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This antibody reacts with extracellular polymorphic determinant on human HLA-DQ1 and HLA-DQ3 molecules (recognized epitope was found on isolated beta chain of DQ1), but does not react with HLA-DQ2. DQ is the isotype of human MHC Class II molecules expressed on antigen-presenting cells (APC; dendritic cells, B lymphocytes, monocytes, macrophages).
Western Blot: non-reducing conditions.
Reacts with polymorphic determinant on human HLA-DQ1 and HLA-DQ3 molecules (recognized epitope was found on isolated b chain of DQ1), but does not react with HLA-DQ2.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HLA class II antigen; HLA class II histocompatibility antigen, DQ beta 1 chain; HLA-D; HLA-DQ; HLADQ; HLADQ1; HLADQ3; lymphocyte antigen; MHC Class 2; MHC class II; MHC class II antigen DQB1; MHC class II antigen HLA-DQ-beta-1; MHC class II DQ beta chain; MHC class II HLA-DQ beta glycoprotein; MHC class2 antigen; MHC DQ beta; MHC HLA-D; MHC II HLA
Gene Aliases: CELIAC1; HLA-DQB; HLA-DQB1; HLA-DRB1; IDDM1
UniProt ID: (Human) Q08GC8
Entrez Gene ID: (Human) 3119
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