Product References
NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling.
Nature
Chowdhry S,Zanca C,Rajkumar U,Koga T,Diao Y,Raviram R,Liu F,Turner K,Yang H,Brunk E,Bi J,Furnari F,Bafna V,Ren B,Mischel PS
Research topic: Cancer, Gene Regulation
Wed May 01 00:00:00 EDT 2019
The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape.
Nature
Weinberg DN,Papillon-Cavanagh S,Chen H,Yue Y,Chen X,Rajagopalan KN,Horth C,McGuire JT,Xu X,Nikbakht H,Lemiesz AE,Marchione DM,Marunde MR,Meiners MJ,Cheek MA,Keogh MC,Bareke E,Djedid A,Harutyunyan AS,Jabado N,Garcia BA,Li H,Allis CD,Majewski J,Lu C
Research topic: DNA Methylation
Sun Sep 01 00:00:00 EDT 2019
Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition.
Science signaling
Augert A,Eastwood E,Ibrahim AH,Wu N,Grunblatt E,Basom R,Liggitt D,Eaton KD,Martins R,Poirier JT,Rudin CM,Milletti F,Cheng WY,Mack F,MacPherson D
Research topic: Lung
Tue Feb 05 00:00:00 EST 2019
Loss of KDM6A characterizes a poor prognostic subtype of human pancreatic cancer and potentiates HDAC inhibitor lethality.
International journal of cancer
Watanabe S,Shimada S,Akiyama Y,Ishikawa Y,Ogura T,Ogawa K,Ono H,Mitsunori Y,Ban D,Kudo A,Yamaoka S,Tanabe M,Tanaka S
Research topic: Pancreatic Cancer
Mon Jul 01 00:00:00 EDT 2019
Epigenetic biomarker screening by FLIM-FRET for combination therapy in ER+ breast cancer.
Clinical epigenetics
Liu W,Cui Y,Ren W,Irudayaraj J
Research topic: Breast Cancer
Wed Jan 30 00:00:00 EST 2019
GemC1 governs multiciliogenesis through direct interaction with and transcriptional regulation of p73.
Journal of cell science
Lalioti ME,Arbi M,Loukas I,Kaplani K,Kalogeropoulou A,Lokka G,Kyrousi C,Mizi A,Georgomanolis T,Josipovic N,Gkikas D,Benes V,Politis PK,Papantonis A,Lygerou Z,Taraviras S
Research topic: Transcription, Cell Fate
Mon Jun 03 00:00:00 EDT 2019
Functional relevance of genes predicted to be affected by epigenetic alterations in atypical teratoid/rhabdoid tumors.
Journal of neuro-oncology
Tegeder I,Thiel K,Erkek S,Johann PD,Berlandi J,Thatikonda V,Frühwald MC,Kool M,Jeibmann A,Hasselblatt M
Research topic: Brain & Nerves
Tue Jan 01 00:00:00 EST 2019
Trim33 is required for appropriate development of pre-cardiogenic mesoderm.
Developmental biology
Rajderkar S,Mann JM,Panaretos C,Yumoto K,Li HD,Mishina Y,Ralston B,Kaartinen V
Research topic: Cardiology, Developmental Biology
Sat Jun 15 00:00:00 EDT 2019
Gonadal supporting cells acquire sex-specific chromatin landscapes during mammalian sex determination.
Developmental biology
Garcia-Moreno SA,Futtner CR,Salamone IM,Gonen N,Lovell-Badge R,Maatouk DM
Research topic: Gene Regulation, Developmental Biology
Fri Feb 15 00:00:00 EST 2019
Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors.
Cell
Huang X,Yan J,Zhang M,Wang Y,Chen Y,Fu X,Wei R,Zheng XL,Liu Z,Zhang X,Yang H,Hao B,Shen YY,Su Y,Cong X,Huang M,Tan M,Ding J,Geng M
Thu Sep 20 00:00:00 EDT 2018
Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses.
Cancer cell
Stewart E,McEvoy J,Wang H,Chen X,Honnell V,Ocarz M,Gordon B,Dapper J,Blankenship K,Yang Y,Li Y,Shaw TI,Cho JH,Wang X,Xu B,Gupta P,Fan Y,Liu Y,Rusch M,Griffiths L,Jeon J,Freeman BB,Clay MR,Pappo A,Easton J,Shurtleff S,Shelat A,Zhou X,Boggs K,Mulder H,Yergeau D,Bahrami A,Mardis ER,Wilson RK,Zhang J,Peng J,Downing JR,Dyer MA
Research topic: Skeletal Muscle - Rhabdomyosarcoma
Mon Sep 10 00:00:00 EDT 2018
Guidance of super-enhancers in regulation of IL-9 induction and airway inflammation.
The Journal of experimental medicine
Xiao X,Fan Y,Li J,Zhang X,Lou X,Dou Y,Shi X,Lan P,Xiao Y,Minze L,Li XC
Research topic: Immunology & Hematology
Mon Feb 05 00:00:00 EST 2018
Systematic perturbation of retroviral LTRs reveals widespread long-range effects on human gene regulation.
eLife
Fuentes DR,Swigut T,Wysocka J
Research topic: Gene Regulation
Thu Aug 02 00:00:00 EDT 2018
OX40 Costimulation Inhibits Foxp3 Expression and Treg Induction via BATF3-Dependent and Independent Mechanisms.
Cell reports
Zhang X,Xiao X,Lan P,Li J,Dou Y,Chen W,Ishii N,Chen S,Xia B,Chen K,Taparowsky E,Li XC
Research topic: Immunology & Hematology
Tue Jul 17 00:00:00 EDT 2018
Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells.
Nature communications
Valsecchi CIK,Basilicata MF,Semplicio G,Georgiev P,Gutierrez NM,Akhtar A
Research topic: Neurology, Gene Regulation
Fri Sep 07 00:00:00 EDT 2018
Integrative epigenetic taxonomy of primary prostate cancer.
Nature communications
Stelloo S,Nevedomskaya E,Kim Y,Schuurman K,Valle-Encinas E,Lobo J,Krijgsman O,Peeper DS,Chang SL,Feng FY,Wessels LFA,Henrique R,Jerónimo C,Bergman AM,Zwart W
Research topic: Prostate Cancer
Wed Nov 21 00:00:00 EST 2018
CRISPR-mediated deletion of prostate cancer risk-associated CTCF loop anchors identifies repressive chromatin loops.
Genome biology
Guo Y,Perez AA,Hazelett DJ,Coetzee GA,Rhie SK,Farnham PJ
Research topic: Prostate Cancer
Mon Oct 08 00:00:00 EDT 2018
Targeting glioma stem cells through combined BMI1 and EZH2 inhibition.
Nature medicine
Jin X,Kim LJY,Wu Q,Wallace LC,Prager BC,Sanvoranart T,Gimple RC,Wang X,Mack SC,Miller TE,Huang P,Valentim CL,Zhou QG,Barnholtz-Sloan JS,Bao S,Sloan AE,Rich JN
Research topic: Brain & Nerves
Wed Nov 01 00:00:00 EDT 2017
The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain.
Nature genetics
Jiang Y,Loh YE,Rajarajan P,Hirayama T,Liao W,Kassim BS,Javidfar B,Hartley BJ,Kleofas L,Park RB,Labonte B,Ho SM,Chandrasekaran S,Do C,Ramirez BR,Peter CJ,C W JT,Safaie BM,Morishita H,Roussos P,Nestler EJ,Schaefer A,Tycko B,Brennand KJ,Yagi T,Shen L,Akbarian S
Research topic: Brain & Nerves
Tue Aug 01 00:00:00 EDT 2017
Resolving Heart Regeneration by Replacement Histone Profiling.
Developmental cell
Goldman JA,Kuzu G,Lee N,Karasik J,Gemberling M,Foglia MJ,Karra R,Dickson AL,Sun F,Tolstorukov MY,Poss KD
Research topic: Cardiology
Mon Feb 27 00:00:00 EST 2017
Coordinate regulation of stress signaling and epigenetic events by Acss2 and HIF-2 in cancer cells.
PloS one
Chen R,Xu M,Nagati J,Garcia JA
Research topic: Cancer, Hypoxia
Tue Feb 06 00:00:00 EST 2018
H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis.
Nature communications
Zhang X,Li B,Rezaeian AH,Xu X,Chou PC,Jin G,Han F,Pan BS,Wang CY,Long J,Zhang A,Huang CY,Tsai FJ,Tsai CH,Logothetis C,Lin HK
Research topic: Cancer
Thu Mar 16 00:00:00 EDT 2017
Prior alcohol use enhances vulnerability to compulsive cocaine self-administration by promoting degradation of HDAC4 and HDAC5.
Science advances
Griffin EA,Melas PA,Zhou R,Li Y,Mercado P,Kempadoo KA,Stephenson S,Colnaghi L,Taylor K,Hu MC,Kandel ER,Kandel DB
Research topic: Brain & Nerves - Addiction
Wed Nov 01 00:00:00 EDT 2017
Using Chromatin Immunoprecipitation in Toxicology: A Step-by-Step Guide to Increasing Efficiency, Reducing Variability, and Expanding Applications.
Current protocols in toxicology
McCullough SD,On DM,Bowers EC
Research topic: Methods Paper
Tue May 02 00:00:00 EDT 2017
A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer.
Nature communications
Betancur PA,Abraham BJ,Yiu YY,Willingham SB,Khameneh F,Zarnegar M,Kuo AH,McKenna K,Kojima Y,Leeper NJ,Ho P,Gip P,Swigut T,Sherwood RI,Clarke MF,Somlo G,Young RA,Weissman IL
Research topic: Breast Cancer
Wed Apr 05 00:00:00 EDT 2017
Active medulloblastoma enhancers reveal subgroup-specific cellular origins.
Nature
Lin CY,Erkek S,Tong Y,Yin L,Federation AJ,Zapatka M,Haldipur P,Kawauchi D,Risch T,Warnatz HJ,Worst BC,Ju B,Orr BA,Zeid R,Polaski DR,Segura-Wang M,Waszak SM,Jones DT,Kool M,Hovestadt V,Buchhalter I,Sieber L,Johann P,Chavez L,Gröschel S,Ryzhova M,Korshunov A,Chen W,Chizhikov VV,Millen KJ,Amstislavskiy V,Lehrach H,Yaspo ML,Eils R,Lichter P,Korbel JO,Pfister SM,Bradner JE,Northcott PA
Research topic: Brain & Nerves
Thu Feb 04 00:00:00 EST 2016
Alterations in nuclear structure promote lupus autoimmunity in a mouse model.
Disease models & mechanisms
Singh N,Johnstone DB,Martin KA,Tempera I,Kaplan MJ,Denny MF
Research topic: Autoimmunity - Lupus (SLE)
Mon Aug 01 00:00:00 EDT 2016
Antibody performance in ChIP-sequencing assays: From quality scores of public data sets to quantitative certification.
F1000Research
Mendoza-Parra MA,Saravaki V,Cholley PE,Blum M,Billoré B,Gronemeyer H
Mon Jun 27 00:00:00 EDT 2016
Retinoic acid is essential for Th1 cell lineage stability and prevents transition to a Th17 cell program.
Immunity
Brown CC,Esterhazy D,Sarde A,London M,Pullabhatla V,Osma-Garcia I,Al-Bader R,Ortiz C,Elgueta R,Arno M,de Rinaldis E,Mucida D,Lord GM,Noelle RJ
Research topic: Immunology & Hematology
Tue Mar 17 00:00:00 EDT 2015
Mesodermal iPSC-derived progenitor cells functionally regenerate cardiac and skeletal muscle.
The Journal of clinical investigation
Quattrocelli M,Swinnen M,Giacomazzi G,Camps J,Barthélemy I,Ceccarelli G,Caluwé E,Grosemans H,Thorrez L,Pelizzo G,Muijtjens M,Verfaillie CM,Blot S,Janssens S,Sampaolesi M
Research topic: Muscular Dystrophies (MDs), Stem Cells
Tue Dec 01 00:00:00 EST 2015
The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains.
Genes & development
Alekseyenko AA,Walsh EM,Wang X,Grayson AR,Hsi PT,Kharchenko PV,Kuroda MI,French CA
Research topic: Squamous cell cancer
Wed Jul 15 00:00:00 EDT 2015
The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains.
Genes & development
Alekseyenko AA,Walsh EM,Wang X,Grayson AR,Hsi PT,Kharchenko PV,Kuroda MI,French CA
Research topic: Squamous cell cancer
Wed Jul 15 00:00:00 EDT 2015
Chromatin analyses of Zymoseptoria tritici: Methods for chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq).
Fungal genetics and biology : FG & B
Soyer JL,Möller M,Schotanus K,Connolly LR,Galazka JM,Freitag M,Stukenbrock EH
Research topic: Methods - ChIP in fungi
Mon Jun 01 00:00:00 EDT 2015
Chromatin analyses of Zymoseptoria tritici: Methods for chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq).
Fungal genetics and biology : FG & B
Soyer JL,Möller M,Schotanus K,Connolly LR,Galazka JM,Freitag M,Stukenbrock EH
Research topic: Methods - ChIP in fungi
Mon Jun 01 00:00:00 EDT 2015
Comparison of the cytotoxicity of cladribine and clofarabine when combined with fludarabine and busulfan in AML cells: Enhancement of cytotoxicity with epigenetic modulators.
Experimental hematology
Valdez BC,Li Y,Murray D,Ji J,Liu Y,Popat U,Champlin RE,Andersson BS
Research topic: AML
Mon Jun 01 00:00:00 EDT 2015
Impact of flanking chromosomal sequences on localization and silencing by the human non-coding RNA XIST.
Genome biology
Kelsey AD,Yang C,Leung D,Minks J,Dixon-McDougall T,Baldry SE,Bogutz AB,Lefebvre L,Brown CJ
Research topic: Gene Regulation
Fri Oct 02 00:00:00 EDT 2015
Tumor-secreted Hsp90 subverts polycomb function to drive prostate tumor growth and invasion.
The Journal of biological chemistry
Nolan KD,Franco OE,Hance MW,Hayward SW,Isaacs JS
Research topic: Prostate Cancer
Fri Mar 27 00:00:00 EDT 2015
Tumor-secreted Hsp90 subverts polycomb function to drive prostate tumor growth and invasion.
The Journal of biological chemistry
Nolan KD,Franco OE,Hance MW,Hayward SW,Isaacs JS
Research topic: Prostate Cancer
Fri Mar 27 00:00:00 EDT 2015
Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.
Nature
Northcott PA,Lee C,Zichner T,Stütz AM,Erkek S,Kawauchi D,Shih DJ,Hovestadt V,Zapatka M,Sturm D,Jones DT,Kool M,Remke M,Cavalli FM,Zuyderduyn S,Bader GD,VandenBerg S,Esparza LA,Ryzhova M,Wang W,Wittmann A,Stark S,Sieber L,Seker-Cin H,Linke L,Kratochwil F,Jäger N,Buchhalter I,Imbusch CD,Zipprich G,Raeder B,Schmidt S,Diessl N,Wolf S,Wiemann S,Brors B,Lawerenz C,Eils J,Warnatz HJ,Risch T,Yaspo ML,Weber UD,Bartholomae CC,von Kalle C,Turányi E,Hauser P,Sanden E,Darabi A,Siesjö P,Sterba J,Zitterbart K,Sumerauer D,van Sluis P,Versteeg R,Volckmann R,Koster J,Schuhmann MU,Ebinger M,Grimes HL,Robinson GW,Gajjar A,Mynarek M,von Hoff K,Rutkowski S,Pietsch T,Scheurlen W,Felsberg J,Reifenberger G,Kulozik AE,von Deimling A,Witt O,Eils R,Gilbertson RJ,Korshunov A,Taylor MD,Lichter P,Korbel JO,Wechsler-Reya RJ,Pfister SM
Research topic: Brain & Nerves
Thu Jul 24 00:00:00 EDT 2014
Identification of a face enhancer reveals direct regulation of LIM homeobox 8 (Lhx8) by wingless-int (WNT)/β-catenin signaling.
The Journal of biological chemistry
Landin Malt A,Cesario JM,Tang Z,Brown S,Jeong J
Research topic: Development
Fri Oct 31 00:00:00 EDT 2014
Locus-specific editing of histone modifications at endogenous enhancers.
Nature biotechnology
Mendenhall EM,Williamson KE,Reyon D,Zou JY,Ram O,Joung JK,Bernstein BE
Research topic: Chromatin Modification
Sun Dec 01 00:00:00 EST 2013
Role of histone acetylation in the stimulatory effect of valproic acid on vascular endothelial tissue-type plasminogen activator expression.
PloS one
Larsson P,Ulfhammer E,Magnusson M,Bergh N,Lunke S,El-Osta A,Medcalf RL,Svensson PA,Karlsson L,Jern S
Research topic: Cardiovascular
Fri Jun 29 00:00:00 EDT 2012
