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Bethyl Laboratories
HVEM/TNFRSF14 Recombinant Rabbit Monoclonal Antibody (BLR062G)
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HVEM/TNFRSF14 Antibody (A700-062) in ICC/IF
Detection of human HVEM/TNFRSF14 in FFPE SK-MEL-28 cells by ICC. Antibody: Rabbit anti-HVEM/TNFRSF14 recombinant monoclonal antibody [BLR062G] (Product # A700-062; lot 1). Secondary: HRP-conjugated goat anti-rabbit IgG (Product # A120-501P). Substrate: DAB.
Product Details
A700-062
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
BLR062G
Immunogen
Recombinant protein representing the extracellular domain of human TNF receptor superfamily member 14, transcript variant 1 (Herpesvirus entry mediator A, HVEM) (residues 39-200).
Conjugate
Form
Liquid
Concentration
1000 µg/mL
Purification
purified
Storage buffer
BBS, pH 7.8 to 8.6
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Wet ice
Target Information
TNFRSF14 is a member of the TNF-receptor superfamily. TNFRSF14 was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to TNFRSF14 has been shown to be part of the viral entry mechanism. The cytoplasmic region of TNFRSF14 was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. Activation of the signal transduction pathway involving TNFRSF14 in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these TNFRSF14 variants have not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD270; CD40-like protein; Herpes virus entry mediator A; Herpesvirus entry mediator A; HGNC:11912; RP3-395M20.6; sCD2710; TR2; tumo; Tumor necrosis factor receptor superfamily member 14; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator); Tumor necrosis factor receptor-like 2; tumor necrosis factor receptor-like gene2
Gene Aliases: ATAR; CD270; HVEA; HVEM; LIGHTR; TNFRSF14; TR2; UNQ329/PRO509
UniProt ID: (Human) Q92956
Entrez Gene ID: (Human) 8764
positive regulation of cytokine secretion involved in immune response
inflammatory response
immune response
cell surface receptor signaling pathway
multicellular organism development
T cell costimulation
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
regulation of cell proliferation
regulation of apoptotic process
positive regulation of MAPK cascade
negative regulation of alpha-beta T cell proliferation
viral entry into host cell
positive regulation of peptidyl-tyrosine phosphorylation
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
apoptotic signaling pathway
positive regulation of T cell migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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