Product References
Systemic administration of novel engineered AAV capsids facilitates enhanced transgene expression in the macaque CNS.
Med (New York, N.Y.)
Stanton AC,Lagerborg KA,Tellez L,Krunnfusz A,King EM,Ye S,Solomon IH,Tabebordbar M,Sabeti PC
32-6700 was used in Immunohistochemistry to highlight the critical need for using appropriate animal models to both identify and evaluate novel AAVs intended for delivery to the human central nervous system.
Fri Jan 13 00:00:00 EST 2023
Mechanisms regulating DMTF1β/γ expression and their functional interplay with DMTF1α.
International journal of oncology
Li J,Shi K,Xu T,Hu J,Li T,Li G,Chen K,Li D,Inoue K,Sui G
32-6700 was used in Western Blotting to investigate the mechanisms regulating the D binding myb‚like transcription factor 1 (DMTF1) isoform expression, and to characterise the functional interplay of DMTF1β and γ with DMTF1α.
Fri Jan 01 00:00:00 EST 2021
Mechanisms regulating DMTF1β/γ expression and their functional interplay with DMTF1α.
International journal of oncology
Li J,Shi K,Xu T,Hu J,Li T,Li G,Chen K,Li D,Inoue K,Sui G
32-6700 was used in Western Blotting to investigate the mechanisms regulating the D binding myb‚like transcription factor 1 (DMTF1) isoform expression, and to characterise the functional interplay of DMTF1β and γ with DMTF1α.
Fri Jan 01 00:00:00 EST 2021
Long-term trans-inhibition of the hepatitis B and D virus receptor NTCP by taurolithocholic acid.
American journal of physiology. Gastrointestinal and liver physiology
Lowjaga KAAT,Kirstgen M,Müller SF,Goldmann N,Lehmann F,Glebe D,Geyer J
32-6700 was used in Immunocytochemistry-immunoflourescence to test a hypothesis that taurolithocholic acid(TLC) rapidly accumulates in hepatocytes and mediates long-lasting trans-inhibition of the transport and receptor function of NTCP via a particular TLC binding site at an intracellularly accessible domain of Na+/taurocholate co-transporting polypeptide.
Fri Jan 01 00:00:00 EST 2021
Mutational Analysis of the GXXXG/A Motifs in the Human Na+/Taurocholate Co-Transporting Polypeptide NTCP on Its Bile Acid Transport Function and Hepatitis B/D Virus Receptor Function.
Frontiers in molecular biosciences
Palatini M,Müller SF,Lowjaga KAAT,Noppes S,Alber J,Lehmann F,Goldmann N,Glebe D,Geyer J
32-6700 was used in Western Blot to demonstrate that the GXXXG/A motifs in TMD2 and even more pronounced in TMD7 are important for proper folding and sorting of NTCP, and so indirectly affect glycosylation, homodimerization, and bile acid transport of NTCP, as well as its HBV/HDV receptor function.
Sat Jul 10 00:00:00 EDT 2021
Mutational Analysis of the GXXXG/A Motifs in the Human Na+/Taurocholate Co-Transporting Polypeptide NTCP on Its Bile Acid Transport Function and Hepatitis B/D Virus Receptor Function.
Frontiers in molecular biosciences
Palatini M,Müller SF,Lowjaga KAAT,Noppes S,Alber J,Lehmann F,Goldmann N,Glebe D,Geyer J
32-6700 was used in Western Blot to demonstrate that the GXXXG/A motifs in TMD2 and even more pronounced in TMD7 are important for proper folding and sorting of NTCP, and so indirectly affect glycosylation, homodimerization, and bile acid transport of NTCP, as well as its HBV/HDV receptor function.
Sat Jul 10 00:00:00 EDT 2021
SRSF5 regulates alternative splicing of DMTF1 pre-mRNA through modulating SF1 binding.
RNA biology
Li J,Li G,Qi Y,Lu Y,Wang H,Shi K,Li D,Shi J,Stovall DB,Sui G
32-6700 was used in ELISA, Immunocytochemistry, Western Blot to identify SRSF5 as a key regulator that modulates alternative splicing of DMTF1 pre-mRNA through interfering with SF1 binding to enhance DMTF1β/γ production.
Fri Oct 15 00:00:00 EDT 2021
Downregulation of E-cadherin in pluripotent stem cells triggers partial EMT.
Scientific reports
Aban CE,Lombardi A,Neiman G,Biani MC,La Greca A,Waisman A,Moro LN,Sevlever G,Miriuka S,Luzzani C
32-6700 was used in Immunocytochemistry to show epithelial to mesenchymal transition can be promoted by downregulation of E-cadherin in pluripotent stem cells.
Thu Jan 21 00:00:00 EST 2021
Cell-Based Phenotypic Drug Screening Identifies Luteolin as Candidate Therapeutic for Nephropathic Cystinosis.
Journal of the American Society of Nephrology : JASN
De Leo E,Elmonem MA,Berlingerio SP,Berquez M,Festa BP,Raso R,Bellomo F,Starborg T,Janssen MJ,Abbaszadeh Z,Cairoli S,Goffredo BM,Masereeuw R,Devuyst O,Lowe M,Levtchenko E,Luciani A,Emma F,Rega LR
32-6700 was used in Immunocytochemistry to identify luteolin as a restorer of normal autophagy defective in cystinosis.
Wed Jul 01 00:00:00 EDT 2020
Cooperative binding of the tandem WW domains of PLEKHA7 to PDZD11 promotes conformation-dependent interaction with tetraspanin 33.
The Journal of biological chemistry
Rouaud F,Tessaro F,Aimaretti L,Scapozza L,Citi S
32-6700 was used in Western Blotting to characterize the mechanisms driving interactions between the N-terminal region of PDZD11 and the N-terminal tandem WW domains of PLEKHA7.
Fri Jul 10 00:00:00 EDT 2020
Cooperative binding of the tandem WW domains of PLEKHA7 to PDZD11 promotes conformation-dependent interaction with tetraspanin 33.
The Journal of biological chemistry
Rouaud F,Tessaro F,Aimaretti L,Scapozza L,Citi S
32-6700 was used in Western Blotting to characterize the mechanisms driving interactions between the N-terminal region of PDZD11 and the N-terminal tandem WW domains of PLEKHA7.
Fri Jul 10 00:00:00 EDT 2020
Stable Occupancy of the Crimean-Congo Hemorrhagic Fever Virus-Encoded Deubiquitinase Blocks Viral Infection.
mBio
Scholte FEM,Hua BL,Spengler JR,Dzimianski JV,Coleman-McCray JD,Welch SR,McMullan LK,Nichol ST,Pegan SD,Spiropoulou CF,Bergeron É
32-6700 was used in Western Blotting to demonstrate that artificially prolonged binding of the ovarian tumour (OTU) to a substrate inhibits virus infection, which provides novel insights into CCHFV OTU function during the viral replicative cycle and highlights the OTU as a potential antiviral target.
Tue Jul 23 00:00:00 EDT 2019
The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins.
Molecular cell
Neal S,Jaeger PA,Duttke SH,Benner C,K Glass C,Ideker T,Hampton RY
32-6700 was used in Western Blotting to study the mechanism by which misfolded proteins exit the endoplasmic reticulum membrane.
Thu Jan 18 00:00:00 EST 2018
OTUB1 non-catalytically stabilizes the E2 ubiquitin-conjugating enzyme UBE2E1 by preventing its autoubiquitination.
The Journal of biological chemistry
Pasupala N,Morrow ME,Que LT,Malynn BA,Ma A,Wolberger C
32-6700 was used in Western Blotting to elucidate a novel role for OTUB1-E2 interactions in modulating E2 protein ubiquitination.
Fri Nov 23 00:00:00 EST 2018
Cdk5-dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development.
Proceedings of the National Academy of Sciences of the United States of America
Huang H,Lin X,Liang Z,Zhao T,Du S,Loy MMT,Lai KO,Fu AKY,Ip NY
32-6700 was used in Western Blot to demonstrate that the Cdk5-dependent phosphorylation of liprinα1 is important for the postsynaptic organization during activity-dependent synapse development.
Tue Aug 15 00:00:00 EDT 2017
Mutations in TGM6 induce the unfolded protein response in SCA35.
Human molecular genetics
Tripathy D,Vignoli B,Ramesh N,Polanco MJ,Coutelier M,Stephen CD,Canossa M,Monin ML,Aeschlimann P,Turberville S,Aeschlimann D,Schmahmann JD,Hadjivassiliou M,Durr A,Pandey UB,Pennuto M,Basso M
32-6700 was used in Immunocytochemistry-immunoflourescence to study the molecular basis of mutant transglutaminase 6-induced neurotoxicity, linked to spinocerebellar ataxia type 35.
Sun Oct 01 00:00:00 EDT 2017
KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination.
eLife
Ramirez-Martinez A,Cenik BK,Bezprozvannaya S,Chen B,Bassel-Duby R,Liu N,Olson EN
32-6700 was used in Western Blotting to show that Kelch-like protein 41 is poly-ubiquitinated and acts, at least in part, by preventing aggregation and degradation of Nebulin.
Wed Aug 09 00:00:00 EDT 2017
N-glycosylation Triggers a Dual Selection Pressure in Eukaryotic Secretory Proteins.
Scientific reports
Medus ML,Gomez GE,Zacchi LF,Couto PM,Labriola CA,Labanda MS,Bielsa RC,Clérico EM,Schulz BL,Caramelo JJ
32-6700 was used in Western Blotting to show that during evolution N-glycosylation triggered a dual selection pressure on secretory pathway proteins.
Fri Aug 18 00:00:00 EDT 2017
Yin Yang 1 promotes mTORC2-mediated AKT phosphorylation.
Journal of molecular cell biology
Zhang Q,Wan M,Shi J,Horita DA,Miller LD,Kute TE,Kridel SJ,Kulik G,Sui G
32-6700 was used in western blot to study promotion of mTORC2-mediated AKT phosphorylation by Yin Yang 1
Wed Jun 01 00:00:00 EDT 2016
Altering the Proteoglycan State of Transforming Growth Factor β Type III Receptor (TβRIII)/Betaglycan Modulates Canonical Wnt/β-Catenin Signaling.
The Journal of biological chemistry
Jenkins LM,Singh P,Varadaraj A,Lee NY,Shah S,Flores HV,O'Connell K,Mythreye K
326700 was used in western blot to describe the dual roles of TbetaRIII/betaglycan
Fri Dec 02 00:00:00 EST 2016
PLEKHA7 Recruits PDZD11 to Adherens Junctions to Stabilize Nectins.
The Journal of biological chemistry
Guerrera D,Shah J,Vasileva E,Sluysmans S,Méan I,Jond L,Poser I,Mann M,Hyman AA,Citi S
32-6700 was used in Western Blotting to show that the PLEKHA7-PDZD11 complex stabilizes nectins to promote efficient early junction assembly and uncover a new molecular mechanism through which PLEKHA7 recruits PDZ-binding membrane proteins to epithelial adherens junctions.
Fri May 20 00:00:00 EDT 2016
Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65.
Scientific reports
Sun X,Li PP,Zhu S,Cohen R,Marque LO,Ross CA,Pulst SM,Chan HY,Margolis RL,Rudnicki DD
32-6700 was used in Western Blotting to suggest that MBNL1 and U2AF65 play a role in nuclear export of expHTT RNA.
Tue Jul 28 00:00:00 EDT 2015
Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia.
Neoplasia (New York, N.Y.)
Varadaraj A,Patel P,Serrao A,Bandyopadhay T,Lee NY,Jazaeri AA,Huang Z,Murphy SK,Mythreye K
32-6700 was used in immunoprecipitation and western blot to survey epigenetic regulation of GDF2 and how it suppresses anoikis in ovarian and breast epithelia
Sun Nov 01 00:00:00 EDT 2015
The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines.
The EMBO journal
Charlaftis N,Suddason T,Wu X,Anwar S,Karin M,Gallagher E
32-6700 was used in western blot to study the function of the PHD motif of MEKK1
Mon Nov 03 00:00:00 EST 2014
A lysine deacetylase Hos3 is targeted to the bud neck and involved in the spindle position checkpoint.
Molecular biology of the cell
Wang M,Collins RN
32-6700 was used in immunoprecipitation and western blot to investigate the localization and function of yeast Hos3
Mon Sep 15 00:00:00 EDT 2014
A lysine deacetylase Hos3 is targeted to the bud neck and involved in the spindle position checkpoint.
Molecular biology of the cell
Wang M,Collins RN
32-6700 was used in immunoprecipitation and western blot to investigate the localization and function of yeast Hos3
Mon Sep 15 00:00:00 EDT 2014
The MAP1B-LC1/UBE2L3 complex catalyzes degradation of cell surface CaV2.2 channels.
Channels (Austin, Tex.)
Gandini MA,Sandoval A,Zamponi GW,Felix R
32-6700 was used in Western Blotting to study the interactions between MAP1B-LC1 and the 2 main variants of the CaV2.2 channels (CaV2.2e37a and CaV2.2e37b) in humans.
Tue Sep 29 00:00:00 EDT 2015
ZO proteins redundantly regulate the transcription factor DbpA/ZONAB.
The Journal of biological chemistry
Spadaro D,Tapia R,Jond L,Sudol M,Fanning AS,Citi S
32-6700 was used in western blot to study the role of ZO proteins in the regulation of transcription factor DbpA/ZONAB
Fri Aug 08 00:00:00 EDT 2014
C-terminal COOH of integrin β1 is necessary for β1 association with the kindlin-2 adapter protein.
The Journal of biological chemistry
Fitzpatrick P,Shattil SJ,Ablooglu AJ
32-6700 was used in ELISA, immunoprecipitation, and western blot to study the role of C-terminal COOH of integrin beta1 in its association with kindlin-2 adapter protein
Fri Apr 18 00:00:00 EDT 2014
Replication protein a links cell cycle progression and the onset of neurogenesis in Drosophila optic lobe development.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhou L,Luo H
32-6700 was used in immunohistochemistry to study cell fate in the Drosophila optic lobe.
Wed Feb 13 00:00:00 EST 2013
Hsp104 suppresses polyglutamine-induced degeneration post onset in a drosophila MJD/SCA3 model.
PLoS genetics
Cushman-Nick M,Bonini NM,Shorter J
32-6700 was used in Immunohistochemistry to establish the first disaggregase or chaperone treatment administered after the onset of pathogenic protein-induced degeneration that mitigates disease progression.
Fri Mar 21 00:00:00 EDT 2014
Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels.
Nature communications
Medrihan L,Cesca F,Raimondi A,Lignani G,Baldelli P,Benfenati F
32-6700 was used in immunoprecipitation to show that inhibitory synapses of the dentate gyrus of Syn II knockout mice have upregulated synchronous neurotransmitter release and a loss of delayed asynchronous release
Thu Jun 20 00:00:00 EDT 2013
The molecular mechanism of a cis-regulatory adaptation in yeast.
PLoS genetics
Chang J,Zhou Y,Hu X,Lam L,Henry C,Green EM,Kita R,Kobor MS,Fraser HB
32-6700 was used in immunoprecipitation to study the molecular mechanism of a cis-acting mutation in ERG28 on the ergosterol biosynthesis pathway.
Fri Mar 21 00:00:00 EDT 2014
The Yersinia virulence effector YopM binds caspase-1 to arrest inflammasome assembly and processing.
Cell host & microbe
LaRock CN,Cookson BT
32-6700 was used in immunocytochemistry to investigate the important role of YopM in Yersinia pestis infection.
Thu Dec 13 00:00:00 EST 2012
Host acyl coenzyme A binding protein regulates replication complex assembly and activity of a positive-strand RNA virus.
Journal of virology
Zhang J,Diaz A,Mao L,Ahlquist P,Wang X
32-6700 was used in western blot to investigate how vesicular spherules and stacks of appressed double-membrane layers are formed.
Tue May 01 00:00:00 EDT 2012
Protein interacting with C kinase (PICK1) is a suppressor of spinocerebellar ataxia 3-associated neurodegeneration in Drosophila.
Human molecular genetics
McGurk L,Bonini NM
32-6700 was used in western blot to assess proteins that interact with Ataxin-3 for their ability to modulate SCA3 pathogenicity using Drosophila.
Sun Jan 01 00:00:00 EST 2012
Interplay between the HTLV-2 Tax and APH-2 proteins in the regulation of the AP-1 pathway.
Retrovirology
Marban C,McCabe A,Bukong TN,Hall WW,Sheehy N
32-6700 was used in western blot to examine the role of APH-2 in basal and Tax2B-mediated activation of the AP-1 pathway
Mon Dec 03 00:00:00 EST 2012
Intersection of the multivesicular body pathway and lipid homeostasis in RNA replication by a positive-strand RNA virus.
Journal of virology
Wang X,Diaz A,Hao L,Gancarz B,den Boon JA,Ahlquist P
32-6700 was used in western blot to investigate the relationship between lipid synthesis and brome mosaic virus RNA replication.
Wed Jun 01 00:00:00 EDT 2011
Polyglutamine genes interact to modulate the severity and progression of neurodegeneration in Drosophila.
PLoS biology
Lessing D,Bonini NM
32-6700 was used in immunohistochemistry - paraffin section to assess if Ataxin-2 activity is critical for spinal cerebellar ataxia 3 degeneration and hastens the onset of associated nuclear inclusions
Fri Feb 01 00:00:00 EST 2008
The binding of DYNLL2 to myosin Va requires alternatively spliced exon B and stabilizes a portion of the myosin's coiled-coil domain.
Biochemistry
Wagner W,Fodor E,Ginsburg A,Hammer JA
32-6700 was used in western blot to map the binding site for DYNLL2 within the myosin Va heavy chain
Tue Sep 26 00:00:00 EDT 2006
Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits.
Molecular biology of the cell
Stang E,Blystad FD,Kazazic M,Bertelsen V,Brodahl T,Raiborg C,Stenmark H,Madshus IH
Sun Aug 01 00:00:00 EDT 2004
Isoforms of the polarity protein par6 have distinct functions.
The Journal of biological chemistry
Gao L,Macara IG
Fri Oct 01 00:00:00 EDT 2004
