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HPSE Polyclonal Antibody

HPSE Antibody in Immunocytochemistry (ICC/IF)

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HPSE Antibody (24529-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 24529-1-AP (HPSE antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG.

HPSE Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

24529-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HPSE Fusion Protein Ag21479 (36-543 aa encoded by BC051321)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.36 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: QDVVDLDFF TQEPLHLVSP SFLSVTIDAN LATDPRFLIL LGSPKLRTLA RGLSPAYLRF GGTKTDFLIF DPKKESTFEE RSYWQSQVNQ DICKYGSIPP DVEEKLRLEW PYQEQLLLRE HYQKKFKNST YSRSSVDVLY TFANCSGLDL IFGLNALLRT ADLQWNSSNA QLLLDYCSSK GYNISWELGN EPNSFLKKAD IFINGSQLGE DFIQLHKLLR KSTFKNAKLY GPDVGQPRRK TAKMLKSFLK AGGEVIDSVT WHHYYLNGRT ATREDFLNPD VLDIFISSVQ KVFQVVESTR PGKKVWLGET SSAYGGGAPL LSDTFAAGFM WLDKLGLSAR MGIEVVMRQV FFGAGNYHLV DENFDPLPDY WLSLLFKKLV GTKVLMASVQ GSKRRKLRVY LHCTNTDNPR YKEGDLTLYA INLHNVTKYL RLPYPFSNKQ VDKYLLRPLG PHGLLSKSVQ LNGLTLKMVD DQTLPPLMEK PLRPGSSLGL PAFSYSFFVI RNAKVAACI (36-543 aa encoded by BC051321)

Target Information

Stem cells offer a therapeutic promise for many diseases. In the case of diabetes, stem cells offer the promise that beta cells may be generated ex vivo for the possible transplantation and cure of Type I diabetes (Couri CE, et al. ). For this to happen, stem cells will need to be isolated and expanded, they will need to be differentiated toward the beta cell lineage, and the differentiated cell progeny used for transplantation may need to be isolated from complex cell mixtures following differentiation. Appropriate markers targeting cell surface molecules on developing and mature pancreatic cells will be required for such research.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

cRGD-targeted heparin nanoparticles for effective dual drug treatment of cisplatin-resistant ovarian cancer.

Journal of controlled release : official journal of the Controlled Release Society

Liang X,Yang Y,Huang C,Ye Z,Lai W,Luo J,Li X,Yi X,Fan JB,Wang Y,Wang Y

Sat Apr 01 00:00:00 EDT 2023

MicroRNA-219a-2-3p modulates the proliferation of thyroid cancer cells via the HPSE/cyclin D1 pathway.

Experimental and therapeutic medicine

Yang C,Zhang S,Chang X,Huang Y,Cui D,Liu Z

Tue Jun 01 00:00:00 EDT 2021

MicroRNA-219a-2-3p modulates the proliferation of thyroid cancer cells via the HPSE/cyclin D1 pathway.

Experimental and therapeutic medicine

Yang C,Zhang S,Chang X,Huang Y,Cui D,Liu Z

Tue Jun 01 00:00:00 EDT 2021

Reducing LncRNA-5657 expression inhibits the brain inflammatory reaction in septic rats.

Neural regeneration research

Zhan YA,Qiu XL,Wang XZ,Zhao N,Qian KJ

Thu Jul 01 00:00:00 EDT 2021

CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells.

EMBO reports

Li Y,Zheng F,Xiao X,Xie F,Tao D,Huang C,Liu D,Wang M,Wang L,Zeng F,Jiang G

Fri Sep 01 00:00:00 EDT 2017

CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells.

EMBO reports

Li Y,Zheng F,Xiao X,Xie F,Tao D,Huang C,Liu D,Wang M,Wang L,Zeng F,Jiang G

Fri Sep 01 00:00:00 EDT 2017

CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells.

EMBO reports

Li Y,Zheng F,Xiao X,Xie F,Tao D,Huang C,Liu D,Wang M,Wang L,Zeng F,Jiang G

Fri Sep 01 00:00:00 EDT 2017

CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells.

EMBO reports

Li Y,Zheng F,Xiao X,Xie F,Tao D,Huang C,Liu D,Wang M,Wang L,Zeng F,Jiang G

Fri Sep 01 00:00:00 EDT 2017

Heparanase-driven inflammation from the AGEs-stimulated macrophages changes the functions of glomerular endothelial cells.

Diabetes research and clinical practice

Xu G,Qin Q,Yang M,Qiao Z,Gu Y,Niu J

Wed Feb 01 00:00:00 EST 2017

Heparanase-driven inflammation from the AGEs-stimulated macrophages changes the functions of glomerular endothelial cells.

Diabetes research and clinical practice

Xu G,Qin Q,Yang M,Qiao Z,Gu Y,Niu J

Wed Feb 01 00:00:00 EST 2017

Shed Syndecan-1 is involved in chemotherapy resistance via the EGFR pathway in colorectal cancer.

British journal of cancer

Wang X,Zuo D,Chen Y,Li W,Liu R,He Y,Ren L,Zhou L,Deng T,Wang X,Ying G,Ba Y

Tue Nov 11 00:00:00 EST 2014

Bioinformatics

Protein Aliases: Endo-glucoronidase; endoglycosidase heparanase; Heparanase; Heparanase-1; Hpa1

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Gene Aliases: HEP; HPA; HPA1; HPR1; HPSE; HPSE1; HSE1

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UniProt ID: (Human) Q9Y251, (Mouse) Q6YGZ1

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Entrez Gene ID: (Human) 10855, (Mouse) 15442

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Function(s)

beta-glucuronidase activity protein binding heparanase activity heparan sulfate proteoglycan binding syndecan binding protein dimerization activity hydrolase activity hydrolase activity, acting on glycosyl bonds glycosidase

Process(es)

carbohydrate metabolic process glycosaminoglycan catabolic process proteoglycan metabolic process cell-matrix adhesion positive regulation of vascular endothelial growth factor production positive regulation of blood coagulation extracellular matrix organization heparan sulfate proteoglycan catabolic process positive regulation of osteoblast proliferation regulation of hair follicle development positive regulation of hair follicle development positive regulation of protein kinase B signaling angiogenesis involved in wound healing vascular wound healing cell adhesion wound healing

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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HPSE Polyclonal Antibody

HPSE Antibody (24529-1-AP) in ICC/IF

Product Details

24529-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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