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Immunogen sequence: TSDDLTQMLD NLGLKYECYD LLSTMDISDC FIDGNENGDL LWDFLTETCN FNATAPPDLR AELGKDLQEP EFSAKKEGKV LFNNTLSFIV IEA
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 83%.
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. HNMT is the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Histamine N-methyltransferase; HMT
Gene Aliases: HMT; HNMT; HNMT-S1; HNMT-S2; MRT51
UniProt ID: (Human) P50135
Entrez Gene ID: (Human) 3176
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