Product References
The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes.
Cell reports
Garipler G,Lu C,Morrissey A,Lopez-Zepeda LS,Pei Y,Vidal SE,Zen Petisco Fiore AP,Aydin B,Stadtfeld M,Ohler U,Mahony S,Sanjana NE,Mazzoni EO
MA1-12429 was used in Immunoprecipitation to find that ZBTB11 and ZFP131 are required for embryonic stem cell pluripotency and elucidate the mechanism behind this.
Tue Mar 15 00:00:00 EDT 2022
TRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway.
Nature communications
Rossitto M,Déjardin S,Rands CM,Le Gras S,Migale R,Rafiee MR,Neirijnck Y,Pruvost A,Nguyen AL,Bossis G,Cammas F,Le Gallic L,Wilhelm D,Lovell-Badge R,Boizet-Bonhoure B,Nef S,Poulat F
MA1-12429 was used in Western Blotting to show that TRIM28 is required to prevent female-to-male sex reversal of the mouse ovary after birth.
Fri Jul 29 00:00:00 EDT 2022
ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function.
Cell reports
Baron DM,Fenton AR,Saez-Atienzar S,Giampetruzzi A,Sreeram A,Keagle PJ,Doocy VR,Smith NJ,Danielson EW,Andresano M,McCormack MC,Garcia J,Bercier V,Van Den Bosch L,Brent JR,Fallini C,Traynor BJ,Holzbaur ELF,Landers JE
MA1-12429 was used in Western Blot to support the hypothesis that causative ALS mutations result in a toxic gain of function in the intracellular motor KIF5A that disrupts intracellular trafficking and neuronal homeostasis.
Tue Apr 05 00:00:00 EDT 2022
Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1.
The Journal of biological chemistry
Gough RE,Jones MC,Zacharchenko T,Le S,Yu M,Jacquemet G,Muench SP,Yan J,Humphries JD,Jørgensen C,Humphries MJ,Goult BT
MA1-12429 was used in Immunocytochemistry to identify an interaction between talin and CDK1 occurring during integrin-mediated adhesion.
Thu Jul 01 00:00:00 EDT 2021
Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1.
The Journal of biological chemistry
Gough RE,Jones MC,Zacharchenko T,Le S,Yu M,Jacquemet G,Muench SP,Yan J,Humphries JD,Jørgensen C,Humphries MJ,Goult BT
MA1-12429 was used in Immunocytochemistry to identify an interaction between talin and CDK1 occurring during integrin-mediated adhesion.
Thu Jul 01 00:00:00 EDT 2021
Evolutionary repair: Changes in multiple functional modules allow meiotic cohesin to support mitosis.
PLoS biology
Hsieh YP,Makrantoni V,Robertson D,Marston AL,Murray AW
MA1-12429 was used in ChIP assay to conclude that changes in known and novel partners allow cells to use an existing protein to participate in new biological functions.
Sun Mar 01 00:00:00 EST 2020
Coupling of 5S RNP rotation with maturation of functional centers during large ribosomal subunit assembly.
Nature communications
Micic J,Li Y,Wu S,Wilson D,Tutuncuoglu B,Gao N,Woolford JL
MA1-12429 was used in Western Blot to investigate the function of the C-terminal domain of Rpf2 during ribosomal anchoring.
Mon Jul 27 00:00:00 EDT 2020
Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response.
Nature communications
Baeuerle PA,Ding J,Patel E,Thorausch N,Horton H,Gierut J,Scarfo I,Choudhary R,Kiner O,Krishnamurthy J,Le B,Morath A,Baldeviano GC,Quinn J,Tavares P,Wei Q,Weiler S,Maus MV,Getts D,Schamel WW,Hofmeister R
MA1-12429 was used in Western Blotting to report that T cell receptor fusion constructs (TRuCs) comprising an antibody-based binding domain fused to T cell receptor (TCR) subunits can effectively reprogram an intact TCR complex to recognize tumor surface antigens.
Tue May 07 00:00:00 EDT 2019
Cadherin-6B proteolysis promotes the neural crest cell epithelial-to-mesenchymal transition through transcriptional regulation.
The Journal of cell biology
Schiffmacher AT,Xie V,Taneyhill LA
MA1-12429 was used in Immunohistochemistry to examine how Cadherin-6B proteolysis orchestrates multiple pro-epithelial-to-mesenchymal transition regulatory inputs to ensure proper cranial neural crest epithelial-to-mesenchymal transition.
Mon Dec 05 00:00:00 EST 2016
A Histidine Cluster in the Cytoplasmic Domain of the Na-H Exchanger NHE1 Confers pH-sensitive Phospholipid Binding and Regulates Transporter Activity.
The Journal of biological chemistry
Webb BA,White KA,Grillo-Hill BK,Schönichen A,Choi C,Barber DL
MA112429 was used in western blot to elucidate pH-dependent NHE1 activity
Fri Nov 11 00:00:00 EST 2016
Secretory pathway-dependent localization of the Saccharomyces cerevisiae Rho GTPase-activating protein Rgd1p at growth sites.
Eukaryotic cell
Lefèbvre F,Prouzet-Mauléon V,Hugues M,Crouzet M,Vieillemard A,McCusker D,Thoraval D,Doignon F
MA1-12429 was used in western blot to suggest that secretory vesicles deliver RhoGAP Rgd1p to the bud tip and bud neck.
Tue May 01 00:00:00 EDT 2012
Budding yeast Dma1 and Dma2 participate in regulation of Swe1 levels and localization.
Molecular biology of the cell
Raspelli E,Cassani C,Lucchini G,Fraschini R
MA1-12429 was used in western blot to elucidate how Dma1 and Dma2 regulate Swe1
Fri Jul 01 00:00:00 EDT 2011
Oxidation state governs structural transitions in peroxiredoxin II that correlate with cell cycle arrest and recovery.
The Journal of cell biology
Phalen TJ,Weirather K,Deming PB,Anathy V,Howe AK,van der Vliet A,Jönsson TJ,Poole LB,Heintz NH
MA1-12429 was used in western blot to investigate the structural transitions in peroxiredoxin II regulated by oxidation state and its correlation with cell cycle arrest and recovery
Mon Dec 04 00:00:00 EST 2006
Negative regulation of TSC1-TSC2 by mammalian D-type cyclins.
Cancer research
Zacharek SJ,Xiong Y,Shumway SD
MA1-12429 was used in western blot to investigate the influence of cyclin D1 on tumor suppressor TSC1 and 2 function
Thu Dec 15 00:00:00 EST 2005
Mcm10 regulates the stability and chromatin association of DNA polymerase-alpha.
Molecular cell
Ricke RM,Bielinsky AK
MA1-12429 was used in immunoprecipitation to study the role of the DNA replication factor Mcm10 in regulating DNA polymerase alpha stability and chromatin association
Fri Oct 22 00:00:00 EDT 2004
Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase.
Proceedings of the National Academy of Sciences of the United States of America
Ahmed NN,Grimes HL,Bellacosa A,Chan TO,Tsichlis PN
MA1-12429 was used in immunocytochemistry to investigate the mechanism for the antiapoptotic and proliferative functions of interleukin 2
Tue Apr 15 00:00:00 EDT 1997
