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Product Details
PA5-142779
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-SHNSHKTSLRLNNS.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2933424
Product Specific Information
Additional Information: This antibody is expected to recognize both reported isoforms (NP_001124527.1; NP_071640.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
H2 Histamine Receptor stimulates adenylate cyclase activity and leads to the release of acids in the stomach. It is also involved in GI motility and intestinal secretion. Treatments for acid-peptic disorders are based on the inhibition of histamine H2 receptor activity. The 3-untranslated region may be involved in differential expression. Histamine H2 receptor has been reported to be expressed in bone marrow, brain, heart, lymph node, nose, placenta, spinal cord, and stomach. An EST has been isolated from a kidney library.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Gastric receptor I; H2R; HH2R; Histamine H2 receptor; histamine receptor
Gene Aliases: H2R; Hrh2
UniProt ID: (Mouse) P97292
Entrez Gene ID: (Rat) 25461, (Mouse) 15466
gastric acid secretion
histamine-induced gastric acid secretion
gastrin-induced gastric acid secretion
epithelial cell morphogenesis
G-protein coupled receptor signaling pathway
memory
visual learning
positive regulation of vasoconstriction
regulation of synaptic plasticity
digestive tract development
gland development
cellular response to histamine
negative regulation of arachidonic acid secretion
toxin transport
synaptic transmission, dopaminergic
immune response
signal transduction
adenylate cyclase-activating dopamine receptor signaling pathway
sensory perception of chemical stimulus
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
phospholipase C-activating dopamine receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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