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Product Details
MA5-31151
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
032
Immunogen
Recombinant Mouse HGF/Hepatocyte Growth Factor Protein (Met1-Leu728)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2786801
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Mouse HGF/Hepatocyte Growth Factor.
Target Information
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Fibroblast derived tumor cytotoxic factor; Hepatocyte growth factor; Hepatocyte growth factor (hepapoietin A; Hepatopoeitin A; Hepatopoietin-A; HepatopoietinA; Lung fibroblast derived mitogen; Scatter factor; scatter factor); SF
Gene Aliases: C230052L06Rik; Hgf; HGF/SF; NK1; NK2; SF; SF/HGF
UniProt ID: (Mouse) Q08048
Entrez Gene ID: (Mouse) 15234
activation of MAPK activity
cell morphogenesis
liver development
proteolysis
cell proliferation
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of cell migration
positive regulation of myelination
cellular response to hepatocyte growth factor stimulus
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of angiogenesis
hepatocyte growth factor receptor signaling pathway
positive regulation of peptidyl-tyrosine phosphorylation
positive chemotaxis
myoblast proliferation
cell chemotaxis
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
positive regulation of neuron projection regeneration
negative regulation of release of cytochrome c from mitochondria
negative regulation of hydrogen peroxide-mediated programmed cell death
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of DNA biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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