Invitrogen

HNF1A Recombinant Rabbit Monoclonal Antibody (2Z4Z0)

View all (22) HNF1A antibodies
Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

MA5-51397

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

2Z4Z0

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 31-128 of human HNF1 alpha (NP_000536.6).
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.08 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_3094272

Product Specific Information

Immunogen sequence: GEPGPYLLAG EGPLDKGESC GGGRGELAEL PNGLGETRGS EDETDDDGED FTPPILKELE NLSPEEAAHQ KAVVETLLQE DPWRVAKMVK SYLQQHNI

Target Information

This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: albumin proximal factor; hepatic nuclear factor 1; hepatic nuclear factor-1-alpha; hepatocyte nuclear factor 1; Hepatocyte nuclear factor 1-alpha; hnf-1 alpha; HNF-1-alpha; HNF-1A; interferon production regulator factor; LF-B1 hepatic nuclear factor (HNF1): albumin proximal factor also TCF1; LF-B1, hepatic nuclear factor (HNF1): albumin proximal factor, also TCF1; LFB1; Liver-specific transcription factor LF-B1; TCF-1; Transcription factor 1; Transcription factor 1 hepatic; Transcription factor 1, hepatic

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Gene Aliases: AI323641; Hnf-1; HNF-1A; HNF1; HNF1-alpha; HNF1[a]; HNF1A; Hnf1alpha; IDDM20; LF-B1; LFB1; MODY3; TCF-1; TCF1

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UniProt ID: (Human) P20823, (Rat) P15257, (Mouse) P22361

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Entrez Gene ID: (Human) 6927, (Rat) 24817, (Mouse) 21405

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor activity, sequence-specific DNA binding protein binding transcription regulatory region DNA binding protein dimerization activity RNA polymerase II core promoter sequence-specific DNA binding transcription cofactor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding double-stranded DNA binding transcription factor binding protein homodimerization activity sequence-specific DNA binding protein heterodimerization activity DNA-binding transcription factor
Process(es)
regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter regulation of pronephros size renal glucose absorption glucose homeostasis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter glucose import positive regulation of transcription initiation from RNA polymerase II promoter negative regulation of transcription from RNA polymerase II promoter blastocyst development liver development placenta development chromatin remodeling regulation of transcription, DNA-templated fatty acid biosynthetic process bile acid biosynthetic process heme biosynthetic process response to oxidative stress protein localization cholesterol metabolic process response to glucose bile acid and bile salt transport fatty acid transport insulin secretion regulation of Wnt signaling pathway embryonic limb morphogenesis endocrine pancreas development reverse cholesterol transport bone resorption regulation of hormone secretion paraxial mesoderm formation reproductive structure development regulation of insulin secretion SMAD protein signal transduction transcription, DNA-templated
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