Proteintech

HDAC4 Polyclonal Antibody

HDAC4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 14

HDAC4 Antibody (17449-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human cervical cancer tissue slide using 17449-1-AP ( HDAC4 Antibody) at dilution of 1:50 (under 40x lens).

HDAC4 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

17449-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 21 publications 21 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 6 publications 6 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

ChIP assay (ChIP)

Assay-dependent

View 2 publications 2 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HDAC4 Fusion Protein Ag11572 (623-972 aa encoded by BC039904)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is a rabbit polyclonal antibody raised against an internal region of human HDAC4. The calculated molecular weight of HDAC4 is 106 kDa, but modified HDAC4 is about 140 kDa.

Immunogen sequence: SKKLLGSLA SVFVRLPCGG VGVDSDTIWN EVHSAGAARL AVGCVVELVF KVATGELKNG FAVVRPPGHH AEESTPMGFC YFNSVAVAAK LLQQRLSVSK ILIVDWDVHH GNGTQQAFYS DPSVLYMSLH RYDDGNFFPG SGAPDEVGTG PGVGFNVNMA FTGGLDPPMG DAEYLAAFRT VVMPIASEFA PDVVLVSSGF DAVEGHPTPL GGYNLSARCF GYLTKQLMGL AGGRIVLALE GGHDLTAICD ASEACVSALL GNELDPLPEK VLQQRPNANA VRSMEKVMEI HSKYWRCLQR TTSTAGRSLI EAQTCENEEA ETVTAMASLS VGVKPAEKRP DEEPMEEEPP L (623-972 aa encoded by BC039904)

Target Information

Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC4 is also involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. It is also involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Mutations to the HDAC4 gene have been found in Brachydactyly-mental retardation syndrome (BDMR).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Histone Deacetylase 4 Inhibition Reduces Rotenone-Induced Alpha-Synuclein Accumulation via Autophagy in SH-SY5Y Cells.

Brain sciences

Wang L,Liu L,Han C,Jiang H,Ma K,Guo S,Xia Y,Wan F,Huang J,Xiong N,Wang T

Sun Apr 16 00:00:00 EDT 2023

Silencing of microRNA-106b-5p prevents doxorubicin-mediated cardiotoxicity through modulation of the PR55α/YY1/sST2 signaling axis.

Molecular therapy. Nucleic acids

Lax A,Soler F,Fernandez Del Palacio MJ,Pascual-Oliver S,Ballester MR,Fuster JJ,Pascual-Figal D,Asensio-Lopez MDC

Tue Jun 13 00:00:00 EDT 2023

Low expression of the intestinal metabolite butyric acid and the corresponding memory pattern regulate HDAC4 to promote apoptosis in rat hippocampal neurons.

Ecotoxicology and environmental safety

Xu Y,Wei S,Zhu L,Huang C,Yang T,Wang S,Zhang Y,Duan Y,Li X,Wang Z,Pan W

Wed Mar 15 00:00:00 EDT 2023

HDAC4 mediated LHPP deacetylation enhances its destabilization and promotes the proliferation and metastasis of nasopharyngeal carcinoma.

Cancer letters

Sun X,Zhang K,Peng X,Zhou P,Qu C,Yang L,Shen L

Sun May 28 00:00:00 EDT 2023

Selective Inhibition of Histone Deacetylase Class IIa With MC1568 Ameliorates Podocyte Injury.

Frontiers in medicine

He X,Sun T,Zhang P,Xia Z,Gao C,Ren H,Ji D

Sat Jul 16 00:00:00 EDT 2022

Selective Inhibition of Histone Deacetylase Class IIa With MC1568 Ameliorates Podocyte Injury.

Frontiers in medicine

He X,Sun T,Zhang P,Xia Z,Gao C,Ren H,Ji D

Sat Jul 16 00:00:00 EDT 2022

Deacetylation of Glutaminase by HDAC4 contributes to Lung Cancer Tumorigenesis.

International journal of biological sciences

Wang T,Lu Z,Han T,Wang Y,Gan M,Wang JB

Mon Jul 25 00:00:00 EDT 2022

Free Fatty Acid Impairs Myogenic Differentiation through the AMPKα-MicroRNA 206 Pathway.

Molecular and cellular biology

Jiang A,Guo H,Zhang L,Jiang X,Zhang X,Wu W,Liu H

Thu Jan 20 00:00:00 EST 2022

WNT5A promotes the metastasis of esophageal squamous cell carcinoma by activating the HDAC7/SNAIL signaling pathway.

Cell death & disease

Feng Y,Ma Z,Pan M,Xu L,Feng J,Zhang Y,Shao C,Guo K,Duan H,Zhang Y,Zhang Y,Zhang J,Lu D,Ren X,Han J,Li X,Yan X

Fri May 20 00:00:00 EDT 2022

Senescence marker protein 30 inhibits tumor growth by reducing HDAC4 expression in non-small cell lung cancer.

Translational lung cancer research

Shao C,Guo K,Xu L,Zhang Y,Duan H,Feng Y,Pan M,Lu D,Ren X,Ganti AK,Hakozaki T,Han J,Yan X,Ma Z

Wed Dec 01 00:00:00 EST 2021

Low levels of AMPK promote epithelial-mesenchymal transition in lung cancer primarily through HDAC4- and HDAC5-mediated metabolic reprogramming.

Journal of cellular and molecular medicine

Feng S,Zhang L,Liu X,Li G,Zhang B,Wang Z,Zhang H,Ma H

Wed Jul 01 00:00:00 EDT 2020

Histone deacetylase 4 mediates high glucose-induced podocyte apoptosis via upregulation of calcineurin.

Biochemical and biophysical research communications

Shi W,Huang Y,Zhao X,Xie Z,Dong W,Li R,Chen Y,Li Z,Wang W,Ye Z,Liu S,Zhang L,Liang X

Thu Dec 17 00:00:00 EST 2020

Transcriptional Factor Yin Yang 1 Promotes the Stemness of Breast Cancer Cells by Suppressing miR-873-5p Transcriptional Activity.

Molecular therapy. Nucleic acids

Guo Q,Wang T,Yang Y,Gao L,Zhao Q,Zhang W,Xi T,Zheng L

Fri Sep 04 00:00:00 EDT 2020

Transcriptional Factor Yin Yang 1 Promotes the Stemness of Breast Cancer Cells by Suppressing miR-873-5p Transcriptional Activity.

Molecular therapy. Nucleic acids

Guo Q,Wang T,Yang Y,Gao L,Zhao Q,Zhang W,Xi T,Zheng L

Fri Sep 04 00:00:00 EDT 2020

Transcriptomic Analysis of Glycolysis-Related Genes Reveals an Independent Signature of Bladder Carcinoma.

Frontiers in genetics

Mou Z,Yang C,Zhang Z,Wu S,Xu C,Cheng Z,Dai X,Chen X,Ou Y,Jiang H

Tue Apr 19 00:00:00 EDT 2022

TMCO1-mediated Ca²⁺ leak underlies osteoblast functions via CaMKII signaling.

Nature communications

Li J,Liu C,Li Y,Zheng Q,Xu Y,Liu B,Sun W,Li Y,Ji S,Liu M,Zhang J,Zhao D,Du R,Liu Z,Zhong G,Sun C,Wang Y,Song J,Zhang S,Qin J,Ling S,Wang X,Li Y

Mon Apr 08 00:00:00 EDT 2019

Resveratrol affects hepatic gluconeogenesis via histone deacetylase 4.

Diabetes, metabolic syndrome and obesity : targets and therapy

Zhao H,Shu L,Huang W,Song G,Ma H

Fri Apr 08 00:00:00 EDT 2022

Expression of HDAC4 in Stage B Hepatocellular Carcinoma and Its Influence on Survival.

Annals of clinical and laboratory science

Wang Z,Wang H,Shen P,Xie R

Fri Mar 01 00:00:00 EST 2019

Hyper-acetylation contributes to the sensitivity of chemo-resistant prostate cancer cells to histone deacetylase inhibitor Trichostatin A.

Journal of cellular and molecular medicine

Xu Q,Liu X,Zhu S,Hu X,Niu H,Zhang X,Zhu D,Nesa EU,Tian K,Yuan H

Thu Mar 01 00:00:00 EST 2018

Hyper-acetylation contributes to the sensitivity of chemo-resistant prostate cancer cells to histone deacetylase inhibitor Trichostatin A.

Journal of cellular and molecular medicine

Xu Q,Liu X,Zhu S,Hu X,Niu H,Zhang X,Zhu D,Nesa EU,Tian K,Yuan H

Thu Mar 01 00:00:00 EST 2018

The HDAC Inhibitor Quisinostat (JNJ-26481585) Supresses Hepatocellular Carcinoma alone and Synergistically in Combination with Sorafenib by G0/G1 phase arrest and Apoptosis induction.

International journal of biological sciences

He B,Dai L,Zhang X,Chen D,Wu J,Feng X,Zhang Y,Xie H,Zhou L,Wu J,Zheng S

Mon Sep 09 00:00:00 EDT 2019

The HDAC Inhibitor Quisinostat (JNJ-26481585) Supresses Hepatocellular Carcinoma alone and Synergistically in Combination with Sorafenib by G0/G1 phase arrest and Apoptosis induction.

International journal of biological sciences

He B,Dai L,Zhang X,Chen D,Wu J,Feng X,Zhang Y,Xie H,Zhou L,Wu J,Zheng S

Mon Sep 09 00:00:00 EDT 2019

Phosphatidylinositol 3-Kinase-DNA Methyltransferase 1-miR-1281-Histone Deacetylase 4 Regulatory Axis Mediates Platelet-Derived Growth Factor-Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells.

Journal of the American Heart Association

Li Y,Li L,Qian Z,Lin B,Chen J,Luo Y,Qu J,Raj JU,Gou D

Wed Mar 07 00:00:00 EST 2018

Journal of the American Heart Association

Li Y,Li L,Qian Z,Lin B,Chen J,Luo Y,Qu J,Raj JU,Gou D

Wed Mar 07 00:00:00 EST 2018

Exercise-induced GLUT4 transcription via inactivation of HDAC4/5 in mouse skeletal muscle in an AMPKα2-dependent manner.

Biochimica et biophysica acta. Molecular basis of disease

Niu Y,Wang T,Liu S,Yuan H,Li H,Fu L

Fri Sep 01 00:00:00 EDT 2017

Exercise-induced GLUT4 transcription via inactivation of HDAC4/5 in mouse skeletal muscle in an AMPKα2-dependent manner.

Biochimica et biophysica acta. Molecular basis of disease

Niu Y,Wang T,Liu S,Yuan H,Li H,Fu L

Fri Sep 01 00:00:00 EDT 2017

Exercise-induced GLUT4 transcription via inactivation of HDAC4/5 in mouse skeletal muscle in an AMPKα2-dependent manner.

Biochimica et biophysica acta. Molecular basis of disease

Niu Y,Wang T,Liu S,Yuan H,Li H,Fu L

Fri Sep 01 00:00:00 EDT 2017

Exercise-induced GLUT4 transcription via inactivation of HDAC4/5 in mouse skeletal muscle in an AMPKα2-dependent manner.

Biochimica et biophysica acta. Molecular basis of disease

Niu Y,Wang T,Liu S,Yuan H,Li H,Fu L

Fri Sep 01 00:00:00 EDT 2017

Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition.

Cancer biology & therapy

Wang F,Zhao J,Liu D,Zhao T,Lu Z,Zhu L,Cao L,Yang J,Jin J,Cai Y

Tue Nov 01 00:00:00 EDT 2016

Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition.

Cancer biology & therapy

Wang F,Zhao J,Liu D,Zhao T,Lu Z,Zhu L,Cao L,Yang J,Jin J,Cai Y

Tue Nov 01 00:00:00 EDT 2016

Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1.

Hepatology (Baltimore, Md.)

Barbier-Torres L,Beraza N,Fernández-Tussy P,Lopitz-Otsoa F,Fernández-Ramos D,Zubiete-Franco I,Varela-Rey M,Delgado TC,Gutiérrez V,Anguita J,Pares A,Banales JM,Villa E,Caballería J,Alvarez L,Lu SC,Mato JM,Martínez-Chantar ML

Thu Oct 01 00:00:00 EDT 2015

Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1.

Hepatology (Baltimore, Md.)

Thu Oct 01 00:00:00 EDT 2015

Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1.

Hepatology (Baltimore, Md.)

Thu Oct 01 00:00:00 EDT 2015

Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1.

Hepatology (Baltimore, Md.)

Thu Oct 01 00:00:00 EDT 2015

Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis.

Oncology reports

Cai M,Hu Z,Liu J,Gao J,Tan M,Zhang D,Zhu L,Liu S,Hou R,Lin B

Sun Feb 01 00:00:00 EST 2015

Expression of hMOF, but not HDAC4, is responsible for the global histone H4K16 acetylation in gastric carcinoma.

International journal of oncology

Zhu L,Yang J,Zhao L,Yu X,Wang L,Wang F,Cai Y,Jin J

Tue Jan 26 00:00:00 EST 2016

Expression of hMOF, but not HDAC4, is responsible for the global histone H4K16 acetylation in gastric carcinoma.

International journal of oncology

Zhu L,Yang J,Zhao L,Yu X,Wang L,Wang F,Cai Y,Jin J

Tue Jan 26 00:00:00 EST 2016

MicroRNA directly enhances mitochondrial translation during muscle differentiation.

Cell

Zhang X,Zuo X,Yang B,Li Z,Xue Y,Zhou Y,Huang J,Zhao X,Zhou J,Yan Y,Zhang H,Guo P,Sun H,Guo L,Zhang Y,Fu XD

Thu Jul 31 00:00:00 EDT 2014

MicroRNA directly enhances mitochondrial translation during muscle differentiation.

Cell

Zhang X,Zuo X,Yang B,Li Z,Xue Y,Zhou Y,Huang J,Zhao X,Zhou J,Yan Y,Zhang H,Guo P,Sun H,Guo L,Zhang Y,Fu XD

Thu Jul 31 00:00:00 EDT 2014

Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.

Kidney international

Wang X,Liu J,Zhen J,Zhang C,Wan Q,Liu G,Wei X,Zhang Y,Wang Z,Han H,Xu H,Bao C,Song Z,Zhang X,Li N,Yi F

Wed Oct 01 00:00:00 EDT 2014

Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.

Kidney international

Wang X,Liu J,Zhen J,Zhang C,Wan Q,Liu G,Wei X,Zhang Y,Wang Z,Han H,Xu H,Bao C,Song Z,Zhang X,Li N,Yi F

Wed Oct 01 00:00:00 EDT 2014

Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.

Kidney international

Wang X,Liu J,Zhen J,Zhang C,Wan Q,Liu G,Wei X,Zhang Y,Wang Z,Han H,Xu H,Bao C,Song Z,Zhang X,Li N,Yi F

Wed Oct 01 00:00:00 EDT 2014

Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.

Kidney international

Wang X,Liu J,Zhen J,Zhang C,Wan Q,Liu G,Wei X,Zhang Y,Wang Z,Han H,Xu H,Bao C,Song Z,Zhang X,Li N,Yi F

Wed Oct 01 00:00:00 EDT 2014

Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.

Kidney international

Wang X,Liu J,Zhen J,Zhang C,Wan Q,Liu G,Wei X,Zhang Y,Wang Z,Han H,Xu H,Bao C,Song Z,Zhang X,Li N,Yi F

Wed Oct 01 00:00:00 EDT 2014

Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.

Kidney international

Wang X,Liu J,Zhen J,Zhang C,Wan Q,Liu G,Wei X,Zhang Y,Wang Z,Han H,Xu H,Bao C,Song Z,Zhang X,Li N,Yi F

Wed Oct 01 00:00:00 EDT 2014

HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury.

Journal of cellular and molecular medicine

He M,Zhang B,Wei X,Wang Z,Fan B,Du P,Zhang Y,Jian W,Chen L,Wang L,Fang H,Li X,Wang PA,Yi F

Mon Apr 01 00:00:00 EDT 2013

HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury.

Journal of cellular and molecular medicine

He M,Zhang B,Wei X,Wang Z,Fan B,Du P,Zhang Y,Jian W,Chen L,Wang L,Fang H,Li X,Wang PA,Yi F

Mon Apr 01 00:00:00 EDT 2013

HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury.

Journal of cellular and molecular medicine

He M,Zhang B,Wei X,Wang Z,Fan B,Du P,Zhang Y,Jian W,Chen L,Wang L,Fang H,Li X,Wang PA,Yi F

Mon Apr 01 00:00:00 EDT 2013

HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury.

Journal of cellular and molecular medicine

He M,Zhang B,Wei X,Wang Z,Fan B,Du P,Zhang Y,Jian W,Chen L,Wang L,Fang H,Li X,Wang PA,Yi F

Mon Apr 01 00:00:00 EDT 2013

HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury.

Journal of cellular and molecular medicine

He M,Zhang B,Wei X,Wang Z,Fan B,Du P,Zhang Y,Jian W,Chen L,Wang L,Fang H,Li X,Wang PA,Yi F

Mon Apr 01 00:00:00 EDT 2013

Bioinformatics

Protein Aliases: DKFZp779K1053; HD4; HDAC; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDRP; Histone deacetylase 4; histone deacetylase A; KIAA0744; MITR

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Gene Aliases: AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A; HDAC4; HDACA; KIAA0288

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UniProt ID: (Human) P56524

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Entrez Gene ID: (Human) 9759

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Function(s)

RNA polymerase III transcription factor binding core promoter binding chromatin binding transcription corepressor activity histone deacetylase activity protein binding transcription factor binding zinc ion binding protein kinase binding potassium ion binding NAD-dependent histone deacetylase activity (H3-K14 specific) protein deacetylase activity activating transcription factor binding histone deacetylase binding sequence-specific DNA binding transcription regulatory region DNA binding repressing transcription factor binding histone modifying enzyme

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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HDAC4 Polyclonal Antibody

HDAC4 Antibody (17449-1-AP) in IHC (P)

Product Details

17449-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

ChIP assay (ChIP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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