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HDAC1 Antibody (MA5-51103) in ICC/IF
Immunocytochemistry analysis of HDAC1 in HeLa cells. Samples were incubated with HDAC1 monoclonal antibody (Product # MA5-51103) using a dilution of 30 µg/mL followed by FITC-Linked Caprine Anti-Mouse IgG secondary antibody at a dilution of 2 µg/mL.
Product Details
MA5-51103
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
E31
Immunogen
Recombinant Human HDAC1 protein, Met1-Ala482 (Accession #Q13547)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% Proclin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_3091302
Target Information
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686H12203; HD1; Histone deacetylase 1; Protein deacetylase HDAC1; Protein decrotonylase HDAC1; reduced potassium dependency, yeast homolog-like 1; RP4-811H24.2
Gene Aliases: GON-10; HD1; HDAC1; RPD3; RPD3L1
UniProt ID: (Human) Q13547
Entrez Gene ID: (Human) 3065
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
core promoter binding
RNA polymerase II transcription factor binding
RNA polymerase II repressing transcription factor binding
RNA polymerase II transcription corepressor activity
transcription factor activity, sequence-specific DNA binding
histone deacetylase activity
protein binding
transcription factor binding
deacetylase activity
enzyme binding
nucleosomal DNA binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
protein deacetylase activity
activating transcription factor binding
histone deacetylase binding
transcription regulatory region DNA binding
protein N-terminus binding
NF-kappaB binding
repressing transcription factor binding
negative regulation of transcription from RNA polymerase II promoter
chromatin remodeling
methylation-dependent chromatin silencing
transcription, DNA-templated
protein deacetylation
blood coagulation
positive regulation of cell proliferation
epidermal cell differentiation
negative regulation of gene expression
negative regulation of myotube differentiation
positive regulation of receptor biosynthetic process
viral process
chromatin modification
histone deacetylation
circadian regulation of gene expression
odontogenesis of dentin-containing tooth
embryonic digit morphogenesis
ATP-dependent chromatin remodeling
negative regulation of apoptotic process
negative regulation by host of viral transcription
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of androgen receptor signaling pathway
hair follicle placode formation
eyelid development in camera-type eye
fungiform papilla formation
histone H3 deacetylation
histone H4 deacetylation
negative regulation of canonical Wnt signaling pathway
regulation of signal transduction by p53 class mediator
beta-catenin-TCF complex assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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