Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
This antibody is raised against residues near the C terminus of human HDAC1. The calculated molecular weight of HDAC1 is 55 kDa, but modified HDAC1 is about 60-65 kDa.
Immunogen sequence: VEEAFYTTD RVMTVSFHKY GEYFPGTGDL RDIGAGKGKY YAVNYPLRDG IDDESYEAIF KPVMSKVMEM FQPSAVVLQC GSDSLSGDRL GCFNLTIKGH AKCVEFVKSF NLPMLMLGGG GYTIRNVARC WTYETAVALD TEIPNELPYN DYFEYFGPDF KLHISPSNMT NQNTNEYLEK IKQRLFENLR MLPHAPGVQM QAIPEDAIPE ESGDEDEDDP DKRISICSSD KRIACEEEFS DSEEEGEGGR KNSSNFKKAK RVKTEDEKEK DPEEKKEVTE EEKTKEEKPE AKGVKEEVKL A (183-482 aa encoded by BC000301)
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DKFZp686H12203; HD1; Histone deacetylase 1; Protein deacetylase HDAC1; Protein decrotonylase HDAC1; reduced potassium dependency, yeast homolog-like 1; RP4-811H24.2
Gene Aliases: GON-10; HD1; HDAC1; Hdac1-ps; MommeD5; RPD3; RPD3L1
UniProt ID: (Human) Q13547, (Mouse) O09106, (Rat) Q4QQW4
Entrez Gene ID: (Human) 3065, (Mouse) 433759, (Rat) 297893
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