Proteintech

HORMAD1 Polyclonal Antibody

FIGURE: 1 / 2

HORMAD1 Antibody (13917-1-AP) in WB

Various lysates were subjected to SDS PAGE followed by western blot with (Product # 13917-1-AP) (HORMAD1 antibody) at dilution of 1:1,000 incubated at room temperature for 1.5 hours.

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Product Details

13917-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2400

View 6 publications 6 publications

Immunocytochemistry (ICC/IF)

Assay-dependent

View 15 publications 15 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HORMAD1 Fusion Protein Ag4914 (1-394 aa encoded by BC047406)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MATAQLQRT PMSALVFPNK ISTEHQSLVL VKRLLAVSVS CITYLRGIFP ECAYGTRYLD DLCVKILRED KNCPGSTQLV KWMLGCYDAL QKKYLRMVVL AVYTNPEDPQ TISECYQFKF KYTNNGPLMD FISKNQSNES SMLSTDTKKA SILLIRKIYI LMQNLGPLPN DVCLTMKLFY YDEVTPPDYQ PPGFKDGDCE GVIFEGEPMY LNVGEVSTPF HIFKVKVTTE RERMENIDST ILSPKQIKTP FQKILRDKDV EDEQEHYTSD DLDIETKMEE QEKNPASSEL EEPSLVCEED EIMRSKESPD LSISHSQVEQ LVNKTSELDM SESKTRSGKV FQNKMANGNQ PVKSSKENRK RSQHESGRIV LHHFDSSSQE SVPKRRKFSE PKEHI (1-394 aa encoded by BC047406)

Target Information

This gene encodes a HORMA domain-containing protein. HORMA domains are involved in chromatin binding and play a role in cell cycle regulation. The encoded protein may play a role in meiosis, and expression of this gene is a potential marker for cancer. A pseudogene of this gene is located on the long arm of chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Bi-allelic MEI1 variants cause meiosis arrest and non-obstructive azoospermia.

Journal of human genetics

Zhang Y,Li N,Ji Z,Bai H,Ou N,Tian R,Li P,Zhi E,Huang Y,Zhao J,Han Y,Zhang J,Zhou Y,Li Z,Yao C

Thu Jun 01 00:00:00 EDT 2023

UHRF1 is indispensable for meiotic sex chromosome inactivation and interacts with the DNA damage response pathway in mice†.

Biology of reproduction

Xiong M,Zhou S,Feng S,Gui Y,Li J,Wu Y,Dong J,Yuan S

Mon Jul 25 00:00:00 EDT 2022

ZFP541 maintains the repression of pre-pachytene transcriptional programs and promotes male meiosis progression.

Cell reports

Xu J,Gao J,Liu J,Huang X,Zhang H,Ma A,Ye J,Zhang X,Li Y,Yang G,Yin H,Khan R,Li T,Fan S,Jiang X,Zhang Y,Jiang H,Ma H,Shi Q

Tue Mar 22 00:00:00 EDT 2022

Temperature sensitivity of DNA double-strand break repair underpins heat-induced meiotic failure in mouse spermatogenesis.

Communications biology

Hirano K,Nonami Y,Nakamura Y,Sato T,Sato T,Ishiguro KI,Ogawa T,Yoshida S

Thu May 26 00:00:00 EDT 2022

FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis.

iScience

Tanno N,Takemoto K,Takada-Horisawa Y,Shimada R,Fujimura S,Tani N,Takeda N,Araki K,Ishiguro KI

Fri Apr 15 00:00:00 EDT 2022

NAT10-mediated N4-acetylcytidine modification is required for meiosis entry and progression in male germ cells.

Nucleic acids research

Chen L,Wang WJ,Liu Q,Wu YK,Wu YW,Jiang Y,Liao XQ,Huang F,Li Y,Shen L,Yu C,Zhang SY,Yan LY,Qiao J,Sha QQ,Fan HY

Fri Oct 28 00:00:00 EDT 2022

SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination.

Nucleic acids research