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Invitrogen
H3.3 K36M oncohistone mutant Recombinant Superclonal Antibody (10HCLC), ChIP-Verified
Advanced Verification
This antibody was verified by EpiCypher™ SNAP-ChIP™ Spike-in Controls to ensure target specificity and enrichment in ChIP.
FIGURE: 1 / 4
H3.3 K36M oncohistone mutant Antibody (711967) in WB
Western blot was performed using Histone H3.3 K36M Recombinant Rabbit Polyclonal Antibody (Product # 711967) and a 17 kDa band corresponding to H3.3 K36M was observed in histone H3.3 K36M overexpressing HEK-293T cells confirming the specificity of H3.3 K36M antibody. Modified whole cell extracts (1% SDS) (30 µg lysate) from control (untransfected) (Lane 1), FLAG-tagged histone H3.3 K36M overexpressing HEK-2... View More
Product Details
711967
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Recombinant Superclonal
Type
Antibody
Clone
10HCLC
Immunogen
Peptide corresponding to human H3.3 K36M [aa32-aa40]
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2811736
Product Specific Information
This antibody is predicted to react with Mouse, Rat, Bovine.
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
Target Information
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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