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Product Details
PA5-112877
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Heat shock 70 kDa protein 1A protein (291-641AA)
Conjugate
Form
Liquid
Concentration
3.15 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Wet ice
RRID
AB_2867611
Target Information
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dnaK-type molecular chaperone HSP70-1; epididymis secretory protein Li 103; Heat shock 70 kDa protein 1; heat shock 70 kDa protein 1/2; Heat shock 70 kDa protein 1A; heat shock 70 kDa protein 1A/1B; Heat shock 70 kDa protein 1B; Heat shock 70 kDa protein 2; heat shock 70kD protein 1A; heat shock 70kDa protein 1A; Heat shock protein family A member 1A; Heat shock protein family A member 1B; heat shock-induced protein; HSP70-1; HSP70-1/HSP70-2; HSP70-2; HSP70.1/HSP70.2
Gene Aliases: HEL-S-103; HSP70-1; HSP70-1A; HSP70.1; HSP70I; HSP72; HSPA1; HSPA1A; HSPA1B; HSX70
UniProt ID: (Human) P0DMV8
Entrez Gene ID: (Human) 3303
virus receptor activity
G-protein coupled receptor binding
receptor binding
protein binding
ATP binding
ATPase activity
enzyme binding
heat shock protein binding
ubiquitin protein ligase binding
ATPase activity, coupled
histone deacetylase binding
protein binding involved in protein folding
unfolded protein binding
C3HC4-type RING finger domain binding
cadherin binding involved in cell-cell adhesion
telomere maintenance
DNA repair
positive regulation of gene expression
regulation of cell death
regulation of protein ubiquitination
negative regulation of protein ubiquitination
positive regulation of interleukin-8 production
cellular response to oxidative stress
cellular response to heat
protein refolding
regulation of mRNA stability
ATP metabolic process
viral entry into host cell
protein stabilization
positive regulation of NF-kappaB transcription factor activity
negative regulation of cell death
cellular heat acclimation
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
negative regulation of inclusion body assembly
cell-cell adhesion
regulation of cellular response to heat
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of endoribonuclease activity
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of mRNA endonucleolytic cleavage involved in unfolded protein response
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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