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Product Details
PA5-117025
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 36-275 of human Heparanase 1 (NP_0010920101)
Conjugate
Form
Liquid
Concentration
2.53 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2901655
Product Specific Information
Positive Samples: Jurkat, DU145, 293T
Immunogen sequence: QDVVDLDFFT QEPLHLVSPS FLSVTIDANL ATDPRFLILL GSPKLRTLAR GLSPAYLRFG GTKTDFLIFD PKKESTFEER SYWQSQVNQD ICKYGSIPPD VEEKLRLEWP YQEQLLLREH YQKKFKNSTY SRSSVDVLYT FANCSGLDLI FGLNALLRTA DLQWNSSNAQ LLLDYCSSKG YNISWELGNE PNSFLKKADI FINGSQLGED FIQLHKLLRK STFKNAKLYG PDVGQPRRKT
Target Information
Stem cells offer a therapeutic promise for many diseases. In the case of diabetes, stem cells offer the promise that beta cells may be generated ex vivo for the possible transplantation and cure of Type I diabetes (Couri CE, et al. ). For this to happen, stem cells will need to be isolated and expanded, they will need to be differentiated toward the beta cell lineage, and the differentiated cell progeny used for transplantation may need to be isolated from complex cell mixtures following differentiation. Appropriate markers targeting cell surface molecules on developing and mature pancreatic cells will be required for such research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Endo-glucoronidase; endoglycosidase heparanase; Heparanase; Heparanase-1; heparanase-like; Hpa1
Gene Aliases: HEP; HPA; HPA1; HPR1; HPSE; HPSE1; HSE1
UniProt ID: (Human) Q9Y251, (Mouse) Q6YGZ1, (Rat) Q71RP1
Entrez Gene ID: (Human) 10855, (Mouse) 15442, (Rat) 64537
carbohydrate metabolic process
glycosaminoglycan catabolic process
proteoglycan metabolic process
cell-matrix adhesion
positive regulation of vascular endothelial growth factor production
positive regulation of blood coagulation
extracellular matrix organization
heparan sulfate proteoglycan catabolic process
positive regulation of osteoblast proliferation
regulation of hair follicle development
positive regulation of hair follicle development
positive regulation of protein kinase B signaling
angiogenesis involved in wound healing
vascular wound healing
cell adhesion
wound healing
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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