Proteintech

HYAL2 Polyclonal Antibody

HYAL2 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 6

HYAL2 Antibody (15115-1-AP) in ICC/IF

Immunofluorescent analysis of Hela cells, using HYAL2 antibody 15115-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

HYAL2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

15115-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,500

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:10-1:100

View 2 publications 2 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HYAL2 Fusion Protein Ag7157 (99-448 aa encoded by BC000692)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.63 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: GVPQNVSLW AHRKMLQKRV EHYIRTQESA GLAVIDWEDW RPVWVRNWQD KDVYRRLSRQ LVASRHPDWP PDRIVKQAQY EFEFAAQQFM LETLRYVKAV RPRHLWGFYL FPDCYNHDYV QNWESYTGRC PDVEVARNDQ LAWLWAESTA LFPSVYLDET LASSRHGRNF VSFRVQEALR VARTHHANHA LPVYVFTRPT YSRRLTGLSE MDLISTIGES AALGAAGVIL WGDAGYTTST ETCQYLKDYL TRLLVPYVVN VSWATQYCSR AQCHGHGRCV RRNPSASTFL HLSTNSFRLV PGHAPGEPQL RPVGELSWAD IDHLQTHFRC QCYLGWSGEQ CQWDHRQAAG G (99-448 aa encoded by BC000692)

Target Information

This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Complement protein C1q stimulates hyaluronic acid degradation via gC1qR/HABP1/p32 in malignant pleural mesothelioma.

Frontiers in immunology

Balduit A,Vidergar R,Zacchi P,Mangogna A,Agostinis C,Grandolfo M,Bottin C,Salton F,Confalonieri P,Rocca A,Zanconati F,Confalonieri M,Kishore U,Ghebrehiwet B,Bulla R

Tue Jun 20 00:00:00 EDT 2023

Complement protein C1q stimulates hyaluronic acid degradation via gC1qR/HABP1/p32 in malignant pleural mesothelioma.

Frontiers in immunology

Balduit A,Vidergar R,Zacchi P,Mangogna A,Agostinis C,Grandolfo M,Bottin C,Salton F,Confalonieri P,Rocca A,Zanconati F,Confalonieri M,Kishore U,Ghebrehiwet B,Bulla R

Tue Jun 20 00:00:00 EDT 2023

Complement protein C1q stimulates hyaluronic acid degradation via gC1qR/HABP1/p32 in malignant pleural mesothelioma.

Frontiers in immunology

Balduit A,Vidergar R,Zacchi P,Mangogna A,Agostinis C,Grandolfo M,Bottin C,Salton F,Confalonieri P,Rocca A,Zanconati F,Confalonieri M,Kishore U,Ghebrehiwet B,Bulla R

Tue Jun 20 00:00:00 EDT 2023

Elucidating the clinical spectrum and molecular basis of HYAL2 deficiency.

Genetics in medicine : official journal of the American College of Medical Genetics

Fasham J,Lin S,Ghosh P,Radio FC,Farrow EG,Thiffault I,Kussman J,Zhou D,Hemming R,Zahka K,Chioza BA,Rawlins LE,Wenger OK,Gunning AC,Pizzi S,Onesimo R,Zampino G,Barker E,Osawa N,Rodriguez MC,Neuhann TM,Zackai EH,Keena B,Capasso J,Levin AV,Bhoj E,Li D,Hakonarson H,Wentzensen IM,Jackson A,Chandler KE,Coban-Akdemir ZH,Posey JE,Banka S,Lupski JR,Sheppard SE,Tartaglia M,Triggs-Raine B,Crosby AH,Baple EL

Tue Mar 01 00:00:00 EST 2022

Elucidating the clinical spectrum and molecular basis of HYAL2 deficiency.

Genetics in medicine : official journal of the American College of Medical Genetics

Tue Mar 01 00:00:00 EST 2022

Role of Momordica charantia in preventing the natural aging process of skin and sexual organs in mice.

Dermatologic therapy

Hiramoto K,Orita K,Yamate Y,Kobayashi H

Sun Nov 01 00:00:00 EDT 2020

Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice.

PLoS genetics

Muggenthaler MM,Chowdhury B,Hasan SN,Cross HE,Mark B,Harlalka GV,Patton MA,Ishida M,Behr ER,Sharma S,Zahka K,Faqeih E,Blakley B,Jackson M,Lees M,Dolinsky V,Cross L,Stanier P,Salter C,Baple EL,Alkuraya FS,Crosby AH,Triggs-Raine B,Chioza BA

Sun Jan 01 00:00:00 EST 2017

Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice.

PLoS genetics

Sun Jan 01 00:00:00 EST 2017

Bioinformatics

Protein Aliases: Hyal-2; hyaluronidase 2; Hyaluronidase-2; Hyaluronoglucosaminidase-2; LuCa-2; Lung carcinoma protein 2; lysosomal hyaluronidase; PH-20 homolog; PH20 homolog

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Gene Aliases: AI256841; AU020858; AW555733; HYAL2; LUCA2

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UniProt ID: (Human) Q12891, (Mouse) O35632

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Entrez Gene ID: (Human) 8692, (Rat) 64468, (Mouse) 15587

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Function(s)

RNA polymerase II transcription coactivator activity virus receptor activity hyalurononglucosaminidase activity protein binding hyaluronic acid binding enzyme binding receptor signaling protein tyrosine kinase inhibitor activity receptor tyrosine kinase binding hyaluronoglucuronidase activity transforming growth factor beta binding catalytic activity hydrolase activity hydrolase activity, acting on glycosyl bonds glycosidase

Process(es)

response to reactive oxygen species kidney development hematopoietic progenitor cell differentiation carbohydrate metabolic process glycosaminoglycan catabolic process response to virus multicellular organism aging negative regulation of fibroblast migration fusion of virus membrane with host plasma membrane transformation of host cell by virus hyaluronan catabolic process negative regulation of cell growth positive regulation of urine volume monocyte activation positive regulation of protein import into nucleus negative regulation of MAP kinase activity cellular response to fibroblast growth factor stimulus positive regulation of transcription from RNA polymerase II promoter response to antibiotic viral entry into host cell skeletal system morphogenesis positive regulation of inflammatory response cartilage development defense response to virus negative regulation of protein kinase B signaling multicellular organismal iron ion homeostasis negative regulation of protein tyrosine kinase activity renal water absorption cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to UV-B cellular response to transforming growth factor beta stimulus positive regulation of interleukin-8 secretion positive regulation of interleukin-6 secretion positive regulation of extrinsic apoptotic signaling pathway metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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HYAL2 Polyclonal Antibody

HYAL2 Antibody (15115-1-AP) in ICC/IF

Product Details

15115-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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