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Product Details
PA5-57658
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human HYAL2. Recombinant protein control fragment (Product #RP-96270).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2642593
Product Specific Information
Immunogen sequence: APPIFTGRPF VVAWDVPTQD CGPRLKVPLD LNAFDVQASP NEGFVNQNIT IFYRDRLGLY PRFDSAGRSV HGGVPQNVSL WAHRK
Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 80%.
Target Information
This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hyal-2; hyaluronidase 2; Hyaluronidase-2; Hyaluronoglucosaminidase-2; LuCa-2; Lung carcinoma protein 2; lysosomal hyaluronidase; PH-20 homolog; PH20 homolog
Gene Aliases: HYAL2; LUCA2
UniProt ID: (Human) Q12891
Entrez Gene ID: (Human) 8692
RNA polymerase II transcription coactivator activity
virus receptor activity
hyalurononglucosaminidase activity
protein binding
hyaluronic acid binding
enzyme binding
receptor signaling protein tyrosine kinase inhibitor activity
receptor tyrosine kinase binding
hyaluronoglucuronidase activity
transforming growth factor beta binding
glycosidase
response to reactive oxygen species
kidney development
hematopoietic progenitor cell differentiation
carbohydrate metabolic process
glycosaminoglycan catabolic process
response to virus
multicellular organism aging
negative regulation of fibroblast migration
fusion of virus membrane with host plasma membrane
transformation of host cell by virus
hyaluronan catabolic process
negative regulation of cell growth
positive regulation of urine volume
monocyte activation
positive regulation of protein import into nucleus
negative regulation of MAP kinase activity
cellular response to fibroblast growth factor stimulus
positive regulation of transcription from RNA polymerase II promoter
response to antibiotic
viral entry into host cell
skeletal system morphogenesis
positive regulation of inflammatory response
cartilage development
defense response to virus
negative regulation of protein kinase B signaling
multicellular organismal iron ion homeostasis
negative regulation of protein tyrosine kinase activity
renal water absorption
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to UV-B
cellular response to transforming growth factor beta stimulus
positive regulation of interleukin-8 secretion
positive regulation of interleukin-6 secretion
positive regulation of extrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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