morandi B,D'Agostino A,Costa R,Ratto G,Forte G,Carrega P,Lui G,Conte R,Strowig T,Moretta A,Münz C,Thiel A,Moretta L,Ferlazzo G
MHGB04 was used in flow cytometry to elucidate the developmental relationship between natural killer subsets
Sun Apr 15 00:00:00 EDT 2007
Flow cytometric detection of degranulation reveals phenotypic heterogeneity of degranulating CMV-specific CD8+ T lymphocytes in rhesus macaques.
Journal of immunological methods
Chan KS,Kaur A
MHGB04 was used in flow cytometry to examine rhesus cytomegalovirus-specific CD8+ T lymphocytes.
Fri Aug 31 00:00:00 EDT 2007
Activated CD4+CD25+ T cells selectively kill B lymphocytes.
Blood
Zhao DM,Thornton AM,DiPaolo RJ,Shevach EM
MHGB04 was used in flow cytometry to study interaction between CD4+CD25+ T cells and B cells
Mon May 15 00:00:00 EDT 2006
Attenuation of CD8(+) T-cell function by CD4(+)CD25(+) regulatory T cells in B-cell non-Hodgkin's lymphoma.
Cancer research
Yang ZZ,Novak AJ,Ziesmer SC,Witzig TE,Ansell SM
MHGB04 was used in flow cytometry to study CD4(+) CD25 (+) regulatory T cells in B-cell non-Hodgkin's lymphoma and attenuation of CD8(+) T-cell function
Sun Oct 15 00:00:00 EDT 2006
Expression of CD8alpha identifies a distinct subset of effector memory CD4+ T lymphocytes.
Immunology
Macchia I,Gauduin MC,Kaur A,Johnson RP
MHGB04 was used in flow cytometry to determine the frequency, phenotype, and function of peripheral CD4+ CD8+ T cells in rhesus macaques infected with simian immunodeficiency virus
Sun Oct 01 00:00:00 EDT 2006
MT110: a novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors.
Molecular immunology
Brischwein K,Schlereth B,Guller B,Steiger C,Wolf A,Lutterbuese R,Offner S,Locher M,Urbig T,Raum T,Kleindienst P,Wimberger P,Kimmig R,Fichtner I,Kufer P,Hofmeister R,da Silva AJ,Baeuerle PA
MHGB04 was used in flow cytometry to evaluate the use of a bispecific antibody to treat human Ep-CAM-overexpressing carcinomas
Wed Mar 01 00:00:00 EST 2006
Polymorphism in the proximal promoter region of the perforin gene and its impact on the course of HIV infection.
International journal of immunogenetics
McIlroy D,Meyer L,Dudoit Y,Samri A,Delfraissy JF,Autran B,Debré P,Theodorou I
MHGB04 was used in flow cytometry to test if perforin polymorphisms influence the progression of HIV infection
Sat Apr 01 00:00:00 EST 2006
Development of hemophagocytic lymphohistiocytosis in triplets infected with HHV-8.
Blood
Grossman WJ,Radhi M,Schauer D,Gerday E,Grose C,Goldman FD
MHGB04 was used in flow cytometry to analyze triplets infected with HHV-8 and the development of hemophagocytic lymphohistiocytosis
Mon Aug 15 00:00:00 EDT 2005
Development and migration of protective CD8+ T cells into the nervous system following ocular herpes simplex virus-1 infection.
Journal of immunology (Baltimore, Md. : 1950)
Lang A,Nikolich-Zugich J
MHGB04 was used in flow cytometry to analyze ocular herpes simplex virus-1 infection and the migration and development of protective CD8+ T cells into the nervous system
Tue Mar 01 00:00:00 EST 2005
Extensive flow cytometric characterization of plasmacytoid dendritic cell leukemia cells.
European journal of haematology
Gopcsa L,Banyai A,Jakab K,Kormos L,Tamaska J,Matolcsy A,Gogolak P,Rajnavolgyi E,Paloczi K
MHGB04 was used in flow cytometry to review characteristics of non-T, non-B cell CD4+CD56+ neoplasms with lymphoblastic morphology
Sat Oct 01 00:00:00 EDT 2005
Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells.
Blood
Grossman WJ,Verbsky JW,Tollefsen BL,Kemper C,Atkinson JP,Ley TJ
MHGB04 was used in flow cytometry to study granzymes A and B and differential expression in human cytotoxic lymphocyte subsets and T regulatory cells
Mon Nov 01 00:00:00 EST 2004
Human neutrophils lack granzyme A, granzyme B, and perforin.
Blood
Metkar SS,Froelich CJ
MHGB04 was used in flow cytometry to report that human neutrophils lack granzyme A, granzyme B, and perforin
Sun Aug 01 00:00:00 EDT 2004
Restriction of de novo nucleotide biosynthesis interferes with clonal expansion and differentiation into effector and memory CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950)
Quéméneur L,Beloeil L,Michallet MC,Angelov G,Tomkowiak M,Revillard JP,Marvel J
MHGB04 was used in flow cytometry to assess the impact of nucleotide synthesis inhibition on CD8 T cell differentiation
Fri Oct 15 00:00:00 EDT 2004
A triple-mutated allele of granzyme B incapable of inducing apoptosis.
Proceedings of the National Academy of Sciences of the United States of America
McIlroy D,Cartron PF,Tuffery P,Dudoit Y,Samri A,Autran B,Vallette FM,Debré P,Theodorou I
MHGB04 was used in flow cytometry to assess genetic variation in granzyme B.
Tue Mar 04 00:00:00 EST 2003
Cutting edge: rapid in vivo CTL activity by polyoma virus-specific effector and memory CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Byers AM,Kemball CC,Moser JM,Lukacher AE
MHGB04 was used in flow cytometry to investigate the role of cytotoxic effector-memory CD8(+) T cell during persistent viral infection.
Tue Jul 01 00:00:00 EDT 2003
