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Product Details
BS-1025R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Sheep,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human HGF alpha, amino acids 201-300.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Fibroblast derived tumor cytotoxic factor; fibroblast-derived tumor cytotoxic factor; Hepatocyte growth factor; Hepatocyte growth factor (hepapoietin A; hepatocyte growth factor (hepapoietin A; scatter factor); Hepatopoeitin A; hepatopoeitin-A; Hepatopoietin-A; HepatopoietinA; Lung fibroblast derived mitogen; lung fibroblast-derived mitogen; Scatter factor; scatter factor); SF
Gene Aliases: C230052L06Rik; DFNB39; F-TCF; HGF; HGF/SF; HGFB; HPTA; NK1; NK2; SF; SF/HGF
UniProt ID: (Human) P14210, (Mouse) Q08048, (Rat) P17945
Entrez Gene ID: (Human) 3082, (Sheep) 443075, (Mouse) 15234, (Rat) 24446
activation of MAPK activity
epithelial to mesenchymal transition
liver development
platelet degranulation
proteolysis
mitotic nuclear division
positive regulation of cell proliferation
negative regulation of autophagy
positive regulation of phosphatidylinositol 3-kinase signaling
hyaluronan metabolic process
positive regulation of cell migration
organ regeneration
positive regulation of myelination
negative regulation of interleukin-6 production
positive regulation of interleukin-10 production
negative regulation of peptidyl-serine phosphorylation
cellular response to hepatocyte growth factor stimulus
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of osteoblast differentiation
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
hepatocyte growth factor receptor signaling pathway
negative regulation of inflammatory response
positive regulation of peptidyl-tyrosine phosphorylation
positive chemotaxis
myoblast proliferation
cell chemotaxis
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
positive regulation of neuron projection regeneration
negative regulation of release of cytochrome c from mitochondria
regulation of p38MAPK cascade
negative regulation of hydrogen peroxide-mediated programmed cell death
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of tau-protein kinase activity
positive regulation of DNA biosynthetic process
cell morphogenesis
cell proliferation
negative regulation of apoptotic process
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