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Product Details
H00023493-M02
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
2B10
Immunogen
HEY2 (NP_036391.1, 1 a.a. approximately 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.47 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Tissue lysate).
Immunogen sequence: MKRPCEETTS ESDMDETIDV GSENNYSGQS TSSVIRLNSP TTTSQIMARK KRRGIIEKRR RDRINNSLSE LRRLVPTAFE KQGSAKLEKA EILQMTVDHL KMLQATGGKG
Target Information
Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLHb32; cardiovascular basic helix-loop-helix factor 1; Cardiovascular helix-loop-helix factor 1; Class B basic helix-loop-helix protein 32; h hHRT2; Hairy and enhancer of split-related protein 2; Hairy-related transcription factor 2; hairy/enhancer-of-split related with YRPW motif 2; Hairy/enhancer-of-split related with YRPW motif protein 2; hCHF1; hes-related family bHLH transcription factor with YRPW motif 2; HES-related repressor protein 1; HES-related repressor protein 2; HESR-2; hHRT2; HRT-2; Protein gridlock homolog
Gene Aliases: BHLHB32; CHF1; GRIDLOCK; GRL; HERP; HERP1; HESR2; HEY2; HRT2
UniProt ID: (Human) Q9UBP5
Entrez Gene ID: (Human) 23493
transcription factor activity, RNA polymerase II core promoter sequence-specific
transcription factor activity, protein binding
RNA polymerase II activating transcription factor binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
microsatellite binding
protein homodimerization activity
histone deacetylase binding
sequence-specific DNA binding
protein heterodimerization activity
basic helix-loop-helix transcription factor
negative regulation of transcription from RNA polymerase II promoter
vasculogenesis
muscular septum morphogenesis
outflow tract morphogenesis
pulmonary valve morphogenesis
tricuspid valve morphogenesis
tricuspid valve formation
endocardial cushion to mesenchymal transition involved in heart valve formation
cardiac ventricle morphogenesis
cardiac left ventricle morphogenesis
cardiac right ventricle morphogenesis
ventricular trabecula myocardium morphogenesis
transcription, DNA-templated
Notch signaling pathway
anterior/posterior axis specification
positive regulation of heart rate
negative regulation of transcription by transcription factor localization
negative regulation of gene expression
negative regulation of cardiac muscle cell apoptotic process
mesenchymal cell development
cardiac muscle hypertrophy in response to stress
ascending aorta morphogenesis
dorsal aorta morphogenesis
umbilical cord morphogenesis
cell fate commitment
regulation of auditory receptor cell differentiation
negative regulation of Notch signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
smooth muscle cell differentiation
ventricular cardiac muscle cell development
positive regulation of cardiac muscle cell proliferation
cardiac epithelial to mesenchymal transition
heart trabecula formation
cardiac septum morphogenesis
ventricular septum morphogenesis
atrial septum morphogenesis
negative regulation of transcription initiation from RNA polymerase II promoter
labyrinthine layer blood vessel development
arterial endothelial cell differentiation
cardiac vascular smooth muscle cell development
coronary vasculature morphogenesis
pulmonary artery morphogenesis
Notch signaling involved in heart development
protein-DNA complex assembly
cochlea development
vascular smooth muscle cell development
negative regulation of transcription regulatory region DNA binding
negative regulation of cardiac vascular smooth muscle cell differentiation
negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
regulation of vasculogenesis
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