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Histone-H3 Polyclonal Antibody

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Antibody Testing Data (19)

Histone-H3 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 19

Histone-H3 Antibody (17168-1-AP) in ICC/IF

Immunofluorescent analysis of HEK-293 cells using 17168-1-AP (Histone-H3 antibody) at dilution of 1:50 and Rhodamine-Goat anti-Rabbit IGG.

Histone-H3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Histone-H3 Antibody in Western Blot (WB)

Histone-H3 Antibody in Flow Cytometry (Flow)

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Product Details

17168-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

View 640 publications 640 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 8 publications 8 publications

Flow Cytometry (Flow)

Assay-dependent

Immunoprecipitation (IP)

View 1 publication 1 publication

ChIP assay (ChIP)

View 6 publications 6 publications

Miscellaneous PubMed (Misc)

View 9 publications 9 publications

Not applicable (N/A)

View 36 publications 36 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Pig, Rat, Xenopus

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Histone-H3 Fusion Protein Ag10644 (1-136 aa encoded by BC015544)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MARTKQTAR KSTGGKAPRK QLATKAARKS APATGGVKKP HRYRPGTVAL REIRRYQKST ELLIRKLPFQ RLVREIAQDF KTDLRFQSSA VMALQEASEA YLVGLFEDTN LCAIHAKRVT IMPKDIQLAR RIRGERA (1-136 aa encoded by BC015544)

Target Information

Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modification that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Discovery of a New-Generation S-Adenosylmethionine-Noncompetitive Covalent Inhibitor Targeting the Lysine Methyltransferase Enhancer of Zeste Homologue 2.

Journal of medicinal chemistry

Zhang Y,Yang H,Li B,Li J,Li H,Shi Q,Li B,Wang Z,Zheng J,Zhang Y,Dong H,Huang X,Wang Y

Thu Jun 08 00:00:00 EDT 2023

Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells.

Acta pharmacologica Sinica

Li ZB,Jiang L,Ni JD,Xu YH,Liu F,Liu WM,Wang SG,Liu ZQ,Wang CY

Thu Jun 01 00:00:00 EDT 2023

Targeting HMGA1 contributes to immunotherapy in aggressive breast cancer while suppressing EMT.

Biochemical pharmacology

Chang X,Liu J,Yang Q,Gao Y,Ding X,Zhao J,Li Y,Liu Z,Li Z,Wu Y,Zuo D

Thu Jun 01 00:00:00 EDT 2023

Hepatocyte ferroptosis contributes to anti-tuberculosis drug-induced liver injury: Involvement of the HIF-1α/SLC7A11/GPx4 axis.

Chemico-biological interactions

Liu Y,Chen W,Cen Y,Zhao X,Chen Z,Liang Y,Huang Z,He X,Yang G

Mon May 01 00:00:00 EDT 2023

Non-Esterified Fatty Acid-Induced Apoptosis in Bovine Granulosa Cells via ROS-Activated PI3K/AKT/FoxO1 Pathway.

Antioxidants (Basel, Switzerland)

Lei Z,Ali I,Yang M,Yang C,Li Y,Li L

Thu Feb 09 00:00:00 EST 2023

Low-Dose Sodium Salicylate Promotes Ovulation by Regulating Steroids via CYP17A1.

International journal of molecular sciences

Li T,Ren X,Li T,Yu L,Teng M,Zheng Y,Lei A

Mon Jan 30 00:00:00 EST 2023

Glycolysis mediates neuron specific histone acetylation in valproic acid-induced human excitatory neuron differentiation.

Frontiers in molecular neuroscience

Chen A,Wang M,Xu C,Zhao Y,Xian P,Li Y,Zheng W,Yi X,Wu S,Wang Y

Tue Apr 25 00:00:00 EDT 2023

NF-κB p65 and SETDB1 expedite lipopolysaccharide-induced intestinal inflammation in mice by inducing IRF7/NLR-dependent macrophage M1 polarization.

International immunopharmacology

Chen L,Dai M,Zuo W,Dai Y,Yang Q,Yu S,Huang M,Liu H

Wed Feb 01 00:00:00 EST 2023

O‑GlcNAcylation mediates endometrial cancer progression by regulating the Hippo‑YAP pathway.

International journal of oncology

Zhai L,Yang X,Dong J,Qian L,Gao Y,Lv Y,Chen L,Chen B,Zhou F

Tue Aug 01 00:00:00 EDT 2023

Maslinic Acid Ameliorates Myocardial Ischemia Reperfusion Injury-Induced Oxidative Stress via Activating Nrf2 and Inhibiting NF-[Formula: see text]B Pathways.

The American journal of Chinese medicine

Li Q,Li Z,Liu C,Xu M,Li T,Wang Y,Feng J,Yin X,Du X,Lu C

Mon Jun 19 00:00:00 EDT 2023

Novel lncRNA-prader willi/angelman region RNA, SNRPN neighbour (PWARSN) aggravates tubular epithelial cell pyroptosis by regulating TXNIP via dual way in diabetic kidney disease.

Cell proliferation

Song Y,Guo F,Zhao YY,Ma XJ,Wu LN,Yu JF,Ji HF,Shao MW,Huang FJ,Zhao L,Fan XJ,Xu YN,Wang QZ,Qin GJ

Wed Feb 01 00:00:00 EST 2023

HMGCL-induced β-hydroxybutyrate production attenuates hepatocellular carcinoma via DPP4-mediated ferroptosis susceptibility.

Hepatology international

Cui X,Yun X,Sun M,Li R,Lyu X,Lao Y,Qin X,Yu W

Sat Apr 01 00:00:00 EDT 2023

FTO-dependent m⁶A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke.

Nature communications

Li B,Xi W,Bai Y,Liu X,Zhang Y,Li L,Bian L,Liu C,Tang Y,Shen L,Yang L,Gu X,Xie J,Zhou Z,Wang Y,Yu X,Wang J,Chao J,Han B,Yao H

Mon Jan 30 00:00:00 EST 2023

9-Butyl-Harmol Exerts Antiviral Activity against Newcastle Disease Virus through Targeting GSK-3β and HSP90β.

Journal of virology

Wang C,Wang T,Hu R,Duan L,Hou Q,Han Y,Dai J,Wang W,Ren S,Liu H,Wang X,Xiao S,Li N,Wang J,Yang Z

Thu Mar 30 00:00:00 EDT 2023

RNA Pol II preferentially regulates ribosomal protein expression by trapping disassociated subunits.

Molecular cell

Li Y,Huang J,Bao L,Zhu J,Duan W,Zheng H,Wang H,Jiang Y,Liu W,Zhang M,Yu Y,Yi C,Ji X

Thu Apr 20 00:00:00 EDT 2023

NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF-κB and TGF-β/Smad signaling pathways in diabetic nephropathy.

Cellular signalling

Qiu D,Song S,Chen N,Bian Y,Yuan C,Zhang W,Duan H,Shi Y

Tue Aug 01 00:00:00 EDT 2023

Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma.

Nature communications

Kuang C,Xia M,An G,Liu C,Hu C,Zhang J,Liu Z,Meng B,Su P,Xia J,Guo J,Zhu Y,Liu X,Wu X,Shen Y,Feng X,He Y,Li J,Qiu L,Zhou J,Zhou W

Thu Apr 13 00:00:00 EDT 2023

Radiation resistance of cancer cells caused by mitochondrial dysfunction depends on SIRT3-mediated mitophagy.

The FEBS journal

Wei Y,Xiao G,Xu H,Sun X,Shi Y,Wang F,Kang J,Peng J,Zhou F

Sat Jul 01 00:00:00 EDT 2023

KSHV RTA antagonizes SMC5/6 complex-induced viral chromatin compaction by hijacking the ubiquitin-proteasome system.

PLoS pathogens

Han C,Zhang D,Gui C,Huang L,Chang S,Dong L,Bai L,Wu S,Lan K

Mon Aug 01 00:00:00 EDT 2022

HDAC3 inhibition improves urinary-concentrating defect in hypokalaemia by promoting AQP2 transcription.

Acta physiologica (Oxford, England)

Xu L,Xie H,Hu S,Zhao X,Han M,Liu Q,Feng P,Wang W,Li C

Fri Apr 01 00:00:00 EDT 2022

Difenoconazole disrupts the blood-brain barrier and results in neurotoxicity in carp by inhibiting the Nrf2 pathway mediated ROS accumulation.

Ecotoxicology and environmental safety

Liu F,Wang Y,Chen L,Bello BK,Zhang T,Yang H,Li X,Pan E,Feng H,Dong J

Sat Oct 01 00:00:00 EDT 2022

HMGB3 promotes PARP inhibitor resistance through interacting with PARP1 in ovarian cancer.

Cell death & disease

Ma H,Qi G,Han F,Lu W,Peng J,Li R,Yan S,Yuan C,Kong B

Thu Mar 24 00:00:00 EDT 2022

Cis- and trans-resveratrol have opposite effects on histone serine-ADP-ribosylation and tyrosine induced neurodegeneration.

Nature communications

Jhanji M,Rao CN,Massey JC,Hope MC,Zhou X,Keene CD,Ma T,Wyatt MD,Stewart JA,Sajish M

Fri Jun 10 00:00:00 EDT 2022

MARCH1 promotes the growth and maintaining of stem cell-like characteristics of gastric cancer cells by activating the Wnt/β-catenin signaling pathway.

Tissue & cell

Liang W,Zhang T,Huo J,Yang J

Sat Oct 01 00:00:00 EDT 2022

Mitochondrial transcription factor B2 overexpression increases M2 macrophage infiltration via cytosolic mitochondrial DNA-stimulated Interleukin-6 secretion in ovarian cancer.

Bioengineered

Wu W,Zhou S,Liu T,Liang D

Sun May 01 00:00:00 EDT 2022

Cornuside Is a Potential Agent against Alzheimer's Disease via Orchestration of Reactive Astrocytes.

Nutrients

Shi JZ,Zheng XM,Zhou YF,Yun LY,Luo DM,Hao JJ,Liu PF,Zhang WK,Xu JK,Yan Y,Xie XM,He YY,Pang XB

Wed Aug 03 00:00:00 EDT 2022

Liquidambaric acid inhibits Wnt/β-catenin signaling and colon cancer via targeting TNF receptor-associated factor 2.

Cell reports

Yan R,Zhu H,Huang P,Yang M,Shen M,Pan Y,Zhang C,Zhou X,Li H,Ke X,Zhang W,Hao P,Qu Y

Tue Feb 01 00:00:00 EST 2022

Mammalian PERIOD2 regulates H2A.Z incorporation in chromatin to orchestrate circadian negative feedback.

Nature structural & molecular biology

Tartour K,Andriani F,Folco EG,Letkova D,Schneider R,Saidi I,Sato T,Welz PS,Benitah SA,Allier C,Padmanabhan K

Wed Jun 01 00:00:00 EDT 2022

Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation.

Nature communications

Xie Z,Hou L,Shen S,Wu Y,Wang J,Jie Z,Zhao X,Li X,Zhang X,Chen J,Xu W,Ning L,Ma Q,Wang S,Wang H,Yuan P,Fang X,Qin A,Fan S

Mon Jan 10 00:00:00 EST 2022

Gut microbiota shapes social dominance through modulating HDAC2 in the medial prefrontal cortex.

Cell reports

Wang T,Xu J,Xu Y,Xiao J,Bi N,Gu X,Wang HL

Tue Mar 08 00:00:00 EST 2022

Andrographolide protects bone marrow mesenchymal stem cells against glucose and serum deprivation under hypoxia via the NRF2 signaling pathway.

Stem cell research & therapy

Sun Y,Xu H,Tan B,Yi Q,Liu H,Chen T,Xiang H,Wang R,Xie Q,Tian J,Zhu J

Mon Jul 18 00:00:00 EDT 2022

Cyclic helix B peptide promotes random-pattern skin flap survival via TFE3-mediated enhancement of autophagy and reduction of ROS levels.

British journal of pharmacology

Lou J,Zhang H,Qi J,Xu Y,Wang X,Jiang J,Hu X,Ni L,Cai Y,Wang X,Gao W,Xiao J,Zhou K

Sat Jan 01 00:00:00 EST 2022

The perinuclear theca protein Calicin helps shape the sperm head and maintain the nuclear structure in mice.

Cell reports

Zhang XZ,Wei LL,Jin HJ,Zhang XH,Chen SR

Tue Jul 05 00:00:00 EDT 2022

TAZ ameliorates the microglia-mediated inflammatory response via the Nrf2-ROS-NF-κB pathway.

Molecular therapy. Nucleic acids

Huang JC,Yue ZP,Yu HF,Yang ZQ,Wang YS,Guo B

Tue Jun 14 00:00:00 EDT 2022

MALAT1 modulates alternative splicing by cooperating with the splicing factors PTBP1 and PSF.

Science advances

Miao H,Wu F,Li Y,Qin C,Zhao Y,Xie M,Dai H,Yao H,Cai H,Wang Q,Song X,Li L

Fri Dec 23 00:00:00 EST 2022

Gut dysbacteriosis attenuates resistance to Mycobacterium bovis infection by decreasing cyclooxygenase 2 to inhibit endoplasmic reticulum stress.

Emerging microbes & infections

Wang H,Yao J,Chen Y,Wang Y,Liu Y,Liao Y,Liang Z,Dong YH,Qu M,Ge X,Zhou X

Thu Dec 01 00:00:00 EST 2022

Kynurenine/Aryl Hydrocarbon Receptor Modulates Mitochondria-Mediated Oxidative Stress and Neuronal Apoptosis in Experimental Intracerebral Hemorrhage.

Antioxidants & redox signaling

Ren R,Fang Y,Sherchan P,Lu Q,Lenahan C,Zhang JH,Zhang J,Tang J

Thu Dec 01 00:00:00 EST 2022

Manganese-Induced Oxidative Stress Contributes to Intestinal Lipid Deposition via the Deacetylation of PPARγ at K339 by SIRT1.

Antioxidants & redox signaling

Lv WH,Zhao T,Pantopoulos K,Chen GH,Wei XL,Zhang DG,Luo Z

Thu Sep 01 00:00:00 EDT 2022

MicroRNA-363-3p/sphingosine-1-phosphate receptor 1 axis inhibits sepsis-induced acute lung injury via the inactivation of nuclear factor kappa-B ligand signaling.

Experimental animals

Meng S,Kang K,Fei D,Yang S,Pan S,Yu K,Zhao M

Fri Aug 05 00:00:00 EDT 2022

A novel ALG10/TGF-β positive regulatory loop contributes to the stemness of colorectal cancer.

Aging

Xu X,Wang H,Li X,Duan X,Wang Y

Thu Jun 09 00:00:00 EDT 2022

Extent and Instability of Trimethylation of Histone H3 Lysine Increases With Degree of Malignancy and Methionine Addiction.

Cancer genomics & proteomics

Yamamoto J,Aoki Y,Inubushi S,Han Q,Hamada K,Tashiro Y,Miyake K,Matsuyama R,Bouvet M,Clarke SG,Endo I,Hoffman RM

Mon Mar 07 00:00:00 EST 2022

Bclaf1 regulates c-FLIP expression and protects cells from TNF-induced apoptosis and tissue injury.

EMBO reports

Zhang R,Xue T,Shao A,Lang Y,Qin C,Zhao M,Kuang Y,Yu Z,Geng Y,Zhao C,Tang J

Wed Jan 05 00:00:00 EST 2022

Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling.

Clinical science (London, England : 1979)

Gao S,Yang Q,Liu Z,Kong W,Chen J,Li X,Peng Y,Bao M,Bian X,Zhang Y,Jiang Q,Li Z,Zhang Y,Yan F,Ye J

Wed Nov 30 00:00:00 EST 2022

MgIG exerts therapeutic effects on crizotinib-induced hepatotoxicity by limiting ROS-mediated autophagy and pyroptosis.

Journal of cellular and molecular medicine

Li M,Wang C,Yu Z,Lan Q,Xu S,Ye Z,Li R,Ying L,Zhang X,Zhou Z

Mon Aug 01 00:00:00 EDT 2022

The RNA polymerase of cytoplasmically replicating Zika virus binds with chromatin DNA in nuclei and regulates host gene transcription.

Proceedings of the National Academy of Sciences of the United States of America

Li P,Wu J,Liu S,Lu R,Jiang H,Wang N,Luo M,Guo L,Xiao J,Bu L,Liu L,Xing F,Peng H,Li C,Ma L,Zhao B,Zhou Z,Guo D

Tue Dec 06 00:00:00 EST 2022

Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival.

Communications biology

Chen Z,Wu H,Yang J,Li B,Ding J,Cheng S,Bsoul N,Zhang C,Li J,Liu H,Lin D,Gao W

Wed Jun 22 00:00:00 EDT 2022

SPOCK1 promotes metastasis in pancreatic cancer via NF-κB-dependent epithelial-mesenchymal transition by interacting with IκB-α.

Cellular oncology (Dordrecht)

Cui X,Wang Y,Lan W,Wang S,Cui Y,Zhang X,Lin Z,Piao J

Tue Feb 01 00:00:00 EST 2022

GSK3β-dependent lysosome biogenesis: An effective pathway to mitigate renal fibrosis with LM49.

Frontiers in pharmacology

Ren J,Wei H,Sun J,Feng X,Zhang Y,Yuan H,Miao J,Qi X,Qiao Y,Xiao B,Li Q

Fri Oct 14 00:00:00 EDT 2022

TJ-M2010-5, A self-developed MyD88 inhibitor, attenuates liver fibrosis by inhibiting the NF-κB pathway.

Chemico-biological interactions

Xie Y,Du D,Zhang L,Yang Y,Zou Z,Li Z,Zhou L,Shang R,Zhou P

Fri Feb 25 00:00:00 EST 2022

Effects of bamboo leaf extract intervention on the growth performance, antioxidant capacity, and hepatic apoptosis in suckling piglets.

Journal of animal science

Yu G,Ji S,Yun Y,Cheng K,Zhang H,Jia P,Wang T,Zhang L

Fri Jul 01 00:00:00 EDT 2022

MiR-200c-3p inhibits LPS-induced M1 polarization of BV2 cells by targeting RIP2.

Genes & genomics

Zhao L,Liu X,Yang J,Wang X,Liu X,Wu J,Li C,Xu D,Hu Y

Fri Apr 01 00:00:00 EDT 2022

Melatonin attenuates bone cancer pain via the SIRT1/HMGB1 pathway.

Neuropharmacology

Yang C,Kang F,Huang X,Zhang W,Wang S,Han M,Zhang Z,Li J

Thu Dec 01 00:00:00 EST 2022

Reversion of methionine addiction of osteosarcoma cells to methionine independence results in loss of malignancy, modulation of the epithelial-mesenchymal phenotype and alteration of histone-H3 lysine-methylation.

Frontiers in oncology

Aoki Y,Han Q,Tome Y,Yamamoto J,Kubota Y,Masaki N,Obara K,Hamada K,Wang JD,Inubushi S,Bouvet M,Clarke SG,Nishida K,Hoffman RM

Tue Nov 22 00:00:00 EST 2022

Role of PARP-1 in Human Cytomegalovirus Infection and Functional Partners Encoded by This Virus.

Viruses

Zhang W,Guo J,Chen Q

Thu Sep 15 00:00:00 EDT 2022

Dysregulated lipid metabolism blunts the sensitivity of cancer cells to EZH2 inhibitor.

EBioMedicine

Zhang T,Guo Z,Huo X,Gong Y,Li C,Huang J,Wang Y,Feng H,Ma X,Jiang C,Yin Q,Xue L

Tue Mar 01 00:00:00 EST 2022

RP105 protects against ischemic and septic acute kidney injury via suppressing TLR4/NF-κB signaling pathways.

International immunopharmacology

Zhu J,Zhang Y,Shi L,Xia Y,Zha H,Li H,Song Z

Mon Aug 01 00:00:00 EDT 2022

Naringenin Promotes Myotube Formation and Maturation for Cultured Meat Production.

Foods (Basel, Switzerland)

Yan Q,Fei Z,Li M,Zhou J,Du G,Guan X

Tue Nov 22 00:00:00 EST 2022

LPS/Bcl3/YAP1 signaling promotes Sox9⁺HNF4α⁺ hepatocyte-mediated liver regeneration after hepatectomy.

Cell death & disease

Shao C,Jing Y,Zhao S,Yang X,Hu Y,Meng Y,Huang Y,Ye F,Gao L,Liu W,Sheng D,Li R,Zhang X,Wei L

Mon Mar 28 00:00:00 EDT 2022

Proteomic Comparison of Three Wild-Type Pseudorabies Virus Strains and the Attenuated Bartha Strain Reveals Reduced Incorporation of Several Tegument Proteins in Bartha Virions.

Journal of virology

Delva JL,Daled S,Van Waesberghe C,Almey R,Jansens RJJ,Deforce D,Dhaenens M,Favoreel HW

Wed Dec 21 00:00:00 EST 2022

Genome-wide gain-of-function screening identifies EZH2 mediating resistance to PI3Kα inhibitors in oesophageal squamous cell carcinoma.

Clinical and translational medicine

Xing H,Gao M,Wang Y,Zhang X,Shi J,Wang X,Liu X,Ma Q,Kong X,Yang C,Ding J,Meng L

Sun May 01 00:00:00 EDT 2022

Acetyl-11-Keto-Beta Boswellic Acid (AKBA) Protects Lens Epithelial Cells Against H₂O₂-Induced Oxidative Injury and Attenuates Cataract Progression by Activating Keap1/Nrf2/HO-1 Signaling.

Frontiers in pharmacology

Yang T,Lin X,Li H,Zhou X,Fan F,Yang J,Luo Y,Liu X

Fri Jul 29 00:00:00 EDT 2022

NLRP3 inflammasome triggers interleukin-37 release from human monocytes.

European journal of immunology

Gritsenko A,Díaz-Pino R,López-Castejón G

Fri Jul 01 00:00:00 EDT 2022

Fructose Induces Insulin Resistance of Gestational Diabetes Mellitus in Mice via the NLRP3 Inflammasome Pathway.

Frontiers in nutrition

Liu Y,Wei Y,Wu L,Lin X,Sun R,Chen H,Shen S,Deng G

Tue May 03 00:00:00 EDT 2022

Malvidin protects against lipopolysaccharide-induced acute liver injury in mice via regulating Nrf2 and NLRP3 pathways and suppressing apoptosis and autophagy.

European journal of pharmacology

Fan H,Cui J,Liu F,Zhang W,Yang H,He N,Dong Z,Dong J

Sat Oct 15 00:00:00 EDT 2022

DNA 6mA Demethylase ALKBH1 Orchestrates Fatty Acid Metabolism and Suppresses Diet-Induced Hepatic Steatosis.

Cellular and molecular gastroenterology and hepatology

Luo L,Liu Y,Nizigiyimana P,Ye M,Xiao Y,Guo Q,Su T,Luo X,Huang Y,Zhou H

Tue Nov 22 00:00:00 EST 2022

A novel O²- (2,4-dinitrophenyl) diazeniumdiolate inhibits hepatocellular carcinoma migration, invasion, and EMT through the Wnt/β-catenin pathway.

Toxicology in vitro : an international journal published in association with BIBRA

Xing Y,Hu Y,Zou H,Xie H,Jiang T,Liu L

Sat Oct 01 00:00:00 EDT 2022

Downregulation of lncRNA APCDD1L-AS1 due to DNA hypermethylation and loss of VHL protein expression promotes the progression of clear cell renal cell carcinoma.

International journal of biological sciences

Yang W,Zhou J,Zhang Z,Zhang K,Xu Y,Li L,Cai L,Gong Y,Gong K

Thu Apr 14 00:00:00 EDT 2022

Procyanidins and its metabolites by gut microbiome improves insulin resistance in gestational diabetes mellitus mice model via regulating NF-κB and NLRP3 inflammasome pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Liu Y,Sun R,Lin X,Wu L,Chen H,Shen S,Li Y,Wei Y,Deng G

Fri Jul 01 00:00:00 EDT 2022

The HDAC inhibitor GCJ-490A suppresses c-Met expression through IKKα and overcomes gefitinib resistance in non-small cell lung cancer.

Cancer biology & medicine

He T,Gao Y,Fang Y,Zhang Y,Zhang S,Nan F,Ding J,Chen Y

Tue Feb 22 00:00:00 EST 2022

Glucocorticoids induce osteonecrosis of the femoral head in rats via PI3K/AKT/FOXO1 signaling pathway.

PeerJ

Sun F,Zhou JL,Wei SX,Jiang ZW,Peng H

Fri Jan 13 00:00:00 EST 2023

Fatostatin inhibits SREBP2-mediated cholesterol uptake via LDLR against selective estrogen receptor α modulator-induced hepatic lipid accumulation.

Chemico-biological interactions

Li M,Lu Q,Zhu Y,Fan X,Zhao W,Zhang L,Jiang Z,Yu Q

Sun Sep 25 00:00:00 EDT 2022

CCL20/CCR6 axis mediates macrophages to promote proliferation and migration of ESCs by blocking autophagic flux in endometriosis.

Stem cell research & therapy

Tan J,Xu T,Gou Y,Wang H,Liang Z,Cao Y,Wang H,Yu Y,Jiao N,Zhang Z

Fri Jul 15 00:00:00 EDT 2022

Irisin lowers blood pressure in Zucker diabetic rats by regulating the functions of renal angiotensin II type 1 receptor via the inhibition of the NF-κB signaling pathway.

Peptides

Huang Y,Chen Q,Jiang Q,Zhao Z,Fang J,Chen L

Sat Jan 01 00:00:00 EST 2022

T-2 Toxin Induces Apoptotic Cell Death and Protective Autophagy in Mouse Microglia BV2 Cells.

Journal of fungi (Basel, Switzerland)

Sun T,Zhang Q,Li M,Tang S,Dai C

Fri Jul 22 00:00:00 EDT 2022

Interaction of Nucleolin with the Fusion Protein of Avian Metapneumovirus Subgroup C Contributes to Viral Replication.

Viruses

Wang D,Hou L,Zhu N,Yang X,Zhou J,Cui Y,Guo J,Feng X,Liu J

Mon Jun 27 00:00:00 EDT 2022

Qingfei Tongluo Formula Mitigates Mycoplasma pneumoniae Infection via the PERK Signaling Pathway.

Disease markers

Liu X,Wang M,Kan Q,Lin Y,Jiang Z

Wed Aug 23 00:00:00 EDT 2023

RBCK1 is an endogenous inhibitor for triple negative breast cancer via hippo/YAP axis.

Cell communication and signaling : CCS

Li Z,Su P,Ding Y,Gao H,Yang H,Li X,Yang X,Xia Y,Zhang C,Fu M,Wang D,Zhang Y,Zhuo S,Zhu J,Zhuang T

Mon Oct 24 00:00:00 EDT 2022

Nuclear accumulation of KPNA2 impacts radioresistance through positive regulation of the PLSCR1-STAT1 loop in lung adenocarcinoma.

Cancer science

Liao WC,Lin TJ,Liu YC,Wei YS,Chen GY,Feng HP,Chang YF,Chang HT,Wang CL,Chi HC,Wang CI,Lin KH,Ou Yang WT,Yu CJ

Sat Jan 01 00:00:00 EST 2022

Grossamide attenuates inflammation by balancing macrophage polarization through metabolic reprogramming of macrophages in mice.

International immunopharmacology

Zhao W,Xu D,Hong W,Zhang L,Wu Q,Gao M,Wang J

Tue Nov 01 00:00:00 EDT 2022

FSH inhibits autophagy and lysosomal biogenesis to regulate protein degradation in cultured goat Sertoli cells.

Molecular and cellular endocrinology

Xi H,Ren F,Li Y,Xian M,Wang L,Hu J

Sat Jan 15 00:00:00 EST 2022

Berberine protects against palmitate induced beta cell injury via promoting mitophagy.

Genes & genomics

Li M,She J,Ma L,Ma L,Ma X,Zhai J

Fri Jul 01 00:00:00 EDT 2022

Toddalolactone protects against osteoarthritis by ameliorating chondrocyte inflammation and suppressing osteoclastogenesis.

Chinese medicine

Xu Y,Xue S,Zhang T,Jin X,Wang C,Lu H,Zhong Y,Chen H,Zhu L,Ma J,Sang W

Sat Feb 05 00:00:00 EST 2022

Methionine and leucine induce ARID1A degradation to promote mTOR expression and milk synthesis in mammary epithelial cells.

The Journal of nutritional biochemistry

Qi H,Wang L,Zhang M,Wang Z,Gao X,Li M

Tue Mar 01 00:00:00 EST 2022

Methionine and leucine induce ARID1A degradation to promote mTOR expression and milk synthesis in mammary epithelial cells.

The Journal of nutritional biochemistry

Qi H,Wang L,Zhang M,Wang Z,Gao X,Li M

Tue Mar 01 00:00:00 EST 2022

ITGA2 overexpression inhibits DNA repair and confers sensitivity to radiotherapies in pancreatic cancer.

Cancer letters

Zhou C,Li S,Bin K,Qin G,Pan P,Ren D,Zhao Y,Xia W,Chen J,Liu J,Wu H,Zhou Y

Fri Oct 28 00:00:00 EDT 2022

DNA damage-induced translocation of mitochondrial factor HIGD1A into the nucleus regulates homologous recombination and radio/chemo-sensitivity.

Oncogene

Chen B,Xu F,Gao Y,Hu G,Zhu K,Lu H,Xu A,Chen S,Wu L,Zhao G

Tue Mar 01 00:00:00 EST 2022

Design, synthesis and biological evaluation of (R)-5-methylpyrrolidin-2-ones as p300 bromodomain inhibitors with Anti-Tumor activities in multiple tumor lines.

Bioorganic chemistry

Liu R,Yang H,Chen Z,Zhou K,Shi Q,Li J,Huang Y,Huang X,Li Y

Fri Jul 01 00:00:00 EDT 2022

Deletion of ACLY Disrupts Histone Acetylation and IL-10 Secretion in Trophoblasts, Which Inhibits M2 Polarization of Macrophages: A Possible Role in Recurrent Spontaneous Abortion.

Oxidative medicine and cellular longevity

Chen X,Song QL,Li ZH,Ji R,Wang JY,Ge C,Xiao ZN,Guo DY,Yang J

Tue May 24 00:00:00 EDT 2022

miR‑30a‑5p induces the adipogenic differentiation of bone marrow mesenchymal stem cells by targeting FAM13A/Wnt/β‑catenin signaling in aplastic anemia.

Molecular medicine reports

Wang E,Zhang Y,Ding R,Wang X,Zhang S,Li X

Sat Jan 01 00:00:00 EST 2022

Oryzanol Ameliorates DSS-Stimulated Gut Barrier Damage via Targeting the Gut Microbiota Accompanied by the TLR4/NF-κB/NLRP3 Cascade Response In Vivo.

Journal of agricultural and food chemistry

Xia X,Lin H,Luo F,Wu X,Zhu L,Chen S,Luo H,Ye F,Peng X,Zhang Y,Yang G,Lin Q

Wed Dec 21 00:00:00 EST 2022

The A-to-I editing of KPC1 promotes intrahepatic cholangiocarcinoma by attenuating proteasomal processing of NF-κB1 p105 to p50.

Journal of experimental & clinical cancer research : CR

Gao C,Zhou G,Shi J,Shi P,Jin L,Li Y,Wang X,Liao S,Yan H,Wu J,Lu Y,Zhai Y,Zhang J,Zhang H,Zhang H,Yang C,Cao P,Cheng S,Zhou G

Thu Dec 08 00:00:00 EST 2022

Stabilizing and upregulating Axin with tankyrase inhibitor reverses 5-fluorouracil chemoresistance and proliferation by targeting the WNT/caveolin-1 axis in colorectal cancer cells.

Cancer gene therapy

Luo F,Li J,Liu J,Liu K

Tue Nov 01 00:00:00 EDT 2022

Extracellular vesicle-mediated delivery of circDYM alleviates CUS-induced depressive-like behaviours.

Journal of extracellular vesicles

Yu X,Bai Y,Han B,Ju M,Tang T,Shen L,Li M,Yang L,Zhang Z,Hu G,Chao J,Zhang Y,Yao H

Sat Jan 01 00:00:00 EST 2022

Combined HASPIN and mTOR inhibition is synergistic against KRAS-driven carcinomas.

Translational oncology

Xu C,Gao Q,Wu Z,Lou W,Li X,Wang M,Wang N,Li Q

Thu Dec 01 00:00:00 EST 2022

Cyclophosphamide Induces the Ferroptosis of Tumor Cells Through Heme Oxygenase-1.

Frontiers in pharmacology

Shi H,Hou B,Li H,Zhou H,Du B

Fri Mar 11 00:00:00 EST 2022

Yap is essential for uterine decidualization through Rrm2/GSH/ROS pathway in response to Bmp2.

International journal of biological sciences

Yu HF,Yang ZQ,Xu MY,Huang JC,Yue ZP,Guo B

Thu Apr 14 00:00:00 EDT 2022

Resveratrol reduces inflammatory response and detrimental effects in chronic cerebral hypoperfusion by down-regulating stimulator of interferon genes/TANK-binding kinase 1/interferon regulatory factor 3 signaling.

Frontiers in aging neuroscience

Kang N,Shi Y,Song J,Gao F,Fan M,Jin W,Gao Y,Lv P

Tue Aug 09 00:00:00 EDT 2022

Taurine stimulates protein synthesis and proliferation of C2C12 myoblast cells through the PI3K-ARID4B-mTOR pathway.

The British journal of nutrition

Hao Q,Wang L,Zhang M,Wang Z,Li M,Gao X

Mon Nov 28 00:00:00 EST 2022

Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix.

Nature metabolism

Kay EJ,Paterson K,Riera-Domingo C,Sumpton D,Däbritz JHM,Tardito S,Boldrini C,Hernandez-Fernaud JR,Athineos D,Dhayade S,Stepanova E,Gjerga E,Neilson LJ,Lilla S,Hedley A,Koulouras G,McGregor G,Jamieson C,Johnson RM,Park M,Kirschner K,Miller C,Kamphorst JJ,Loayza-Puch F,Saez-Rodriguez J,Mazzone M,Blyth K,Zagnoni M,Zanivan S

Wed Jun 01 00:00:00 EDT 2022

Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-κB and NLRP3 inflammasome.

Journal of ethnopharmacology

Zhou GQ,Chen G,Yang J,Qin WY,Ping J

Sun Jan 30 00:00:00 EST 2022

Treatment of Membranous Nephropathy by Disulfiram through Inhibition of Podocyte Pyroptosis.

Kidney diseases (Basel, Switzerland)

Lv D,Jiang S,Zhang M,Zhu X,Yang F,Wang H,Li S,Liu F,Zeng C,Qin W,Li L,Liu Z

Fri Jul 01 00:00:00 EDT 2022

Potential dual protective effects of melatonin on spermatogonia against hexavalent chromium.

Reproductive toxicology (Elmsford, N.Y.)

Li T,Zheng Y,Li T,Guo M,Wu X,Liu R,Liu Q,You X,Zeng W,Lv Y

Mon Aug 01 00:00:00 EDT 2022

Transcriptional and H3K27ac related genome profiles in oral squamous cell carcinoma cells treated with metformin.

Journal of Cancer

Liu S,Shi C,Hou X,Tian X,Li C,Ma X,Wang X,Gao P

Wed Apr 13 00:00:00 EDT 2022

Targeting macrophage TFEB-14-3-3 epsilon Interface by naringenin inhibits abdominal aortic aneurysm.

Cell discovery

Jia Y,Zhang L,Liu Z,Mao C,Ma Z,Li W,Yu F,Wang Y,Huang Y,Zhang W,Zheng J,Wang X,Xu Q,Zhang J,Feng W,Yun C,Liu C,Sun J,Fu Y,Cui Q,Kong W

Tue Mar 01 00:00:00 EST 2022

Characterization and subcellular localization of Alongshan virus proteins.

Frontiers in microbiology

Zhao Y,Wu P,Liu L,Ma B,Pan M,Huang Y,Du N,Yu H,Sui L,Wang ZD,Hou Z,Liu Q

Sat Oct 15 00:00:00 EDT 2022

Protective Effect of Cardiomyocyte-Specific Prolyl-4-Hydroxylase 2 Inhibition on Ischemic Injury in a Mouse MI Model.

Journal of the American College of Surgeons

Pradeep SR,Lim ST,Thirunavukkarasu M,Joshi M,Cernuda B,Palesty JA,Maulik N

Mon Aug 01 00:00:00 EDT 2022

Fucoidan inhibits EGFR redistribution and potentiates sorafenib to overcome sorafenib-resistant hepatocellular carcinoma.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Luo J,Li L,Zhu Z,Chang B,Deng F,Wang D,Lu X,Zuo D,Chen Q,Zhou J

Sat Oct 01 00:00:00 EDT 2022

ERK/p38/ROS burst responses to environmentally relevant concentrations of diphenyl phosphate-evoked neutrophil extracellular traps formation: Assessing the role of autophagy.

Journal of hazardous materials

Li S,Ma Y,Ye S,Hu D,Xiao F

Wed Jan 05 00:00:00 EST 2022

ERK/p38/ROS burst responses to environmentally relevant concentrations of diphenyl phosphate-evoked neutrophil extracellular traps formation: Assessing the role of autophagy.

Journal of hazardous materials

Li S,Ma Y,Ye S,Hu D,Xiao F

Wed Jan 05 00:00:00 EST 2022

Mitochondrial Proteins Unveil the Mechanism by Which Physical Exercise Ameliorates Memory, Learning and Motor Activity in Hypoxic Ischemic Encephalopathy Rat Model.

International journal of molecular sciences

Gendi F,Pei F,Wang Y,Li H,Fu J,Chang C

Mon Apr 11 00:00:00 EDT 2022

Caspase-1-mediated extracellular vesicles derived from pyroptotic alveolar macrophages promote inflammation in acute lung injury.

International journal of biological sciences

Qin X,Zhou Y,Jia C,Chao Z,Qin H,Liang J,Liu X,Liu Z,Sun T,Yuan Y,Zhang H

Fri Apr 15 00:00:00 EDT 2022

Tumor-promoting mechanisms of macrophage-derived extracellular vesicles-enclosed microRNA-660 in breast cancer progression.

Breast cancer research and treatment

Li C,Li R,Hu X,Zhou G,Jiang G

Fri Apr 01 00:00:00 EDT 2022

Blockade of Nuclear β-Catenin Signaling via Direct Targeting of RanBP3 with NU2058 Induces Cell Senescence to Suppress Colorectal Tumorigenesis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Zheng CC,Liao L,Liu YP,Yang YM,He Y,Zhang GG,Li SJ,Liu T,Xu WW,Li B

Thu Dec 01 00:00:00 EST 2022

MCTR1 inhibits ferroptosis by promoting NRF2 expression to attenuate hepatic ischemia-reperfusion injury.

American journal of physiology. Gastrointestinal and liver physiology

Ye J,Peng J,Liu K,Zhang T,Huang W

Thu Sep 01 00:00:00 EDT 2022

Hepatoprotective Effects of Albumin-Encapsulated Nanoparticles of a Curcumin Derivative COP-22 against Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Injury in Mice.

International journal of molecular sciences

Mu W,Wang Q,Jia M,Dong S,Li S,Yang J,Liu G

Thu Apr 28 00:00:00 EDT 2022

SETDB1 Regulates Porcine Spermatogonial Adhesion and Proliferation through Modulating MMP3/10 Transcription.

Cells

Liu R,Liu Z,Guo M,Zeng W,Zheng Y

Sat Jan 22 00:00:00 EST 2022

Dietary curcumin supplementation ameliorates placental inflammation in rats with intra-uterine growth retardation by inhibiting the NF-κB signaling pathway.

The Journal of nutritional biochemistry

Qi L,Jiang J,Yu G,Zhang X,Qi X,Zhang J,Zhang L,Wang T

Wed Jun 01 00:00:00 EDT 2022

TRIM36 inhibits tumorigenesis through the Wnt/β-catenin pathway and promotes caspase-dependent apoptosis in hepatocellular carcinoma.

Cancer cell international

Tong Q,Yi M,Kong P,Xu L,Huang W,Niu Y,Gan X,Zhan H,Tian R,Yan D

Tue Sep 06 00:00:00 EDT 2022

Deficiency of CFB attenuates renal tubulointerstitial damage by inhibiting ceramide synthesis in diabetic kidney disease.

JCI insight

Sun ZJ,Chang DY,Chen M,Zhao MH

Thu Dec 22 00:00:00 EST 2022

Hyperphosphorylated tau mediates neuronal death by inducing necroptosis and inflammation in Alzheimer's disease.

Journal of neuroinflammation

Dong Y,Yu H,Li X,Bian K,Zheng Y,Dai M,Feng X,Sun Y,He Y,Yu B,Zhang H,Wu J,Yu X,Wu H,Kong W

Mon Aug 15 00:00:00 EDT 2022

Salidroside alleviates oxidative stress and apoptosis via AMPK/Nrf2 pathway in DHT-induced human granulosa cell line KGN.

Archives of biochemistry and biophysics

Ji R,Jia FY,Chen X,Wang ZH,Jin WY,Yang J

Sat Jan 15 00:00:00 EST 2022

Attenuation of Activated eIF2α Signaling by ISRIB Treatment After Spinal Cord Injury Improves Locomotor Function.

Journal of molecular neuroscience : MN

Chang L,Liu X,Chen J,Liu H,Wang G,Wang G,Liao X,Shen X

Tue Mar 01 00:00:00 EST 2022

Stimulator of Interferon Genes (STING) Promotes Staphylococcus aureus-Induced Extracellular Traps Formation via the ROS-ERK Signaling Pathway.

Frontiers in cell and developmental biology

Liu ZZ,Chen W,Zhou CK,Ma K,Gao Y,Yang YJ

Wed Apr 13 00:00:00 EDT 2022

Linkage of methionine addiction, histone lysine hypermethylation, and malignancy.

iScience

Yamamoto J,Inubushi S,Han Q,Tashiro Y,Sugisawa N,Hamada K,Aoki Y,Miyake K,Matsuyama R,Bouvet M,Clarke SG,Endo I,Hoffman RM

Fri Apr 15 00:00:00 EDT 2022

Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Shen Y,Fan X,Qu Y,Tang M,Huang Y,Peng Y,Fu Q

Thu Sep 01 00:00:00 EDT 2022

Characterization of the Eimeria tenella rhoptry protein with a nuclear localization sequence (EtROP30).

Parasitology research

Bingxiang W,Ningning Z,Yakun W,Lingyu S,Hongmei L,Zhang X,Zhao X

Sun May 01 00:00:00 EDT 2022

An assembly-inducing PDC enabling the efficient nuclear delivery of nucleic acid for cancer stem-like cell suppression.

Nanoscale

Wang D,Tian Y,Zhang Y,Sun X,Wu Y,Liu R,Zeng F,Du J,Hu K

Thu Oct 27 00:00:00 EDT 2022

B16 Membrane-Coated Vesicles for Combined Photodynamic Therapy and Immunotherapy Shift Immune Microenvironment of Melanoma.

International journal of nanomedicine

Wang Y,Zhao Z,Liu C,Hao M,Kong C,Zhao X,Gao Y,Zhang Y,Cui W,Zhang C,Jiang J

Mon Apr 04 00:00:00 EDT 2022

Histone chaperone HIRA complex regulates retrotransposons in embryonic stem cells.

Stem cell research & therapy

Zhang M,Zhao X,Feng X,Hu X,Zhao X,Lu W,Lu X

Fri Apr 01 00:00:00 EDT 2022

Notch4 affects the proliferation and differentiation of deer antler chondrocytes through the Smad3/lncRNA27785.1 axis.

Cellular signalling

Chen DY,Yang M,Sun ZT,Song MM,Yao HB,Long GH,Hu W

Sat Oct 01 00:00:00 EDT 2022

Flavonoid 4,4'-dimethoxychalcone induced ferroptosis in cancer cells by synergistically activating Keap1/Nrf2/HMOX1 pathway and inhibiting FECH.

Free radical biology & medicine

Yang C,Wang T,Zhao Y,Meng X,Ding W,Wang Q,Liu C,Deng H

Mon Aug 01 00:00:00 EDT 2022

O-GlcNAcylation of SIRT1 Protects against Cold Stress-Induced Skeletal Muscle Damage via Amelioration of Mitochondrial Homeostasis.

International journal of molecular sciences

Cao Y,Zhang M,Li Y,Lu J,Zhou W,Li X,Shi H,Xu B,Li S

Tue Nov 22 00:00:00 EST 2022

Maltol Promotes Mitophagy and Inhibits Oxidative Stress via the Nrf2/PINK1/Parkin Pathway after Spinal Cord Injury.

Oxidative medicine and cellular longevity

Mao Y,Du J,Chen X,Al Mamun A,Cao L,Yang Y,Mubwandarikwa J,Zaeem M,Zhang W,Chen Y,Dai Y,Xiao J,Ye K

Fri Mar 18 00:00:00 EDT 2022

Maackiain protects against sepsis via activating AMPK/Nrf2/HO-1 pathway.

International immunopharmacology

Bai X,Zhu Y,Jie J,Li D,Song L,Luo J

Fri Jul 01 00:00:00 EDT 2022

Motoneurons innervation determines the distinct gene expressions in multinucleated myofibers.

Cell & bioscience

Bai L,Tu WY,Xiao Y,Zhang K,Shen C

Tue Aug 30 00:00:00 EDT 2022

CCL25 Inhibition Alleviates Sepsis-Induced Acute Lung Injury and Inflammation.

Infection and drug resistance

Xia D,Wang S,Liu A,Li L,Zhou P,Xu S

Sat Jul 16 00:00:00 EDT 2022

HB-EGF induces mitochondrial dysfunction via estrogen hypersecretion in granulosa cells dependent on cAMP-PKA-JNK/ERK-Ca²⁺-FOXO1 pathway.

International journal of biological sciences

Huang JC,Duan CC,Jin S,Sheng CB,Wang YS,Yue ZP,Guo B

Fri Apr 15 00:00:00 EDT 2022

CircNFIX regulates chondrogenesis and cartilage homeostasis by targeting the miR758-3p/KDM6A axis.

Cell proliferation

Liao H,Tu Q,Kang Y,Mao G,Li Z,Hu S,Sheng P,Wang X,Xu Y,Long D,Xu Y,Kang Y,Zhang Z

Tue Nov 01 00:00:00 EDT 2022

NRF2 Serves a Critical Role in Regulation of Immune Checkpoint Proteins (ICPs) During Trophoblast Differentiation.

Endocrinology

Hong K,Muralimanoharan S,Kwak YT,Mendelson CR

Fri Jul 01 00:00:00 EDT 2022

Leonurine inhibits the TXNIP/NLRP3 and NF-κB pathways via Nrf2 activation to alleviate carrageenan-induced pleurisy in mice.

Phytotherapy research : PTR

Yan K,Hu J,Hou T,Ci X,Peng L

Sun May 01 00:00:00 EDT 2022

The Effect of Circumscribed Exposure to the Pan-Aurora Kinase Inhibitor VX-680 on Proliferating Euploid Cells.

International journal of molecular sciences

Liu X,Shi Q,Choudhry N,Zhang T,Liu H,Zhang S,Zhang J,Yang D

Tue Oct 11 00:00:00 EDT 2022

Inhibition of APE1 Expression Enhances the Antitumor Activity of Olaparib in Triple-Negative Breast Cancer.

Evidence-based complementary and alternative medicine : eCAM

Jian D,Li XM,Dai N,Liang DD,Zhang G,Mao CY,Wang D,Song GB,Li MX,Luo H

Sat Jul 16 00:00:00 EDT 2022

Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress.

Journal of Zhejiang University. Science. B

Lu J,Fu S,Dai J,Hu J,Li S,Ji H,Wang Z,Yu J,Bao J,Xu B,Guo J,Yang H

Wed Jun 15 00:00:00 EDT 2022

HDAC inhibitor quisinostat prevents estrogen deficiency-induced bone loss by suppressing bone resorption and promoting bone formation in mice.

European journal of pharmacology

Sun S,Xiu C,Chai L,Chen X,Zhang L,Liu Q,Chen J,Zhou H

Fri Jul 15 00:00:00 EDT 2022

POU6F1 cooperates with RORA to suppress the proliferation of lung adenocarcinoma by downregulation HIF1A signaling pathway.

Cell death & disease

Xiao W,Geng W,Zhou M,Xu J,Wang S,Huang Q,Sun Y,Li Y,Yang G,Jin Y

Tue May 03 00:00:00 EDT 2022

4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.

Cancer cell international

Li W,Huang BS,Xiong YY,Yang LJ,Wu LX

Tue Jan 18 00:00:00 EST 2022

Shoc2 recognizes bacterial flagellin and mediates antibacterial Erk/Stat signaling in an invertebrate.

PLoS pathogens

Zhao BR,Wang XX,Wang XW

Sat Jan 01 00:00:00 EST 2022

Deficiency of CD93 exacerbates inflammation-induced activation and migration of BV2 microglia by regulating the TAK1/NF-κB pathway.

Neuroscience letters

Hong X,Xia M,Zhang Q,Zhao T,Zhang Y,Qian Z,Bao J,Li H

Sun Nov 20 00:00:00 EST 2022

TRIM46 aggravated high glucose-induced hyper permeability and inflammatory response in human retinal capillary endothelial cells by promoting IκBα ubiquitination.

Eye and vision (London, England)

Shen H,Gong Q,Zhang J,Wang H,Qiu Q,Zhang J,Luo D

Mon Sep 05 00:00:00 EDT 2022

EST12 regulates Myc expression and enhances anti-mycobacterial inflammatory response via RACK1-JNK-AP1-Myc immune pathway.

Frontiers in immunology

Wu J,Luo FL,Xie Y,Xiong H,Gao Y,Liu G,Zhang XL

Thu Nov 16 00:00:00 EST 2023

EST12 regulates Myc expression and enhances anti-mycobacterial inflammatory response via RACK1-JNK-AP1-Myc immune pathway.

Frontiers in immunology

Wu J,Luo FL,Xie Y,Xiong H,Gao Y,Liu G,Zhang XL

Thu Nov 16 00:00:00 EST 2023

Guanxinping Tablets Inhibit ET-1-Induced Proliferation and Migration of MOVAS by Suppressing Activated PI3K/Akt/NF-κB Signaling Cascade.

Evidence-based complementary and alternative medicine : eCAM

Wu YY,Huang YL,Dai B,Liu JW,Han X

Sat Jul 16 00:00:00 EDT 2022

Deacetylation of Caveolin-1 by Sirt6 induces autophagy and retards high glucose-stimulated LDL transcytosis and atherosclerosis formation.

Metabolism: clinical and experimental

Zhao Y,Jia X,Yang X,Bai X,Lu Y,Zhu L,Cheng W,Shu M,Zhu Y,Du X,Wang L,Shu Y,Song Y,Jin S

Wed Jun 01 00:00:00 EDT 2022

CREB3L1 promotes tumor growth and metastasis of anaplastic thyroid carcinoma by remodeling the tumor microenvironment.

Molecular cancer

Pan Z,Xu T,Bao L,Hu X,Jin T,Chen J,Chen J,Qian Y,Lu X,Li L,Zheng G,Zhang Y,Zou X,Song F,Zheng C,Jiang L,Wang J,Tan Z,Huang P,Ge M

Mon Oct 03 00:00:00 EDT 2022

Alphaherpesvirus US3 protein-mediated inhibition of the m6A mRNA methyltransferase complex.

Cell reports

Jansens RJJ,Verhamme R,Mirza AH,Olarerin-George A,Van Waesberghe C,Jaffrey SR,Favoreel HW

Tue Jul 19 00:00:00 EDT 2022

PPAR-γ integrates obesity and adipocyte clock through epigenetic regulation of Bmal1.

Theranostics

Wang S,Lin Y,Gao L,Yang Z,Lin J,Ren S,Li F,Chen J,Wang Z,Dong Z,Sun P,Wu B

Thu Apr 21 00:00:00 EDT 2022

The PRMT5-LSD1 axis confers Slug dual transcriptional activities and promotes breast cancer progression.

Journal of experimental & clinical cancer research : CR

Zhang J,Fan X,Zhou Y,Chen L,Rao H

Thu Jun 02 00:00:00 EDT 2022

Nucleophagic Degradation of Progerin Ameliorates Defenestration in Liver Sinusoidal Endothelium Due to SIRT1-Mediated Deacetylation of Nuclear LC3.

Cells

Bai Y,Liu J,Jiang X,Li X,Zhang B,Luo X

Sat Dec 03 00:00:00 EST 2022

Sestrin2 attenuates renal damage by regulating Hippo pathway in diabetic nephropathy.

Cell and tissue research

Bian Y,Shi C,Song S,Mu L,Wu M,Qiu D,Dong J,Zhang W,Yuan C,Wang D,Zhou Z,Dong X,Shi Y

Sat Oct 01 00:00:00 EDT 2022

Capsaicin suppresses hepatocarcinogenesis by inhibiting the stemness of hepatic progenitor cells via SIRT1/SOX2 signaling pathway.

Cancer medicine

Xie ZQ,Li HX,Hou XJ,Huang MY,Zhu ZM,Wei LX,Tang CX

Tue Nov 01 00:00:00 EDT 2022

D-Mannose ameliorates DNCB-induced atopic dermatitis in mice and TNF-α-induced inflammation in human keratinocytes via mTOR/NF-κB pathway.

International immunopharmacology

Luo J,Li Y,Zhai Y,Liu Y,Zeng J,Wang D,Li L,Zhu Z,Chang B,Deng F,Zhang J,Zhou J,Sun L

Thu Dec 01 00:00:00 EST 2022

Dietary Selenium Alleviated Mouse Liver Oxidative Stress and NAFLD Induced by Obesity by Regulating the KEAP1/NRF2 Pathway.

Antioxidants (Basel, Switzerland)

Wang Y,Liu B,Wu P,Chu Y,Gui S,Zheng Y,Chen X

Thu Feb 10 00:00:00 EST 2022

Copper (Cu) induced changes of lipid metabolism through oxidative stress-mediated autophagy and Nrf2/PPARγ pathways.

The Journal of nutritional biochemistry

Zhong CC,Zhao T,Hogstrand C,Chen F,Song CC,Luo Z

Tue Feb 01 00:00:00 EST 2022

RNF31 represses cell progression and immune evasion via YAP/PD-L1 suppression in triple negative breast Cancer.

Journal of experimental & clinical cancer research : CR

Yang H,Xue M,Su P,Zhou Y,Li X,Li Z,Xia Y,Zhang C,Fu M,Zheng X,Luo G,Wei T,Wang X,Ding Y,Zhu J,Zhuang T

Thu Dec 29 00:00:00 EST 2022

Immobilized Titanium (IV) Ion Affinity Chromatography Contributes to Efficient Proteomics Analysis of Cellular Nucleic Acid-Binding Proteins.

Journal of proteome research

Wang H,Qian L,Shang Z,Wang Z,Zhang Y,Cao C,Xiao H

Fri Jan 07 00:00:00 EST 2022

CGG repeat expansion in NOTCH2NLC causes mitochondrial dysfunction and progressive neurodegeneration in Drosophila model.

Proceedings of the National Academy of Sciences of the United States of America

Yu J,Liufu T,Zheng Y,Xu J,Meng L,Zhang W,Yuan Y,Hong D,Charlet-Berguerand N,Wang Z,Deng J

Tue Oct 11 00:00:00 EDT 2022

Bisphenol A drives di(2-ethylhexyl) phthalate promoting thyroid tumorigenesis via regulating HDAC6/PTEN and c-MYC signaling.

Journal of hazardous materials

Zhang X,Guo N,Jin H,Liu R,Zhang Z,Cheng C,Fan Z,Zhang G,Xiao M,Wu S,Zhao Y,Lu X

Sat Mar 05 00:00:00 EST 2022

iASPP is essential for HIF-1α stabilization to promote angiogenesis and glycolysis via attenuating VHL-mediated protein degradation.

Oncogene

Zhao D,Zheng S,Wang X,Liu H,Zhao K,Li L,Hu Y

Tue Mar 01 00:00:00 EST 2022

The transcriptional repressors VAL1 and VAL2 mediate genome-wide recruitment of the CHD3 chromatin remodeler PICKLE in Arabidopsis.

The Plant cell

Liang Z,Yuan L,Xiong X,Hao Y,Song X,Zhu T,Yu Y,Fu W,Lei Y,Xu J,Liu J,Li JF,Li C

Tue Sep 27 00:00:00 EDT 2022

Acquired temozolomide resistance in MGMT^low gliomas is associated with regulation of homologous recombination repair by ROCK2.

Cell death & disease

Zhang X,Li T,Yang M,Du Q,Wang R,Fu B,Tan Y,Cao M,Chen Y,Wang Q,Hu R

Thu Feb 10 00:00:00 EST 2022

Wilforlide A ameliorates the progression of rheumatoid arthritis by inhibiting M1 macrophage polarization.

Journal of pharmacological sciences

Cao Y,Liu J,Huang C,Tao Y,Wang Y,Chen X,Huang D

Sat Jan 01 00:00:00 EST 2022

Inhibition of translocator protein 18 kDa suppressed the progression of glioma via the ELAV-like RNA-binding protein 1/MAPK-activated protein kinase 3 axis.

Bioengineered

Wang J,Ren P,Zeng Z,Ma L,Li Y,Zhang H,Guo W

Tue Mar 01 00:00:00 EST 2022

1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42) inhibits cell proliferation and induces apoptosis via inhibiting ALK and its downstream pathways in Karpas299 cells.

Toxicology and applied pharmacology

Chang X,Wang J,Bian J,Liu Z,Guo M,Li Z,Wu Y,Zhai X,Zuo D

Thu Sep 01 00:00:00 EDT 2022

Recruitment of DNA to tumor-derived microvesicles.

Cell reports

Clancy JW,Sheehan CS,Boomgarden AC,D'Souza-Schorey C

Tue Mar 01 00:00:00 EST 2022

circNup188/miR-760-3p/Map3k8 axis regulates inflammation in cerebral ischemia.

Molecular and cellular probes

Zhang H,Deng J,Huang K,He Y,Cai Z,He Y

Mon Aug 01 00:00:00 EDT 2022

Regulation of ZO-1 on β-catenin mediates sulforaphane suppressed colorectal cancer stem cell properties in colorectal cancer.

Food & function

Chen Y,Tang L,Ye X,Chen Y,Shan E,Han H,Zhong C

Mon Nov 28 00:00:00 EST 2022

Vibrio splendidus flagellin C binds tropomodulin to induce p38 MAPK-mediated p53-dependent coelomocyte apoptosis in Echinodermata.

The Journal of biological chemistry

Dai F,Guo M,Shao Y,Li C

Fri Jul 01 00:00:00 EDT 2022

Isoleucine stimulates mTOR and SREBP-1c gene expression for milk synthesis in mammary epithelial cells through BRG1-mediated chromatin remodelling.

The British journal of nutrition

Hao Q,Wang Z,Wang L,Han M,Zhang M,Gao X

Fri May 20 00:00:00 EDT 2022

The H2A.Z-KDM1A complex promotes tumorigenesis by localizing in the nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells.

BMC cancer

Wang Q,Qi Y,Xiong F,Wang D,Wang B,Chen Y

Fri Nov 11 00:00:00 EST 2022

The role of junctional adhesion molecule-C in trophoblast differentiation and function during normal pregnancy and preeclampsia.

Placenta

Cao C,Dai Y,Wang Z,Zhao G,Duan H,Zhu X,Wang J,Zheng M,Weng Q,Wang L,Gou W,Zhang H,Li C,Liu D,Hu Y

Tue Feb 01 00:00:00 EST 2022

Small immune effectors coordinate peptidoglycan-derived immunity to regulate intestinal bacteria in shrimp.

PLoS pathogens

Liu PP,Wei Z,Cheng ZH,Wang XW

Tue Nov 01 00:00:00 EDT 2022

GPR108 is required for gambogic acid inhibiting NF-κB signaling in cancer.

Pharmacological research

Lyu S,Zhang X,Tu Z,Zhou H,Ke X,Qu Y

Mon Aug 01 00:00:00 EDT 2022

Nrf2 loss of function exacerbates endoplasmic reticulum stress-induced apoptosis in TBI mice.

Neuroscience letters

Sun G,Zhao Z,Lang J,Sun B,Zhao Q

Sun Jan 23 00:00:00 EST 2022

Biosynthesis of a water solubility-enhanced succinyl glucoside derivative of luteolin and its neuroprotective effect.

Microbial biotechnology

Chen L,Chang S,Zhao L,Li B,Zhang S,Yun C,Wu X,Meng J,Li G,Guo S,Duan J

Thu Sep 01 00:00:00 EDT 2022

Overexpression of Tfap2a in Mouse Oocytes Impaired Spindle and Chromosome Organization.

International journal of molecular sciences

Lin J,Ji Z,Di Z,Zhang Y,Yan C,Zeng S

Sat Nov 19 00:00:00 EST 2022

Overexpression of Tfap2a in Mouse Oocytes Impaired Spindle and Chromosome Organization.

International journal of molecular sciences

Lin J,Ji Z,Di Z,Zhang Y,Yan C,Zeng S

Sat Nov 19 00:00:00 EST 2022

A systems biological analysis of the ATF4-GADD34-CHOP regulatory triangle upon endoplasmic reticulum stress.

FEBS open bio

Márton M,Bánhegyi G,Gyöngyösi N,Kálmán EÉ,Pettkó-Szandtner A,Káldi K,Kapuy O

Tue Nov 01 00:00:00 EDT 2022

Regulation of host factor γ-H2AX level and location by enterovirus A71 for viral replication.

Virulence

Yu J,Zhang W,Huo W,Meng X,Zhong T,Su Y,Liu Y,Liu J,Wang Z,Song F,Zhang S,Li Z,Yu X,Yu X,Hua S

Thu Dec 01 00:00:00 EST 2022

Global phosphoproteomic analysis identified key kinases regulating male meiosis in mouse.

Cellular and molecular life sciences : CMLS

Li H,Chen H,Zhang X,Qi Y,Wang B,Cui Y,Ren J,Zhao Y,Chen Y,Zhu T,Wang Y,Yao L,Guo Y,Zhu H,Li Y,Situ C,Guo X

Fri Aug 05 00:00:00 EDT 2022

Verteporfin inhibits the dedifferentiation of tubular epithelial cells via TGF-β1/Smad pathway but induces podocyte loss in diabetic nephropathy.

Life sciences

Qi C,Hu Y,Zeng M,Chen H,Shi J,Jue H,Zhao Z,Liu J,Zhang Z,Xu Y,Wu H

Thu Dec 15 00:00:00 EST 2022

Effect of propiconazole on neutrophil extracellular traps formation: Assessing the role of autophagy.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Ma Y,Li S,Ye S,Hu D,Luo S,Wei L,Xiao F

Sat Oct 01 00:00:00 EDT 2022

Loss of Cep72 affects the morphology of spermatozoa in mice.

Frontiers in physiology

Chen Z,Xu Y,Ma D,Li C,Yu Z,Liu C,Jin T,Du Z,Li Z,Sun Q,Xu Y,Liu R,Wu Y,Luo M

Tue Oct 25 00:00:00 EDT 2022

Blocking iASPP/Nrf2/M-CSF axis improves anti-cancer effect of chemotherapy-induced senescence by attenuating M2 polarization.

Cell death & disease

Liu H,Zhao D,Li H,Zhang W,Lin Q,Wang X,Zheng S,Zhang L,Li L,Hu S,Hu Y

Mon Feb 21 00:00:00 EST 2022

The BcLAE1 is involved in the regulation of ABA biosynthesis in Botrytis cinerea TB-31.

Frontiers in microbiology

Wei Z,Shu D,Sun Q,Chen DB,Li ZM,Luo D,Yang J,Tan H

Tue Aug 23 00:00:00 EDT 2022

Mutual dependency between lncRNA LETN and protein NPM1 in controlling the nucleolar structure and functions sustaining cell proliferation.

Cell research

Wang X,Hu X,Song W,Xu H,Xiao Z,Huang R,Bai Q,Zhang F,Chen Y,Liu Y,Fang J,Li X,Shen Q,Zhao H,Yang X

Tue Jun 01 00:00:00 EDT 2021

Programmed cell death 4 modulates lysosomal function by inhibiting TFEB translation.

Cell death and differentiation

Chen X,Guan Y,Zhang Y,Jia Y,Li W,Guo C,Li Y,Wang X,Shi Y,Wang Q,Zhu F,Li Y,Zhang L

Thu Apr 01 00:00:00 EDT 2021

GDF-11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3-Mediated Autophagy Augmentation.

Oxidative medicine and cellular longevity

Xu Y,Hu X,Li F,Zhang H,Lou J,Wang X,Wang H,Yin L,Ni W,Kong J,Wang X,Li Y,Zhou K,Xu H

Mon Feb 07 00:00:00 EST 2022

Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA-cGAS-STING Signaling Axis.

Journal of immunology (Baltimore, Md. : 1950)

Torres-Odio S,Lei Y,Gispert S,Maletzko A,Key J,Menissy SS,Wittig I,Auburger G,West AP

Thu Apr 15 00:00:00 EDT 2021

Hepatocyte growth factor overexpression promotes osteoclastogenesis and exacerbates bone loss in CIA mice.

Journal of orthopaedic translation

Huang C,Zheng Y,Bai J,Shi C,Shi X,Shan H,Zhou X

Mon Mar 01 00:00:00 EST 2021

TAS2R16 Activation Suppresses LPS-Induced Cytokine Expression in Human Gingival Fibroblasts.

Frontiers in immunology

Zhou Z,Xi R,Liu J,Peng X,Zhao L,Zhou X,Li J,Zheng X,Xu X

Thu Feb 10 00:00:00 EST 2022

Downregulated MicroRNA-327 Attenuates Oxidative Stress-Mediated Myocardial Ischemia Reperfusion Injury Through Regulating the FGF10/Akt/Nrf2 Signaling Pathway.

Frontiers in pharmacology

Zheng T,Yang J,Zhang J,Yang C,Fan Z,Li Q,Zhai Y,Liu H,Yang J

Wed May 26 00:00:00 EDT 2021

Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis.

Free radical biology & medicine

Zhang Y,Huang W,Zheng Z,Wang W,Yuan Y,Hong Q,Lin J,Li X,Meng Y

Thu Apr 01 00:00:00 EDT 2021

Protective Effects of Fisetin on Hepatic Ischemia-reperfusion Injury Through Alleviation of Apoptosis and Oxidative Stress.

Archives of medical research

Li Z,Wang Y,Zhang Y,Wang X,Gao B,Li Y,Li R,Wang J

Mon Feb 01 00:00:00 EST 2021

Over-methylation of Histone H3 Lysines Is a Common Molecular Change Among the Three Major Types of Soft-tissue Sarcoma in Patient-derived Xenograft (PDX) Mouse Models.

Cancer genomics & proteomics

Aoki Y,Yamamoto J,Tome Y,Hamada K,Masaki N,Inubushi S,Tashiro Y,Bouvet M,Endo I,Nishida K,Hoffman RM

Wed Feb 16 00:00:00 EST 2022

The transcriptional repressors VAL1 and VAL2 recruit PRC2 for genome-wide Polycomb silencing in Arabidopsis.

Nucleic acids research

Yuan L,Song X,Zhang L,Yu Y,Liang Z,Lei Y,Ruan J,Tan B,Liu J,Li C

Mon Jan 11 00:00:00 EST 2021

Glutaredoxin 1 protects neurons from oxygen-glucose deprivation/reoxygenation (OGD/R)-induced apoptosis and oxidative stress via the modulation of GSK-3β/Nrf2 signaling.

Journal of bioenergetics and biomembranes

Qiu Z,Li X,Duan C,Li R,Han L

Sun Aug 01 00:00:00 EDT 2021

HDAC9 in the Injury of Vascular Endothelial Cell Mediated by P38 MAPK Pathway.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

Kuang X,Chen S,Lao J,Chen Y,Jia D,Tu L,Ma L,Liao X,Zhao W,Li Q

Wed Dec 01 00:00:00 EST 2021

PLK2 protects retinal ganglion cells from oxidative stress by potentiating Nrf2 signaling via GSK-3β.

Journal of biochemical and molecular toxicology

Fan Y,Wang J,He N,Feng H

Sun Aug 01 00:00:00 EDT 2021

Hsa_circ_0004296 inhibits metastasis of prostate cancer by interacting with EIF4A3 to prevent nuclear export of ETS1 mRNA.

Journal of experimental & clinical cancer research : CR

Mao S,Zhang W,Yang F,Guo Y,Wang H,Wu Y,Wang R,Maskey N,Zheng Z,Li C,Ma W,Zhang J,Yan Y,Yao X

Mon Oct 25 00:00:00 EDT 2021

The p38 MAPK/NF-κB pathway mediates GLT-1 up-regulation during cerebral ischemic preconditioning-induced brain ischemic tolerance in rats.

Brain research bulletin

Sun YW,Zhang LY,Gong SJ,Hu YY,Zhang JG,Xian XH,Li WB,Zhang M

Fri Oct 01 00:00:00 EDT 2021

Mitochondrial dysfunction induces radioresistance in colorectal cancer by activating [Ca²⁺]_m-PDP1-PDH-histone acetylation retrograde signaling.

Cell death & disease

Shi Y,Wang Y,Jiang H,Sun X,Xu H,Wei X,Wei Y,Xiao G,Song Z,Zhou F

Mon Sep 06 00:00:00 EDT 2021

ChREBP deficiency alleviates apoptosis by inhibiting TXNIP/oxidative stress in diabetic nephropathy.

Journal of diabetes and its complications

Chen N,Song S,Yang Z,Wu M,Mu L,Zhou T,Shi Y

Wed Dec 01 00:00:00 EST 2021

Expression, Localization, and Function of the Nucleolar Protein BOP1 in Prostate Cancer Progression.

The American journal of pathology

Vellky JE,Ricke EA,Huang W,Ricke WA

Fri Jan 01 00:00:00 EST 2021

Core Histones Are Constituents of the Perinuclear Theca of Murid Spermatozoa: An Assessment of Their Synthesis and Assembly during Spermiogenesis and Function after Gametic Fusion.

International journal of molecular sciences

Hamilton LE,Lion M,Aguila L,Suzuki J,Acteau G,Protopapas N,Xu W,Sutovsky P,Baker M,Oko R

Thu Jul 29 00:00:00 EDT 2021

Sirtuin 1 ameliorates defenestration in hepatic sinusoidal endothelial cells during liver fibrosis via inhibiting stress-induced premature senescence.

Cell proliferation

Luo X,Bai Y,He S,Sun S,Jiang X,Yang Z,Lu D,Wei P,Liang Y,Peng C,Wang Y,Sheng R,Han S,Li X,Zhang B

Mon Mar 01 00:00:00 EST 2021

Nox2 impairs VEGF-A-induced angiogenesis in placenta via mitochondrial ROS-STAT3 pathway.

Redox biology

Hu C,Wu Z,Huang Z,Hao X,Wang S,Deng J,Yin Y,Tan C

Wed Sep 01 00:00:00 EDT 2021

Shenkang Injection and Its Three Anthraquinones Ameliorates Renal Fibrosis by Simultaneous Targeting I¿B/NF-¿B and Keap1/Nrf2 Signaling Pathways.

Frontiers in pharmacology

Luo LP,Suo P,Ren LL,Liu HJ,Zhang Y,Zhao YY

Tue Jan 11 00:00:00 EST 2022

Role of Intracellular Distribution of Feline and Bovine SAMHD1 Proteins in Lentiviral Restriction.

Virologica Sinica

Wang C,Meng L,Wang J,Zhang K,Duan S,Ren P,Wei Y,Fu X,Yu B,Wu J,Yu X

Fri Oct 01 00:00:00 EDT 2021

miRNA-27a Transcription Activated by c-Fos Regulates Myocardial Ischemia-Reperfusion Injury by Targeting ATAD3a.

Oxidative medicine and cellular longevity

Bao Y,Qiao Y,Yu H,Zhang Z,Yang H,Xin X,Chen Y,Guo Y,Wu N,Jia D

Tue Jan 11 00:00:00 EST 2022

Psychostimulants and opioids differentially influence the epigenetic modification of histone acetyltransferase and histone deacetylase in astrocytes.

PloS one

Doke M,Pendyala G,Samikkannu T

Tue Nov 16 00:00:00 EST 2021

PML Suppresses Influenza Virus Replication by Promoting FBXW7 Expression.

Virologica Sinica

Yan HY,Wang HQ,Zhong M,Wu S,Yang L,Li K,Li YH

Fri Oct 01 00:00:00 EDT 2021

Aagab acts as a novel regulator of NEDD4-1-mediated Pten nuclear translocation to promote neurological recovery following hypoxic-ischemic brain damage.

Cell death and differentiation

Dai C,Wu B,Chen Y,Li X,Bai Y,Du Y,Pang Y,Wang YT,Dong Z

Sun Aug 01 00:00:00 EDT 2021

Impaired 26S Proteasome Assembly Precedes Neuronal Loss in Mutant UBQLN2 Rats.

International journal of molecular sciences

Zhang W,Huang B,Gao L,Huang C

Wed Apr 21 00:00:00 EDT 2021

Discovery of Phenolic Glycoside from Hyssopus cuspidatus Attenuates LPS-Induced Inflammatory Responses by Inhibition of iNOS and COX-2 Expression through Suppression of NF-κB Activation.

International journal of molecular sciences

Liu X,Su J,Wang G,Zheng L,Wang G,Sun Y,Bao Y,Wang S,Huang Y

Tue Nov 09 00:00:00 EST 2021

Histone H2B ubiquitination mediated chromatin relaxation is essential for the induction of somatic cell reprogramming.

Cell proliferation

Wang L,Xu Z,Wang L,Liu C,Wei H,Zhang R,Chen Y,Wang L,Liu W,Xiao S,Li W,Li W

Sun Aug 01 00:00:00 EDT 2021

Long noncoding RNA DGCR5 involves in tumorigenesis of esophageal squamous cell carcinoma via SRSF1-mediated alternative splicing of Mcl-1.

Cell death & disease

Duan Y,Jia Y,Wang J,Liu T,Cheng Z,Sang M,Lv W,Qin J,Liu L

Mon Jun 07 00:00:00 EDT 2021

Activation of the Hippocampal LXRβ Improves Sleep-Deprived Cognitive Impairment by Inhibiting Neuroinflammation.

Molecular neurobiology

Qiu C,Wang M,Yu W,Rong Z,Zheng HS,Sun T,Liu SB,Zhao MG,Wu YM

Fri Oct 01 00:00:00 EDT 2021

Lovastatin Alleviates α-Synuclein Aggregation and Phosphorylation in Cellular Models of Synucleinopathy.

Frontiers in molecular neuroscience

Dai L,Wang J,He M,Xiong M,Tian Y,Liu C,Zhang Z

Fri Aug 13 00:00:00 EDT 2021

MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway.

Physiological research

Guo H,Wang Y,Jia W,Liu L

Wed Mar 17 00:00:00 EDT 2021

Clock Gene Nr1d1 Alleviates Retinal Inflammation Through Repression of Hmga2 in Microglia.

Journal of inflammation research

Wang Z,Huang Y,Chu F,Ji S,Liao K,Cui Z,Chen J,Tang S

Thu Apr 28 00:00:00 EDT 2022

Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson's Disease Models.

Cells

Verma DK,Seo BA,Ghosh A,Ma SX,Hernandez-Quijada K,Andersen JK,Ko HS,Kim YH

Mon Jul 05 00:00:00 EDT 2021

Phenethyl Isothiocyanate Enhances the Cytotoxic Effects of PARP Inhibitors in High-Grade Serous Ovarian Cancer Cells.

Frontiers in oncology

Jia Y,Wang M,Sang X,Liu P,Gao J,Jiang K,Cheng H

Wed Feb 16 00:00:00 EST 2022

Cisplatin remodels the tumor immune microenvironment via the transcription factor EB in ovarian cancer.

Cell death discovery

Liu W,Wang Y,Xie Y,Dai T,Fan M,Li C,Zou Y

Sat Jun 05 00:00:00 EDT 2021

CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2/CSF1 axis.

Signal transduction and targeted therapy

Huang YH,Cai K,Xu PP,Wang L,Huang CX,Fang Y,Cheng S,Sun XJ,Liu F,Huang JY,Ji MM,Zhao WL

Mon Jan 11 00:00:00 EST 2021

Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy.

Cancer biology & medicine

Zhang T,Yang X,Xu W,Wang J,Wu D,Hong Z,Yuan S,Zeng Z,Jia X,Lu S,Safadi R,Han S,Yang Z,Neckers LM,Liangpunsakul S,Zhou W,Lu Y

Thu Mar 25 00:00:00 EDT 2021

Tanshinone I Mitigates Steroid-Induced Osteonecrosis of the Femoral Head and Activates the Nrf2 Signaling Pathway in Rats.

Evidence-based complementary and alternative medicine : eCAM

Xu X,Shen Y,Lv H,Zhao J,Li X,Gao L,Ren S,Zhang X

Fri Feb 04 00:00:00 EST 2022

Paeonol ameliorates CFA-induced inflammatory pain by inhibiting HMGB1/TLR4/NF-κB p65 pathway.

Metabolic brain disease

Qiu C,Yang LD,Yu W,Tian DD,Gao MR,Wang WJ,Li XB,Wu YM,Wang M

Mon Feb 01 00:00:00 EST 2021

HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity.

Cell death & disease

Luo W,Li J,Li Z,Lin T,Zhang L,Yang W,Mai Y,Liu R,Chen M,Dai C,Yang H,Lu J,Li H,Guan G,Huang M,Liu P,Li Z

Mon Jul 26 00:00:00 EDT 2021

Discovery of a novel HDACi structure that inhibits the proliferation of ovarian cancer cells in vivo and in vitro.

International journal of biological sciences

Bai M,Cui M,Li M,Yao X,Wu Y,Zheng L,Sun L,Song Q,Wang S,Liu L,Yu C,Huang Y

Tue Feb 22 00:00:00 EST 2022

OGT regulated O-GlcNacylation promotes migration and invasion by activating IL-6/STAT3 signaling in NSCLC cells.

Pathology, research and practice

Ge X,Peng X,Li M,Ji F,Chen J,Zhang D

Wed Sep 01 00:00:00 EDT 2021

Pentagalloylglucose reduces AGE-induced inflammation by activating Nrf2/HO-1 and inhibiting the JAK2/STAT3 pathway in mesangial cells.

Journal of pharmacological sciences

Tong J,Fang J,Zhu T,Xiang P,Shang J,Chen L,Zhao J,Wang Y,Tong L,Sun M

Wed Dec 01 00:00:00 EST 2021

Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.

Neuron

Li X,Zhang J,Li D,He C,He K,Xue T,Wan L,Zhang C,Liu Q

Wed Mar 17 00:00:00 EDT 2021

NOD2-mediated P2Y₁₂ upregulation increases platelet activation and thrombosis in sepsis.

Biochemical pharmacology

Zhong H,Waresi M,Zhang W,Han L,Zhao Y,Chen Y,Zhou P,Chang L,Pan G,Wu B,Li J,Zhang S,Shi H,Luo X,Gao W,Qi Z,Ding Z

Wed Dec 01 00:00:00 EST 2021

ADAM17 and NF-κB p65 form a positive feedback loop that facilitates human esophageal squamous cell carcinoma cell viability.

International journal of clinical and experimental pathology

Gao L,Liu H,Xu R,Qiu J,Peng X,Yang Y,Zhang D,Qian J

Tue Aug 10 00:00:00 EDT 2021

Identification of Histone Modifications Reveals a Role of H2b Monoubiquitination in Transcriptional Regulation of dmrt1 in Monopterus albus.

International journal of biological sciences

Lai F,Cheng Y,Zou J,Wang H,Zhu W,Wang X,Cheng H,Zhou R

Fri Mar 25 00:00:00 EDT 2022

S-allyl cysteine ameliorates heat stress-induced oxidative stress by activating Nrf2/HO-1 signaling pathway in BMECs.

Toxicology and applied pharmacology

Wang Y,Wang HL,Xing GD,Qian Y,Zhong JF,Chen KL

Thu Apr 01 00:00:00 EDT 2021

SGLT2 promotes pancreatic cancer progression by activating the Hippo signaling pathway via the hnRNPK-YAP1 axis.

Cancer letters

Ren D,Sun Y,Zhang D,Li D,Liu Z,Jin X,Wu H

Thu Oct 28 00:00:00 EDT 2021

ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H⁺-ATPases is essential for brain development in humans and mice.

Nature communications

Aoto K,Kato M,Akita T,Nakashima M,Mutoh H,Akasaka N,Tohyama J,Nomura Y,Hoshino K,Ago Y,Tanaka R,Epstein O,Ben-Haim R,Heyman E,Miyazaki T,Belal H,Takabayashi S,Ohba C,Takata A,Mizuguchi T,Miyatake S,Miyake N,Fukuda A,Matsumoto N,Saitsu H

Thu Apr 08 00:00:00 EDT 2021

Ischemic heart injury leads to HIF1-dependent differential splicing of CaMK2γ.

Scientific reports

Williams AL,Walton CB,Pinell B,Khadka VS,Dunn B,Lee K,Anagaran MCT,Avelar A,Shohet RV

Wed Jun 23 00:00:00 EDT 2021

Downregulation of miR-497-5p prevents liver ischemia-reperfusion injury in association with MED1/TIMP-2 axis and the NF-κB pathway.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Wu K,Tao G,Xu T,An Y,Yu X,Wang Y,Wang S,Guo W,Ma L

Thu Apr 01 00:00:00 EDT 2021

A phase-separated nuclear GBPL circuit controls immunity in plants.

Nature

Huang S,Zhu S,Kumar P,MacMicking JD

Tue Jun 01 00:00:00 EDT 2021

Frontiers in physiology

Ying C,Dai J,Fan G,Zhou Z,Gan T,Zhang Y,Song Y,Zhou X

Fri Jul 02 00:00:00 EDT 2021

Dietary Inorganic Nitrate Protects Hepatic Ischemia-Reperfusion Injury Through NRF2-Mediated Antioxidative Stress.

Frontiers in pharmacology

Li S,Jin H,Sun G,Zhang C,Wang J,Xu H,Zhang D,Wang S

Fri Jun 25 00:00:00 EDT 2021

Calcitriol Alleviates MPP⁺- and MPTP-Induced Parthanatos Through the VDR/PARP1 Pathway in the Model of Parkinson's Disease.

Frontiers in aging neuroscience

Hu J,Wu J,Wan F,Kou L,Yin S,Sun Y,Li Y,Zhou Q,Wang T

Tue Aug 17 00:00:00 EDT 2021

Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer.

Cell reports. Medicine

Huang D,Chowdhury S,Wang H,Savage SR,Ivey RG,Kennedy JJ,Whiteaker JR,Lin C,Hou X,Oberg AL,Larson MC,Eskandari N,Delisi DA,Gentile S,Huntoon CJ,Voytovich UJ,Shire ZJ,Yu Q,Gygi SP,Hoofnagle AN,Herbert ZT,Lorentzen TD,Calinawan A,Karnitz LM,Weroha SJ,Kaufmann SH,Zhang B,Wang P,Birrer MJ,Paulovich AG

Tue Dec 21 00:00:00 EST 2021

Interferon functional analog activates antiviral Jak/Stat signaling through integrin in an arthropod.

Cell reports

Gao J,Zhao BR,Zhang H,You YL,Li F,Wang XW

Tue Sep 28 00:00:00 EDT 2021

Peony seed oil ameliorates neuroinflammation-mediated cognitive deficits by suppressing microglial activation through inhibition of NF-κB pathway in presenilin 1/2 conditional double knockout mice.

Journal of leukocyte biology

Gao J,Wang L,Zhao C,Wu Y,Lu Z,Gu Y,Ba Z,Wang X,Wang J,Xu Y

Wed Dec 01 00:00:00 EST 2021

Caspase-1 inhibits IFN-β production via cleavage of cGAS during M. bovis infection.

Veterinary microbiology

Liao Y,Liu C,Wang J,Song Y,Sabir N,Hussain T,Yao J,Luo L,Wang H,Cui Y,Yang L,Zhao D,Zhou X

Thu Jul 01 00:00:00 EDT 2021

Activation of microglial G‑protein-coupled receptor 30 protects neurons against excitotoxicity through NF-κB/MAPK pathways.

Brain research bulletin

Yang LK,Lu L,Yue J,Wang XS,Qi JY,Yang F,Liu SB

Thu Jul 01 00:00:00 EDT 2021

CDDO-Im exerts antidepressant-like effects via the Nrf2/ARE pathway in a rat model of post-stroke depression.

Brain research bulletin

Hou X,Liu H,Ping Y,Zhang F,Zhi L,Jiang X,Zhang F,Song C,Zhang Z,Song J

Sun Aug 01 00:00:00 EDT 2021

Lactobacillus johnsonii L531 Alleviates the Damage Caused by Salmonella Typhimurium via Inhibiting TLR4, NF-κB, and NLRP3 Inflammasome Signaling Pathways.

Microorganisms

Chen S,Li Y,Chu B,Yuan L,Liu N,Zhu Y,Wang J

Fri Sep 17 00:00:00 EDT 2021

Cellular FADD-like IL-1β-converting enzyme-inhibitory protein attenuates myocardial ischemia/reperfusion injury via suppressing apoptosis and autophagy simultaneously.

Nutrition, metabolism, and cardiovascular diseases : NMCD

Liu D,Wu H,Li YZ,Yang J,Yang J,Ding JW,Zhou G,Zhang J,Wang X,Fan ZX

Mon Jun 07 00:00:00 EDT 2021

Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment.

Journal of cellular physiology

Li J,Chen H,Lou J,Bao G,Wu C,Lou Z,Wang X,Ding J,Li Z,Xiao J,Xu H,Gao W,Zhou K

Sat May 01 00:00:00 EDT 2021

Induction of mitochondrial apoptosis pathway mediated through caspase-8 and c-Jun N-terminal kinase by cadmium-activated Fas in rat cortical neurons.

Metallomics : integrated biometal science

Wen S,Wang L,Zhang W,Xu M,Song R,Zou H,Gu J,Bian J,Yuan Y,Liu Z

Mon Jul 12 00:00:00 EDT 2021

Bluetongue virus non-structural protein 3 (NS3) and NS4 coordinatively antagonize type ¿ interferon signaling by targeting STAT1.

Veterinary microbiology

Li Z,Lu D,Yang H,Li Z,Zhu P,Xie J,Liao D,Zheng Y,Li H

Mon Mar 01 00:00:00 EST 2021

Pretreatment of Indobufen and Aspirin and their Combinations with Clopidogrel or Ticagrelor Alleviates Inflammasome Mediated Pyroptosis Via Inhibiting NF-κB/NLRP3 Pathway in Ischemic Stroke.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology

Li F,Xu D,Hou K,Gou X,Lv N,Fang W,Li Y

Wed Dec 01 00:00:00 EST 2021

Glaucocalyxin A induces cell cycle arrest and apoptosis via inhibiting NF-κB/p65 signaling pathway in melanoma cells.

Life sciences

Chen J,Zhang W,Pan C,Fan J,Zhong X,Tang S

Thu Apr 15 00:00:00 EDT 2021

Bromodomain-containing proteins BRD1, BRD2, and BRD13 are core subunits of SWI/SNF complexes and vital for their genomic targeting in Arabidopsis.

Molecular plant

Yu Y,Fu W,Xu J,Lei Y,Song X,Liang Z,Zhu T,Liang Y,Hao Y,Yuan L,Li C

Mon Jun 07 00:00:00 EDT 2021

GLIS Family Zinc Finger 1 was First Linked With Preaxial Polydactyly I in Humans by Stepwise Genetic Analysis.

Frontiers in cell and developmental biology

Jin JY,Wu PF,Luo FM,Guo BB,Zeng L,Fan LL,Tang JY,Xiang R

Sat Jan 29 00:00:00 EST 2022

LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome.

Cell death discovery

Wang G,Jin S,Huang W,Li Y,Wang J,Ling X,Huang Y,Hu Y,Li C,Meng Y,Li X

Sat Nov 06 00:00:00 EDT 2021

Attenuated lncRNA NKILA Enhances the Secretory Function of Airway Epithelial Cells Stimulated by Mycoplasma pneumoniae via NF-κB.

BioMed research international

Zhang F,Zhang J,Liu F,Zhou Y,Guo Y,Duan Q,Zhu Y,Zhao D,Gu H

Wed May 26 00:00:00 EDT 2021

NAP1L5 Promotes Nucleolar Hypertrophy and Is Required for Translation Activation During Cardiomyocyte Hypertrophy.

Frontiers in cardiovascular medicine

Guo N,Zheng D,Sun J,Lv J,Wang S,Fang Y,Zhao Z,Zeng S,Guo Q,Tong J,Wang Z

Tue Jan 04 00:00:00 EST 2022

Resveratrol and its derivative pterostilbene ameliorate intestine injury in intrauterine growth-retarded weanling piglets by modulating redox status and gut microbiota.

Journal of animal science and biotechnology

Chen Y,Zhang H,Chen Y,Jia P,Ji S,Zhang Y,Wang T

Thu Jun 10 00:00:00 EDT 2021

p53 induces ARTS to promote mitochondrial apoptosis.

Cell death & disease

Hao Q,Chen J,Liao J,Huang Y,Gan Y,Larisch S,Zeng SX,Lu H,Zhou X

Wed Feb 24 00:00:00 EST 2021

Scutellarin alleviates depression-like behaviors induced by LPS in mice partially through inhibition of astrocyte-mediated neuroinflammation.

Neuroscience letters

Lu L,Yang LK,Yue J,Wang XS,Qi JY,Yang F,Feng B,Liu SB

Sat Nov 20 00:00:00 EST 2021

GABAB receptor inhibits tumor progression and epithelial-mesenchymal transition via the regulation of Hippo/YAP1 pathway in colorectal cancer.

International journal of biological sciences

Wang H,Zhang H,Sun Z,Chen W,Miao C

Fri Mar 25 00:00:00 EDT 2022

ITGB1 enhances the Radioresistance of human Non-small Cell Lung Cancer Cells by modulating the DNA damage response and YAP1-induced Epithelial-mesenchymal Transition.

International journal of biological sciences

Li Y,Sun C,Tan Y,Zhang H,Li Y,Zou H

Mon Jan 03 00:00:00 EST 2022

Identification of small molecules that mitigate vincristine-induced neurotoxicity while sensitizing leukemia cells to vincristine.

Clinical and translational science

Diouf B,Wing C,Panetta JC,Eddins D,Lin W,Yang W,Fan Y,Pei D,Cheng C,Delaney SM,Zhang W,Bonten EJ,Crews KR,Paugh SW,Li L,Freeman BB,Autry RJ,Beard JA,Ferguson DC,Janke LJ,Ness KK,Chen T,Zakharenko SS,Jeha S,Pui CH,Relling MV,Eileen Dolan M,Evans WE

Thu Jul 01 00:00:00 EDT 2021

Pseudoginsenoside F11 Enhances the Viability of Random-Pattern Skin Flaps by Promoting TFEB Nuclear Translocation Through AMPK-mTOR Signal Pathway.

Frontiers in pharmacology

Zhou F,Zhang X,Jiang L,Li S,Chen Y,Wu J

Tue May 18 00:00:00 EDT 2021

PP1 regulatory subunit NIPP1 regulates transcription of E2F1 target genes following DNA damage.

Cancer science

Hanaki S,Habara M,Masaki T,Maeda K,Sato Y,Nakanishi M,Shimada M

Thu Jul 01 00:00:00 EDT 2021

miR-140-3p enhanced the osteo/odontogenic differentiation of DPSCs via inhibiting KMT5B under hypoxia condition.

International journal of oral science

Zheng H,Wang N,Li L,Ge L,Jia H,Fan Z

Tue Dec 07 00:00:00 EST 2021

Establishment of an Efficient Immortalization Strategy Using HMEJ-Based bTERT Insertion for Bovine Cells.

International journal of molecular sciences

Zhang Z,Han Z,Guo Y,Liu X,Gao Y,Zhang Y

Sun Nov 21 00:00:00 EST 2021

Panax notoginseng saponins promote endothelial progenitor cell angiogenesis via the Wnt/β-catenin pathway.

BMC complementary medicine and therapies

Zhu P,Jiang W,He S,Zhang T,Liao F,Liu D,An X,Huang X,Zhou N

Mon Feb 08 00:00:00 EST 2021

Liraglutide, a TFEB-Mediated Autophagy Agonist, Promotes the Viability of Random-Pattern Skin Flaps.

Oxidative medicine and cellular longevity

Zhu X,Hu X,Lou J,Li J,Xu Y,Yu G,Wu C,Ding J,Gao W,Xiao J,Zhou K,Jia C

Fri May 28 00:00:00 EDT 2021

Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia.

Molecular immunology

Li M,Lu H,Wang X,Duan C,Zhu X,Zhang Y,Ge X,Ji F,Wang X,Su J,Zhang D

Wed Dec 01 00:00:00 EST 2021

Protective Effect of Uric Acid on ox-LDL-Induced HUVECs Injury via Keap1-Nrf2-ARE Pathway.

Journal of immunology research

Lin Y,Xie Y,Hao Z,Bi H,Liu Y,Yang X,Xia Y

Thu Mar 03 00:00:00 EST 2022

Neutrophil Extracellular Traps Caused by Gut Leakage Trigger the Autoimmune Response in Nonobese Diabetic Mice.

Frontiers in immunology

You Q,Shen Y,Wu Y,Li Y,Liu C,Huang F,Gu HF,Wu J

Wed Feb 23 00:00:00 EST 2022

Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.

Alcohol (Fayetteville, N.Y.)

Chen M,Sun X,Wei W,Cucarella C,Martín-Sanz P,Casado M,Pi L,Ren B,Cao Q

Sat May 01 00:00:00 EDT 2021

Stress-induced phosphoprotein 1 restrains spinal cord ischaemia-reperfusion injury by modulating NF-κB signalling.

Journal of cellular and molecular medicine

Jin H,Ge X,Huan Z,Yao H,Xu C,Cai J

Wed Dec 01 00:00:00 EST 2021

GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis.

Blood science (Baltimore, Md.)

Yang X,Cong T,He H,Wang J

Thu Apr 01 00:00:00 EDT 2021

OGA is associated with deglycosylation of NONO and the KU complex during DNA damage repair.

Cell death & disease

Cui Y,Xie R,Zhang X,Liu Y,Hu Y,Li Y,Liu X,Yu X,Wu C

Wed Jun 16 00:00:00 EDT 2021

Histone H3 lysine-trimethylation markers are decreased by recombinant methioninase and increased by methotrexate at concentrations which inhibit methionine-addicted osteosarcoma cell proliferation.

Biochemistry and biophysics reports

Aoki Y,Tome Y,Han Q,Yamamoto J,Hamada K,Masaki N,Bouvet M,Nishida K,Hoffman RM

Wed Dec 01 00:00:00 EST 2021

Harpagide alleviate neuronal apoptosis and blood-brain barrier leakage by inhibiting TLR4/MyD88/NF-κB signaling pathway in Angiotensin II-induced microglial activation in vitro.

Chemico-biological interactions

Lu Y,Hao R,Hu Y,Wei Y,Xie Y,Shen Y,Rui Q,Yu G

Fri Oct 01 00:00:00 EDT 2021

Lactobacillus casei relieves liver injury by regulating immunity and suppression of the enterogenic endotoxin-induced inflammatory response in rats cotreated with alcohol and iron.

Food science & nutrition

Li X,Han J,Liu Y,Liang H

Fri Oct 01 00:00:00 EDT 2021

Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans.

The EMBO journal

Liu C,Liu H,Zhang H,Wang L,Li M,Cai F,Wang X,Wang L,Zhang R,Yang S,Liu W,Liang Y,Wang L,Song X,Su S,Gao H,Jiang J,Li J,Luo M,Gao F,Chen Q,Li W,Chen ZJ

Thu Jul 01 00:00:00 EDT 2021

miR-937-5p targets SOX17 to modulate breast cancer cell cycle and cell proliferation through the Wnt signaling pathway.

Cellular signalling

Xiong X,Xu W,Gong J,Wang L,Dai M,Chen G,Yuan L

Fri Jan 01 00:00:00 EST 2021

Propofol Inhibits Ischemia/Reperfusion-Induced Cardiotoxicity Through the Protein Kinase C/Nuclear Factor Erythroid 2-Related Factor Pathway.

Frontiers in pharmacology

Li S,Lei Z,Zhao M,Hou Y,Wang D,Xu X,Lin X,Li J,Tang S,Yu J,Meng T

Tue Jun 01 00:00:00 EDT 2021

Buyang Huanwu Decoction Enhances Revascularization via Akt/GSK3β/NRF2 Pathway in Diabetic Hindlimb Ischemia.

Oxidative medicine and cellular longevity

Bao XY,Deng LH,Huang ZJ,Daror AS,Wang ZH,Jin WJ,Zhuang Z,Tong Q,Zheng GQ,Wang Y

Tue Feb 22 00:00:00 EST 2022

PD-L1 lncRNA splice isoform promotes lung adenocarcinoma progression via enhancing c-Myc activity.

Genome biology

Qu S,Jiao Z,Lu G,Yao B,Wang T,Rong W,Xu J,Fan T,Sun X,Yang R,Wang J,Yao Y,Xu G,Yan X,Wang T,Liang H,Zen K

Tue Apr 13 00:00:00 EDT 2021

Nucleolar and spindle‑associated protein 1 promotes non‑small cell lung cancer progression and serves as an effector of myocyte enhancer factor 2D.

Oncology reports

Ling B,Wei P,Xiao J,Cen B,Wei H,Feng X,Ye G,Li S,Zhang Z,Liang W,Huang S,Huang W

Mon Mar 01 00:00:00 EST 2021

Yixin-Fumai granules improve sick sinus syndrome in aging mice through Nrf-2/HO-1 pathway: A new target for sick sinus syndrome.

Journal of ethnopharmacology

Zhang H,Li L,Hao M,Chen K,Lu Y,Qi J,Chen W,Ren L,Cai X,Chen C,Liu Z,Zhao B,Li Z,Hou P

Wed Sep 15 00:00:00 EDT 2021

Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo.

Chinese medicine

Liu Y,Zhou J,Luo Y,Li J,Shang L,Zhou F,Yang S

Mon Nov 29 00:00:00 EST 2021

5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats.

Aging

Liu L,Zhang P,Zhang Z,Liang Y,Chen H,He Z,Sun X,Guo Z,Deng Y

Tue Apr 20 00:00:00 EDT 2021

Chinese Herbal Preparation SaiLuoTong Alleviates Brain Ischemia via Nrf2 Antioxidation Pathway-Dependent Cerebral Microvascular Protection.

Frontiers in pharmacology

Fan XD,Yao MJ,Yang B,Han X,Zhang YH,Wang GR,Li P,Xu L,Liu JX

Sat Nov 20 00:00:00 EST 2021

Proteomic analysis of lung cancer cells reveals a critical role of BCAT1 in cancer cell metastasis.

Theranostics

Mao L,Chen J,Lu X,Yang C,Ding Y,Wang M,Zhang Y,Tian Y,Li X,Fu Y,Yang Y,Gu Y,Gao F,Huang J,Liao L

Mon Feb 07 00:00:00 EST 2022

Hexavalent chromium inhibits the formation of neutrophil extracellular traps and promotes the apoptosis of neutrophils via AMPK signaling pathway.

Ecotoxicology and environmental safety

Ma Y,Li S,Ye S,Tang S,Hu D,Wei L,Xiao F

Fri Oct 15 00:00:00 EDT 2021

Hexavalent chromium inhibits the formation of neutrophil extracellular traps and promotes the apoptosis of neutrophils via AMPK signaling pathway.

Ecotoxicology and environmental safety

Ma Y,Li S,Ye S,Tang S,Hu D,Wei L,Xiao F

Fri Oct 15 00:00:00 EDT 2021

BCL7C suppresses ovarian cancer growth by inactivating mutant p53.

Journal of molecular cell biology

Huang C,Hao Q,Shi G,Zhou X,Zhang Y

Fri May 07 00:00:00 EDT 2021

Exogenous H₂ S prevents the nuclear translocation of PDC-E1 and inhibits vascular smooth muscle cell proliferation in the diabetic state.

Journal of cellular and molecular medicine

Zhang L,Jiang X,Liu N,Li M,Kang J,Chen L,Tang J,Dong S,Lu F,Zhang W

Wed Sep 01 00:00:00 EDT 2021

Ulinastatin protects against acetaminophen-induced liver injury by alleviating ferroptosis via the SIRT1/NRF2/HO-1 pathway.

American journal of translational research

Wang C,Liu T,Tong Y,Cui R,Qu K,Liu C,Zhang J

Tue Jul 27 00:00:00 EDT 2021

The scaffold protein IQGAP1 links heat-induced stress signals to alternative splicing regulation in gastric cancer cells.

Oncogene

Birladeanu AM,Rogalska M,Potiri M,Papadaki V,Andreadou M,Kontoyiannis DL,Lewis JD,Erpapazoglou Z,Kafasla P

Wed Sep 01 00:00:00 EDT 2021

BATF Regulates T Regulatory Cell Functional Specification and Fitness of Triglyceride Metabolism in Restraining Allergic Responses.

Journal of immunology (Baltimore, Md. : 1950)

Xu C,Fu Y,Liu S,Trittipo J,Lu X,Qi R,Du H,Yan C,Zhang C,Wan J,Kaplan MH,Yang K

Sat May 01 00:00:00 EDT 2021

Curcumin hinders PBDE-47-induced neutrophil extracellular traps release via Nrf2-associated ROS inhibition.

Ecotoxicology and environmental safety

Ye S,Li S,Ma Y,Hu D,Xiao F

Wed Dec 01 00:00:00 EST 2021

Curcumin hinders PBDE-47-induced neutrophil extracellular traps release via Nrf2-associated ROS inhibition.

Ecotoxicology and environmental safety

Ye S,Li S,Ma Y,Hu D,Xiao F

Wed Dec 01 00:00:00 EST 2021

Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells.

Archives of pharmacal research

Wang J,Su Q,Wu Q,Chen K,Ullah A,Ghauri MA,Zhang Y

Mon Nov 01 00:00:00 EDT 2021

Kaempferide enhances antioxidant capacity to promote osteogenesis through FoxO1/β-catenin signaling pathway.

European journal of pharmacology

Ma X,Tian Y,Xue K,Huai Y,Patil S,Deng X,Hao Q,Li D,Miao Z,Zhang W,Qian A

Mon Nov 15 00:00:00 EST 2021

Protective effects of oridonin against cerebral ischemia/reperfusion injury by inhibiting the NLRP3 inflammasome activation.

Tissue & cell

Jia Y,Tong Y,Min L,Li Y,Cheng Y

Sun Aug 01 00:00:00 EDT 2021

Virtual screening identified natural Keap1-Nrf2 PPI inhibitor alleviates inflammatory osteoporosis through Nrf2-mir214-Traf3 axis.

Free radical biology & medicine

Hong J,Shi Z,Li C,Ji X,Li S,Chen Y,Jiang G,Shi M,Wang W,Zhang Y,Hu B,Yan S

Sun Aug 01 00:00:00 EDT 2021

New insights into Vitamin C function: Vitamin C induces JAK2 activation through its receptor-like transporter SVCT2.

International journal of biological macromolecules

Han Z,Zhang Z,Guan Y,Chen B,Yu M,Zhang L,Fang J,Gao Y,Guo Z

Mon Mar 15 00:00:00 EDT 2021

Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo.

Oxidative medicine and cellular longevity

Lu S,Song Y,Luo R,Li S,Li G,Wang K,Liao Z,Wang B,Ke W,Xiang Q,Chen C,Wu X,Zhang Y,Ling L,Yang C

Thu Sep 09 00:00:00 EDT 2021

The molecular basis of tight nuclear tethering and inactivation of cGAS.

Nature

Zhao B,Xu P,Rowlett CM,Jing T,Shinde O,Lei Y,West AP,Liu WR,Li P

Sun Nov 01 00:00:00 EDT 2020

The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor.

Signal transduction and targeted therapy

Ouyang L,Yan B,Liu Y,Mao C,Wang M,Liu N,Wang Z,Liu S,Shi Y,Chen L,Wang X,Cheng Y,Cao Y,Xiao D,Zhang L,Liu S,Tao Y

Wed Jun 17 00:00:00 EDT 2020

TGFB1-induced autophagy affects the pattern of pancreatic cancer progression in distinct ways depending on SMAD4 status.

Autophagy

Liang C,Xu J,Meng Q,Zhang B,Liu J,Hua J,Zhang Y,Shi S,Yu X

Sun Mar 01 00:00:00 EST 2020

Pseudorabies Virus Infection of Epithelial Cells Leads to Persistent but Aberrant Activation of the NF-κB Pathway, Inhibiting Hallmark NF-κB-Induced Proinflammatory Gene Expression.

Journal of virology

Romero N,Van Waesberghe C,Favoreel HW

Mon May 04 00:00:00 EDT 2020

FERMT1 promotes gastric cancer progression by activating the NF-κB pathway and predicts poor prognosis.

Cancer biology & therapy

Fan H,Zhang S,Zhang Y,Liang W,Cao B

Tue Sep 01 00:00:00 EDT 2020

MFP-FePt-GO Nanocomposites Promote Radiosensitivity of Non-Small Cell Lung Cancer Via Activating Mitochondrial-Mediated Apoptosis and Impairing DNA Damage Repair.

International journal of biological sciences

Peng S,Sun Y,Luo Y,Ma S,Sun W,Tang G,Li S,Zhang N,Ren J,Xiao Y,Liu X,Zhang J,Gong Y,Xie C

Mon Nov 15 00:00:00 EST 2021

Capsaicin suppressed activity of prostate cancer stem cells by inhibition of Wnt/β-catenin pathway.

Phytotherapy research : PTR

Zhu M,Yu X,Zheng Z,Huang J,Yang X,Shi H

Wed Apr 01 00:00:00 EDT 2020

Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition.

European journal of medicinal chemistry

Fan C,Zhong T,Yang H,Yang Y,Wang D,Yang X,Xu Y,Fan Y

Sun Mar 15 00:00:00 EDT 2020

Ochratoxin A induces reprogramming of glucose metabolism by switching energy metabolism from oxidative phosphorylation to glycolysis in human gastric epithelium GES-1 cells in vitro.

Toxicology letters

Wang Y,Zhao M,Cui J,Wu X,Li Y,Wu W,Zhang X

Thu Oct 15 00:00:00 EDT 2020

TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress.

Theranostics

Zhou K,Zheng Z,Li Y,Han W,Zhang J,Mao Y,Chen H,Zhang W,Liu M,Xie L,Zhang H,Xu H,Xiao J

Fri May 28 00:00:00 EDT 2021

δ-Catenin regulates proliferation and apoptosis in renal cell carcinoma via promoting β-catenin nuclear localization and activating its downstream target genes.

Cancer medicine

Ju L,Shan L,Yin B,Song Y

Sun Mar 01 00:00:00 EST 2020

CCAAT/Enhancer-Binding Protein β Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor.

Journal of diabetes research

Li T,Cai X,Wang X,Zhang X,Zhang H,Xu B,Li S,Hu J,Wu Q

Wed Jan 06 00:00:00 EST 2021

Rosmarinic Acid Alleviates Inflammation, Apoptosis, and Oxidative Stress through Regulating miR-155-5p in a Mice Model of Parkinson's Disease.

ACS chemical neuroscience

Lv R,Du L,Zhou F,Yuan X,Liu X,Zhang L

Wed Oct 21 00:00:00 EDT 2020

Oxymatrine Attenuates Dopaminergic Neuronal Damage and Microglia-Mediated Neuroinflammation Through Cathepsin D-Dependent HMGB1/TLR4/NF-κB Pathway in Parkinson's Disease.

Frontiers in pharmacology

Gan P,Ding L,Hang G,Xia Q,Huang Z,Ye X,Qian X

Mon Sep 28 00:00:00 EDT 2020

Oxymatrine Inhibits Renal Cell Carcinoma Progression by Suppressing β-Catenin Expression.

Frontiers in pharmacology

Jin Y,Liu J,Liu Y,Liu Y,Guo G,Yu S,An R

Fri Apr 15 00:00:00 EDT 2022

Spinal N-Cadherin/CREB Signaling Contributes to Chronic Alcohol Consumption-Enhanced Postsurgical Pain.

Journal of pain research

Ma Y,Zhang X,Li C,Liu S,Xing Y,Tao F

Sat Apr 16 00:00:00 EDT 2022

GSPE alleviates renal fibrosis by inhibiting the activation of C3/ HMGB1/ TGF-β1 pathway.

Chemico-biological interactions

Wang K,Wei H,Zhan J,Liang X,Zhang C,Liu Y,Xu G

Sat Jan 25 00:00:00 EST 2020

USP38 regulates the stemness and chemoresistance of human colorectal cancer via regulation of HDAC3.

Oncogenesis

Zhan W,Liao X,Liu J,Tian T,Yu L,Li R

Wed May 13 00:00:00 EDT 2020

Insulin Promotes Corneal Nerve Repair and Wound Healing in Type 1 Diabetic Mice by Enhancing Wnt/β-Catenin Signaling.

The American journal of pathology

Yang S,Zhang Y,Zhang Z,Dan J,Zhou Q,Wang X,Li W,Zhou L,Yang L,Xie L

Sun Nov 01 00:00:00 EDT 2020

CLPTM1L induces estrogen receptor β signaling-mediated radioresistance in non-small cell lung cancer cells.

Cell communication and signaling : CCS

Li H,Che J,Jiang M,Cui M,Feng G,Dong J,Zhang S,Lu L,Liu W,Fan S

Thu Sep 17 00:00:00 EDT 2020

Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis.

Autophagy

Wang H,Wang N,Xu D,Ma Q,Chen Y,Xu S,Xia Q,Zhang Y,Prehn JHM,Wang G,Ying Z

Tue Sep 01 00:00:00 EDT 2020

Hsa-miR-425-5p promotes tumor growth and metastasis by activating the CTNND1-mediated β-catenin pathway and EMT in colorectal cancer.

Cell cycle (Georgetown, Tex.)

Liu D,Zhang H,Cui M,Chen C,Feng Y

Sat Aug 01 00:00:00 EDT 2020

LncRNA MALAT1 Affects Mycoplasma pneumoniae Pneumonia via NF-κB Regulation.

Frontiers in cell and developmental biology

Gu H,Zhu Y,Zhou Y,Huang T,Zhang S,Zhao D,Liu F

Tue Nov 03 00:00:00 EST 2020

Poricoic acid A as a modulator of TPH-1 expression inhibits renal fibrosis via modulating protein stability of β-catenin and β-catenin-mediated transcription.

Therapeutic advances in chronic disease

Chen DQ,Wu XQ,Chen L,Hu HH,Wang YN,Zhao YY

Sun Apr 17 00:00:00 EDT 2022

Emodin inhibiting neutrophil elastase-induced epithelial-mesenchymal transition through Notch1 signalling in alveolar epithelial cells.

Journal of cellular and molecular medicine

Zhou L,Gao R,Hong H,Li X,Yang J,Shen W,Wang Z,Yang J

Thu Oct 01 00:00:00 EDT 2020

NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology.

Cellular & molecular immunology

He X,Yang W,Zeng Z,Wei Y,Gao J,Zhang B,Li L,Liu L,Wan Y,Zeng Q,Gong Z,Liu L,Zhang H,Li Y,Yang S,Hu T,Wu L,Masliah E,Huang S,Cao H

Sun Mar 01 00:00:00 EST 2020

LYW-6, a novel cryptotanshinone derived STAT3 targeting inhibitor, suppresses colorectal cancer growth and metastasis.

Pharmacological research

Wang H,Liu Z,Guan L,Li J,Chen S,Yu W,Lai M

Sun Mar 01 00:00:00 EST 2020

PGN and LTA from Staphylococcus aureus Induced Inflammation and Decreased Lactation through Regulating DNA Methylation and Histone H3 Acetylation in Bovine Mammary Epithelial Cells.

Toxins

Wu Y,Chen J,Sun Y,Dong X,Wang Z,Chen J,Dong G

Thu Apr 09 00:00:00 EDT 2020

PIGU promotes hepatocellular carcinoma progression through activating NF-κB pathway and increasing immune escape.

Life sciences

Wei X,Yang W,Zhang F,Cheng F,Rao J,Lu L

Sun Nov 01 00:00:00 EDT 2020

Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways.

Toxicology and applied pharmacology

Ma Z,Lu Y,Yang F,Li S,He X,Gao Y,Zhang G,Ren E,Wang Y,Kang X

Sun Apr 19 00:00:00 EDT 2020

The Wnt/β-catenin/VASP positive feedback loop drives cell proliferation and migration in breast cancer.

Oncogene

Li K,Zhang J,Tian Y,He Y,Xu X,Pan W,Gao Y,Chen F,Wei L

Sun Mar 01 00:00:00 EST 2020

Cathelicidin Modulates Vascular Smooth Muscle Cell Phenotypic Switching through ROS/IL-6 Pathway.

Antioxidants (Basel, Switzerland)

Dong X,Wu D,Zhang Y,Jia L,Pan X,Sun J,Pan LL

Fri Jun 05 00:00:00 EDT 2020

Daphnetin ameliorates glucocorticoid-induced osteoporosis via activation of Wnt/GSK-3β/β-catenin signaling.

Toxicology and applied pharmacology

Wang Y,Chen J,Chen J,Dong C,Yan X,Zhu Z,Lu P,Song Z,Liu H,Chen S

Tue Dec 15 00:00:00 EST 2020

EHF promotes colorectal carcinoma progression by activating TGF-β1 transcription and canonical TGF-β signaling.

Cancer science

Wang L,Ai M,Nie M,Zhao L,Deng G,Hu S,Han Y,Zeng W,Wang Y,Yang M,Wang S

Wed Jul 01 00:00:00 EDT 2020

Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.

Redox biology

Wang Y,Chen J,Li S,Zhang X,Guo Z,Hu J,Shao X,Song N,Zhao Y,Li H,Yang G,Xu C,Wei C

Fri May 01 00:00:00 EDT 2020

TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents.

Experimental and therapeutic medicine

Yang H,Chen Y,Jiang Y,Wang D,Yan J,Zhou Z

Sat Aug 01 00:00:00 EDT 2020

Bclaf1 is a direct target of HIF-1 and critically regulates the stability of HIF-1α under hypoxia.

Oncogene

Shao A,Lang Y,Wang M,Qin C,Kuang Y,Mei Y,Lin D,Zhang S,Tang J

Sun Mar 01 00:00:00 EST 2020

Extracellular Vesicles From Adipose Tissue-Derived Stem Cells Affect Notch-miR148a-3p Axis to Regulate Polarization of Macrophages and Alleviate Sepsis in Mice.

Frontiers in immunology

Bai X,Li J,Li L,Liu M,Liu Y,Cao M,Tao K,Xie S,Hu D

Mon Apr 05 00:00:00 EDT 2021

Notch signal deficiency alleviates hypertrophic scar formation after wound healing through the inhibition of inflammation.

Archives of biochemistry and biophysics

He T,Bai X,Jing J,Liu Y,Wang H,Zhang W,Li X,Li Y,Wang L,Xie S,Hu D

Mon Mar 30 00:00:00 EDT 2020

CaCBL1 Acts as a Positive Regulator in Pepper Response to Ralstonia solanacearum.

Molecular plant-microbe interactions : MPMI

Shen L,Yang S,Yang F,Guan D,He S

Wed Jul 01 00:00:00 EDT 2020

Deletion of newly described pro-survival molecule Pellino-1 increases oxidative stress, downregulates cIAP2/NF-κB cell survival pathway, reduces angiogenic response, and thereby aggravates tissue function in mouse ischemic models.

Basic research in cardiology

Selvaraju V,Thirunavukkarasu M,Joshi M,Oriowo B,Shaikh IA,Rishi MT,Tapias L,Coca-Soliz V,Saad I,Campbell J,Pradeep SR,Swaminathan S,Yee SP,McFadden DW,Alexander Palesty J,Maulik N

Sun Jun 14 00:00:00 EDT 2020

N⁶-Methyladenosine co-transcriptionally directs the demethylation of histone H3K9me2.

Nature genetics

Li Y,Xia L,Tan K,Ye X,Zuo Z,Li M,Xiao R,Wang Z,Liu X,Deng M,Cui J,Yang M,Luo Q,Liu S,Cao X,Zhu H,Liu T,Hu J,Shi J,Xiao S,Xia L

Tue Sep 01 00:00:00 EDT 2020

lncMGPF is a novel positive regulator of muscle growth and regeneration.

Journal of cachexia, sarcopenia and muscle

Lv W,Jin J,Xu Z,Luo H,Guo Y,Wang X,Wang S,Zhang J,Zuo H,Bai W,Peng Y,Tang J,Zhao S,Zuo B

Tue Dec 01 00:00:00 EST 2020

C9orf72 associates with inactive Rag GTPases and regulates mTORC1-mediated autophagosomal and lysosomal biogenesis.

Aging cell

Wang M,Wang H,Tao Z,Xia Q,Hao Z,Prehn JHM,Zhen X,Wang G,Ying Z

Wed Apr 01 00:00:00 EDT 2020

Silibinin ameliorats H₂O₂-induced cell apoptosis and oxidative stress response by activating Nrf2 signaling in trophoblast cells.

Acta histochemica

Guo H,Wang Y,Liu D

Tue Dec 01 00:00:00 EST 2020

Sevoflurane Exposure Induces Neuronal Cell Parthanatos Initiated by DNA Damage in the Developing Brain via an Increase of Intracellular Reactive Oxygen Species.

Frontiers in cellular neuroscience

Piao M,Wang Y,Liu N,Wang X,Chen R,Qin J,Ge P,Feng C

Tue Jan 12 00:00:00 EST 2021

1,25-dihydroxyvitamin D3 signaling-induced decreases in IRX4 inhibits NANOG-mediated cancer stem-like properties and gefitinib resistance in NSCLC cells.

Cell death & disease

Jia Z,Zhang Y,Yan A,Wang M,Han Q,Wang K,Wang J,Qiao C,Pan Z,Chen C,Hu D,Ding X

Thu Aug 20 00:00:00 EDT 2020

Non-Esterified Fatty Acid-Induced Reactive Oxygen Species Mediated Granulosa Cells Apoptosis Is Regulated by Nrf2/p53 Signaling Pathway.

Antioxidants (Basel, Switzerland)

Wang Y,Li C,Li J,Wang G,Li L

Sun Jun 14 00:00:00 EDT 2020

WISP-2, an upregulated gene in hip cartilage from the DDH model rats, induces chondrocyte apoptosis through PPARγ in vitro.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Ji X,Liu T,Zhao S,Li J,Li L,Wang E

Wed Apr 01 00:00:00 EDT 2020

Zbtb20 deficiency causes cardiac contractile dysfunction in mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Ren AJ,Chen C,Zhang S,Liu M,Wei C,Wang K,Ma X,Song Y,Wang R,Zhang H,Chen YX,Wu H,Xie Z,Zhang Y,Zhang WJ

Thu Oct 01 00:00:00 EDT 2020

PCNA and GSK3β interact with each other to regulate H1299 lung adenocarcinoma cells apoptosis.

Neoplasma

Liu XH,Tang DE,Dai Y,Gao XJ,Liu LX

Wed Jan 01 00:00:00 EST 2020

GDF15 induced by compressive force contributes to osteoclast differentiation in human periodontal ligament cells.

Experimental cell research

Li S,Li Q,Zhu Y,Hu W

Sat Feb 01 00:00:00 EST 2020

ABA-responsive ABRE-BINDING FACTOR3 activates DAM3 expression to promote bud dormancy in Asian pear.

Plant, cell & environment

Yang Q,Yang B,Li J,Wang Y,Tao R,Yang F,Wu X,Yan X,Ahmad M,Shen J,Bai S,Teng Y

Mon Jun 01 00:00:00 EDT 2020

miR-766-3p Targeting BCL9L Suppressed Tumorigenesis, Epithelial-Mesenchymal Transition, and Metastasis Through the β-Catenin Signaling Pathway in Osteosarcoma Cells.

Frontiers in cell and developmental biology

Zhang S,Chen H,Liu W,Fang L,Qian Z,Kong R,Zhang Q,Li J,Cao X

Thu Nov 30 00:00:00 EST 2023

MicroRNA-34a Inhibition Alleviates Lung Injury in Cecal Ligation and Puncture Induced Septic Mice.

Frontiers in immunology

Chen S,Ding R,Hu Z,Yin X,Xiao F,Zhang W,Yan S,Lv C

Mon Apr 12 00:00:00 EDT 2021

Echinacea polysaccharide alleviates LPS-induced lung injury via inhibiting inflammation, apoptosis and activation of the TLR4/NF-κB signal pathway.

International immunopharmacology

Zhang H,Lang W,Wang S,Li B,Li G,Shi Q

Sun Nov 01 00:00:00 EDT 2020

Computational repositioning of dimethyl fumarate for treating alcoholic liver disease.

Cell death & disease

Zhang Y,Zhao S,Fu Y,Yan L,Feng Y,Chen Y,Wu Y,Deng Y,Zhang G,Chen Z,Chen Y,Liu T

Tue Aug 18 00:00:00 EDT 2020

RNA binding protein FXR1-miR301a-3p axis contributes to p21WAF1 degradation in oral cancer.

PLoS genetics

Majumder M,Palanisamy V

Wed Jan 01 00:00:00 EST 2020

Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2-KEAP1-CUL3 Interactions in Chronic Kidney Disease.

Antioxidants (Basel, Switzerland)

Sun B,Wang X,Liu X,Wang L,Ren F,Wang X,Leng X

Tue Aug 25 00:00:00 EDT 2020

Acetylharpagide Protects Mice from Staphylococcus Aureus-Induced Acute Lung Injury by Inhibiting NF-κB Signaling Pathway.

Molecules (Basel, Switzerland)

Zhang Z,Wang Y,Shan Y,Yin W

Wed Nov 25 00:00:00 EST 2020

NFE2L3 promotes malignant behavior and EMT of human hepatocellular carcinoma (HepG2) cells via Wnt/β‑catenin pathway.

Journal of Cancer

Ren Y,Wang Y,Hao S,Yang Y,Xiong W,Qiu L,Tao J,Tang A

Sat Oct 31 00:00:00 EDT 2020

RGFP966 Suppresses Tumor Growth and Migration Through Inhibition of EGFR Expression in Hepatocellular Carcinoma Cells in vitro.

Drug design, development and therapy

Yu X,Yang F,Jiang H,Fan L

Tue Dec 22 00:00:00 EST 2020

A Novel STAT3-Mediated GATA6 Pathway Contributes to tert-Butylhydroquinone- (tBHQ-) Protected TNFα-Activated Vascular Cell Adhesion Molecule 1 (VCAM-1) in Vascular Endothelium.

Oxidative medicine and cellular longevity

Zhou L,Ning H,Wei H,Xu T,Zhao X,Fu A,Qian Q,Yang Z,Dou X,Li S

Thu May 20 00:00:00 EDT 2021

MiR-146a down-regulates inflammatory response by targeting TLR3 and TRAF6 in Coxsackievirus B infection.

RNA (New York, N.Y.)

Fei Y,Chaulagain A,Wang T,Chen Y,Liu J,Yi M,Wang Y,Huang Y,Lin L,Chen S,Xu W,Tong L,Wu X,Zhao D,Zhang F,Zhao W,Zhong Z

Wed Jan 01 00:00:00 EST 2020

Comprehensive identification of signaling pathways for idiopathic pulmonary arterial hypertension.

American journal of physiology. Cell physiology

Liu B,Zhu L,Yuan P,Marsboom G,Hong Z,Liu J,Zhang P,Hu Q

Fri May 01 00:00:00 EDT 2020

BRAHMA-interacting proteins BRIP1 and BRIP2 are core subunits of Arabidopsis SWI/SNF complexes.

Nature plants

Yu Y,Liang Z,Song X,Fu W,Xu J,Lei Y,Yuan L,Ruan J,Chen C,Fu W,Cui Y,Huang S,Li C

Sat Aug 01 00:00:00 EDT 2020

mTORC1-dependent TFEB nucleus translocation and pro-survival autophagy induced by zeolitic imidazolate framework-8.

Biomaterials science

Ding H,Song Y,Huang X,Wang L,Luo S,Zhang H,Pan H,Jiang W,Qian J,Yao G,Wen L,Zhang Y

Tue Jul 28 00:00:00 EDT 2020

Camptothecin induced DDX5 degradation increased the camptothecin resistance of osteosarcoma.

Experimental cell research

Zhao X,Bao M,Zhang F,Wang W

Tue Sep 15 00:00:00 EDT 2020

Antiviral Activity of Feline BCA2 Is Mainly Dependent on Its Interference With Proviral Transcription Rather Than Degradation of FIV Gag.

Frontiers in microbiology

Qu M,Wang W,Li W,Cao J,Zhang X,Wang C,Wu J,Yu B,Zhang H,Wu H,Kong W,Yu X

Mon Sep 28 00:00:00 EDT 2020

Metformin promotes osteogenic differentiation and protects against oxidative stress-induced damage in periodontal ligament stem cells via activation of the Akt/Nrf2 signaling pathway.

Experimental cell research

Jia L,Xiong Y,Zhang W,Ma X,Xu X

Wed Jan 15 00:00:00 EST 2020

Intracellular expression of arginine deiminase activates the mitochondrial apoptosis pathway by inhibiting cytosolic ferritin and inducing chromatin autophagy.

BMC cancer

Feng Q,Bian X,Liu X,Wang Y,Zhou H,Ma X,Quan C,Yao Y,Zheng Z

Thu Jul 16 00:00:00 EDT 2020

Targeting the NCOA3-SP1-TERT axis for tumor growth in hepatocellular carcinoma.

Cell death & disease

Li W,Yan Y,Zheng Z,Zhu Q,Long Q,Sui S,Luo M,Chen M,Li Y,Hua Y,Deng W,Lai R,Li L

Wed Nov 25 00:00:00 EST 2020

Functional analysis of MTF-1 and MT promoters and their transcriptional response to zinc (Zn) and copper (Cu) in yellow catfish Pelteobagrus fulvidraco.

Chemosphere

Chen GH,Lv W,Xu YH,Wei XL,Xu YC,Luo Z

Fri May 01 00:00:00 EDT 2020

Curcumin Protects Human Trophoblast HTR8/SVneo Cells from H₂O₂-Induced Oxidative Stress by Activating Nrf2 Signaling Pathway.

Antioxidants (Basel, Switzerland)

Qi L,Jiang J,Zhang J,Zhang L,Wang T

Sat Feb 01 00:00:00 EST 2020

Glutathione S-transferases P1-mediated interleukin-6 in tumor-associated macrophages augments drug-resistance in MCF-7 breast cancer.

Biochemical pharmacology

Dong X,Sun R,Wang J,Yu S,Cui J,Guo Z,Pan X,Sun J,Yang J,Pan LL

Tue Dec 01 00:00:00 EST 2020

Berberine protects against diabetic retinopathy by inhibiting cell apoptosis via deactivation of the NF‑κB signaling pathway.

Molecular medicine reports

Zhai J,Li Z,Zhang H,Ma L,Ma Z,Zhang Y,Zou J,Li M,Ma L,Wang X,Li X

Sun Nov 01 00:00:00 EDT 2020

The bromodomain containing protein BRD-9 orchestrates RAD51-RAD54 complex formation and regulates homologous recombination-mediated repair.

Nature communications

Zhou Q,Huang J,Zhang C,Zhao F,Kim W,Tu X,Zhang Y,Nowsheen S,Zhu Q,Deng M,Chen Y,Qin B,Luo K,Liu B,Lou Z,Mutter RW,Yuan J

Tue May 26 00:00:00 EDT 2020

Histone chaperone FACT represses retrotransposon MERVL and MERVL-derived cryptic promoters.

Nucleic acids research

Chen F,Zhang W,Xie D,Gao T,Dong Z,Lu X

Fri Oct 09 00:00:00 EDT 2020

Mechanisms by which electroacupuncture‑mediated histone acetylation mitigates bone loss in rats with ovariectomy‑induced osteoporosis.

Molecular medicine reports

Shu Q,Shao Y,Liu R,Hu Y,Peng Z,Tian J

Thu Oct 01 00:00:00 EDT 2020

ARID1A-dependent permissive chromatin accessibility licenses estrogen-receptor signaling to regulate circadian rhythms genes in endometrial cancer.

Cancer letters

Hu H,Chen Z,Ji L,Wang Y,Yang M,Lai R,Zhong Y,Zhang X,Wang L

Sun Nov 01 00:00:00 EDT 2020

Effects of taraxasterol against ethanol and high-fat diet-induced liver injury by regulating TLR4/MyD88/NF-κB and Nrf2/HO-1 signaling pathways.

Life sciences

Li Z,Lian Y,Wei R,Jin L,Cao H,Zhao T,Ma X,Zhong M,Gao Y,Zhang K

Tue Dec 01 00:00:00 EST 2020

TRIM59 Protects Mice From Sepsis by Regulating Inflammation and Phagocytosis in Macrophages.

Frontiers in immunology

Jin Z,Zhu Z,Liu S,Hou Y,Tang M,Zhu P,Tian Y,Li D,Yan D,Zhu X

Thu Mar 25 00:00:00 EDT 2021

The interaction of lead exposure and CCM3 defect plays an important role in regulating angiogenesis through eNOS/NO pathway.

Environmental toxicology and pharmacology

Sun Y,Zhao Z,Zhang H,Li J,Chen J,Luan X,Min W,He Y

Thu Oct 01 00:00:00 EDT 2020

Calcium Channel Blocker Nifedipine Suppresses Colorectal Cancer Progression and Immune Escape by Preventing NFAT2 Nuclear Translocation.

Cell reports

Wu L,Lin W,Liao Q,Wang H,Lin C,Tang L,Lian W,Chen Z,Li K,Xu L,Zhou R,Ding Y,Zhao L

Tue Oct 27 00:00:00 EDT 2020

Active Peptide KF-8 from Rice Bran Attenuates Oxidative Stress in a Mouse Model of Aging Induced by d-Galactose.

Journal of agricultural and food chemistry

Wang Y,Cui X,Lin Q,Cai J,Tang L,Liang Y

Wed Nov 04 00:00:00 EST 2020

A Noncoding Regulatory RNAs Network Driven by Circ-CDYL Acts Specifically in the Early Stages Hepatocellular Carcinoma.

Hepatology (Baltimore, Md.)

Wei Y,Chen X,Liang C,Ling Y,Yang X,Ye X,Zhang H,Yang P,Cui X,Ren Y,Xin X,Li H,Wang R,Wang W,Jiang F,Liu S,Ding J,Zhang B,Li L,Wang H

Wed Jan 01 00:00:00 EST 2020

Novel poricoic acids attenuate renal fibrosis through regulating redox signalling and aryl hydrocarbon receptor activation.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Wang M,Hu HH,Chen YY,Chen L,Wu XQ,Zhao YY

Tue Dec 01 00:00:00 EST 2020

CHK2-FOXK axis promotes transcriptional control of autophagy programs.

Science advances

Chen Y,Wu J,Liang G,Geng G,Zhao F,Yin P,Nowsheen S,Wu C,Li Y,Li L,Kim W,Zhou Q,Huang J,Liu J,Zhang C,Guo G,Deng M,Tu X,Gao X,Liu Z,Chen Y,Lou Z,Luo K,Yuan J

Wed Jan 01 00:00:00 EST 2020

Protective effect of hydrogen sulfide on endothelial cells through Sirt1-FoxO1-mediated autophagy.

Annals of translational medicine

Zhu L,Duan W,Wu G,Zhang D,Wang L,Chen D,Chen Z,Yang B

Tue Dec 01 00:00:00 EST 2020

Exogenous CGRP Regulates Apoptosis and Autophagy to Alleviate Traumatic Brain Injury Through Akt/mTOR Signalling Pathway.

Neurochemical research

Tian J,Yang L,Wang P,Yang L,Fan Z

Tue Dec 01 00:00:00 EST 2020

lncRNA PCBP1-AS1 Aggravates the Progression of Hepatocellular Carcinoma via Regulating PCBP1/PRL-3/AKT Pathway.

Cancer management and research

Luo T,Gao Y,Zhangyuan G,Xu X,Xue C,Jin L,Zhang W,Zhu C,Sun B,Qin X

Sat Apr 16 00:00:00 EDT 2022

Karyopherin α 2 promotes proliferation, migration and invasion through activating NF-κB/p65 signaling pathways in melanoma cells.

Life sciences

Yang F,Li S,Cheng Y,Li J,Han X

Wed Jul 01 00:00:00 EDT 2020

TCF7L2 rs290487 C allele aberrantly enhances hepatic gluconeogenesis through allele-specific changes in transcription and chromatin binding.

Aging

Zhang X,Ye P,Huang H,Wang B,Dong F,Ling Q

Fri Jul 10 00:00:00 EDT 2020

MiR-146a-5p Mimic Inhibits NLRP3 Inflammasome Downstream Inflammatory Factors and CLIC4 in Neonatal Necrotizing Enterocolitis.

Frontiers in cell and developmental biology

Chen J,Chen T,Zhou J,Zhao X,Sheng Q,Lv Z

Tue Feb 16 00:00:00 EST 2021

An NF-κB-driven lncRNA orchestrates colitis and circadian clock.

Science advances

Wang S,Lin Y,Li F,Qin Z,Zhou Z,Gao L,Yang Z,Wang Z,Wu B

Thu Oct 01 00:00:00 EDT 2020

Interaction of BACH2 with FUS promotes malignant progression of glioma cells via the TSLNC8-miR-10b-5p-WWC3 pathway.

Molecular oncology

Yang Y,Liu X,Zheng J,Xue Y,Liu L,Ma J,Wang P,Yang C,Wang D,Shao L,Ruan X,Liu Y

Sun Nov 01 00:00:00 EDT 2020

Loganin and catalpol exert cooperative ameliorating effects on podocyte apoptosis upon diabetic nephropathy by targeting AGEs-RAGE signaling.

Life sciences

Chen Y,Chen J,Jiang M,Fu Y,Zhu Y,Jiao N,Liu L,Du Q,Wu H,Xu H,Sun J

Wed Jul 01 00:00:00 EDT 2020

Valproic acid targets HDAC1/2 and HDAC1/PTEN/Akt signalling to inhibit cell proliferation via the induction of autophagy in gastric cancer.

The FEBS journal

Sun J,Piao J,Li N,Yang Y,Kim KY,Lin Z

Fri May 01 00:00:00 EDT 2020

Inhibition of PIM1 attenuates the stem cell-like traits of breast cancer cells by promoting RUNX3 nuclear retention.

Journal of cellular and molecular medicine

Liu H,Chen C,Ma D,Li Y,Yin Q,Li Q,Xiang C

Mon Jun 01 00:00:00 EDT 2020

AKT/FOXO1 axis links cross-talking of endothelial cell and pericyte in TIE2-mutated venous malformations.

Cell communication and signaling : CCS

Si Y,Huang J,Li X,Fu Y,Xu R,Du Y,Cheng J,Jiang H

Mon Aug 31 00:00:00 EDT 2020

Laminar Flow Protects Vascular Endothelial Tight Junctions and Barrier Function via Maintaining the Expression of Long Non-coding RNA MALAT1.

Frontiers in bioengineering and biotechnology

Yang F,Zhang Y,Zhu J,Wang J,Jiang Z,Zhao C,Yang Q,Huang Y,Yao W,Pang W,Han L,Zhou J

Mon Sep 28 00:00:00 EDT 2020

HMGB1 Inhibits HNF1A to Modulate Liver Fibrogenesis via p65/miR-146b Signaling.

DNA and cell biology

Ge S,Wu X,Xiong Y,Xie J,Liu F,Zhang W,Yang L,Zhang S,Lai L,Huang J,Li M,Yu YQ

Tue Sep 01 00:00:00 EDT 2020

GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.

International immunopharmacology

Lang L,Xu B,Yuan J,Li S,Lian S,Chen Y,Guo J,Yang H

Tue Dec 01 00:00:00 EST 2020

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.

Cancer cell

Huang Y,Su R,Sheng Y,Dong L,Dong Z,Xu H,Ni T,Zhang ZS,Zhang T,Li C,Han L,Zhu Z,Lian F,Wei J,Deng Q,Wang Y,Wunderlich M,Gao Z,Pan G,Zhong D,Zhou H,Zhang N,Gan J,Jiang H,Mulloy JC,Qian Z,Chen J,Yang CG

Mon Apr 15 00:00:00 EDT 2019

TFEB Mediates Immune Evasion and Resistance to mTOR Inhibition of Renal Cell Carcinoma via Induction of PD-L1.

Clinical cancer research : an official journal of the American Association for Cancer Research

Zhang C,Duan Y,Xia M,Dong Y,Chen Y,Zheng L,Chai S,Zhang Q,Wei Z,Liu N,Wang J,Sun C,Tang Z,Cheng X,Wu J,Wang G,Zheng F,Laurence A,Li B,Yang XP

Fri Nov 15 00:00:00 EST 2019

HSPA12A Is a Novel Player in Nonalcoholic Steatohepatitis via Promoting Nuclear PKM2-Mediated M1 Macrophage Polarization.

Diabetes

Kong Q,Li N,Cheng H,Zhang X,Cao X,Qi T,Dai L,Zhang Z,Chen X,Li C,Li Y,Xue B,Fang L,Liu L,Ding Z

Fri Feb 01 00:00:00 EST 2019

HSPA12A Is a Novel Player in Nonalcoholic Steatohepatitis via Promoting Nuclear PKM2-Mediated M1 Macrophage Polarization.

Diabetes

Kong Q,Li N,Cheng H,Zhang X,Cao X,Qi T,Dai L,Zhang Z,Chen X,Li C,Li Y,Xue B,Fang L,Liu L,Ding Z

Fri Feb 01 00:00:00 EST 2019

5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson's disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells against oxidative stress.

Free radical biology & medicine

Xu LL,Wu YF,Yan F,Li CC,Dai Z,You QD,Jiang ZY,Di B

Mon Apr 01 00:00:00 EDT 2019

Free radical biology & medicine

Xu LL,Wu YF,Yan F,Li CC,Dai Z,You QD,Jiang ZY,Di B

Mon Apr 01 00:00:00 EDT 2019

CP-25 combined with MTX/ LEF ameliorates the progression of adjuvant-induced arthritis by the inhibition on GRK2 translocation.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Yang X,Zhao Y,Jia X,Wang C,Wu Y,Zhang L,Chang Y,Wei W

Fri Feb 01 00:00:00 EST 2019

CP-25 combined with MTX/ LEF ameliorates the progression of adjuvant-induced arthritis by the inhibition on GRK2 translocation.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Yang X,Zhao Y,Jia X,Wang C,Wu Y,Zhang L,Chang Y,Wei W

Fri Feb 01 00:00:00 EST 2019

CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in vivo through inhibition of HDAC6 to downregulate c-Myc expression.

Acta pharmacologica Sinica

Fu XH,Zhang X,Yang H,Xu XW,Hu ZL,Yan J,Zheng XL,Wei RR,Zhang ZQ,Tang SR,Geng MY,Huang X

Wed May 01 00:00:00 EDT 2019

CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in vivo through inhibition of HDAC6 to downregulate c-Myc expression.

Acta pharmacologica Sinica

Fu XH,Zhang X,Yang H,Xu XW,Hu ZL,Yan J,Zheng XL,Wei RR,Zhang ZQ,Tang SR,Geng MY,Huang X

Wed May 01 00:00:00 EDT 2019

OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice.

Biochimica et biophysica acta. Molecular basis of disease

Yuan C,Guo X,Zhou Q,Du F,Jiang W,Zhou X,Liu P,Chi T,Ji X,Gao J,Chen C,Lang H,Xu J,Liu D,Yang Y,Qiu S,Tang X,Chen G,Zou L

Tue Jan 01 00:00:00 EST 2019

OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice.

Biochimica et biophysica acta. Molecular basis of disease

Yuan C,Guo X,Zhou Q,Du F,Jiang W,Zhou X,Liu P,Chi T,Ji X,Gao J,Chen C,Lang H,Xu J,Liu D,Yang Y,Qiu S,Tang X,Chen G,Zou L

Tue Jan 01 00:00:00 EST 2019

Diminished membrane recruitment of Akt is instrumental in alcohol-associated osteopenia via the PTEN/Akt/GSK-3β/β-catenin axis.

The FEBS journal

Chen YX,Zhu DY,Gao J,Xu ZL,Tao SC,Yin WJ,Zhang YL,Gao YS,Zhang CQ

Fri Mar 01 00:00:00 EST 2019

Diminished membrane recruitment of Akt is instrumental in alcohol-associated osteopenia via the PTEN/Akt/GSK-3β/β-catenin axis.

The FEBS journal

Chen YX,Zhu DY,Gao J,Xu ZL,Tao SC,Yin WJ,Zhang YL,Gao YS,Zhang CQ

Fri Mar 01 00:00:00 EST 2019

Blockade of YAP alleviates hepatic fibrosis through accelerating apoptosis and reversion of activated hepatic stellate cells.

Molecular immunology

Yu HX,Yao Y,Bu FT,Chen Y,Wu YT,Yang Y,Chen X,Zhu Y,Wang Q,Pan XY,Meng XM,Huang C,Li J

Fri Mar 01 00:00:00 EST 2019

Blockade of YAP alleviates hepatic fibrosis through accelerating apoptosis and reversion of activated hepatic stellate cells.

Molecular immunology

Yu HX,Yao Y,Bu FT,Chen Y,Wu YT,Yang Y,Chen X,Zhu Y,Wang Q,Pan XY,Meng XM,Huang C,Li J

Fri Mar 01 00:00:00 EST 2019

Activation of brain endothelium by Escherichia coli K1 virulence factor cglD promotes polymorphonuclear leukocyte transendothelial migration.

Medical microbiology and immunology

Zhang K,Shi MJ,Niu Z,Chen X,Wei JY,Miao ZW,Zhao WD,Chen YH

Fri Feb 01 00:00:00 EST 2019

Activation of brain endothelium by Escherichia coli K1 virulence factor cglD promotes polymorphonuclear leukocyte transendothelial migration.

Medical microbiology and immunology

Zhang K,Shi MJ,Niu Z,Chen X,Wei JY,Miao ZW,Zhao WD,Chen YH

Fri Feb 01 00:00:00 EST 2019

Knockdown of cathepsin D protects dopaminergic neurons against neuroinflammation-mediated neurotoxicity through inhibition of NF-κB signalling pathway in Parkinson's disease model.

Clinical and experimental pharmacology & physiology

Gan P,Xia Q,Hang G,Zhou Y,Qian X,Wang X,Ding L

Mon Apr 01 00:00:00 EDT 2019

Knockdown of cathepsin D protects dopaminergic neurons against neuroinflammation-mediated neurotoxicity through inhibition of NF-κB signalling pathway in Parkinson's disease model.

Clinical and experimental pharmacology & physiology

Gan P,Xia Q,Hang G,Zhou Y,Qian X,Wang X,Ding L

Mon Apr 01 00:00:00 EDT 2019

HepaCAM Regulates Warburg Effect of Renal Cell Carcinoma via HIF-1α/NF-κB Signaling Pathway.

Urology

Fan Y,Ou L,Fan J,Li L,Wu X,Luo C,Gao Y,Niu L

Wed May 01 00:00:00 EDT 2019

HepaCAM Regulates Warburg Effect of Renal Cell Carcinoma via HIF-1α/NF-κB Signaling Pathway.

Urology

Fan Y,Ou L,Fan J,Li L,Wu X,Luo C,Gao Y,Niu L

Wed May 01 00:00:00 EDT 2019

Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-κB and CaSR.

Mediators of inflammation

Leng B,Zhang Y,Liu X,Zhang Z,Liu Y,Wang H,Lu M

Mon Jul 22 00:00:00 EDT 2019

Astragaloside IV Regulates the PI3K/Akt/HO-1 Signaling Pathway and Inhibits H9c2 Cardiomyocyte Injury Induced by Hypoxia-Reoxygenation.

Biological & pharmaceutical bulletin

Yang P,Zhou Y,Xia Q,Yao L,Chang X

Wed May 01 00:00:00 EDT 2019

SRT1720 retards renal fibrosis via inhibition of HIF1α /GLUT1 in diabetic nephropathy.

The Journal of endocrinology

Han W,Wang C,Yang Z,Mu L,Wu M,Chen N,Du C,Duan H,Shi Y

Fri Feb 01 00:00:00 EST 2019

Carnosine Protects Mouse Podocytes from High Glucose Induced Apoptosis through PI3K/AKT and Nrf2 Pathways.

BioMed research international

Zhao K,Li Y,Wang Z,Han N,Wang Y

Thu Dec 12 00:00:00 EST 2019

FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival.

Cell death & disease

Zhou K,Chen H,Lin J,Xu H,Wu H,Bao G,Li J,Deng X,Shui X,Gao W,Ding J,Xiao J,Xu H

Mon Nov 18 00:00:00 EST 2019

Bclaf1 critically regulates the type I interferon response and is degraded by alphaherpesvirus US3.

PLoS pathogens

Qin C,Zhang R,Lang Y,Shao A,Xu A,Feng W,Han J,Wang M,He W,Yu C,Tang J

Tue Jan 01 00:00:00 EST 2019

TFEB Probably Involved in Midazolam-Disturbed Lysosomal Homeostasis and Its Induced β-Amyloid Accumulation.

Frontiers in human neuroscience

Cheng D,Tan Q,Zhu Q,Zhang J,Han X,Fang P,Jin W,Liu X

Wed Sep 30 00:00:00 EDT 2020

Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.

Cells

Xu B,Lang LM,Li SZ,Guo JR,Wang JF,Wang D,Zhang LP,Yang HM,Lian S

Tue Jun 18 00:00:00 EDT 2019

Propofol Alleviates DNA Damage Induced by Oxygen Glucose Deprivation and Reperfusion via FoxO1 Nuclear Translocation in H9c2 Cells.

Frontiers in physiology

Zhou D,Zhuang J,Wang Y,Zhao D,Zhao L,Zhu S,Pu J,Yin M,Zhang H,Wang Z,Hong J

Fri Apr 15 00:00:00 EDT 2022

Abnormal expression of TBX4 during anorectal development in rat embryos with ethylenethiourea-induced anorectal malformations.

Biological research

Li M,Zhang H,Liu H,Tian H,Tang X,Bai Y,Wang W

Sat May 04 00:00:00 EDT 2019

β-elemene inhibits radiation and hypoxia-induced macrophages infiltration via Prx-1/NF-κB/HIF-1α signaling pathway.

OncoTargets and therapy

Yu X,Li Z,Zhang Y,Xu M,Che Y,Tian X,Wang R,Zou K,Zou L

Tue Sep 29 00:00:00 EDT 2020

MicroRNA-126 Regulates Angiogenesis and Neurogenesis in a Mouse Model of Focal Cerebral Ischemia.

Molecular therapy. Nucleic acids

Qu M,Pan J,Wang L,Zhou P,Song Y,Wang S,Jiang L,Geng J,Zhang Z,Wang Y,Tang Y,Yang GY

Fri Jun 07 00:00:00 EDT 2019

Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis.

Aging

Huang X,Ni B,Xi Y,Chu X,Zhang R,You H

Mon Dec 16 00:00:00 EST 2019

Clematichinenoside Facilitates Recovery of Neurological and Motor Function in Rats after Cerebral Ischemic Injury through Inhibiting Notch/NF-κB Pathway.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Xu D,Xia N,Hou K,Li F,Chen S,Hu Y,Fang W,Li Y

Fri Nov 01 00:00:00 EDT 2019

Dl-3-n-Butylphthalide Exerts Dopaminergic Neuroprotection Through Inhibition of Neuroinflammation.

Frontiers in aging neuroscience

Chen Y,Wu T,Li H,Li X,Li Q,Zhu X,Yu M,Kuo SH,Huang F,Wu YC

Fri Jul 23 00:00:00 EDT 2021

Silencing or inhibition of H3K79 methyltransferase DOT1L induces cell cycle arrest by epigenetically modulating c-Myc expression in colorectal cancer.

Clinical epigenetics

Yang L,Lei Q,Li L,Yang J,Dong Z,Cui H

Mon Dec 30 00:00:00 EST 2019

HO-1 reduces heat stress-induced apoptosis in bovine granulosa cells by suppressing oxidative stress.

Aging

Wang Y,Yang C,Elsheikh NAH,Li C,Yang F,Wang G,Li L

Mon Aug 12 00:00:00 EDT 2019

Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus.

PLoS pathogens

Gao P,Chai Y,Song J,Liu T,Chen P,Zhou L,Ge X,Guo X,Han J,Yang H

Fri Nov 01 00:00:00 EDT 2019

Role of Antioxidants in the Protection from Aging-Related Diseases.

Oxidative medicine and cellular longevity

Monti DM,Rigano MM,Monti SM,Peixoto HS

Mon Mar 25 00:00:00 EDT 2019

Interaction between p53 and Ras signaling controls cisplatin resistance via HDAC4- and HIF-1α-mediated regulation of apoptosis and autophagy.

Theranostics

Zhang X,Qi Z,Yin H,Yang G

Wed Jan 15 00:00:00 EST 2020

Peroxisome proliferator-activated receptor gamma participates in the acquisition of brain ischemic tolerance induced by ischemic preconditioning via glial glutamate transporter 1 in vivo and in vitro.

Journal of neurochemistry

Zhao CC,Jiang MY,Zhang LY,Hu YY,Hu ZJ,Zhang MY,Qi J,Su AC,Lou N,Xian XH,Zhang JG,Li WB,Zhang M

Sun Dec 01 00:00:00 EST 2019

Tempol alleviates chronic intermittent hypoxia-induced pancreatic injury through repressing inflammation and apoptosis.

Physiological research

Wang Y,Ai L,Hai B,Cao Y,Li R,Li H,Li Y

Sun Jun 30 00:00:00 EDT 2019

The selective HDAC6 inhibitor Nexturastat A induces apoptosis, overcomes drug resistance and inhibits tumor growth in multiple myeloma.

Bioscience reports

Sun X,Xie Y,Sun X,Yao Y,Li H,Li Z,Yao R,Xu K

Fri Mar 29 00:00:00 EDT 2019

ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex.

Nature communications

Kim W,Zhao F,Wu R,Qin S,Nowsheen S,Huang J,Zhou Q,Chen Y,Deng M,Guo G,Luo K,Lou Z,Yuan J

Fri Nov 22 00:00:00 EST 2019

Stabilized Peptide HDAC Inhibitors Derived from HDAC1 Substrate H3K56 for the Treatment of Cancer Stem-Like Cells In Vivo.

Cancer research

Wang D,Li W,Zhao R,Chen L,Liu N,Tian Y,Zhao H,Xie M,Lu F,Fang Q,Liang W,Yin F,Li Z

Mon Apr 15 00:00:00 EDT 2019

A novel, highly-water-soluble apigenin derivative provides neuroprotection following ischemia in male rats by regulating the ERK/Nrf2/HO-1 pathway.

European journal of pharmacology

Zhang S,Xu S,Duan H,Zhu Z,Yang Z,Cao J,Zhao Y,Huang Z,Wu Q,Duan J

Mon Jul 15 00:00:00 EDT 2019

PI3K p110α inhibition sensitizes cervical cancer cells with aberrant PI3K signaling activation to PARP inhibitor BMN673.

Oncology reports

Cao P,Wang Y,Lv Y,Jiang N,Zhong L,Ma X,Xiao X,Ding D,Gu J,Lin L,Li S

Fri Nov 01 00:00:00 EDT 2019

The Therapeutic Effects of Treadmill Exercise on Osteoarthritis in Rats by Inhibiting the HDAC3/NF-KappaB Pathway in vivo and in vitro.

Frontiers in physiology

Zhang H,Ji L,Yang Y,Wei Y,Zhang X,Gang Y,Lu J,Bai L

Fri Oct 13 00:00:00 EDT 2023

Bilirubin alleviates alum-induced peritonitis through inactivation of NLRP3 inflammasome.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Lin Y,Wang S,Yang Z,Gao L,Zhou Z,Yu P,Wu B

Thu Aug 01 00:00:00 EDT 2019

The perforatorium and postacrosomal sheath of rat spermatozoa share common developmental origins and protein constituents†.

Biology of reproduction

Protopapas N,Hamilton LE,Warkentin R,Xu W,Sutovsky P,Oko R

Sat Jun 01 00:00:00 EDT 2019

AZD9291 inactivates the PRC2 complex to mediate tumor growth inhibition.

Acta pharmacologica Sinica

Zhang KL,Shen QQ,Fang YF,Sun YM,Ding J,Chen Y

Sun Dec 01 00:00:00 EST 2019

PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis.

Stem cell research & therapy

Jiang Y,Liu F,Zou F,Zhang Y,Wang B,Zhang Y,Lian A,Han X,Liu Z,Liu X,Jin M,Wang D,Li G,Liu J

Fri Aug 23 00:00:00 EDT 2019

Chlorogenic acid effectively treats cancers through induction of cancer cell differentiation.

Theranostics

Huang S,Wang LL,Xue NN,Li C,Guo HH,Ren TK,Zhan Y,Li WB,Zhang J,Chen XG,Han YX,Zhang JL,Jiang JD

Fri Jul 24 00:00:00 EDT 2020

Suppression of puerarin on polymethylmethacrylate-induced lesion of peri-implant by inhibiting NF-κB activation in vitro and in vivo.

Pathology, research and practice

Yan B,Zhou H,Chu J,Cao X

Sat Jun 01 00:00:00 EDT 2019

Calcium-sensing stromal interaction molecule 2 upregulates nuclear factor of activated T cells 1 and transforming growth factor-β signaling to promote breast cancer metastasis.

Breast cancer research : BCR

Miao Y,Shen Q,Zhang S,Huang H,Meng X,Zheng X,Yao Z,He Z,Lu S,Cai C,Zou F

Thu Aug 29 00:00:00 EDT 2019

LXA4 ameliorates cerebrovascular endothelial dysfunction by reducing acute inflammation after subarachnoid hemorrhage in rats.

Neuroscience

Liu L,Zhang P,Zhang Z,Hu Q,He J,Liu H,Zhao J,Liang Y,He Z,Li X,Sun X,Guo Z

Sat Jun 01 00:00:00 EDT 2019

Wnt7a, frequently silenced by CpG methylation, inhibits tumor growth and metastasis via suppressing epithelial-mesenchymal transition in gastric cancer.

Journal of cellular biochemistry

Liu Y,Qiao Y,Zhang H,Li W,Zheng J

Tue Oct 01 00:00:00 EDT 2019

Milk fat globule-epidermal growth factor 8 (MFG-E8) attenuates sepsis-induced acute kidney injury by inhibiting NF-κB signaling pathway1.

Acta cirurgica brasileira

Zhao Y,Wang Q,Zang B

Thu Feb 28 00:00:00 EST 2019

Liraglutide Improves Non-Alcoholic Fatty Liver Disease In Diabetic Mice By Modulating Inflammatory Signaling Pathways.

Drug design, development and therapy

Luo Y,Yang P,Li Z,Luo Y,Shen J,Li R,Zheng H,Liang Y,Xia N

Wed Jun 03 00:00:00 EDT 2020

Micro-RNA-27a/b negatively regulates hepatic gluconeogenesis by targeting FOXO1.

American journal of physiology. Endocrinology and metabolism

Wang S,Ai H,Liu L,Zhang X,Gao F,Zheng L,Yi J,Sun L,Yu C,Zhao H,Li Y

Fri Nov 01 00:00:00 EDT 2019

LncRNA HOTAIRM1 promotes osteogenesis by controlling JNK/AP-1 signalling-mediated RUNX2 expression.

Journal of cellular and molecular medicine

Fu L,Peng S,Wu W,Ouyang Y,Tan D,Fu X

Fri Nov 01 00:00:00 EDT 2019

Metformin Promotes the Survival of Random-Pattern Skin Flaps by Inducing Autophagy via the AMPK-mTOR-TFEB signaling pathway.

International journal of biological sciences

Wu H,Ding J,Li S,Lin J,Jiang R,Lin C,Dai L,Xie C,Lin D,Xu H,Gao W,Zhou K

Mon Jan 13 00:00:00 EST 2020

Regulation of position effect variegation at pericentric heterochromatin by Drosophila Keap1-Nrf2 xenobiotic response factors.

Genesis (New York, N.Y. : 2000)

Carlson J,Swisse T,Smith C,Deng H

Mon Apr 01 00:00:00 EDT 2019

Neuroprotective Effect of Swertiamain on Cerebral Ischemia/Reperfusion Injury by Inducing the Nrf2 Protective Pathway.

ACS chemical neuroscience

Wang H,Wei W,Lan X,Liu N,Li Y,Ma H,Sun T,Peng X,Zhuang C,Yu J

Wed May 15 00:00:00 EDT 2019

m⁶A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner.

Cell death & disease

Wu R,Liu Y,Zhao Y,Bi Z,Yao Y,Liu Q,Wang F,Wang Y,Wang X

Wed Feb 20 00:00:00 EST 2019

Nonmuscle Myosin Heavy Chain IIA Recognizes Sialic Acids on Sialylated RNA Viruses To Suppress Proinflammatory Responses via the DAP12-Syk Pathway.

mBio

Liu Y,Li R,Chen XX,Zhi Y,Deng R,Zhou EM,Qiao S,Zhang G

Tue May 07 00:00:00 EDT 2019

The therapeutic effect of verapamil in lipopolysaccharide-induced acute lung injury.

Biochemical and biophysical research communications

Song Z,Li S,Zhang C,Yuan L,Han L,Liu Y

Tue Oct 01 00:00:00 EDT 2019

In the human sperm nucleus, nucleosomes form spatially restricted domains consistent with programmed nucleosome positioning.

Biology open

Zhang MZ,Cao XM,Xu FQ,Liang XW,Fu LL,Li B,Liu WG,Li SG,Sun FZ,Huang XY,Huang WH

Wed Jul 10 00:00:00 EDT 2019

Bavachinin exhibits antitumor activity against non‑small cell lung cancer by targeting PPARγ.

Molecular medicine reports

Ge LN,Yan L,Li C,Cheng K

Sun Sep 01 00:00:00 EDT 2019

Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology.

Nutrition & metabolism

Xue M,Liang H,Ji X,Liu Y,Ge Y,Hou L,Sun T

Tue Apr 12 00:00:00 EDT 2022

Sirtuin 7 promotes 45S pre-rRNA cleavage at site 2 and determines the processing pathway.

Journal of cell science

Sirri V,Grob A,Berthelet J,Jourdan N,Roussel P

Mon Sep 02 00:00:00 EDT 2019

KMT2D deficiency enhances the anti-cancer activity of L48H37 in pancreatic ductal adenocarcinoma.

World journal of gastrointestinal oncology

Li SS,Jiang WL,Xiao WQ,Li K,Zhang YF,Guo XY,Dai YQ,Zhao QY,Jiang MJ,Lu ZJ,Wan R

Thu Aug 15 00:00:00 EDT 2019

NEDD4 protects vascular endothelial cells against Angiotensin II-induced cell death via enhancement of XPO1-mediated nuclear export.

Experimental cell research

Xu J,Sheng Z,Li F,Wang S,Yuan Y,Wang M,Yu Z

Tue Oct 01 00:00:00 EDT 2019

Rosmarinic acid attenuates inflammatory responses through inhibiting HMGB1/TLR4/NF-κB signaling pathway in a mouse model of Parkinson's disease.

Life sciences

Lv R,Du L,Liu X,Zhou F,Zhang Z,Zhang L

Mon Apr 15 00:00:00 EDT 2019

Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors.

Cell reports

Wang Y,Zhang J,Ren S,Sun D,Huang HY,Wang H,Jin Y,Li F,Zheng C,Yang L,Deng L,Jiang Z,Jiang T,Han X,Hou S,Guo C,Li F,Gao D,Qin J,Gao D,Chen L,Lin SH,Wong KK,Li C,Hu L,Zhou C,Ji H

Tue Jul 09 00:00:00 EDT 2019

Endogenous ET-1 promotes ANP secretion through activation of COX2-L-PGDS-PPARγ signaling in hypoxic beating rat atria.

Peptides

Li X,Han ZN,Liu Y,Hong L,Cui BR,Cui X

Sun Dec 01 00:00:00 EST 2019

CyclinD1 inhibits dicer and crucial miRNA expression by chromatin modification to promote the progression of intrahepatic cholangiocarcinoma.

Journal of experimental & clinical cancer research : CR

Qi Y,Wang D,Huang W,Wang B,Huang D,Xiong F,Chen X,Chen Y

Mon Oct 07 00:00:00 EDT 2019

Microglia Activated by Excess Cortisol Induce HMGB1 Acetylation and Neuroinflammation in the Hippocampal DG Region of Mice Following Cold Exposure.

Biomolecules

Xu B,Lang LM,Li SZ,Guo JR,Wang JF,Yang HM,Lian S

Fri Aug 30 00:00:00 EDT 2019

MiR-26a promotes fracture healing of nonunion rats possibly by targeting SOSTDC1 and further activating Wnt/β-catenin signaling pathway.

Molecular and cellular biochemistry

Sun L,Li Z,Xue H,Ma T,Ren C,Li M,Lu Y,Sun H,Zhang K

Tue Oct 01 00:00:00 EDT 2019

MD-2 Homologue Recognizes the White Spot Syndrome Virus Lipid Component and Induces Antiviral Molecule Expression in Shrimp.

Journal of immunology (Baltimore, Md. : 1950)

Gao J,Wang JX,Wang XW

Sun Sep 01 00:00:00 EDT 2019

TFEB-driven autophagy potentiates TGF-β induced migration in pancreatic cancer cells.

Journal of experimental & clinical cancer research : CR

He R,Wang M,Zhao C,Shen M,Yu Y,He L,Zhao Y,Chen H,Shi X,Zhou M,Pan S,Liu Y,Guo X,Li X,Qin R

Tue Aug 06 00:00:00 EDT 2019

Epigenetic suppression of liver X receptor β in anterior cingulate cortex by HDAC5 drives CFA-induced chronic inflammatory pain.

Journal of neuroinflammation

Li YJ,Zhang K,Sun T,Wang J,Guo YY,Yang L,Yang Q,Li YJ,Liu SB,Zhao MG,Wu YM

Sat Jun 29 00:00:00 EDT 2019

Naringin mitigates myocardial strain and the inflammatory response in sepsis-induced myocardial dysfunction through regulation of PI3K/AKT/NF-κB pathway.

International immunopharmacology

Sun LJ,Qiao W,Xiao YJ,Cui L,Wang X,Ren WD

Tue Oct 01 00:00:00 EDT 2019

Protective effects of a neurokinin 1 receptor antagonist on airway epithelial mitochondria dysfunction in asthmatic mice via Nrf2/HO-1 activation.

International immunopharmacology

Wang Z,Li M,Zhou Q,Shang Y

Sun Dec 01 00:00:00 EST 2019

Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay.

Molecular cell

Fish L,Navickas A,Culbertson B,Xu Y,Nguyen HCB,Zhang S,Hochman M,Okimoto R,Dill BD,Molina H,Najafabadi HS,Alarcón C,Ruggero D,Goodarzi H

Thu Sep 05 00:00:00 EDT 2019

Chrysophanol attenuates airway inflammation and remodeling through nuclear factor-kappa B signaling pathway in asthma.

Phytotherapy research : PTR

Song G,Zhang Y,Yu S,Lv W,Guan Z,Sun M,Wang J

Tue Oct 01 00:00:00 EDT 2019

Identification of RE1-Silencing Transcription Factor as a Promoter of Metastasis in Pancreatic Cancer.

Frontiers in oncology

Jin H,Liu P,Kong L,Fei X,Gao Y,Wu T,Sun D,Tan X

Wed Sep 30 00:00:00 EDT 2020

Trans-cinnamaldehyde improves neuroinflammation-mediated NMDA receptor dysfunction and memory deficits through blocking NF-κB pathway in presenilin1/2 conditional double knockout mice.

Brain, behavior, and immunity

Zhao Y,Deng H,Li K,Wang L,Wu Y,Dong X,Wang X,Chen Y,Xu Y

Fri Nov 01 00:00:00 EDT 2019

Stella protein facilitates DNA demethylation by disrupting the chromatin association of the RING finger-type E3 ubiquitin ligase UHRF1.

The Journal of biological chemistry

Du W,Dong Q,Zhang Z,Liu B,Zhou T,Xu RM,Wang H,Zhu B,Li Y

Fri May 31 00:00:00 EDT 2019

CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation.

Redox biology

Lu MC,Zhao J,Liu YT,Liu T,Tao MM,You QD,Jiang ZY

Sun Sep 01 00:00:00 EDT 2019

SIRT4 enhances the sensitivity of ER-positive breast cancer to tamoxifen by inhibiting the IL-6/STAT3 signal pathway.

Cancer medicine

Xing J,Li J,Fu L,Gai J,Guan J,Li Q

Fri Nov 01 00:00:00 EDT 2019

Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors.

Cell

Huang X,Yan J,Zhang M,Wang Y,Chen Y,Fu X,Wei R,Zheng XL,Liu Z,Zhang X,Yang H,Hao B,Shen YY,Su Y,Cong X,Huang M,Tan M,Ding J,Geng M

Thu Sep 20 00:00:00 EDT 2018

Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors.

Cell

Huang X,Yan J,Zhang M,Wang Y,Chen Y,Fu X,Wei R,Zheng XL,Liu Z,Zhang X,Yang H,Hao B,Shen YY,Su Y,Cong X,Huang M,Tan M,Ding J,Geng M

Thu Sep 20 00:00:00 EDT 2018

Yes-Associated Protein Promotes Angiogenesis via Signal Transducer and Activator of Transcription 3 in Endothelial Cells.

Circulation research

He J,Bao Q,Zhang Y,Liu M,Lv H,Liu Y,Yao L,Li B,Zhang C,He S,Zhai G,Zhu Y,Liu X,Zhang K,Wang XJ,Zou MH,Zhu Y,Ai D

Fri Feb 16 00:00:00 EST 2018

Yes-Associated Protein Promotes Angiogenesis via Signal Transducer and Activator of Transcription 3 in Endothelial Cells.

Circulation research

He J,Bao Q,Zhang Y,Liu M,Lv H,Liu Y,Yao L,Li B,Zhang C,He S,Zhai G,Zhu Y,Liu X,Zhang K,Wang XJ,Zou MH,Zhu Y,Ai D

Fri Feb 16 00:00:00 EST 2018

Key Role of TFEB Nucleus Translocation for Silver Nanoparticle-Induced Cytoprotective Autophagy.

Small (Weinheim an der Bergstrasse, Germany)

Lin J,Liu Y,Wu H,Huang Z,Ma J,Guo C,Gao F,Jin P,Wei P,Zhang Y,Liu L,Zhang R,Qiu L,Gu N,Wen L

Thu Mar 01 00:00:00 EST 2018

Key Role of TFEB Nucleus Translocation for Silver Nanoparticle-Induced Cytoprotective Autophagy.

Small (Weinheim an der Bergstrasse, Germany)

Lin J,Liu Y,Wu H,Huang Z,Ma J,Guo C,Gao F,Jin P,Wei P,Zhang Y,Liu L,Zhang R,Qiu L,Gu N,Wen L

Thu Mar 01 00:00:00 EST 2018

Mitotic Phosphorylation of SENP3 Regulates DeSUMOylation of Chromosome-Associated Proteins and Chromosome Stability.

Cancer research

Wei B,Huang C,Liu B,Wang Y,Xia N,Fan Q,Chen GQ,Cheng J

Tue May 01 00:00:00 EDT 2018

Mitotic Phosphorylation of SENP3 Regulates DeSUMOylation of Chromosome-Associated Proteins and Chromosome Stability.

Cancer research

Wei B,Huang C,Liu B,Wang Y,Xia N,Fan Q,Chen GQ,Cheng J

Tue May 01 00:00:00 EDT 2018

27-Hydroxycholesterol Inhibits Sterol Regulatory Element-Binding Protein 1 Activation and Hepatic Lipid Accumulation in Mice.

Obesity (Silver Spring, Md.)

Li D,Long W,Huang R,Chen Y,Xia M

Sun Apr 01 00:00:00 EDT 2018

27-Hydroxycholesterol Inhibits Sterol Regulatory Element-Binding Protein 1 Activation and Hepatic Lipid Accumulation in Mice.

Obesity (Silver Spring, Md.)

Li D,Long W,Huang R,Chen Y,Xia M

Sun Apr 01 00:00:00 EDT 2018

3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1,2,4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation.

Oxidative medicine and cellular longevity

Xu LL,Liu T,Wang L,Li L,Wu YF,Li CC,Di B,You QD,Jiang ZY

Fri Oct 26 00:00:00 EDT 2018

Oxidative medicine and cellular longevity

Xu LL,Liu T,Wang L,Li L,Wu YF,Li CC,Di B,You QD,Jiang ZY

Fri Oct 26 00:00:00 EDT 2018

Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury.

Neurobiology of disease

He J,Liu H,Zhong J,Guo Z,Wu J,Zhang H,Huang Z,Jiang L,Li H,Zhang Z,Liu L,Wu Y,Qi L,Sun X,Cheng C

Sat Sep 01 00:00:00 EDT 2018

Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury.

Neurobiology of disease

He J,Liu H,Zhong J,Guo Z,Wu J,Zhang H,Huang Z,Jiang L,Li H,Zhang Z,Liu L,Wu Y,Qi L,Sun X,Cheng C

Sat Sep 01 00:00:00 EDT 2018

CDK5-mediated phosphorylation of Sirt2 contributes to depressive-like behavior induced by social defeat stress.

Biochimica et biophysica acta. Molecular basis of disease

Zhang Z,Zhang P,Qi GJ,Jiao FJ,Wang QZ,Yan JG,He F,Zhang Q,Lv ZX,Peng X,Cai HW,Chen X,Sun N,Tian B

Thu Feb 01 00:00:00 EST 2018

CDK5-mediated phosphorylation of Sirt2 contributes to depressive-like behavior induced by social defeat stress.

Biochimica et biophysica acta. Molecular basis of disease

Zhang Z,Zhang P,Qi GJ,Jiao FJ,Wang QZ,Yan JG,He F,Zhang Q,Lv ZX,Peng X,Cai HW,Chen X,Sun N,Tian B

Thu Feb 01 00:00:00 EST 2018

Modulation of autophagy in the protective effect of resveratrol on PM2.5-induced pulmonary oxidative injury in mice.

Phytotherapy research : PTR

Li Y,Fu S,Li E,Sun X,Xu H,Meng Y,Wang X,Chen Y,Xie C,Geng S,Wu J,Zhong C,Xu P

Sat Dec 01 00:00:00 EST 2018

Modulation of autophagy in the protective effect of resveratrol on PM2.5-induced pulmonary oxidative injury in mice.

Phytotherapy research : PTR

Li Y,Fu S,Li E,Sun X,Xu H,Meng Y,Wang X,Chen Y,Xie C,Geng S,Wu J,Zhong C,Xu P

Sat Dec 01 00:00:00 EST 2018

Regulation of osteogenesis by micro/nano hierarchical titanium surfaces through a Rock-Wnt5a feedback loop.

Colloids and surfaces. B, Biointerfaces

Yu Y,Shen X,Liu J,Hu Y,Ran Q,Mu C,Cai K

Mon Oct 01 00:00:00 EDT 2018

Regulation of osteogenesis by micro/nano hierarchical titanium surfaces through a Rock-Wnt5a feedback loop.

Colloids and surfaces. B, Biointerfaces

Yu Y,Shen X,Liu J,Hu Y,Ran Q,Mu C,Cai K

Mon Oct 01 00:00:00 EDT 2018

Aryl hydrocarbon receptor activated by benzo (a) pyrene promotes SMARCA6 expression in NSCLC.

American journal of cancer research

Mao C,Wang M,Qian B,Ouyang L,Shi Y,Liu N,Chen L,Xiao D,Wang X,Cao Y,Liu S,Tao Y,Liu W

Wed Sep 30 00:00:00 EDT 2020

Aryl hydrocarbon receptor activated by benzo (a) pyrene promotes SMARCA6 expression in NSCLC.

American journal of cancer research

Mao C,Wang M,Qian B,Ouyang L,Shi Y,Liu N,Chen L,Xiao D,Wang X,Cao Y,Liu S,Tao Y,Liu W

Wed Sep 30 00:00:00 EDT 2020

Citrus Tangeretin Improves Skeletal Muscle Mitochondrial Biogenesis via Activating the AMPK-PGC1-α Pathway In Vitro and In Vivo: A Possible Mechanism for Its Beneficial Effect on Physical Performance.

Journal of agricultural and food chemistry

Kou G,Li Z,Wu C,Liu Y,Hu Y,Guo L,Xu X,Zhou Z

Wed Nov 14 00:00:00 EST 2018

Journal of agricultural and food chemistry

Kou G,Li Z,Wu C,Liu Y,Hu Y,Guo L,Xu X,Zhou Z

Wed Nov 14 00:00:00 EST 2018

Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

He W,Ye S,Zeng C,Xue S,Hu X,Zhang X,Gao S,Xiong Y,He X,Vivalda S,Li L,Wang Y,Ye Q

Tue Jun 05 00:00:00 EDT 2018

Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

He W,Ye S,Zeng C,Xue S,Hu X,Zhang X,Gao S,Xiong Y,He X,Vivalda S,Li L,Wang Y,Ye Q

Tue Jun 05 00:00:00 EDT 2018

JMJD3 is involved in neutrophil membrane proteinase 3 overexpression during the hyperinflammatory response in early sepsis.

International immunopharmacology

Chen Y,Liu Z,Pan T,Chen E,Mao E,Chen Y,Tan R,Wang X,Tian R,Liu J,Qu H

Fri Jun 01 00:00:00 EDT 2018

JMJD3 is involved in neutrophil membrane proteinase 3 overexpression during the hyperinflammatory response in early sepsis.

International immunopharmacology

Chen Y,Liu Z,Pan T,Chen E,Mao E,Chen Y,Tan R,Wang X,Tian R,Liu J,Qu H

Fri Jun 01 00:00:00 EDT 2018

Neurochondrin interacts with the SMN protein suggesting a novel mechanism for spinal muscular atrophy pathology.

Journal of cell science

Thompson LW,Morrison KD,Shirran SL,Groen EJN,Gillingwater TH,Botting CH,Sleeman JE

Tue Apr 17 00:00:00 EDT 2018

Neurochondrin interacts with the SMN protein suggesting a novel mechanism for spinal muscular atrophy pathology.

Journal of cell science

Thompson LW,Morrison KD,Shirran SL,Groen EJN,Gillingwater TH,Botting CH,Sleeman JE

Tue Apr 17 00:00:00 EDT 2018

Thymol alleviates lipopolysaccharide-stimulated inflammatory response via downregulation of RhoA-mediated NF-κB signalling pathway in human peritoneal mesothelial cells.

European journal of pharmacology

Wang Q,Cheng F,Xu Y,Zhang J,Qi J,Liu X,Wang R

Wed Aug 15 00:00:00 EDT 2018

Thymol alleviates lipopolysaccharide-stimulated inflammatory response via downregulation of RhoA-mediated NF-κB signalling pathway in human peritoneal mesothelial cells.

European journal of pharmacology

Wang Q,Cheng F,Xu Y,Zhang J,Qi J,Liu X,Wang R

Wed Aug 15 00:00:00 EDT 2018

The Role of the RhoA/ROCK Signaling Pathway in Mechanical Strain-Induced Scleral Myofibroblast Differentiation.

Investigative ophthalmology & visual science

Yuan Y,Li M,To CH,Lam TC,Wang P,Yu Y,Chen Q,Hu X,Ke B

Mon Jul 02 00:00:00 EDT 2018

The Role of the RhoA/ROCK Signaling Pathway in Mechanical Strain-Induced Scleral Myofibroblast Differentiation.

Investigative ophthalmology & visual science

Yuan Y,Li M,To CH,Lam TC,Wang P,Yu Y,Chen Q,Hu X,Ke B

Mon Jul 02 00:00:00 EDT 2018

Inhibition of microRNA-143-3p attenuates myocardial hypertrophy by inhibiting inflammatory response.

Cell biology international

Yu B,Zhao Y,Zhang H,Xie D,Nie W,Shi K

Thu Nov 01 00:00:00 EDT 2018

Inhibition of microRNA-143-3p attenuates myocardial hypertrophy by inhibiting inflammatory response.

Cell biology international

Yu B,Zhao Y,Zhang H,Xie D,Nie W,Shi K

Thu Nov 01 00:00:00 EDT 2018

6-Hydroxydopamine induces autophagic flux dysfunction by impairing transcription factor EB activation and lysosomal function in dopaminergic neurons and SH-SY5Y cells.

Toxicology letters

He X,Yuan W,Li Z,Hou Y,Liu F,Feng J

Thu Feb 01 00:00:00 EST 2018

6-Hydroxydopamine induces autophagic flux dysfunction by impairing transcription factor EB activation and lysosomal function in dopaminergic neurons and SH-SY5Y cells.

Toxicology letters

He X,Yuan W,Li Z,Hou Y,Liu F,Feng J

Thu Feb 01 00:00:00 EST 2018

Role of Peroxiredoxin 2 in the Protection Against Ferrous Sulfate-Induced Oxidative and Inflammatory Injury in PC12 Cells.

Cellular and molecular neurobiology

Xu W,Li F,Xu Z,Sun B,Cao J,Liu Y

Sun Apr 01 00:00:00 EDT 2018

Role of Peroxiredoxin 2 in the Protection Against Ferrous Sulfate-Induced Oxidative and Inflammatory Injury in PC12 Cells.

Cellular and molecular neurobiology

Xu W,Li F,Xu Z,Sun B,Cao J,Liu Y

Sun Apr 01 00:00:00 EDT 2018

BRMS1L suppresses ovarian cancer metastasis via inhibition of the β-catenin-wnt pathway.

Experimental cell research

Cao P,Zhao S,Sun Z,Jiang N,Shang Y,Wang Y,Gu J,Li S

Mon Oct 01 00:00:00 EDT 2018

BRMS1L suppresses ovarian cancer metastasis via inhibition of the β-catenin-wnt pathway.

Experimental cell research

Cao P,Zhao S,Sun Z,Jiang N,Shang Y,Wang Y,Gu J,Li S

Mon Oct 01 00:00:00 EDT 2018

Anticancer effect of histone deacetylase inhibitor scriptaid as a single agent for hepatocellular carcinoma.

Bioscience reports

Liu L,Sun X,Xie Y,Zhuang Y,Yao R,Xu K

Fri Aug 31 00:00:00 EDT 2018

Anticancer effect of histone deacetylase inhibitor scriptaid as a single agent for hepatocellular carcinoma.

Bioscience reports

Liu L,Sun X,Xie Y,Zhuang Y,Yao R,Xu K

Fri Aug 31 00:00:00 EDT 2018

Lithium chloride inhibits cell survival, overcomes drug resistance, and triggers apoptosis in multiple myeloma via activation of the Wnt/β-catenin pathway.

American journal of translational research

Yao R,Sun X,Xie Y,Liu L,Han D,Yao Y,Li H,Li Z,Xu K

Wed Sep 30 00:00:00 EDT 2020

Lithium chloride inhibits cell survival, overcomes drug resistance, and triggers apoptosis in multiple myeloma via activation of the Wnt/β-catenin pathway.

American journal of translational research

Yao R,Sun X,Xie Y,Liu L,Han D,Yao Y,Li H,Li Z,Xu K

Wed Sep 30 00:00:00 EDT 2020

Resveratrol relieves particulate matter (mean diameter < 2.5 μm)-induced oxidative injury of lung cells through attenuation of autophagy deregulation.

Journal of applied toxicology : JAT

Li Y,Qian W,Wang D,Meng Y,Wang X,Chen Y,Li X,Xie C,Zhong C,Fu S

Sat Sep 01 00:00:00 EDT 2018

Resveratrol relieves particulate matter (mean diameter < 2.5 μm)-induced oxidative injury of lung cells through attenuation of autophagy deregulation.

Journal of applied toxicology : JAT

Li Y,Qian W,Wang D,Meng Y,Wang X,Chen Y,Li X,Xie C,Zhong C,Fu S

Sat Sep 01 00:00:00 EDT 2018

XPO1-mediated nuclear export of RNF146 protects from angiotensin II-induced endothelial cellular injury.

Biochemical and biophysical research communications

Sheng Z,Xu Y,Wang S,Yuan Y,Huang T,Lu P

Mon Sep 10 00:00:00 EDT 2018

XPO1-mediated nuclear export of RNF146 protects from angiotensin II-induced endothelial cellular injury.

Biochemical and biophysical research communications

Sheng Z,Xu Y,Wang S,Yuan Y,Huang T,Lu P

Mon Sep 10 00:00:00 EDT 2018

Tempol relieves lung injury in a rat model of chronic intermittent hypoxia via suppression of inflammation and oxidative stress.

Iranian journal of basic medical sciences

Wang Y,Hai B,Ai L,Cao Y,Li R,Li H,Li Y

Sat Dec 01 00:00:00 EST 2018

Tempol relieves lung injury in a rat model of chronic intermittent hypoxia via suppression of inflammation and oxidative stress.

Iranian journal of basic medical sciences

Wang Y,Hai B,Ai L,Cao Y,Li R,Li H,Li Y

Sat Dec 01 00:00:00 EST 2018

Integrin αvβ3-associated DAAM1 is essential for collagen-induced invadopodia extension and cell haptotaxis in breast cancer cells.

The Journal of biological chemistry

Yan T,Zhang A,Shi F,Chang F,Mei J,Liu Y,Zhu Y

Fri Jun 29 00:00:00 EDT 2018

Integrin αvβ3-associated DAAM1 is essential for collagen-induced invadopodia extension and cell haptotaxis in breast cancer cells.

The Journal of biological chemistry

Yan T,Zhang A,Shi F,Chang F,Mei J,Liu Y,Zhu Y

Fri Jun 29 00:00:00 EDT 2018

Isopsoralen Enhanced Osteogenesis by Targeting AhR/ERα.

Molecules (Basel, Switzerland)

Ge L,Cui Y,Cheng K,Han J

Thu Oct 11 00:00:00 EDT 2018

Isopsoralen Enhanced Osteogenesis by Targeting AhR/ERα.

Molecules (Basel, Switzerland)

Ge L,Cui Y,Cheng K,Han J

Thu Oct 11 00:00:00 EDT 2018

The lncRNA MACC1-AS1 promotes gastric cancer cell metabolic plasticity via AMPK/Lin28 mediated mRNA stability of MACC1.

Molecular cancer

Zhao Y,Liu Y,Lin L,Huang Q,He W,Zhang S,Dong S,Wen Z,Rao J,Liao W,Shi M

Tue Mar 06 00:00:00 EST 2018

The lncRNA MACC1-AS1 promotes gastric cancer cell metabolic plasticity via AMPK/Lin28 mediated mRNA stability of MACC1.

Molecular cancer

Zhao Y,Liu Y,Lin L,Huang Q,He W,Zhang S,Dong S,Wen Z,Rao J,Liao W,Shi M

Tue Mar 06 00:00:00 EST 2018

The histone methyltransferase SETD2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice.

The Journal of biological chemistry

Zuo X,Rong B,Li L,Lv R,Lan F,Tong MH

Fri Jun 15 00:00:00 EDT 2018

The histone methyltransferase SETD2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice.

The Journal of biological chemistry

Zuo X,Rong B,Li L,Lv R,Lan F,Tong MH

Fri Jun 15 00:00:00 EDT 2018

Flavagline analog FL3 induces cell cycle arrest in urothelial carcinoma cell of the bladder by inhibiting the Akt/PHB interaction to activate the GADD45α pathway.

Journal of experimental & clinical cancer research : CR

Yuan G,Chen X,Liu Z,Wei W,Shu Q,Abou-Hamdan H,Jiang L,Li X,Chen R,Désaubry L,Zhou F,Xie D

Wed Feb 07 00:00:00 EST 2018

Flavagline analog FL3 induces cell cycle arrest in urothelial carcinoma cell of the bladder by inhibiting the Akt/PHB interaction to activate the GADD45α pathway.

Journal of experimental & clinical cancer research : CR

Yuan G,Chen X,Liu Z,Wei W,Shu Q,Abou-Hamdan H,Jiang L,Li X,Chen R,Désaubry L,Zhou F,Xie D

Wed Feb 07 00:00:00 EST 2018

miR-203 Inhibits Alcohol-Induced Hepatic Steatosis by Targeting Lipin1.

Frontiers in pharmacology

Cheng XY,Liu JD,Lu XY,Yan X,Huang C,Meng XM,Li J

Thu Oct 01 00:00:00 EDT 2020

miR-203 Inhibits Alcohol-Induced Hepatic Steatosis by Targeting Lipin1.

Frontiers in pharmacology

Cheng XY,Liu JD,Lu XY,Yan X,Huang C,Meng XM,Li J

Thu Oct 01 00:00:00 EDT 2020

Anti-Proliferative Activity of HPOB against Multiple Myeloma Cells via p21 Transcriptional Activation.

Molecules (Basel, Switzerland)

Liu L,Sun X,Xie Y,Zhuang Y,Yao R,Xu K

Mon Apr 30 00:00:00 EDT 2018

Ubiquitin-Specific Protease USP6 Regulates the Stability of the c-Jun Protein.

Molecular and cellular biology

Li L,Yang H,He Y,Li T,Feng J,Chen W,Ao L,Shi X,Lin Y,Liu H,Zheng E,Lin Q,Bu J,Zeng Y,Zheng M,Xu Y,Liao Z,Lin J,Lin D

Mon Jan 15 00:00:00 EST 2018

DNase-1 Treatment Exerts Protective Effects in a Rat Model of Intestinal Ischemia-Reperfusion Injury.

Scientific reports

Wang S,Xie T,Sun S,Wang K,Liu B,Wu X,Ding W

Wed Dec 12 00:00:00 EST 2018

DNase-1 Treatment Exerts Protective Effects in a Rat Model of Intestinal Ischemia-Reperfusion Injury.

Scientific reports

Wang S,Xie T,Sun S,Wang K,Liu B,Wu X,Ding W

Wed Dec 12 00:00:00 EST 2018

Flavonoid-Rich Ethanol Extract from the Leaves of Diospyros kaki Attenuates D-Galactose-Induced Oxidative Stress and Neuroinflammation-Mediated Brain Aging in Mice.

Oxidative medicine and cellular longevity

Ma Y,Ma B,Shang Y,Yin Q,Wang D,Xu S,Hong Y,Hou X,Liu X

Thu Jan 31 00:00:00 EST 2019

Adipocytes fuel gastric cancer omental metastasis via PITPNC1-mediated fatty acid metabolic reprogramming.

Theranostics

Tan Y,Lin K,Zhao Y,Wu Q,Chen D,Wang J,Liang Y,Li J,Hu J,Wang H,Liu Y,Zhang S,He W,Huang Q,Hu X,Yao Z,Liang B,Liao W,Shi M

Fri Sep 06 00:00:00 EDT 2019

Adipocytes fuel gastric cancer omental metastasis via PITPNC1-mediated fatty acid metabolic reprogramming.

Theranostics

Tan Y,Lin K,Zhao Y,Wu Q,Chen D,Wang J,Liang Y,Li J,Hu J,Wang H,Liu Y,Zhang S,He W,Huang Q,Hu X,Yao Z,Liang B,Liao W,Shi M

Fri Sep 06 00:00:00 EDT 2019

Small molecules capable of activating DNA methylation-repressed genes targeted by the p38 mitogen-activated protein kinase pathway.

The Journal of biological chemistry

Li X,Shang E,Dong Q,Li Y,Zhang J,Xu S,Zhao Z,Shao W,Lv C,Zheng Y,Wang H,Lei X,Zhu B,Zhang Z

Fri May 11 00:00:00 EDT 2018

Sphingosine-1-phosphate ameliorates the cardiac hypertrophic response through inhibiting the activity of histone deacetylase-2.

International journal of molecular medicine

Yan H,Yi S,Zhuang H,Wu L,Wang DW,Jiang J

Thu Mar 01 00:00:00 EST 2018

REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis.

Nature communications

Wang S,Lin Y,Yuan X,Li F,Guo L,Wu B

Fri Oct 12 00:00:00 EDT 2018

REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis.

Nature communications

Wang S,Lin Y,Yuan X,Li F,Guo L,Wu B

Fri Oct 12 00:00:00 EDT 2018

Shp2 promotes liver cancer stem cell expansion by augmenting β-catenin signaling and predicts chemotherapeutic response of patients.

Hepatology (Baltimore, Md.)

Xiang D,Cheng Z,Liu H,Wang X,Han T,Sun W,Li X,Yang W,Chen C,Xia M,Liu N,Yin S,Jin G,Lee T,Dong L,Hu H,Wang H,Ding J

Mon May 01 00:00:00 EDT 2017

Shp2 promotes liver cancer stem cell expansion by augmenting β-catenin signaling and predicts chemotherapeutic response of patients.

Hepatology (Baltimore, Md.)

Xiang D,Cheng Z,Liu H,Wang X,Han T,Sun W,Li X,Yang W,Chen C,Xia M,Liu N,Yin S,Jin G,Lee T,Dong L,Hu H,Wang H,Ding J

Mon May 01 00:00:00 EDT 2017

Targeting NF-kB signaling with polymeric hybrid micelles that co-deliver siRNA and dexamethasone for arthritis therapy.

Biomaterials

Wang Q,Jiang H,Li Y,Chen W,Li H,Peng K,Zhang Z,Sun X

Sat Apr 01 00:00:00 EDT 2017

Targeting NF-kB signaling with polymeric hybrid micelles that co-deliver siRNA and dexamethasone for arthritis therapy.

Biomaterials

Wang Q,Jiang H,Li Y,Chen W,Li H,Peng K,Zhang Z,Sun X

Sat Apr 01 00:00:00 EDT 2017

YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63-GPX2 Axis and ROS Accumulation.

Cancer research

Huang H,Zhang W,Pan Y,Gao Y,Deng L,Li F,Li F,Ma X,Hou S,Xu J,Li P,Li X,Hu G,Li C,Chen H,Zhang L,Ji H

Wed Nov 01 00:00:00 EDT 2017

YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63-GPX2 Axis and ROS Accumulation.

Cancer research

Huang H,Zhang W,Pan Y,Gao Y,Deng L,Li F,Li F,Ma X,Hou S,Xu J,Li P,Li X,Hu G,Li C,Chen H,Zhang L,Ji H

Wed Nov 01 00:00:00 EDT 2017

Epstein-Barr Virus miR-BART6-3p Inhibits the RIG-I Pathway.

Journal of innate immunity

Lu Y,Qin Z,Wang J,Zheng X,Lu J,Zhang X,Wei L,Peng Q,Zheng Y,Ou C,Ye Q,Xiong W,Li G,Fu Y,Yan Q,Ma J

Tue Jul 24 00:00:00 EDT 2018

Epstein-Barr Virus miR-BART6-3p Inhibits the RIG-I Pathway.

Journal of innate immunity

Lu Y,Qin Z,Wang J,Zheng X,Lu J,Zhang X,Wei L,Peng Q,Zheng Y,Ou C,Ye Q,Xiong W,Li G,Fu Y,Yan Q,Ma J

Tue Jul 24 00:00:00 EDT 2018

Rabphilin 3A: A novel target for the treatment of levodopa-induced dyskinesias.

Neurobiology of disease

Stanic J,Mellone M,Napolitano F,Racca C,Zianni E,Minocci D,Ghiglieri V,Thiolat ML,Li Q,Longhi A,De Rosa A,Picconi B,Bezard E,Calabresi P,Di Luca M,Usiello A,Gardoni F

Fri Dec 01 00:00:00 EST 2017

Rabphilin 3A: A novel target for the treatment of levodopa-induced dyskinesias.

Neurobiology of disease

Stanic J,Mellone M,Napolitano F,Racca C,Zianni E,Minocci D,Ghiglieri V,Thiolat ML,Li Q,Longhi A,De Rosa A,Picconi B,Bezard E,Calabresi P,Di Luca M,Usiello A,Gardoni F

Fri Dec 01 00:00:00 EST 2017

Rosiglitazone Exerts an Anti-depressive Effect in Unpredictable Chronic Mild-Stress-Induced Depressive Mice by Maintaining Essential Neuron Autophagy and Inhibiting Excessive Astrocytic Apoptosis.

Frontiers in molecular neuroscience

Zhao Z,Zhang L,Guo XD,Cao LL,Xue TF,Zhao XJ,Yang DD,Yang J,Ji J,Huang JY,Sun XL

Wed Sep 30 00:00:00 EDT 2020

Rosiglitazone Exerts an Anti-depressive Effect in Unpredictable Chronic Mild-Stress-Induced Depressive Mice by Maintaining Essential Neuron Autophagy and Inhibiting Excessive Astrocytic Apoptosis.

Frontiers in molecular neuroscience

Zhao Z,Zhang L,Guo XD,Cao LL,Xue TF,Zhao XJ,Yang DD,Yang J,Ji J,Huang JY,Sun XL

Wed Sep 30 00:00:00 EDT 2020

EGFRwt/vIII-PKM2-β-catenin cascade affects proliferation and chemo-sensitivity in head and neck squamous cell carcinoma.

American journal of cancer research

Jing C,Qu X,Li Z,Wu C,Zhao M,Wang Y,Sun S,Zhang S,Chen J,Qiao Y,Hu X,Yao X,Jin R,Wang X,Zhang L,Zhou X

Wed Sep 30 00:00:00 EDT 2020

EGFRwt/vIII-PKM2-β-catenin cascade affects proliferation and chemo-sensitivity in head and neck squamous cell carcinoma.

American journal of cancer research

Jing C,Qu X,Li Z,Wu C,Zhao M,Wang Y,Sun S,Zhang S,Chen J,Qiao Y,Hu X,Yao X,Jin R,Wang X,Zhang L,Zhou X

Wed Sep 30 00:00:00 EDT 2020

Quinocetone induces mitochondrial apoptosis in HepG2 cells through ROS-dependent promotion of VDAC1 oligomerization and suppression of Wnt1/β-catenin signaling pathway.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Yang X,Tang S,Dai C,Li D,Zhang S,Deng S,Zhou Y,Xiao X

Sat Jul 01 00:00:00 EDT 2017

Quinocetone induces mitochondrial apoptosis in HepG2 cells through ROS-dependent promotion of VDAC1 oligomerization and suppression of Wnt1/β-catenin signaling pathway.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Yang X,Tang S,Dai C,Li D,Zhang S,Deng S,Zhou Y,Xiao X

Sat Jul 01 00:00:00 EDT 2017

Tert-butylhydroquinone protects PC12 cells against ferrous sulfate-induced oxidative and inflammatory injury via the Nrf2/ARE pathway.

Chemico-biological interactions

Xu W,Li F,Xu Z,Sun B,Cao J,Liu Y

Tue Aug 01 00:00:00 EDT 2017

Tert-butylhydroquinone protects PC12 cells against ferrous sulfate-induced oxidative and inflammatory injury via the Nrf2/ARE pathway.

Chemico-biological interactions

Xu W,Li F,Xu Z,Sun B,Cao J,Liu Y

Tue Aug 01 00:00:00 EDT 2017

BTP2, a Store-Operated Calcium Channel Inhibitor, Attenuates Lung Ischemia-Reperfusion Injury in Rats.

Inflammation

Zhang W,Qi Z,Wang Y

Thu Jun 01 00:00:00 EDT 2017

BTP2, a Store-Operated Calcium Channel Inhibitor, Attenuates Lung Ischemia-Reperfusion Injury in Rats.

Inflammation

Zhang W,Qi Z,Wang Y

Thu Jun 01 00:00:00 EDT 2017

miR-181a-5p, an inducer of Wnt-signaling, facilitates cell proliferation in acute lymphoblastic leukemia.

Oncology reports

Lyu X,Li J,Yun X,Huang R,Deng X,Wang Y,Chen Y,Xiao G

Wed Mar 01 00:00:00 EST 2017

miR-181a-5p, an inducer of Wnt-signaling, facilitates cell proliferation in acute lymphoblastic leukemia.

Oncology reports

Lyu X,Li J,Yun X,Huang R,Deng X,Wang Y,Chen Y,Xiao G

Wed Mar 01 00:00:00 EST 2017

Early-Life Social Isolation-Induced Depressive-Like Behavior in Rats Results in Microglial Activation and Neuronal Histone Methylation that Are Mitigated by Minocycline.

Neurotoxicity research

Wang HT,Huang FL,Hu ZL,Zhang WJ,Qiao XQ,Huang YQ,Dai RP,Li F,Li CQ

Mon May 01 00:00:00 EDT 2017

Early-Life Social Isolation-Induced Depressive-Like Behavior in Rats Results in Microglial Activation and Neuronal Histone Methylation that Are Mitigated by Minocycline.

Neurotoxicity research

Wang HT,Huang FL,Hu ZL,Zhang WJ,Qiao XQ,Huang YQ,Dai RP,Li F,Li CQ

Mon May 01 00:00:00 EDT 2017

TSPAN31 is a critical regulator on transduction of survival and apoptotic signals in hepatocellular carcinoma cells.

FEBS letters

Wang J,Zhou Y,Li D,Sun X,Deng Y,Zhao Q

Fri Sep 01 00:00:00 EDT 2017

TSPAN31 is a critical regulator on transduction of survival and apoptotic signals in hepatocellular carcinoma cells.

FEBS letters

Wang J,Zhou Y,Li D,Sun X,Deng Y,Zhao Q

Fri Sep 01 00:00:00 EDT 2017

Aspirin suppresses the abnormal lipid metabolism in liver cancer cells via disrupting an NFκB-ACSL1 signaling.

Biochemical and biophysical research communications

Yang G,Wang Y,Feng J,Liu Y,Wang T,Zhao M,Ye L,Zhang X

Sat May 06 00:00:00 EDT 2017

Aspirin suppresses the abnormal lipid metabolism in liver cancer cells via disrupting an NFκB-ACSL1 signaling.

Biochemical and biophysical research communications

Yang G,Wang Y,Feng J,Liu Y,Wang T,Zhao M,Ye L,Zhang X

Sat May 06 00:00:00 EDT 2017

Triptolide induces DNA breaks, activates caspase-3-dependent apoptosis and sensitizes B-cell lymphoma to poly(ADP-ribose) polymerase 1 and phosphoinositide 3-kinase inhibitors.

Oncology letters

Guan J,Zhao Q,Lv J,Zhang Z,Sun S,Mao W

Sun Oct 01 00:00:00 EDT 2017

Triptolide induces DNA breaks, activates caspase-3-dependent apoptosis and sensitizes B-cell lymphoma to poly(ADP-ribose) polymerase 1 and phosphoinositide 3-kinase inhibitors.

Oncology letters

Guan J,Zhao Q,Lv J,Zhang Z,Sun S,Mao W

Sun Oct 01 00:00:00 EDT 2017

trans-Cinnamaldehyde Inhibits Microglial Activation and Improves Neuronal Survival against Neuroinflammation in BV2 Microglial Cells with Lipopolysaccharide Stimulation.

Evidence-based complementary and alternative medicine : eCAM

Fu Y,Yang P,Zhao Y,Zhang L,Zhang Z,Dong X,Wu Z,Xu Y,Chen Y

Fri Apr 08 00:00:00 EDT 2022

trans-Cinnamaldehyde Inhibits Microglial Activation and Improves Neuronal Survival against Neuroinflammation in BV2 Microglial Cells with Lipopolysaccharide Stimulation.

Evidence-based complementary and alternative medicine : eCAM

Fu Y,Yang P,Zhao Y,Zhang L,Zhang Z,Dong X,Wu Z,Xu Y,Chen Y

Fri Apr 08 00:00:00 EDT 2022

Hypoxia induces oncogene yes-associated protein 1 nuclear translocation to promote pancreatic ductal adenocarcinoma invasion via epithelial-mesenchymal transition.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Wei H,Xu Z,Liu F,Wang F,Wang X,Sun X,Li J

Mon May 01 00:00:00 EDT 2017

Hypoxia induces oncogene yes-associated protein 1 nuclear translocation to promote pancreatic ductal adenocarcinoma invasion via epithelial-mesenchymal transition.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Wei H,Xu Z,Liu F,Wang F,Wang X,Sun X,Li J

Mon May 01 00:00:00 EDT 2017

Loss of Polycomb Group Protein Pcgf1 Severely Compromises Proper Differentiation of Embryonic Stem Cells.

Scientific reports

Yan Y,Zhao W,Huang Y,Tong H,Xia Y,Jiang Q,Qin J

Mon Apr 10 00:00:00 EDT 2017

Loss of Polycomb Group Protein Pcgf1 Severely Compromises Proper Differentiation of Embryonic Stem Cells.

Scientific reports

Yan Y,Zhao W,Huang Y,Tong H,Xia Y,Jiang Q,Qin J

Mon Apr 10 00:00:00 EDT 2017

RACK1 promotes lung cancer cell growth via an MCM7/RACK1/ Akt signaling complex.

Oncotarget

Fei L,Ma Y,Zhang M,Liu X,Luo Y,Wang C,Zhang H,Zhang W,Han Y

Tue Jun 20 00:00:00 EDT 2017

6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 spatially mediates autophagy through the AMPK signaling pathway.

Oncotarget

Yan S,Wei X,Xu S,Sun H,Wang W,Liu L,Jiang X,Zhang Y,Che Y

Fri Oct 06 00:00:00 EDT 2017

6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 spatially mediates autophagy through the AMPK signaling pathway.

Oncotarget

Yan S,Wei X,Xu S,Sun H,Wang W,Liu L,Jiang X,Zhang Y,Che Y

Fri Oct 06 00:00:00 EDT 2017

Kaiso protects human umbilical vein endothelial cells against apoptosis by differentially regulating the expression of B-cell CLL/lymphoma 2 family members.

Scientific reports

Xue X,Zhang J,Lan H,Xu Y,Wang H

Wed Aug 02 00:00:00 EDT 2017

Kaiso protects human umbilical vein endothelial cells against apoptosis by differentially regulating the expression of B-cell CLL/lymphoma 2 family members.

Scientific reports

Xue X,Zhang J,Lan H,Xu Y,Wang H

Wed Aug 02 00:00:00 EDT 2017

Long noncoding RNA CRNDE stabilized by hnRNPUL2 accelerates cell proliferation and migration in colorectal carcinoma via activating Ras/MAPK signaling pathways.

Cell death & disease

Jiang H,Wang Y,Ai M,Wang H,Duan Z,Wang H,Zhao L,Yu J,Ding Y,Wang S

Thu Jun 08 00:00:00 EDT 2017

Long noncoding RNA CRNDE stabilized by hnRNPUL2 accelerates cell proliferation and migration in colorectal carcinoma via activating Ras/MAPK signaling pathways.

Cell death & disease

Jiang H,Wang Y,Ai M,Wang H,Duan Z,Wang H,Zhao L,Yu J,Ding Y,Wang S

Thu Jun 08 00:00:00 EDT 2017

CDK5-mediated phosphorylation of XBP1s contributes to its nuclear translocation and activation in MPP⁺-induced Parkinson's disease model.

Scientific reports

Jiao FJ,Wang QZ,Zhang P,Yan JG,Zhang Z,He F,Zhang Q,Lv ZX,Peng X,Cai HW,Tian B

Mon Jul 17 00:00:00 EDT 2017

CDK5-mediated phosphorylation of XBP1s contributes to its nuclear translocation and activation in MPP⁺-induced Parkinson's disease model.

Scientific reports

Jiao FJ,Wang QZ,Zhang P,Yan JG,Zhang Z,He F,Zhang Q,Lv ZX,Peng X,Cai HW,Tian B

Mon Jul 17 00:00:00 EDT 2017

MicroRNA-27b inhibition promotes Nrf2/ARE pathway activation and alleviates intracerebral hemorrhage-induced brain injury.

Oncotarget

Xu W,Li F,Liu Z,Xu Z,Sun B,Cao J,Liu Y

Tue Sep 19 00:00:00 EDT 2017

MicroRNA-27b inhibition promotes Nrf2/ARE pathway activation and alleviates intracerebral hemorrhage-induced brain injury.

Oncotarget

Xu W,Li F,Liu Z,Xu Z,Sun B,Cao J,Liu Y

Tue Sep 19 00:00:00 EDT 2017

Transcription factors regulate GPR91-mediated expression of VEGF in hypoxia-induced retinopathy.

Scientific reports

Li T,Hu J,Gao F,Du X,Chen Y,Wu Q

Tue Apr 04 00:00:00 EDT 2017

Transcription factors regulate GPR91-mediated expression of VEGF in hypoxia-induced retinopathy.

Scientific reports

Li T,Hu J,Gao F,Du X,Chen Y,Wu Q

Tue Apr 04 00:00:00 EDT 2017

An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them against Oxidative Stress.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Liu J,Wang L,Du Y,Liu S

Sun Oct 01 00:00:00 EDT 2017

An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them against Oxidative Stress.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Liu J,Wang L,Du Y,Liu S

Sun Oct 01 00:00:00 EDT 2017

Involvement of aberrantly activated HOTAIR/EZH2/miR-193a feedback loop in progression of prostate cancer.

Journal of experimental & clinical cancer research : CR

Ling Z,Wang X,Tao T,Zhang L,Guan H,You Z,Lu K,Zhang G,Chen S,Wu J,Qian J,Liu H,Xu B,Chen M

Wed Nov 15 00:00:00 EST 2017

Involvement of aberrantly activated HOTAIR/EZH2/miR-193a feedback loop in progression of prostate cancer.

Journal of experimental & clinical cancer research : CR

Ling Z,Wang X,Tao T,Zhang L,Guan H,You Z,Lu K,Zhang G,Chen S,Wu J,Qian J,Liu H,Xu B,Chen M

Wed Nov 15 00:00:00 EST 2017

Dicer promotes tumorigenesis by translocating to nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells.

Cell death & disease

Cheng W,Qi Y,Tian L,Wang B,Huang W,Chen Y

Thu Feb 23 00:00:00 EST 2017

Dicer promotes tumorigenesis by translocating to nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells.

Cell death & disease

Cheng W,Qi Y,Tian L,Wang B,Huang W,Chen Y

Thu Feb 23 00:00:00 EST 2017

Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents.

Nucleic acids research

Zhang PY,Li G,Deng ZJ,Liu LY,Chen L,Tang JZ,Wang YQ,Cao ST,Fang YX,Wen F,Xu Y,Chen X,Shi KQ,Li WF,Xie C,Tang KF

Thu May 05 00:00:00 EDT 2016

Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents.

Nucleic acids research

Zhang PY,Li G,Deng ZJ,Liu LY,Chen L,Tang JZ,Wang YQ,Cao ST,Fang YX,Wen F,Xu Y,Chen X,Shi KQ,Li WF,Xie C,Tang KF

Thu May 05 00:00:00 EDT 2016

S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.

Proceedings of the National Academy of Sciences of the United States of America

Jayaram H,Hoelper D,Jain SU,Cantone N,Lundgren SM,Poy F,Allis CD,Cummings R,Bellon S,Lewis PW

Tue May 31 00:00:00 EDT 2016

S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.

Proceedings of the National Academy of Sciences of the United States of America

Jayaram H,Hoelper D,Jain SU,Cantone N,Lundgren SM,Poy F,Allis CD,Cummings R,Bellon S,Lewis PW

Tue May 31 00:00:00 EDT 2016

Downregulation of ACE2/Ang-(1-7)/Mas axis promotes breast cancer metastasis by enhancing store-operated calcium entry.

Cancer letters

Yu C,Tang W,Wang Y,Shen Q,Wang B,Cai C,Meng X,Zou F

Fri Jul 01 00:00:00 EDT 2016

Downregulation of ACE2/Ang-(1-7)/Mas axis promotes breast cancer metastasis by enhancing store-operated calcium entry.

Cancer letters

Yu C,Tang W,Wang Y,Shen Q,Wang B,Cai C,Meng X,Zou F

Fri Jul 01 00:00:00 EDT 2016

Compositional Analysis of Asymmetric and Symmetric Dimethylated H3R2 Using Liquid Chromatography-Tandem Mass Spectrometry-Based Targeted Proteomics.

Analytical chemistry

Xu Q,Xu F,Liu L,Chen Y

Tue Sep 06 00:00:00 EDT 2016

Compositional Analysis of Asymmetric and Symmetric Dimethylated H3R2 Using Liquid Chromatography-Tandem Mass Spectrometry-Based Targeted Proteomics.

Analytical chemistry

Xu Q,Xu F,Liu L,Chen Y

Tue Sep 06 00:00:00 EDT 2016

Anticancer effect of SZC015 on lung cancer cells through ROS-dependent apoptosis and autophagy induction mechanisms in vitro.

International immunopharmacology

Sun B,Gao L,Ahsan A,Chu P,Song Y,Li H,Zhang Z,Lin Y,Peng J,Song Z,Wang S,Tang Z

Tue Nov 01 00:00:00 EDT 2016

Anticancer effect of SZC015 on lung cancer cells through ROS-dependent apoptosis and autophagy induction mechanisms in vitro.

International immunopharmacology

Sun B,Gao L,Ahsan A,Chu P,Song Y,Li H,Zhang Z,Lin Y,Peng J,Song Z,Wang S,Tang Z

Tue Nov 01 00:00:00 EDT 2016

IL-17 intensifies IFN-γ-induced NOS2 upregulation in RAW 264.7 cells by further activating STAT1 and NF-κB.

International journal of molecular medicine

Gao Q,Liu Y,Wu Y,Zhao Q,Wang L,Gao S,Wen W,Zhang W,Guo N,Zhou J,Yuan Z

Mon Feb 01 00:00:00 EST 2016

IL-17 intensifies IFN-γ-induced NOS2 upregulation in RAW 264.7 cells by further activating STAT1 and NF-κB.

International journal of molecular medicine

Gao Q,Liu Y,Wu Y,Zhao Q,Wang L,Gao S,Wen W,Zhang W,Guo N,Zhou J,Yuan Z

Mon Feb 01 00:00:00 EST 2016

SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells.

Chemico-biological interactions

Wu J,Yang C,Guo C,Li X,Yang N,Zhao L,Hang H,Liu S,Chu P,Sun Z,Sun B,Lin Y,Peng J,Han G,Wang S,Tang Z

Mon Jan 25 00:00:00 EST 2016

SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells.

Chemico-biological interactions

Wu J,Yang C,Guo C,Li X,Yang N,Zhao L,Hang H,Liu S,Chu P,Sun Z,Sun B,Lin Y,Peng J,Han G,Wang S,Tang Z

Mon Jan 25 00:00:00 EST 2016

Anticancer effect of SZC017, a novel derivative of oleanolic acid, on human gastric cancer cells.

Oncology reports

Gao L,Xu Z,Wang Y,Sun B,Song Z,Yang B,Liu X,Lin Y,Peng J,Han G,Wang S,Tang Z

Mon Feb 01 00:00:00 EST 2016

Anticancer effect of SZC017, a novel derivative of oleanolic acid, on human gastric cancer cells.

Oncology reports

Gao L,Xu Z,Wang Y,Sun B,Song Z,Yang B,Liu X,Lin Y,Peng J,Han G,Wang S,Tang Z

Mon Feb 01 00:00:00 EST 2016

Bioorganic & medicinal chemistry

Xu LL,Zhang X,Jiang ZY,You QD

Mon Aug 15 00:00:00 EDT 2016

Bioorganic & medicinal chemistry

Xu LL,Zhang X,Jiang ZY,You QD

Mon Aug 15 00:00:00 EDT 2016

TGF-β1 activates the canonical NF-κB signaling to promote cell survival and proliferation in dystrophic muscle fibroblasts in vitro.

Biochemical and biophysical research communications

Ma ZY,Zhong ZG,Qiu MY,Zhong YH,Zhang WX

Fri Mar 18 00:00:00 EDT 2016

TGF-β1 activates the canonical NF-κB signaling to promote cell survival and proliferation in dystrophic muscle fibroblasts in vitro.

Biochemical and biophysical research communications

Ma ZY,Zhong ZG,Qiu MY,Zhong YH,Zhang WX

Fri Mar 18 00:00:00 EDT 2016

Daphnetin Protects against Cerebral Ischemia/Reperfusion Injury in Mice via Inhibition of TLR4/NF-κB Signaling Pathway.

BioMed research international

Liu J,Chen Q,Jian Z,Xiong X,Shao L,Jin T,Zhu X,Wang L

Thu Feb 09 00:00:00 EST 2017

Daphnetin Protects against Cerebral Ischemia/Reperfusion Injury in Mice via Inhibition of TLR4/NF-κB Signaling Pathway.

BioMed research international

Liu J,Chen Q,Jian Z,Xiong X,Shao L,Jin T,Zhu X,Wang L

Thu Feb 09 00:00:00 EST 2017

Downregulation of HP1α suppresses proliferation of cholangiocarcinoma by restoring SFRP1 expression.

Oncotarget

Cheng W,Tian L,Wang B,Qi Y,Huang W,Li H,Chen YJ

Tue Jul 26 00:00:00 EDT 2016

Downregulation of HP1α suppresses proliferation of cholangiocarcinoma by restoring SFRP1 expression.

Oncotarget

Cheng W,Tian L,Wang B,Qi Y,Huang W,Li H,Chen YJ

Tue Jul 26 00:00:00 EDT 2016

Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus.

eLife

Dinamarca MC,Guzzetti F,Karpova A,Lim D,Mitro N,Musardo S,Mellone M,Marcello E,Stanic J,Samaddar T,Burguière A,Caldarelli A,Genazzani AA,Perroy J,Fagni L,Canonico PL,Kreutz MR,Gardoni F,Di Luca M

Tue Mar 15 00:00:00 EDT 2016

Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus.

eLife

Dinamarca MC,Guzzetti F,Karpova A,Lim D,Mitro N,Musardo S,Mellone M,Marcello E,Stanic J,Samaddar T,Burguière A,Caldarelli A,Genazzani AA,Perroy J,Fagni L,Canonico PL,Kreutz MR,Gardoni F,Di Luca M

Tue Mar 15 00:00:00 EDT 2016

Downregulation of vimentin expression increased drug resistance in ovarian cancer cells.

Oncotarget

Huo Y,Zheng Z,Chen Y,Wang Q,Zhang Z,Deng H

Tue Jul 19 00:00:00 EDT 2016

Downregulation of vimentin expression increased drug resistance in ovarian cancer cells.

Oncotarget

Huo Y,Zheng Z,Chen Y,Wang Q,Zhang Z,Deng H

Tue Jul 19 00:00:00 EDT 2016

Early ketamine exposure results in cardiac enlargement and heart dysfunction in Xenopus embryos.

BMC anesthesiology

Guo R,Liu G,Du M,Shi Y,Jiang P,Liu X,Liu L,Liu J,Xu Y

Mon Apr 18 00:00:00 EDT 2016

Early ketamine exposure results in cardiac enlargement and heart dysfunction in Xenopus embryos.

BMC anesthesiology

Guo R,Liu G,Du M,Shi Y,Jiang P,Liu X,Liu L,Liu J,Xu Y

Mon Apr 18 00:00:00 EDT 2016

New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats.

Scientific reports

Ding C,Zhao Y,Shi X,Zhang N,Zu G,Li Z,Zhou J,Gao D,Lv L,Tian X,Yao J

Mon Jun 27 00:00:00 EDT 2016

New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats.

Scientific reports

Ding C,Zhao Y,Shi X,Zhang N,Zu G,Li Z,Zhou J,Gao D,Lv L,Tian X,Yao J

Mon Jun 27 00:00:00 EDT 2016

HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis.

The Journal of biological chemistry

Chen Y,Pan K,Wang P,Cao Z,Wang W,Wang S,Hu N,Xue J,Li H,Jiang W,Li G,Zhang X

Fri Jun 10 00:00:00 EDT 2016

HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis.

The Journal of biological chemistry

Chen Y,Pan K,Wang P,Cao Z,Wang W,Wang S,Hu N,Xue J,Li H,Jiang W,Li G,Zhang X

Fri Jun 10 00:00:00 EDT 2016

Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.

PloS one

Gao Z,Han Y,Hu Y,Wu X,Wang Y,Zhang X,Fu J,Zou X,Zhang J,Chen X,Jose PA,Lu X,Zeng C

Mon Jul 25 00:00:00 EDT 2016

Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.

PloS one

Gao Z,Han Y,Hu Y,Wu X,Wang Y,Zhang X,Fu J,Zou X,Zhang J,Chen X,Jose PA,Lu X,Zeng C

Mon Jul 25 00:00:00 EDT 2016

Genetic variants in microRNAs predict non-small cell lung cancer prognosis in Chinese female population in a prospective cohort study.

Oncotarget

Lingzi X,Zhihua Y,Xuelian L,Yangwu R,Haibo Z,Yuxia Z,Baosen Z

Tue Dec 13 00:00:00 EST 2016

Genetic variants in microRNAs predict non-small cell lung cancer prognosis in Chinese female population in a prospective cohort study.

Oncotarget

Lingzi X,Zhihua Y,Xuelian L,Yangwu R,Haibo Z,Yuxia Z,Baosen Z

Tue Dec 13 00:00:00 EST 2016

Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.

Journal of medicinal chemistry

Xu LL,Zhu JF,Xu XL,Zhu J,Li L,Xi MY,Jiang ZY,Zhang MY,Liu F,Lu MC,Bao QC,Li Q,Zhang C,Wei JL,Zhang XJ,Zhang LS,You QD,Sun HP

Thu Jul 23 00:00:00 EDT 2015

Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.

Journal of medicinal chemistry

Xu LL,Zhu JF,Xu XL,Zhu J,Li L,Xi MY,Jiang ZY,Zhang MY,Liu F,Lu MC,Bao QC,Li Q,Zhang C,Wei JL,Zhang XJ,Zhang LS,You QD,Sun HP

Thu Jul 23 00:00:00 EDT 2015

SZC017, a novel oleanolic acid derivative, induces apoptosis and autophagy in human breast cancer cells.

Apoptosis : an international journal on programmed cell death

Gao L,Wang Y,Xu Z,Li X,Wu J,Liu S,Chu P,Sun Z,Sun B,Lin Y,Peng J,Han G,Wang S,Tang Z

Tue Dec 01 00:00:00 EST 2015

SZC017, a novel oleanolic acid derivative, induces apoptosis and autophagy in human breast cancer cells.

Apoptosis : an international journal on programmed cell death

Gao L,Wang Y,Xu Z,Li X,Wu J,Liu S,Chu P,Sun Z,Sun B,Lin Y,Peng J,Han G,Wang S,Tang Z

Tue Dec 01 00:00:00 EST 2015

Scutellarein inhibits cancer cell metastasis in vitro and attenuates the development of fibrosarcoma in vivo.

International journal of molecular medicine

Shi X,Chen G,Liu X,Qiu Y,Yang S,Zhang Y,Fang X,Zhang C,Liu X

Thu Jan 01 00:00:00 EST 2015

Scutellarein inhibits cancer cell metastasis in vitro and attenuates the development of fibrosarcoma in vivo.

International journal of molecular medicine

Shi X,Chen G,Liu X,Qiu Y,Yang S,Zhang Y,Fang X,Zhang C,Liu X

Thu Jan 01 00:00:00 EST 2015

O-Alkylated derivatives of quercetin induce apoptosis of MCF-7 cells via a caspase-independent mitochondrial pathway.

Chemico-biological interactions

Liao H,Bao X,Zhu J,Qu J,Sun Y,Ma X,Wang E,Guo X,Kang Q,Zhen Y

Sat Dec 05 00:00:00 EST 2015

O-Alkylated derivatives of quercetin induce apoptosis of MCF-7 cells via a caspase-independent mitochondrial pathway.

Chemico-biological interactions

Liao H,Bao X,Zhu J,Qu J,Sun Y,Ma X,Wang E,Guo X,Kang Q,Zhen Y

Sat Dec 05 00:00:00 EST 2015

The Steroid Hormone 20-Hydroxyecdysone Up-regulates Ste-20 Family Serine/Threonine Kinase Hippo to Induce Programmed Cell Death.

The Journal of biological chemistry

Dong DJ,Jing YP,Liu W,Wang JX,Zhao XF

Fri Oct 09 00:00:00 EDT 2015

The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer.

The Journal of biological chemistry

Li H,Liu Q,Wang Z,Fang R,Shen Y,Cai X,Gao Y,Li Y,Zhang X,Ye L

Fri Sep 11 00:00:00 EDT 2015

The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer.

The Journal of biological chemistry

Li H,Liu Q,Wang Z,Fang R,Shen Y,Cai X,Gao Y,Li Y,Zhang X,Ye L

Fri Sep 11 00:00:00 EDT 2015

Mulberry fruit prevents LPS-induced NF-κB/pERK/MAPK signals in macrophages and suppresses acute colitis and colorectal tumorigenesis in mice.

Scientific reports

Qian Z,Wu Z,Huang L,Qiu H,Wang L,Li L,Yao L,Kang K,Qu J,Wu Y,Luo J,Liu JJ,Yang Y,Yang W,Gou D

Mon Nov 30 00:00:00 EST 2015

Mulberry fruit prevents LPS-induced NF-κB/pERK/MAPK signals in macrophages and suppresses acute colitis and colorectal tumorigenesis in mice.

Scientific reports

Qian Z,Wu Z,Huang L,Qiu H,Wang L,Li L,Yao L,Kang K,Qu J,Wu Y,Luo J,Liu JJ,Yang Y,Yang W,Gou D

Mon Nov 30 00:00:00 EST 2015

FUS Interacts with HSP60 to Promote Mitochondrial Damage.

PLoS genetics

Deng J,Yang M,Chen Y,Chen X,Liu J,Sun S,Cheng H,Li Y,Bigio EH,Mesulam M,Xu Q,Du S,Fushimi K,Zhu L,Wu JY

Tue Sep 01 00:00:00 EDT 2015

FUS Interacts with HSP60 to Promote Mitochondrial Damage.

PLoS genetics

Deng J,Yang M,Chen Y,Chen X,Liu J,Sun S,Cheng H,Li Y,Bigio EH,Mesulam M,Xu Q,Du S,Fushimi K,Zhu L,Wu JY

Tue Sep 01 00:00:00 EDT 2015

Role of NSD1 in H2O2-induced GSTM3 suppression.

Cellular signalling

Chu G,Li Y,Dong X,Liu J,Zhao Y

Mon Dec 01 00:00:00 EST 2014

Role of NSD1 in H2O2-induced GSTM3 suppression.

Cellular signalling

Chu G,Li Y,Dong X,Liu J,Zhao Y

Mon Dec 01 00:00:00 EST 2014

Histone methyltransferase G9a and H3K9 dimethylation inhibit the self-renewal of glioma cancer stem cells.

Molecular and cellular biochemistry

Tao H,Li H,Su Y,Feng D,Wang X,Zhang C,Ma H,Hu Q

Mon Sep 01 00:00:00 EDT 2014

Histone methyltransferase G9a and H3K9 dimethylation inhibit the self-renewal of glioma cancer stem cells.

Molecular and cellular biochemistry

Tao H,Li H,Su Y,Feng D,Wang X,Zhang C,Ma H,Hu Q

Mon Sep 01 00:00:00 EDT 2014

CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells.

The Biochemical journal

Gong K,Xie J,Yi H,Li W

Tue May 01 00:00:00 EDT 2012

CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells.

The Biochemical journal

Gong K,Xie J,Yi H,Li W

Tue May 01 00:00:00 EDT 2012

The oncoprotein HBXIP uses two pathways to up-regulate S100A4 in promotion of growth and migration of breast cancer cells.

The Journal of biological chemistry

Liu S,Li L,Zhang Y,Zhang Y,Zhao Y,You X,Lin Z,Zhang X,Ye L

Fri Aug 31 00:00:00 EDT 2012

The oncoprotein HBXIP uses two pathways to up-regulate S100A4 in promotion of growth and migration of breast cancer cells.

The Journal of biological chemistry

Liu S,Li L,Zhang Y,Zhang Y,Zhao Y,You X,Lin Z,Zhang X,Ye L

Fri Aug 31 00:00:00 EDT 2012

Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells attenuates palmitic acid-induced inflammation and reduction in nitric oxide bioavailability.

Cardiovascular diabetology

Tian D,Qiu Y,Zhan Y,Li X,Zhi X,Wang X,Yin L,Ning Y

Wed Nov 21 00:00:00 EST 2012

Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells attenuates palmitic acid-induced inflammation and reduction in nitric oxide bioavailability.

Cardiovascular diabetology

Tian D,Qiu Y,Zhan Y,Li X,Zhi X,Wang X,Yin L,Ning Y

Wed Nov 21 00:00:00 EST 2012

Bioinformatics

Protein Aliases: H3 histone family, member A; H3 histone family, member I; H3 histone family, member J; H3 histone family, member K; H3 histone family, member L; H3 histone family, member M; H3 histone, family 2; H3-clustered histone 13; H3-clustered histone 14; H3-clustered histone 15; H3-clustered histone 2; H3-clustered histone 3; H3-clustered histone 4; H3-clustered histone 6; H3-clustered histone 7; H3/b; H3/d; H3/f; H3/j; H3S10ph; histone 1, H3a; histone 1, H3b; histone 1, H3f; histone 1, H3h; histone 1, H3j; histone 2, H3a; histone 2, H3c; histone 2, H3c2; histone 2, H3ca2; Histone 3; histone cluster 1, H3a; Histone Cluster 2 H3a; histone cluster 2, H3c2, pseudogene; histone cluster 3, H3; histone gene complex 1; histone H3; Histone H3.1; Histone H3.2; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l; Histone H3/m; Histone H3/o

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Gene Aliases: H3; H3-143; H3-291; H3-53; H3-614; H3-B; H3-F; H3.1-221; H3.1-291; H3.1-I; H3.2; H3.2-221; H3.2-614; H3.2-615; H3.2-616; H3/A; H3/i; H3/j; H3/k; H3/l; H3/M; H3/n; H3/o; H3a; H3b; H3C1; H3C10; H3C11; H3C12; H3C13; H3C14; H3C15; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3f; H3F1K; H3F2; H3FA; H3FB; H3FC HIST1H3C; H3FD; H3FF; H3FH; H3FI; H3FJ; H3FK; H3FL; H3FM; H3FN; H3g; H3h; H3i; Hist1; HIST1H3A; HIST1H3B; Hist1h3c; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; HIST2H3A; Hist2h3b; HIST2H3C; Hist2h3c1; Hist2h3c2; Hist2h3c2-ps; Hist2h3ca1; Hist2h3ca2; HIST2H3D; M32461

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UniProt ID: (Human) P68431, (Human) Q71DI3, (Mouse) P68433, (Mouse) P84228, (Mouse) Q8CGN9

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Entrez Gene ID: (Human) 8350, (Human) 8358, (Human) 8968, (Human) 8357, (Human) 8356, (Human) 333932, (Human) 126961, (Mouse) 360198, (Rat) 679994, (Mouse) 319150, (Mouse) 260423, (Mouse) 319152, (Mouse) 97114

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Function(s)

DNA binding protein binding histone binding protein heterodimerization activity cadherin binding involved in cell-cell adhesion histone

Process(es)

chromatin silencing at rDNA positive regulation of defense response to virus by host nucleosome assembly DNA replication-dependent nucleosome assembly blood coagulation gene silencing by RNA telomere organization cellular protein metabolic process negative regulation of gene expression, epigenetic positive regulation of gene expression, epigenetic protein heterotetramerization regulation of gene silencing cell-cell adhesion xenophagy

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Histone-H3 Polyclonal Antibody

Histone-H3 Antibody (17168-1-AP) in ICC/IF

Product Details

17168-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

ChIP assay (ChIP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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