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Product Details
H00009464-M10
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
3F10
Immunogen
HAND2 (NP_068808.1, 135 a.a. approximately 216 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: LSKIKTLRLA TSYIAYLMDL LAKDDQNGEA EAFKAEIKKT DVKEEKRKKE LNEILKSTVS SNDKKTKGRT GWPQHVWALE LK
Target Information
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: basic helix-loop-helix transcription factor HAND2; bHLHa26; Class A basic helix-loop-helix protein 26; Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; dHAND; Heart- and neural crest derivatives-expressed protein 2
Gene Aliases: BHLHA26; DHAND; DHAND2; HAND2; Hed; Thing2
UniProt ID: (Human) P61296
Entrez Gene ID: (Human) 9464
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
AT DNA binding
transcription coactivator activity
protein binding
transcription factor binding
activating transcription factor binding
protein homodimerization activity
transcription regulatory region DNA binding
protein heterodimerization activity
E-box binding
basic helix-loop-helix transcription factor
angiogenesis
in utero embryonic development
heart looping
suckling behavior
cardiac right ventricle formation
cardiac neural crest cell migration involved in outflow tract morphogenesis
regulation of secondary heart field cardioblast proliferation
apoptotic process involved in heart morphogenesis
noradrenergic neuron differentiation
transcription from RNA polymerase II promoter
heart development
adult heart development
mesenchymal cell proliferation
positive regulation of cardiac muscle hypertrophy
positive regulation of gene expression
negative regulation of gene expression
negative regulation of cardiac muscle cell apoptotic process
regulation of tissue remodeling
odontogenesis of dentin-containing tooth
embryonic digit morphogenesis
negative regulation of DNA binding
negative regulation of sequence-specific DNA binding transcription factor activity
tongue development
negative regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
sympathetic nervous system development
thymus development
peripheral nervous system neuron development
palate development
cartilage morphogenesis
coronary artery morphogenesis
visceral serous pericardium development
cardiac neural crest cell development involved in outflow tract morphogenesis
cell proliferation involved in outflow tract morphogenesis
positive regulation of ERK1 and ERK2 cascade
positive regulation of p38MAPK cascade
positive regulation of transcription regulatory region DNA binding
positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process
positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis
Performance Guarantee
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