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Positive control: HIV infected tissue
Cellular location: Cell Membrane.
Nef is a multifunctional protein of 27 kDa in HIV-1 and 35 kDa in HIV-2. It induces the endocytosis of CD4 Receptor and reduces the MHC-1 Receptors. Thereby it enhances viral infectivity and affects T-cell signalling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HIV-2; HIV-2 nef; HIV2 nef protein; Nefprotein
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