Invitrogen

HDAC3 Recombinant Rabbit Monoclonal Antibody (8H2L16)

Advanced Verification

This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.

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Datasheet
Protocols
Questions & Answers

Product Details

702440

Applications
Tested Dilution
Publications

Western Blot (WB)

1 µg/mL
-
Product Specifications

Species Reactivity

Cynomolgus monkey, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

8H2L16

Immunogen

Protein corresponding to human HDAC3

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2689475

Product Specific Information

This antibody is predicted to react with Pig, Rat, Rabbit

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HD3; HDAC3 splicing HDAC3alpha; HDAC3 splicing HDAC3beta; HDAC3 splicing HDAC3delta; HDAC3 splicing HDAC3gamma; Histone deacetylase 3; Protein deacetylase HDAC3; Protein deacylase HDAC3; RPD3-2; SMAP45

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Gene Aliases: AW537363; HD3; HDAC3; RPD3; RPD3-2

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UniProt ID: (Human) O15379, (Mouse) O88895, (Rat) Q6P6W3

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Entrez Gene ID: (Cynomolgus monkey) 102119873, (Human) 8841, (Mouse) 15183, (Rat) 84578

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Function(s)
chromatin binding transcription corepressor activity histone deacetylase activity protein binding transcription factor binding enzyme binding cyclin binding NAD-dependent histone deacetylase activity (H3-K14 specific) protein deacetylase activity histone deacetylase binding NF-kappaB binding DNA binding hydrolase activity histone deacetylase activity (H3-K14 specific) chromatin DNA binding histone deacetylase activity (H3-K9 specific) histone deacetylase activity (H4-K16 specific) NAD-dependent histone deacetylase activity (H3-K9 specific) NAD-dependent histone deacetylase activity (H4-K16 specific) GTPase binding NAD-dependent histone deacetylase activity (H3-K18 specific)
Process(es)
negative regulation of transcription from RNA polymerase II promoter positive regulation of protein phosphorylation transcription, DNA-templated regulation of transcription, DNA-templated protein deacetylation regulation of mitotic cell cycle chromatin modification histone deacetylation regulation of protein stability positive regulation of TOR signaling negative regulation of interleukin-1 production negative regulation of tumor necrosis factor production circadian regulation of gene expression regulation of multicellular organism growth positive regulation of transcription factor import into nucleus negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of neuron apoptotic process negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of JNK cascade negative regulation of protein export from nucleus spindle assembly cellular response to fluid shear stress positive regulation of type B pancreatic cell apoptotic process negative regulation of cardiac muscle cell differentiation negative regulation of myotube differentiation response to nutrient levels response to drug histone H3-K9 modification histone H3 deacetylation histone H4 deacetylation cellular response to mechanical stimulus cellular response to parathyroid hormone stimulus response to dexamethasone circadian rhythm negative regulation of apoptotic process cellular lipid metabolic process
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