Product References
Hepatitis C virus core protein uses triacylglycerols to fold onto the endoplasmic reticulum membrane.
Traffic (Copenhagen, Denmark)
Ajjaji D,Ben M'barek K,Boson B,Omrane M,Gassama-Diagne A,Blaud M,Penin F,Diaz E,Ducos B,Cosset FL,Thiam AR
MA1-080 was used in Western Blotting to uncover a critical function of TG in the folding of core and HCV replication and reveals, more broadly, how TG accumulation in the ER may provoke the binding of soluble amphipathic helix-containing proteins to the ER bilayer.
Sat Jan 01 00:00:00 EST 2022
A Simple and Effective Method to Concentrate Hepatitis C Virus: Aqueous Two-Phase System Allows Highly Efficient Enrichment of Enveloped Viruses.
Viruses
Kim H,Yi J,Yu J,Park J,Jang SK
MA1-080 was used in Immunocytochemistry to develop a new, simple and effective ATPS-based method of HCV concentration.
Thu Sep 08 00:00:00 EDT 2022
Adult human liver slice cultures: Modelling of liver fibrosis and evaluation of new anti-fibrotic drugs.
World journal of hepatology
Kartasheva-Ebertz D,Gaston J,Lair-Mehiri L,Massault PP,Scatton O,Vaillant JC,Morozov VA,Pol S,Lagaye S
MA1-080 was used in Western Blot to investigate human liver fibrogenesis and anti-fibrotic therapies, through evaluating the three dimensional ex vivo liver slice model.
Sat Feb 27 00:00:00 EST 2021
Unlike for cellular mRNAs and other viral internal ribosome entry sites (IRESs), the eIF3 subunit e is not required for the translational activity of the HCV IRES.
The Journal of biological chemistry
Panthu B,Denolly S,Faivre-Moskalenko C,Ohlmann T,Cosset FL,Jalinot P
MA1-080 was used in Western Blotting to conclude that unlike for host cellular mRNAs, the entire eIF3 is not required for HCV RNA translation, favoring viral expression under conditions of low eIF3e levels.
Fri Feb 14 00:00:00 EST 2020
Targeting Autophagy Augments BBR-Mediated Cell Death in Human Hepatoma Cells Harboring Hepatitis C Virus RNA.
Cells
Tai CJ,Jassey A,Liu CH,Tai CJ,Richardson CD,Wong SH,Lin LT
MA1-080 was used in Western Blotting to show that berberine treatment induced a biphasic cell death irrespective of the presence of HCV subgenomic replicon RNA.
Wed Apr 08 00:00:00 EDT 2020
Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy.
eLife
Shaw J,Gosain R,Kalita MM,Foster TL,Kankanala J,Mahato DR,Abas S,King BJ,Scott C,Brown E,Bentham MJ,Wetherill L,Bloy A,Samson A,Harris M,Mankouri J,Rowlands DJ,Macdonald A,Tarr AW,Fischer WB,Foster R,Griffin S
MA1-080 was used in Western Blotting to describe the first rationally designed viroporin inhibitor with a comprehensive structure-activity relationship (SAR).
Tue Nov 10 00:00:00 EST 2020
HCV and flaviviruses hijack cellular mechanisms for nuclear STAT2 degradation: Up-regulation of PDLIM2 suppresses the innate immune response.
PLoS pathogens
Joyce MA,Berry-Wynne KM,Dos Santos T,Addison WR,McFarlane N,Hobman T,Tyrrell DL
MA1-080 was used in Immunocytochemistry-immunoflourescence to investigate the paradoxical induction of an innate immune response by HCV despite a multitude of mechanisms combating the host response.
Thu Aug 01 00:00:00 EDT 2019
MicroRNA-122 supports robust innate immunity in hepatocytes by targeting the RTKs/STAT3 signaling pathway.
eLife
Xu H,Xu SJ,Xie SJ,Zhang Y,Yang JH,Zhang WQ,Zheng MN,Zhou H,Qu LH
MA1-080 was used in Western Blotting to determine the role of microRNA-122 in hepatocyte intrinsic innate immunity.
Fri Feb 08 00:00:00 EST 2019
Endoplasmic Reticulum Detergent-Resistant Membranes Accommodate Hepatitis C Virus Proteins for Viral Assembly.
Cells
Boyer A,Dreneau J,Dumans A,Burlaud-Gaillard J,Bull-Maurer A,Roingeard P,Meunier JC
MA1-080 was used in Immunoprecipitation to study the assembly mechanisms of Hepatitis C virus in association with endoplasmic reticulum detergent-resistant membranes.
Wed May 22 00:00:00 EDT 2019
Fibrogenic Gene Expression in Hepatic Stellate Cells Induced by HCV and HIV Replication in a Three Cell Co-Culture Model System.
Scientific reports
Akil A,Endsley M,Shanmugam S,Saldarriaga O,Somasunderam A,Spratt H,Stevenson HL,Utay NS,Ferguson M,Yi M
MA1-080 was used in Immunocytochemistry to assess the effects of human immunodeficiency virus and hepatitis C virus infections on the phenotypic changes and fibrogenic gene expression in LX-2 cells.
Thu Jan 24 00:00:00 EST 2019
Unexpected Replication Boost by Simeprevir for Simeprevir-Resistant Variants in Genotype 1a Hepatitis C Virus.
Antimicrobial agents and chemotherapy
Murai K,Shimakami T,Welsch C,Shirasaki T,Liu F,Kitabayashi J,Tanaka S,Funaki M,Omura H,Nishikawa T,Sumiyadorj A,Honda M,Kaneko S
MA1-080 was used in Western Blotting to elucidate the mechanisms of Simeprevir treatment of Hepatitis C virus failure due to NS3-Q80K.
Sun Jul 01 00:00:00 EDT 2018
Interferon down-regulation of miR-1225-3p as an antiviral mechanism through modulating Grb2-associated binding protein 3 expression.
The Journal of biological chemistry
Cheng M,Niu Y,Fan J,Chi X,Liu X,Yang W
MA1-080 was used in Western Blotting to study the mechanism of miRNA in IFN mediated host response.
Fri Apr 20 00:00:00 EDT 2018
Ultrastructural organisation of HCV from the bloodstream of infected patients revealed by electron microscopy after specific immunocapture.
Gut
Piver E,Boyer A,Gaillard J,Bull A,Beaumont E,Roingeard P,Meunier JC
MA1080 was used in immunocytochemistry to describe a method to preserve the native structure of lipo-viro particles for characterization
Tue Aug 01 00:00:00 EDT 2017
RPLP1 and RPLP2 Are Essential Flavivirus Host Factors That Promote Early Viral Protein Accumulation.
Journal of virology
Campos RK,Wong B,Xie X,Lu YF,Shi PY,Pompon J,Garcia-Blanco MA,Bradrick SS
MA1-080 was used in Immunocytochemistry-immunoflourescence to show the importance of host ribosomal proteins RPLP1 and RPLP2 in flavivirus infection.
Wed Feb 15 00:00:00 EST 2017
The Paradoxical Effects of Different Hepatitis C Viral Loads on Host DNA Damage and Repair Abilities.
PloS one
Wang SC,Lai KR,Li CY,Chiang CS,Yu GY,Sakamoto N,Tu WY,Hsieh MH,Huang JF,Chuang WL,Dai CY,Yu ML
MA1080 was used in western blot to determine the effect of the hepatitis C viral load on host DNA damage
Wed Aug 09 00:00:00 EDT 2017
Hepatitis C virus infection in inclusion body myositis: A case-control study.
Neurology
Uruha A,Noguchi S,Hayashi YK,Tsuburaya RS,Yonekawa T,Nonaka I,Nishino I
MA1-080 was used in immunohistochemistry - paraffin section to determine if there is an association between inclusion body myositis and hepatitis C virus infection
Tue Jan 19 00:00:00 EST 2016
Characterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus Replication.
PLoS pathogens
Suzuki Y,Chin WX,Han Q,Ichiyama K,Lee CH,Eyo ZW,Ebina H,Takahashi H,Takahashi C,Tan BH,Hishiki T,Ohba K,Matsuyama T,Koyanagi Y,Tan YJ,Sawasaki T,Chu JJ,Vasudevan SG,Sano K,Yamamoto N
MA1-080 was used in Flow cytometry/Cell sorting to identify C19orf66 as an interferon-stimulated gene that inhibits Dengue virus replication.
Fri Jan 01 00:00:00 EST 2016
Role of apoptotic hepatocytes in HCV dissemination: regulation by acetaldehyde.
American journal of physiology. Gastrointestinal and liver physiology
Ganesan M,Natarajan SK,Zhang J,Mott JL,Poluektova LI,McVicker BL,Kharbanda KK,Tuma DJ,Osna NA
MA1-080 was used in immunocytochemistry to analyze HCV dissemination and the role of apoptotic hepatocytes and regulation by acetaldehyde
Wed Jun 01 00:00:00 EDT 2016
Characterization of α-taxilin as a novel factor controlling the release of hepatitis C virus.
The Biochemical journal
Elgner F,Donnerhak C,Ren H,Medvedev R,Schreiber A,Weber L,Heilmann M,Ploen D,Himmelsbach K,Finkernagel M,Klingel K,Hildt E
MA1-080 was used in western blot to study the release of hepatitis C virus controlled by alpha-taxilin
Fri Jan 15 00:00:00 EST 2016
Distinct subpopulations of hepatitis C virus infectious cells with different levels of intracellular hepatitis C virus core protein.
The Kaohsiung journal of medical sciences
Wang SC,Yang JF,Wang CL,Huang CF,Lin YY,Chen YY,Lo CT,Lee PY,Wu KT,Lin CI,Hsieh MH,Chuang HY,Ho CK,Yu ML,Dai CY
MA1080 was used in flow cytometry and immunocytochemistry to determine the gene alternation and association between different viral loads of hepatitis C virus-infected cells
Sat Oct 01 00:00:00 EDT 2016
Design and evaluation of novel interferon lambda analogs with enhanced antiviral activity and improved drug attributes.
Drug design, development and therapy
Yu D,Zhao M,Dong L,Zhao L,Zou M,Sun H,Zhang M,Liu H,Zou Z
MA1-080 was used in immunocytochemistry to design and characterize novel IFN-lambda analogs as antiviral biologics
Tue Oct 11 00:00:00 EDT 2016
Antiviral and Immunoregulatory Effects of Indoleamine-2,3-Dioxygenase in Hepatitis C Virus Infection.
Journal of innate immunity
Lepiller Q,Soulier E,Li Q,Lambotin M,Barths J,Fuchs D,Stoll-Keller F,Liang TJ,Barth H
MA1-080 was used in Flow cytometry/Cell sorting to suggest that hepatic IDO plays a dual role during HCV infection by slowing down viral replication and also regulating host immune responses.
Mon Jun 20 00:00:00 EDT 2016
Dynamic Interaction of Stress Granules, DDX3X, and IKK-α Mediates Multiple Functions in Hepatitis C Virus Infection.
Journal of virology
Pène V,Li Q,Sodroski C,Hsu CS,Liang TJ
MA1-080 was used in immunocytochemistry to investigate the role of DDX3X in productive HCV infection
Fri May 01 00:00:00 EDT 2015
Acetaldehyde accelerates HCV-induced impairment of innate immunity by suppressing methylation reactions in liver cells.
American journal of physiology. Gastrointestinal and liver physiology
Ganesan M,Zhang J,Bronich T,Poluektova LI,Donohue TM,Tuma DJ,Kharbanda KK,Osna NA
MA1-080 was used in immunocytochemistry to test if ethanol metabolism enhances hepatitis C virus-mediated dysregulation of IFN-alpha signaling in liver cells via impairment of methylation reactions
Thu Oct 01 00:00:00 EDT 2015
Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation.
Nature medicine
Yamane D,McGivern DR,Wauthier E,Yi M,Madden VJ,Welsch C,Antes I,Wen Y,Chugh PE,McGee CE,Widman DG,Misumi I,Bandyopadhyay S,Kim S,Shimakami T,Oikawa T,Whitmire JK,Heise MT,Dittmer DP,Kao CC,Pitson SM,Merrill AH,Reid LM,Lemon SM
MA1-080 was used in immunocytochemistry to study the role of lipid peroxidation in infection with hepatitis C virus.
Fri Aug 01 00:00:00 EDT 2014
RACK1 controls IRES-mediated translation of viruses.
Cell
Majzoub K,Hafirassou ML,Meignin C,Goto A,Marzi S,Fedorova A,Verdier Y,Vinh J,Hoffmann JA,Martin F,Baumert TF,Schuster C,Imler JL
MA1-080 was used in Immunocytochemistry to demonstrate a specific function for RACK1 in selective mRNA translation and uncover a target for the development of broad antiviral intervention.
Thu Nov 20 00:00:00 EST 2014
Hepatitis C virus NS5A hijacks ARFGAP1 to maintain a phosphatidylinositol 4-phosphate-enriched microenvironment.
Journal of virology
Li H,Yang X,Yang G,Hong Z,Zhou L,Yin P,Xiao Y,Chen L,Chung RT,Zhang L
MA1-080 was used in western blot to study the role of the interaction between HCV NS5A and host ARFGAP1 in the mechanism by which high levels of phosphatidylinositol 4-phosphate are maintained at sites of HCV infection
Sun Jun 01 00:00:00 EDT 2014
Dynamic imaging of the hepatitis C virus NS5A protein during a productive infection.
Journal of virology
Eyre NS,Fiches GN,Aloia AL,Helbig KJ,McCartney EM,McErlean CS,Li K,Aggarwal A,Turville SG,Beard MR
MA1-080 was used in immunocytochemistry to study the HCV NS5A protein during productive viral infection using dynamic imaging techniques
Tue Apr 01 00:00:00 EDT 2014
Hepatitis C virus stimulates low-density lipoprotein receptor expression to facilitate viral propagation.
Journal of virology
Syed GH,Tang H,Khan M,Hassanein T,Liu J,Siddiqui A
MA1-080 was used in immunocytochemistry to study the role of SREBPs and PCSK9 in the mechanism by which HCV upregulates expression of the LDL receptor to promote propagation of the virus
Sat Mar 01 00:00:00 EST 2014
In vitro activity and resistance profile of samatasvir, a novel NS5A replication inhibitor of hepatitis C virus.
Antimicrobial agents and chemotherapy
Bilello JP,Lallos LB,McCarville JF,La Colla M,Serra I,Chapron C,Gillum JM,Pierra C,Standring DN,Seifer M
MA1-080 was used in ELISA to study the in vitro anti-viral activity of a novel anti-HCV compound likely targeting NS5A on the basis of resistance selection experiments
Fri Aug 01 00:00:00 EDT 2014
Protein phosphatase 2A promotes hepatocellular carcinogenesis in the diethylnitrosamine mouse model through inhibition of p53.
Carcinogenesis
Duong FH,Dill MT,Matter MS,Makowska Z,Calabrese D,Dietsche T,Ketterer S,Terracciano L,Heim MH
MA1-080 was used in western blot to study the role of p53 function in the mechanism by which overexpression of protein phosphatase-2A promotes hepatocellular carcinogenesis
Wed Jan 01 00:00:00 EST 2014
Hepatitis C virus (HCV) interaction with astrocytes: nonproductive infection and induction of IL-18.
Journal of neurovirology
Liu Z,Zhao F,He JJ
MA1-080 was used in immunocytochemistry to study the non-productive infection of astrocytes by HCV and the induction of neurotoxic IL-18 expression
Sun Jun 01 00:00:00 EDT 2014
Hepatitis C virus impairs TLR3 signaling and inhibits IFN-λ 1 expression in human hepatoma cell line.
Innate immunity
Wang Y,Li J,Wang X,Ye L,Zhou Y,Thomas RM,Ho W
MA1-080 was used in immunocytochemistry to study the suppression of TLR3 signaling and IFN-lambda1 expression by HCV and a number of HCV non-structural proteins in human hepatoma cells
Wed Jan 01 00:00:00 EST 2014
The association of hepatitis C virus glycoproteins with apolipoproteins E and B early in assembly is conserved in lipoviral particles.
The Journal of biological chemistry
Boyer A,Dumans A,Beaumont E,Etienne L,Roingeard P,Meunier JC
MA1-080 was used in immunocytochemistry to study HCV lipoviral formation and the role of interactions between viral glucoproteins and the ApoE and ApoB apolipoproteins
Fri Jul 04 00:00:00 EDT 2014
HCV core residues critical for infectivity are also involved in core-NS5A complex formation.
PloS one
Gawlik K,Baugh J,Chatterji U,Lim PJ,Bobardt MD,Gallay PA
MA1-080 was used in western blot to study basic residues in the HCV core that are essential both for NS5A complex formation and viral infectivity
Tue Jan 27 00:00:00 EST 2015
Elucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approaches.
Molecular & cellular proteomics : MCP
Germain MA,Chatel-Chaix L,Gagné B,Bonneil É,Thibault P,Pradezynski F,de Chassey B,Meyniel-Schicklin L,Lotteau V,Baril M,Lamarre D
MA1-080 was used in immunocytochemistry to use a combination of proteomics and functional genomics to identify novel HCV-host interactions
Wed Jan 01 00:00:00 EST 2014
Visualization and analysis of hepatitis C virus structural proteins at lipid droplets by super-resolution microscopy.
PloS one
Eggert D,Rösch K,Reimer R,Herker E
MA1-080 was used in western blot to use super-resolution microscopy to visualize and analyze hepatitis C virus structural proteins at lipid droplets
Fri Jan 01 00:00:00 EST 2016
Casein kinase II inhibitor enhances production of infectious genotype 1a hepatitis C virus (H77S).
PloS one
Kim S,Jin B,Choi SH,Han KH,Ahn SH
MA1-080 was used in western blot to study HCV assembly using genotype 1a H77S
Mon Aug 31 00:00:00 EDT 2015
Antiviral peptide nanocomplexes as a potential therapeutic modality for HIV/HCV co-infection.
Biomaterials
Zhang J,Mulvenon A,Makarov E,Wagoner J,Knibbe J,Kim JO,Osna N,Bronich TK,Poluektova LY
MA1-080 was used in immunocytochemistry to study the therapeutic potential of antiviral nanoparticles containing a HCV NS5A-based peptide in HIV/HCV co-infected patients
Wed May 01 00:00:00 EDT 2013
Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells.
Proceedings of the National Academy of Sciences of the United States of America
Ramakrishnaiah V,Thumann C,Fofana I,Habersetzer F,Pan Q,de Ruiter PE,Willemsen R,Demmers JA,Stalin Raj V,Jenster G,Kwekkeboom J,Tilanus HW,Haagmans BL,Baumert TF,van der Laan LJ
MA1-080 was used in immunocytochemistry to study the role of exosomes in the transfer of HCV between human hepatoma cells
Tue Aug 06 00:00:00 EDT 2013
High-throughput profiling of alpha interferon- and interleukin-28B-regulated microRNAs and identification of let-7s with anti-hepatitis C virus activity by targeting IGF2BP1.
Journal of virology
Cheng M,Si Y,Niu Y,Liu X,Li X,Zhao J,Jin Q,Yang W
MA1-080 was used in immunocytochemistry and western blot to study the role of IGF2BP1 downregulation in the anti-HCV activity of the IFN-alpha/IL-28B-regulated let7 miRNA
Sun Sep 01 00:00:00 EDT 2013
5-(Perylen-3-yl)ethynyl-arabino-uridine (aUY11), an arabino-based rigid amphipathic fusion inhibitor, targets virion envelope lipids to inhibit fusion of influenza virus, hepatitis C virus, and other enveloped viruses.
Journal of virology
Colpitts CC,Ustinov AV,Epand RF,Epand RM,Korshun VA,Schang LM
MA1-080 was used in immunocytochemistry to study the ability of 5-(perylen-3-yl)ethynyl-arabino-uridine to inhibit the fusion of enveloped viruses by mimicing the shape and amphipathicity of phospholipids
Mon Apr 01 00:00:00 EDT 2013
Efficiency of E2-p7 processing modulates production of infectious hepatitis C virus.
Journal of virology
Shanmugam S,Yi M
MA1-080 was used in immunohistochemistry and western blot to study how the production of infectious HCV is affected by the rate of proteolytic processing of E2-p7
Tue Oct 01 00:00:00 EDT 2013
MicroRNA-27a regulates lipid metabolism and inhibits hepatitis C virus replication in human hepatoma cells.
Journal of virology
Shirasaki T,Honda M,Shimakami T,Horii R,Yamashita T,Sakai Y,Sakai A,Okada H,Watanabe R,Murakami S,Yi M,Lemon SM,Kaneko S
MA1-080 was used in immunocytochemistry and western blot to study the mechanisms underlying the modulation of hepatic lipid metabolism and the inhibition of HCV replication by miRNA-27a
Wed May 01 00:00:00 EDT 2013
Hepatitis C virus infection upregulates CD55 expression on the hepatocyte surface and promotes association with virus particles.
Journal of virology
Mazumdar B,Kim H,Meyer K,Bose SK,Di Bisceglie AM,Ray RB,Diamond MS,Atkinson JP,Ray R
MA1-080 was used in flow cytometry to study the upregulation of hepatocyte cell surface expression of CD55 in response to HCV infection and the significance for immune evasion
Mon Jul 01 00:00:00 EDT 2013
Inhibition of hepatitis C virus (HCV) replication by specific RNA aptamers against HCV NS5B RNA replicase.
Journal of virology
Lee CH,Lee YJ,Kim JH,Lim JH,Kim JH,Han W,Lee SH,Noh GJ,Lee SW
MA1-080 was used in western blot to study the ability of aptamers against HCV NS5B RNA helicase to inhibit viral replication
Sat Jun 01 00:00:00 EDT 2013
Cell-cell contact-mediated hepatitis C virus (HCV) transfer, productive infection, and replication and their requirement for HCV receptors.
Journal of virology
Liu Z,He JJ
MA1-080 was used in western blot to study the mechanisms underlying cell-cell contact-mediated HCV transfer and infection
Thu Aug 01 00:00:00 EDT 2013
Evidence suggesting that HCV p7 protects E2 glycoprotein from premature degradation during virus production.
Virus research
Atoom AM,Jones DM,Russell RS
MA1-080 was used in immunocytochemistry and western blot to study the role of the HCV p7 protein in preventing the premature degradation of HCV glycoproteins during virus generation
Sun Sep 01 00:00:00 EDT 2013
TIP47 is associated with the hepatitis C virus and its interaction with Rab9 is required for release of viral particles.
European journal of cell biology
Ploen D,Hafirassou ML,Himmelsbach K,Schille SA,Biniossek ML,Baumert TF,Schuster C,Hildt E
MA1-080 was used in immunocytochemistry and western blot to study the role of the interaction between TIP47 and Rab9 in the release of HCV viral particles
Sun Dec 01 00:00:00 EST 2013
The kinase inhibitor Sorafenib impairs the antiviral effect of interferon α on hepatitis C virus replication.
European journal of cell biology
Himmelsbach K,Hildt E
MA1-080 was used in immunocytochemistry and western blot to study the mechanism by which sorafenib blocks the ability of IFN-alpha to inhibit replication of HCV
Tue Jan 01 00:00:00 EST 2013
Hepatitis C and alcohol exacerbate liver injury by suppression of FOXO3.
The American journal of pathology
Tumurbaatar B,Tikhanovich I,Li Z,Ren J,Ralston R,Kuravi S,Campbell R,Chaturvedi G,Huang TT,Zhao J,Hao J,O'Neil M,Weinman SA
MA1-080 was used in immunocytochemistry to study the involvement of FOXO3 in the effect of hepatitis C and alcohol on liver injury
Sun Dec 01 00:00:00 EST 2013
Protein phosphatase 2A impairs IFNα-induced antiviral activity against the hepatitis C virus through the inhibition of STAT1 tyrosine phosphorylation.
Journal of viral hepatitis
Shanker V,Trincucci G,Heim HM,Duong HT
MA1-080 was used in immunocytochemistry and western blot to study the role of decreased STAT1 phosphorylation in the mechanism by which PP2A blocks the anti-HCV activity of IFN-alpha
Sun Sep 01 00:00:00 EDT 2013
Retinoic acid inducible gene-I (RIG-I) signaling of hepatic stellate cells inhibits hepatitis C virus replication in hepatocytes.
Innate immunity
Wang Y,Ye L,Wang X,Li J,Song L,Ho W
MA1-080 was used in immunocytochemistry to study the mechanisms underlying the inhibition of hepatocyte HCV replication by RIG-1 signaling in hepatic stellate cells
Mon Sep 30 00:00:00 EDT 2013
Antiviral lectins from red and blue-green algae show potent in vitro and in vivo activity against hepatitis C virus.
PloS one
Takebe Y,Saucedo CJ,Lund G,Uenishi R,Hase S,Tsuchiura T,Kneteman N,Ramessar K,Tyrrell DL,Shirakura M,Wakita T,McMahon JB,O'Keefe BR
MA1-080 was used in western blot to study the anti-HCV activity of lectins isolated from red and blue-green algae and the mechanisms involved
Mon Nov 25 00:00:00 EST 2013
Interferon and ribavirin combination treatment synergistically inhibit HCV internal ribosome entry site mediated translation at the level of polyribosome formation.
PloS one
Panigrahi R,Hazari S,Chandra S,Chandra PK,Datta S,Kurt R,Cameron CE,Huang Z,Zhang H,Garry RF,Balart LA,Dash S
Ma1-080 was used in immunohistochemistry to study the role of inhibition of IRES entry in the synergistic HCV antiviral activity of IFN plus ribovirin
Wed Apr 16 00:00:00 EDT 2014
Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core.
The Journal of biological chemistry
Camus G,Herker E,Modi AA,Haas JT,Ramage HR,Farese RV,Ott M
MA1-080 was used in immunocytochemistry, immunoprecipitation, and western blot to study the role of the DGAT-1-HCV NS5A interaction in the localization of NS5A to lipid droplets and the implications for therapeutic intervention
Fri Apr 05 00:00:00 EDT 2013
A functional genomic screen reveals novel host genes that mediate interferon-alpha's effects against hepatitis C virus.
Journal of hepatology
Zhao H,Lin W,Kumthip K,Cheng D,Fusco DN,Hofmann O,Jilg N,Tai AW,Goto K,Zhang L,Hide W,Jang JY,Peng LF,Chung RT
MA1-080 was used in western blot to identify host genes involved in producing the antiviral effect of interferon-alpha
Wed Feb 01 00:00:00 EST 2012
HCV glycoprotein E2 is a novel BDCA-2 ligand and acts as an inhibitor of IFN production by plasmacytoid dendritic cells.
Blood
Florentin J,Aouar B,Dental C,Thumann C,Firaguay G,Gondois-Rey F,Soumelis V,Baumert TF,Nunès JA,Olive D,Hirsch I,Stranska R
MA1-080 was used in immunocytochemistry to investigate the role of HCV E2 protein in plasmacytoid DCs
Thu Nov 29 00:00:00 EST 2012
CD59 incorporation protects hepatitis C virus against complement-mediated destruction.
Hepatology (Baltimore, Md.)
Amet T,Ghabril M,Chalasani N,Byrd D,Hu N,Grantham A,Liu Z,Qin X,He JJ,Yu Q
MA1-080 was used in immunocytochemistry to investigate the incorporation of CD59 into HCV virions
Wed Feb 01 00:00:00 EST 2012
Let-7b is a novel regulator of hepatitis C virus replication.
Cellular and molecular life sciences : CMLS
Cheng JC,Yeh YJ,Tseng CP,Hsu SD,Chang YL,Sakamoto N,Huang HD
MA1-080 was used in western blot to study the regulation of HCV replication by let-7b
Wed Aug 01 00:00:00 EDT 2012
Evaluation of ITX 5061, a scavenger receptor B1 antagonist: resistance selection and activity in combination with other hepatitis C virus antivirals.
The Journal of infectious diseases
Zhu H,Wong-Staal F,Lee H,Syder A,McKelvy J,Schooley RT,Wyles DL
MA1-080 was used in immunocytochemistry to evaluate the effect of ITX 5061 on HCV infection in combination with other HCV antivirals
Wed Feb 15 00:00:00 EST 2012
Hepatitis C virus infection alters P-body composition but is independent of P-body granules.
Journal of virology
Pérez-Vilaró G,Scheller N,Saludes V,Díez J
MA1-080 was used in immunohistochemistry to study changes in P-body composition following HCV infection
Wed Aug 01 00:00:00 EDT 2012
Reconstitution of the entire hepatitis C virus life cycle in nonhepatic cells.
Journal of virology
Da Costa D,Turek M,Felmlee DJ,Girardi E,Pfeffer S,Long G,Bartenschlager R,Zeisel MB,Baumert TF
MA1-080 was used in immunocytochemistry to study the ability of exogenously expressed host factors to enable the entire HCV life cycle to be reconsituted in human non-hepatic cells
Thu Nov 01 00:00:00 EDT 2012
Broadly neutralizing immune responses against hepatitis C virus induced by vectored measles viruses and a recombinant envelope protein booster.
Journal of virology
Reyes-del Valle J,de la Fuente C,Turner MA,Springfeld C,Apte-Sengupta S,Frenzke ME,Forest A,Whidby J,Marcotrigiano J,Rice CM,Cattaneo R
MA1-080 was used in western blot to study the ability of measles viruses expressing HCV capsid and envelope proteins to elicit an HCV neutralizing immune response
Thu Nov 01 00:00:00 EDT 2012
Hepatitis C virus fails to activate NF-κB signaling in plasmacytoid dendritic cells.
Journal of virology
Dental C,Florentin J,Aouar B,Gondois-Rey F,Durantel D,Baumert TF,Nunes JA,Olive D,Hirsch I,Stranska R
MA1-080 was used in Flow Cytometry to investigate the molecular mechanism of Hepatitis C virus sensing by plasmacytoid dendritic cells.
Sun Jan 01 00:00:00 EST 2012
Ketoamide resistance and hepatitis C virus fitness in val55 variants of the NS3 serine protease.
Antimicrobial agents and chemotherapy
Welsch C,Schweizer S,Shimakami T,Domingues FS,Kim S,Lemon SM,Antes I
MA1-080 was used in immunocytochemistry to study the mechanism for the drug-resistance of direct-acting antiviral agents in chronic hepatitis C
Sun Apr 01 00:00:00 EDT 2012
Liver X receptor α-mediated regulation of lipogenesis by core and NS5A proteins contributes to HCV-induced liver steatosis and HCV replication.
Laboratory investigation; a journal of technical methods and pathology
García-Mediavilla MV,Pisonero-Vaquero S,Lima-Cabello E,Benedicto I,Majano PL,Jorquera F,González-Gallego J,Sánchez-Campos S
MA1-080 was used in immunocytochemistry, immunoprecipitation, and western blot to study HCV-induced hepatic steatosis and HCV replication and the role of LXR-alpha
Wed Aug 01 00:00:00 EDT 2012
Modulation of the type I interferon pathways by culture-adaptive hepatitis C virus core mutants.
FEBS letters
Kang JI,Kwon YC,Ahn BY
MA1-080 was used in Western Blotting to suggest a mechanism by which the viruses adapt to attenuate cellular antiviral activity and to establish persistent infection.
Mon May 07 00:00:00 EDT 2012
Matrigel-embedded 3D culture of Huh-7 cells as a hepatocyte-like polarized system to study hepatitis C virus cycle.
Virology
Molina-Jimenez F,Benedicto I,Dao Thi VL,Gondar V,Lavillette D,Marin JJ,Briz O,Moreno-Otero R,Aldabe R,Baumert TF,Cosset FL,Lopez-Cabrera M,Majano PL
MA1-080 was used in immunocytochemistry to investigate hepatitis C virus cycle in Matrigel-embedded Huh-7.5 cell cultures
Fri Mar 30 00:00:00 EDT 2012
Tetherin has negligible activity in restricting hepatitis C virus in hepatocytes.
Innate immunity
Ye L,Wang X,Li J,Liu J,Ramirez SH,Wu J,Ho W
MA1-080 was used in immunocytochemistry to investigate the anti-viral effect of tetherin against hepatitis C virus release from infected hepatocytes
Fri Jun 01 00:00:00 EDT 2012
High-throughput screening and rapid inhibitor triage using an infectious chimeric Hepatitis C virus.
PloS one
Wichroski MJ,Fang J,Eggers BJ,Rose RE,Mazzucco CE,Pokornowski KA,Baldick CJ,Anthony MN,Dowling CJ,Barber LE,Leet JE,Beno BR,Gerritz SW,Agler ML,Cockett MI,Tenney DJ
MA1-080 was used in immunocytochemistry to develop an HCV growth assay suitable for the rapid screening of compound libraries for molecules with antiviral activity
Thu Jan 10 00:00:00 EST 2013
Role of phosphatidylinositol 4-phosphate (PI4P) and its binding protein GOLPH3 in hepatitis C virus secretion.
The Journal of biological chemistry
Bishé B,Syed GH,Field SJ,Siddiqui A
MA1-080 was used in immunocytochemistry to study the secretion of HCV and the roles played by phosphatidylinositol 4-phosphate and GOLPH3
Fri Aug 10 00:00:00 EDT 2012
ARF1 and GBF1 generate a PI4P-enriched environment supportive of hepatitis C virus replication.
PloS one
Zhang L,Hong Z,Lin W,Shao RX,Goto K,Hsu VW,Chung RT
MA1-080 was used in western blot to study the role of elevated phosphatidylinositol 4-phosphate levels in promoting HCV infection and the involvement of ARF1 and GBF1
Fri Aug 03 00:00:00 EDT 2012
Focal adhesion kinase (FAK) mediates the induction of pro-oncogenic and fibrogenic phenotypes in hepatitis C virus (HCV)-infected cells.
PloS one
Alisi A,Arciello M,Petrini S,Conti B,Missale G,Balsano C
MA1-080 was used in immunocytochemistry and western blot to study the induction of pro-oncogenic and pro-fibrotic phenotypes in cells infected with HCV and the role of FAK
Tue Feb 12 00:00:00 EST 2013
IL28B inhibits hepatitis C virus replication through the JAK-STAT pathway.
Journal of hepatology
Zhang L,Jilg N,Shao RX,Lin W,Fusco DN,Zhao H,Goto K,Peng LF,Chen WC,Chung RT
MA1-080 was used in western blot to investigate the inhibitory effect of IL28B on hepatitis C virus replication and its mechanism
Mon Aug 01 00:00:00 EDT 2011
HIV infection increases HCV-induced hepatocyte apoptosis.
Journal of hepatology
Jang JY,Shao RX,Lin W,Weinberg E,Chung WJ,Tsai WL,Zhao H,Goto K,Zhang L,Mendez-Navarro J,Jilg N,Peng LF,Brockman MA,Chung RT
MA1-080 was used in western blot to investigate the effect of HCV-HIV co-infection on hepatocyte apoptosis
Fri Apr 01 00:00:00 EDT 2011
Effects of hepatitis C virus on suppressor of cytokine signaling mRNA levels: comparison between different genotypes and core protein sequence analysis.
Journal of medical virology
Pascarella S,Clément S,Guilloux K,Conzelmann S,Penin F,Negro F
MA1-080 was used in immunocytochemistry to investigate the SOCS transactivation by hepatitis C virus
Wed Jun 01 00:00:00 EDT 2011
Vitamin D: an innate antiviral agent suppressing hepatitis C virus in human hepatocytes.
Hepatology (Baltimore, Md.)
Gal-Tanamy M,Bachmetov L,Ravid A,Koren R,Erman A,Tur-Kaspa R,Zemel R
MA1-080 was used in western blot to investigate the effectiveness of vitamin D for HCV treatment
Tue Nov 01 00:00:00 EDT 2011
A new model to produce infectious hepatitis C virus without the replication requirement.
PLoS pathogens
Triyatni M,Berger EA,Saunier B
MA1-080 was used in western blot to produce non-replicative, yet infectious, HCV virions
Fri Apr 01 00:00:00 EDT 2011
Hepatitis C virus NS2 coordinates virus particle assembly through physical interactions with the E1-E2 glycoprotein and NS3-NS4A enzyme complexes.
Journal of virology
Stapleford KA,Lindenbach BD
MA1-080 was used in western blot to study the role of Hepatitis C virus NS2 in viral particle assembly and its mechanism
Tue Feb 01 00:00:00 EST 2011
The acidic domain of hepatitis C virus NS4A contributes to RNA replication and virus particle assembly.
Journal of virology
Phan T,Kohlway A,Dimberu P,Pyle AM,Lindenbach BD
MA1-080 was used in western blot to investigate the effect of NS4A and NS4B on viral genome replication and assembly
Tue Feb 01 00:00:00 EST 2011
Inhibition of hepatitis C virus replicon RNA synthesis by PSI-352938, a cyclic phosphate prodrug of β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methylguanosine.
Antimicrobial agents and chemotherapy
Lam AM,Espiritu C,Murakami E,Zennou V,Bansal S,Micolochick Steuer HM,Niu C,Keilman M,Bao H,Bourne N,Veselenak RL,Reddy PG,Chang W,Du J,Nagarathnam D,Sofia MJ,Otto MJ,Furman PA
MA1-080 was used in immunocytochemistry to investigate the ability of PSI-352938 to inhibit hepatitis C virus replicon RNA synthesis
Wed Jun 01 00:00:00 EDT 2011
Alterations in microRNA expression profile in HCV-infected hepatoma cells: involvement of miR-491 in regulation of HCV replication via the PI3 kinase/Akt pathway.
Biochemical and biophysical research communications
Ishida H,Tatsumi T,Hosui A,Nawa T,Kodama T,Shimizu S,Hikita H,Hiramatsu N,Kanto T,Hayashi N,Takehara T
MA1-080 was used in western blot to investigate microRNAs affected by HCV infection in Huh7 cells
Fri Aug 19 00:00:00 EDT 2011
Inhibition of hepatitis C virus replication through adenosine monophosphate-activated protein kinase-dependent and -independent pathways.
Microbiology and immunology
Nakashima K,Takeuchi K,Chihara K,Hotta H,Sada K
MA1-080 was used in immunocytochemistry and western blot to study the AMP kinase-independent inhibition of HCV replication by metformin and glucose
Tue Nov 01 00:00:00 EDT 2011
Efficient production of antibodies against a mammalian integral membrane protein by phage display.
Protein engineering, design & selection : PEDS
Hötzel I,Chiang V,Diao J,Pantua H,Maun HR,Kapadia SB
MA1-080 was used in immunocytochemistry to optimize phage display methods for membrane proteins
Thu Sep 01 00:00:00 EDT 2011
Persistent expression of hepatitis C virus non-structural proteins leads to increased autophagy and mitochondrial injury in human hepatoma cells.
PloS one
Chu VC,Bhattacharya S,Nomoto A,Lin J,Zaidi SK,Oberley TD,Weinman SA,Azhar S,Huang TT
MA1-080 was used in immunocytochemistry to explore the various cytopathic effects of and cellular responses to HCV proteins
Fri Jul 20 00:00:00 EDT 2012
Protein kinase D negatively regulates hepatitis C virus secretion through phosphorylation of oxysterol-binding protein and ceramide transfer protein.
The Journal of biological chemistry
Amako Y,Syed GH,Siddiqui A
MA1-080 was used in western blot to study the role of protein kinase D in HCV secretion via its effects on ceramide transfer protein and oxysterol binding protein.
Fri Apr 01 00:00:00 EDT 2011
HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response.
PloS one
Merquiol E,Uzi D,Mueller T,Goldenberg D,Nahmias Y,Xavier RJ,Tirosh B,Shibolet O
MA1-080 was used in immunocytochemistry to investigate the effect of HCV infection on chronic ER stress and unfolded protein response
Mon Jan 30 00:00:00 EST 2012
Generation of a cell culture-adapted hepatitis C virus with longer half life at physiological temperature.
PloS one
Kim CS,Keum SJ,Jang SK
MA1-080 was used in immunocytochemistry to develop a cell culture-adapted hepatitis C virus with a longer lifespan in cells
Tue Dec 27 00:00:00 EST 2011
Hepatitis C virus regulates transforming growth factor beta1 production through the generation of reactive oxygen species in a nuclear factor kappaB-dependent manner.
Gastroenterology
Lin W,Tsai WL,Shao RX,Wu G,Peng LF,Barlow LL,Chung WJ,Zhang L,Zhao H,Jang JY,Chung RT
MA1-080 was used in western blot to investigate the mechanism for the regulatory effect of hepatitis C virus on and transforming growth factor beta 1 in hepatic fibrosis
Tue Jun 01 00:00:00 EDT 2010
Iron inhibits replication of infectious hepatitis C virus in permissive Huh7.5.1 cells.
Journal of hepatology
Fillebeen C,Pantopoulos K
MA1-080 was used in western blot to investigate the influence of iron on hepatitis C virus replication
Wed Dec 01 00:00:00 EST 2010
Hepatitis C virus-induced up-regulation of protein phosphatase 2A inhibits histone modification and DNA damage repair.
Hepatology (Baltimore, Md.)
Duong FH,Christen V,Lin S,Heim MH
MA1-080 was used in immunocytochemistry to investigate the mechanism for the effect of hepatitis C virus on DNA repair inhibition
Mon Mar 01 00:00:00 EST 2010
Identification of hepatoprotective flavonolignans from silymarin.
Proceedings of the National Academy of Sciences of the United States of America
Polyak SJ,Morishima C,Lohmann V,Pal S,Lee DY,Liu Y,Graf TN,Oberlies NH
MA1-080 was used in western blot to identify the hepatoprotective component in silymarin
Tue Mar 30 00:00:00 EDT 2010
Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells.
Proceedings of the National Academy of Sciences of the United States of America
Pollock S,Nichita NB,Böhmer A,Radulescu C,Dwek RA,Zitzmann N
MA1-080 was used in immunocytochemistry to study the anti-viral activity of polyunsaturated liposomes.
Tue Oct 05 00:00:00 EDT 2010
A peptide derived from hepatitis C virus E2 envelope protein inhibits a post-binding step in HCV entry.
Antiviral research
Liu R,Tewari M,Kong R,Zhang R,Ingravallo P,Ralston R
MA1-080 was used in immunocytochemistry to investigate th effect of a fragement of hepatitis C virus E2 protein on hepatitis C virus entry
Sat May 01 00:00:00 EDT 2010
A novel small molecule inhibitor of hepatitis C virus entry.
PLoS pathogens
Baldick CJ,Wichroski MJ,Pendri A,Walsh AW,Fang J,Mazzucco CE,Pokornowski KA,Rose RE,Eggers BJ,Hsu M,Zhai W,Zhai G,Gerritz SW,Poss MA,Meanwell NA,Cockett MI,Tenney DJ
MA1-080 was used in immunocytochemistry to evaluate a hepatitis C virus entry inhibitor
Thu Sep 02 00:00:00 EDT 2010
Persistent growth of a human plasma-derived hepatitis C virus genotype 1b isolate in cell culture.
PLoS pathogens
Silberstein E,Mihalik K,Ulitzky L,Plant EP,Puig M,Gagneten S,Yu MY,Kaushik-Basu N,Feinstone SM,Taylor DR
MA1-080 was used in immunocytochemistry to evaluate a hepatitis C virus tissue culture model
Thu May 20 00:00:00 EDT 2010
Suppressor of cytokine signaling 3 suppresses hepatitis C virus replication in an mTOR-dependent manner.
Journal of virology
Shao RX,Zhang L,Peng LF,Sun E,Chung WJ,Jang JY,Tsai WL,Hyppolite G,Chung RT
MA1-080 was used in western blot to investigate the effect of suppressor of cytokine signaling 3 SOCS3 on hepatitis C virus replication and its mechanism
Tue Jun 01 00:00:00 EDT 2010
RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP.
RNA (New York, N.Y.)
Malathi K,Saito T,Crochet N,Barton DJ,Gale M,Silverman RH
MA1-080 was used in western blot to investigate the effect of RNase L on Hepatitis C viral RNA cleavage
Mon Nov 01 00:00:00 EDT 2010
Role of Hepatitis C virus core protein in viral-induced mitochondrial dysfunction.
Journal of viral hepatitis
Wang T,Campbell RV,Yi MK,Lemon SM,Weinman SA
MA1-080 was used in western blot to study the role of hepatitis C virus core protein in the changes of mitochondrial function
Mon Nov 01 00:00:00 EDT 2010
Cell-based hepatitis C virus infection fluorescence resonance energy transfer (FRET) assay for antiviral compound screening.
Current protocols in microbiology
Yu X,Uprichard SL
MA1-080 was used in ELISA to develop a cellular HCV infection FRET assay for antiviral compound screening
Sun Aug 01 00:00:00 EDT 2010
Trans-complementation of an NS2 defect in a late step in hepatitis C virus (HCV) particle assembly and maturation.
PLoS pathogens
Yi M,Ma Y,Yates J,Lemon SM
MA1-080 was used in immunocytochemistry and western blot to study the role of the NS2 viral protein in HCV infectivity
Fri May 01 00:00:00 EDT 2009
Hepatitis C virus NS2 protein contributes to virus particle assembly via opposing epistatic interactions with the E1-E2 glycoprotein and NS3-NS4A enzyme complexes.
Journal of virology
Phan T,Beran RK,Peters C,Lorenz IC,Lindenbach BD
MA1-080 was used in western blot to study the mechanism by which hepatitis C virus NS2 protein contributes to virus particle assembly
Tue Sep 01 00:00:00 EDT 2009
Cell culture-adaptive mutations in the NS5B gene of hepatitis C virus with delayed replication and reduced cytotoxicity.
Virus research
Kang JI,Kim JP,Wakita T,Ahn BY
MA1-080 was used in immunocytochemistry to investigate cell culture-adaptive NS5B mutations during subculturing of HCV JFH1 in Huh-7 cells
Tue Sep 01 00:00:00 EDT 2009
Development of a cell-based hepatitis C virus infection fluorescent resonance energy transfer assay for high-throughput antiviral compound screening.
Antimicrobial agents and chemotherapy
Yu X,Sainz B,Uprichard SL
MA1-080 was used in western blot to develop a cell-based FRET assay for high-throughput anti-HCV compound screening
Thu Oct 01 00:00:00 EDT 2009
Induction of NKG2D ligands on human dendritic cells by TLR ligand stimulation and RNA virus infection.
International immunology
Ebihara T,Masuda H,Akazawa T,Shingai M,Kikuta H,Ariga T,Matsumoto M,Seya T
MA1-080 was used in western blot to identify the specific Toll-like receptor agonists and RNA viruses that can induce the expression of NKG2DLs on mDCs
Mon Oct 01 00:00:00 EDT 2007
p21-activated kinase 1 is activated through the mammalian target of rapamycin/p70 S6 kinase pathway and regulates the replication of hepatitis C virus in human hepatoma cells.
The Journal of biological chemistry
Ishida H,Li K,Yi M,Lemon SM
MA1-080 was used in western blot to investigate the mechanism for phosphatidylinositol 3-kinase- and ERK-mediated regulation of hepatitis C virus RNA replication.
Fri Apr 20 00:00:00 EDT 2007
Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells.
Proceedings of the National Academy of Sciences of the United States of America
Yi M,Villanueva RA,Thomas DL,Wakita T,Lemon SM
MA1-080 was used in immunocytochemistry and western blot to develop a system for the production of HCV genotype 1a virus in cultured human hepatoma cells
Tue Feb 14 00:00:00 EST 2006
Cell culture and infection system for hepatitis C virus.
Nature protocols
Kato T,Date T,Murayama A,Morikawa K,Akazawa D,Wakita T
MA1-080 was used in immunocytochemistry to develop a cell culture and infection system for HCV
Tue Oct 23 00:00:00 EDT 2007
Expression of hepatitis C virus core protein impairs DNA repair in human hepatoma cells.
Cancer letters
van Pelt JF,Severi T,Crabbé T,Eetveldt AV,Verslype C,Roskams T,Fevery J
MA1-080 was used in immunohistochemistry to study the effect of hepatitis C virus core protein on DNA repair in hepatoma cells
Fri Jun 25 00:00:00 EDT 2004
Unique features of hepatitis C virus capsid formation revealed by de novo cell-free assembly.
Journal of virology
Klein KC,Polyak SJ,Lingappa JR
MA1-080 was used in western blot to investigate the features of hepatitis C virus capsid formation through de novo cell-free assembly
Wed Sep 01 00:00:00 EDT 2004
