Proteintech

HNF1A Polyclonal Antibody

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HNF1A Antibody (22426-1-AP) in WB

Rat liver tissue were subjected to SDS PAGE followed by western blot with 22426-1-AP (HNF1A antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

HNF1A Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

22426-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 3 publications 3 publications

ChIP assay (ChIP)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HNF1A Fusion Protein Ag18188 (467-631 aa encoded by BC104910)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.56 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: PLHPSYQQP LMPPVQSHVT QSPFMATMAQ LQSPHALYSH KPEVAQYTHT GLLPQTMLIT DTTNLSALAS LTPTKQVFTS DTEASSESGL HTPASQATTL HVPSQDPAGI QHLQPAHRLS ASPTVSSSSL VLYQSSDSSN GQSHLLPSNH SVIETFISTQ MASSSQ (467-631 aa encoded by BC104910)

Target Information

This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.

Journal of experimental & clinical cancer research : CR

Dong S,Liang S,Cheng Z,Zhang X,Luo L,Li L,Zhang W,Li S,Xu Q,Zhong M,Zhu J,Zhang G,Hu S

Sat Jan 08 00:00:00 EST 2022

ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.

Journal of experimental & clinical cancer research : CR

Dong S,Liang S,Cheng Z,Zhang X,Luo L,Li L,Zhang W,Li S,Xu Q,Zhong M,Zhu J,Zhang G,Hu S

Sat Jan 08 00:00:00 EST 2022

ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.

Journal of experimental & clinical cancer research : CR

Dong S,Liang S,Cheng Z,Zhang X,Luo L,Li L,Zhang W,Li S,Xu Q,Zhong M,Zhu J,Zhang G,Hu S

Sat Jan 08 00:00:00 EST 2022

The accessible promoter-mediated supplementary effect of host factors provides new insight into the tropism of SARS-CoV-2.

Molecular therapy. Nucleic acids

Du G,Xu X,Wang J,Wang X,Ding Y,Li F,Sun Y,Tao H,Luo Y,Li H,Bo X,Chen H

Tue Jun 14 00:00:00 EDT 2022

CBP/p300 HAT maintains the gene network critical for β cell identity and functional maturity.

Cell death & disease

Zhang L,Sheng C,Zhou F,Zhu K,Wang S,Liu Q,Yuan M,Xu Z,Liu Y,Lu J,Liu J,Zhou L,Wang X

Wed May 12 00:00:00 EDT 2021

Effect of fucoidan on ethanol-induced liver injury and steatosis in mice and the underlying mechanism.

Food & nutrition research

Xue M,Liang H,Zhou Z,Liu Y,He X,Zhang Z,Sun T,Yang J,Qin Y,Qin K

Sat Nov 11 00:00:00 EST 2023

Aloe-emodin exerts cholesterol-lowering effects by inhibiting proprotein convertase subtilisin/kexin type 9 in hyperlipidemic rats.

Acta pharmacologica Sinica

Su ZL,Hang PZ,Hu J,Zheng YY,Sun HQ,Guo J,Liu KY,Du ZM

Sat Aug 01 00:00:00 EDT 2020

Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer.

Cell research

Teng S,Li YE,Yang M,Qi R,Huang Y,Wang Q,Zhang Y,Chen S,Li S,Lin K,Cao Y,Ji Q,Gu Q,Cheng Y,Chang Z,Guo W,Wang P,Garcia-Bassets I,Lu ZJ,Wang D

Wed Jan 01 00:00:00 EST 2020

Hepatocyte nuclear factor 1 alpha (HNF1A) regulates transcription of O-GlcNAc transferase in a negative feedback mechanism.

FEBS letters

Zhang C,Xie F,Li L,Zhang C,Zhang Y,Ying W,Liu L,Yan X,Yin F,Zhang L

Wed May 01 00:00:00 EDT 2019

Hepatocyte nuclear factor 1 alpha (HNF1A) regulates transcription of O-GlcNAc transferase in a negative feedback mechanism.

FEBS letters

Zhang C,Xie F,Li L,Zhang C,Zhang Y,Ying W,Liu L,Yan X,Yin F,Zhang L

Wed May 01 00:00:00 EDT 2019

Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity.

Theranostics

Zhang T,Yu F,Guo L,Chen M,Yuan X,Wu B

Fri Sep 06 00:00:00 EDT 2019

Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity.

Theranostics

Zhang T,Yu F,Guo L,Chen M,Yuan X,Wu B

Fri Sep 06 00:00:00 EDT 2019

Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity.

Theranostics

Zhang T,Yu F,Guo L,Chen M,Yuan X,Wu B

Fri Sep 06 00:00:00 EDT 2019

Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity.

Theranostics

Zhang T,Yu F,Guo L,Chen M,Yuan X,Wu B

Fri Sep 06 00:00:00 EDT 2019

6-Formylindolo(3,2-b)carbazole induced aryl hydrocarbon receptor activation prevents intestinal barrier dysfunction through regulation of claudin-2 expression.

Chemico-biological interactions

Ma Y,Wang Q,Yu K,Fan X,Xiao W,Cai Y,Xu P,Yu M,Yang H

Fri May 25 00:00:00 EDT 2018

Bioinformatics

Protein Aliases: albumin proximal factor; hepatic nuclear factor 1; hepatic nuclear factor-1-alpha; hepatocyte nuclear factor 1; Hepatocyte nuclear factor 1-alpha; hnf-1 alpha; HNF-1-alpha; HNF-1A; interferon production regulator factor; LF-B1 hepatic nuclear factor (HNF1): albumin proximal factor also TCF1; LF-B1, hepatic nuclear factor (HNF1): albumin proximal factor, also TCF1; LFB1; Liver-specific transcription factor LF-B1; TCF-1; Transcription factor 1; Transcription factor 1 hepatic; Transcription factor 1, hepatic

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Gene Aliases: AI323641; Hnf-1; HNF-1A; HNF1; HNF1-alpha; HNF1[a]; HNF1A; Hnf1alpha; IDDM20; LF-B1; LFB1; MODY3; TCF-1; TCF1

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UniProt ID: (Human) P20823, (Rat) P15257, (Mouse) P22361

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Entrez Gene ID: (Human) 6927, (Rat) 24817, (Mouse) 21405

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Function(s)

RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor activity, sequence-specific DNA binding protein binding transcription regulatory region DNA binding protein dimerization activity RNA polymerase II core promoter sequence-specific DNA binding transcription cofactor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding double-stranded DNA binding transcription factor binding protein homodimerization activity sequence-specific DNA binding protein heterodimerization activity DNA-binding transcription factor

Process(es)

regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter regulation of pronephros size renal glucose absorption glucose homeostasis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter glucose import positive regulation of transcription initiation from RNA polymerase II promoter negative regulation of transcription from RNA polymerase II promoter blastocyst development liver development placenta development chromatin remodeling regulation of transcription, DNA-templated fatty acid biosynthetic process bile acid biosynthetic process heme biosynthetic process response to oxidative stress protein localization cholesterol metabolic process response to glucose bile acid and bile salt transport fatty acid transport insulin secretion regulation of Wnt signaling pathway embryonic limb morphogenesis endocrine pancreas development reverse cholesterol transport bone resorption regulation of hormone secretion paraxial mesoderm formation reproductive structure development regulation of insulin secretion SMAD protein signal transduction transcription, DNA-templated

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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HNF1A Polyclonal Antibody

HNF1A Antibody (22426-1-AP) in WB

Product Details

22426-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunoprecipitation (IP)

ChIP assay (ChIP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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