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Invitrogen
HSP90 alpha Monoclonal Antibody (5G5)
Advanced Verification
This Antibody was verified by Independent antibody to ensure that the antibody binds to the antigen stated.
Product Details
MA5-17091
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
5G5
Immunogen
Purified recombinant fragment of human HSP90AA1 expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2538562
Product Specific Information
MA5-17091 targets HSP90AA1 in indirect ELISA, FACS, IHC and WB applications and shows reactivity with Human, Mouse, and Non-human primate samples.
The MA5-17091 immunogen is purified recombinant fragment of human HSP90AA1 expressed in E. Coli.
MA5-17091 detects HSP90AA1 which has a predicted molecular weight of approximately 90kDa.
Target Information
Heat shock proteins (HSP) are proteins that are expressed in response to various biological stress, including heat. HSP90 is a 90 kDa protein that is induced under stress conditions, but is also one of the most abundant cellular proteins found under non-stress conditions. HSP90 has been found to be associated with a number of other intracellular proteins, including steroid receptors, actin, tubulin, and some kinases. It has been suggested that HSP90 is necessary to maintain structural integrity of at least some steroid receptors to allow for ligand binding during receptor activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis luminal secretory protein 52; epididymis secretory sperm binding protein Li 65p; Heat shock 86 kDa; heat shock 90kD protein 1, alpha; heat shock 90kD protein 1, alpha-like 4; heat shock 90kD protein, alpha-like 4; heat shock 90kDa protein 1, alpha; Heat shock protein; heat shock protein 1, alpha; heat shock protein 90kDa alpha (cytosolic), class A member 1; heat shock protein 90kDa alpha family class A member 1; Heat shock protein family C member 1; Heat shock protein HSP 90-alpha; heat shock protein, 1; heat shock protein, 86 kDa 1; heat shock protein, 89 kDa; Heat shock protein90; HSP; HSP 86; HSP 90 alpha; HSP86; LAP-2; Lipopolysaccharide-associated protein 2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38; TSTA; Tumor-specific transplantation 86 kDa antigen
Gene Aliases: 86kDa; 89kDa; AL024080; AL024147; EL52; HEL-S-65p; hsp4; HSP86; Hsp86-1; Hsp89; HSP89A; Hsp90; HSP90A; HSP90AA1; HSP90N; HSPC1; HSPCA; HSPCAL1; HSPCAL4; HSPN; LAP-2; LAP2
UniProt ID: (Human) P07900, (Mouse) P07901
Entrez Gene ID: (Human) 3320, (Mouse) 15519
nucleotide binding
UTP binding
CTP binding
mRNA binding
protein tyrosine kinase activity
protein binding
ATP binding
GTP binding
ATPase activity
sulfonylurea receptor binding
protein kinase binding
protein phosphatase binding
MHC class II protein complex binding
nitric-oxide synthase regulator activity
TPR domain binding
dATP binding
identical protein binding
protein homodimerization activity
histone deacetylase binding
ion channel binding
poly(A) RNA binding
GTPase binding
Rho GDP-dissociation inhibitor binding
unfolded protein binding
Hsp90 family chaperone
G2/M transition of mitotic cell cycle
neuron migration
skeletal muscle contraction
mitochondrial transport
receptor-mediated endocytosis
response to unfolded protein
signal transduction
response to heat
response to cold
response to salt stress
positive regulation of lamellipodium assembly
cardiac muscle cell apoptotic process
peptidyl-tyrosine phosphorylation
regulation of protein ubiquitination
positive regulation of protein import into nucleus, translocation
Fc-gamma receptor signaling pathway involved in phagocytosis
ERBB2 signaling pathway
protein refolding
regulation of protein complex assembly
protein unfolding
response to estrogen
protein import into mitochondrial outer membrane
positive regulation of nitric oxide biosynthetic process
positive regulation of cell size
response to antibiotic
vascular endothelial growth factor receptor signaling pathway
protein stabilization
regulation of nitric-oxide synthase activity
chaperone-mediated protein complex assembly
positive regulation of cardiac muscle contraction
chaperone-mediated autophagy
regulation of cellular response to heat
protein folding
nitric oxide biosynthetic process
response to stress
positive regulation of cytotoxic T cell differentiation
regulation of catalytic activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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