Invitrogen

Huntingtin Polyclonal Antibody

Advanced Verification

This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.

View all (48) Huntingtin antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-17247

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunoprecipitation (IP)

1:50
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide surrounding Pro1220 of human huntingtin.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

14 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10984024

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

Huntingtin is a disease gene linked to Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. HD is a mid-life onset autosomal dominant neurodegenerative disease that is characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10-20 years.The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HD protein; HD protein homolog; Huntingtin; huntingtin (Huntington disease); Huntington disease gene homolog; Huntington disease protein; huntington disease protein homolog

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Gene Aliases: AI256365; C430023I11Rik; HD; Hdh; HTT; IT15

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UniProt ID: (Human) P42858

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Entrez Gene ID: (Human) 3064, (Rat) 29424, (Mouse) 15194

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Function(s)
p53 binding receptor binding protein binding profilin binding transcription factor binding dynactin binding identical protein binding ion channel binding dynein intermediate chain binding beta-tubulin binding diazepam binding
Process(es)
urea cycle citrulline metabolic process establishment of mitotic spindle orientation protein import into nucleus mitochondrial transport ER to Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to ER apoptotic process mitochondrion organization endoplasmic reticulum organization Golgi organization dopamine receptor signaling pathway spermatogenesis gastrulation central nervous system development brain development cell aging learning or memory learning grooming behavior locomotory behavior axo-dendritic transport associative learning determination of adult lifespan visual learning anatomical structure morphogenesis anterior/posterior pattern specification endosomal transport lactate biosynthetic process from pyruvate quinolinate biosynthetic process striatum development olfactory lobe development neural plate formation neurogenesis peptide hormone secretion insulin secretion positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity regulation of protein phosphatase type 2A activity social behavior hormone metabolic process negative regulation of apoptotic process negative regulation of neuron apoptotic process regulation of mitochondrial membrane permeability vesicle transport along microtubule regulation of synaptic plasticity paraxial mesoderm formation animal organ development neuron development mRNA transport neuron apoptotic process response to calcium ion regulation of mitochondrial membrane potential L-glutamate import iron ion homeostasis negative regulation of neuron death negative regulation of cysteine-type endopeptidase activity negative regulation of extrinsic apoptotic signaling pathway vocal learning positive regulation of cilium assembly embryo development
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