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H3.3 K4M oncohistone mutant Antibody (MA5-33393) in ICC/IF
Immunocytochemistry analysis of H3.3K4M on formalin fixed and paraffin embedded 293T cells transfected with a DNA construct encoding wild type (WT) proteins of Histone H3, stained with H3.3 K4M oncohistone mutant Recombinant Monoclonal antibody (Product # MA5-33393).
Product Details
MA5-33393
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
All,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
RM363
Immunogen
A peptide corresponding to Histone H3 K4M mutant
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Protein A
Storage buffer
PBS with 50% glycerol, 1% BSA
Contains
0.09% sodium azide
Storage conditions
-20°C
Shipping conditions
Dry ice
RRID
AB_2815528
Product Specific Information
This product reacts to the Histone H3 K4M mutant. No cross reactivity with wild type Histone H3.
Click here for Master Lot linking information.
Target Information
Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modification that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: H3 histone, family 3B (H3.3B); H3 K4; H3 K4M; H3/b; H3/d; H3/f; H3/j; H3K4 mutant; H3K4M; Histone 3; Histone H3 K4M; Histone H3.3; Histone H3K4M
Gene Aliases: H3-3A; H3-3B; H3.3A; H3.3B; H3F3; H3F3A; H3F3B; PP781
UniProt ID: (Human) P84243
Entrez Gene ID: (Human) 3020, (Human) 3021
chromatin silencing at rDNA
nucleosome assembly
DNA replication-independent nucleosome assembly
brain development
blood coagulation
response to hormone
positive regulation of cell growth
gene silencing by RNA
telomere organization
cellular protein metabolic process
negative regulation of gene expression, epigenetic
positive regulation of gene expression, epigenetic
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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