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Product Details
MA5-16983
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
WR18
Immunogen
Human HLA Class II (DP, DQ, DR)
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Purification
Protein G
Storage buffer
PBS with 1% BSA
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2538456
Product Specific Information
For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
Target Information
MHC class II molecules are transmembrane glycoproteins composed of an alpha chain (36 kDa) and a beta chain (27 kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: beta1 domain MHC class II HLA DPB; class II HLA beta chain; DR beta-5; DR-9; DR2-beta-2; DR7; DR9; DRB1 transplantation antigen; Dw2; DW2.2/DR2.2; FLJ75017; FLJ76359; histocompatibility antigen HLA-DR alpha; HLA class II antigen; HLA class II histocompatibility antigen, DP beta 1 chain; HLA class II histocompatibility antigen, DP(W4) beta chain; HLA class II histocompatibility antigen, DQ beta 1 chain; HLA class II histocompatibility antigen, DR alpha chain; HLA class II histocompatibility antigen, DR beta 3 chain; HLA class II histocompatibility antigen, DR beta 4 chain; HLA class II histocompatibility antigen, DR beta 5 chain; HLA class II histocompatibility antigen, DR-1 beta chain; HLA class II histocompatibility antigen, DR-5 beta chain; HLA class II histocompatibility antigen, DRB1 beta chain; HLA class II histocompatibility antigen, DRB1-7 beta chain; HLA class II histocompatibility antigen, DRB1-9 beta chain; HLA DP14-beta chain; HLA-D; HLA-DP histocompatibility type, beta-1 subunit; HLA-DQ; HLA-DR; HLA-DRB1; HLA-DRB5; human leucocyte antigen DRB1; human leucocyte antigen DRB3; human leucocyte antigen DRB4; human leucocyte antigen DRB5; Human leukocyte antigen DRB1; leukocyte antigen; leukocyte antigen class II; lymphocyte antigen; lymphocyte antigen DRB1; major histocompatibility complex class II antigen beta chain; MHC cell surface glycoprotein; MHC Class 2; MHC class I antigen; MHC class II; MHC Class II antigen; MHC class II antigen beta chain; MHC class II antigen DP beta 1 chain; MHC class II antigen DPB1; MHC class II antigen DPbeta1; MHC class II antigen DQB1; MHC class II antigen DR beta 3 chain; MHC class II antigen DRA; MHC class II antigen DRB1*9; MHC class II antigen DRB3; MHC class II antigen DRB4; MHC class II antigen DRB5; MHC class II antigen HLA-DQ-beta-1; MHC class II antigen HLA-DR-beta; MHC class II DQ beta chain; MHC class II HLA beta chain; MHC class II HLA-DP-beta-1; MHC class II HLA-DQ beta glycoprotein; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR beta 3 chain; MHC class II HLA-DR-beta cell surface glycoprotein; MHC class II HLA-DRB1; MHC class II HLA-DRw10-beta; MHC class2 antigen; MHC DQ beta; MHC HLA DPB1; MHC HLA DR-beta chain; MHC HLA-D; MHC HLA-DR-beta cell surface glycoprotein; MHC HLA-DR-beta chain; MHC II HLA; XXbac-BPG161M6.1
Gene Aliases: CELIAC1; DPB1; DR-4; DR4; DRB1; DRB4; DRw10; HLA-DP; HLA-DP1B; HLA-DPB; HLA-DPB1; HLA-DQB; HLA-DQB1; HLA-DR1B; HLA-DR3B; HLA-DR4B; HLA-DRA; HLA-DRA1; HLA-DRB; HLA-DRB1; HLA-DRB3; HLA-DRB4; HLA-DRB5; IDDM1; MLRW; SS1
UniProt ID: (Human) Q30015, (Human) C9DRQ3, (Human) P01903, (Human) Q5UBA2, (Human) P79483, (Human) P13762, (Human) Q30154
Entrez Gene ID: (Human) 3115, (Human) 3119, (Human) 3122, (Human) 3123, (Human) 3125, (Human) 3126, (Human) 3127
antigen processing and presentation of exogenous peptide antigen via MHC class II
T cell costimulation
positive regulation of interferon-gamma production
positive regulation of T cell proliferation
T cell receptor signaling pathway
positive regulation of T cell activation
interferon-gamma-mediated signaling pathway
immunoglobulin production involved in immunoglobulin mediated immune response
humoral immune response mediated by circulating immunoglobulin
immune response
peptide antigen assembly with MHC class II protein complex
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
polysaccharide assembly with MHC class II protein complex
viral process
cognition
signal transduction
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